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Protein

Sulfate permease 2

Gene

SUL2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High affinity uptake of sulfate into the cell.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32242-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate permease 2
Alternative name(s):
High-affinity sulfate transporter 2
Gene namesi
Name:SUL2
Synonyms:SEL2
Ordered Locus Names:YLR092W
ORF Names:L9449.1
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR092W.
SGDiS000004082. SUL2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 131131CytoplasmicSequence analysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence analysisAdd
BLAST
Topological domaini153 – 16311ExtracellularSequence analysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Topological domaini185 – 1884CytoplasmicSequence analysis
Transmembranei189 – 20921HelicalSequence analysisAdd
BLAST
Topological domaini210 – 22112ExtracellularSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Topological domaini243 – 2442CytoplasmicSequence analysis
Transmembranei245 – 26521HelicalSequence analysisAdd
BLAST
Topological domaini266 – 30540ExtracellularSequence analysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence analysisAdd
BLAST
Topological domaini327 – 35024CytoplasmicSequence analysisAdd
BLAST
Transmembranei351 – 37121HelicalSequence analysisAdd
BLAST
Topological domaini372 – 39928ExtracellularSequence analysisAdd
BLAST
Transmembranei400 – 42021HelicalSequence analysisAdd
BLAST
Topological domaini421 – 44323CytoplasmicSequence analysisAdd
BLAST
Transmembranei444 – 46421HelicalSequence analysisAdd
BLAST
Topological domaini465 – 48319ExtracellularSequence analysisAdd
BLAST
Transmembranei484 – 50421HelicalSequence analysisAdd
BLAST
Topological domaini505 – 53228CytoplasmicSequence analysisAdd
BLAST
Transmembranei533 – 55119HelicalSequence analysisAdd
BLAST
Topological domaini552 – 5598ExtracellularSequence analysis
Transmembranei560 – 58021HelicalSequence analysisAdd
BLAST
Topological domaini581 – 893313CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 893893Sulfate permease 2PRO_0000080185Add
BLAST

Proteomic databases

TopDownProteomicsiQ12325.

Interactioni

Protein-protein interaction databases

BioGridi31365. 24 interactions.
DIPiDIP-5082N.
IntActiQ12325. 3 interactions.
MINTiMINT-575339.

Structurei

3D structure databases

ProteinModelPortaliQ12325.
SMRiQ12325. Positions 136-279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini676 – 854179STASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119026.
HOGENOMiHOG000210988.
InParanoidiQ12325.
KOiK14708.
OMAiNTRAATY.
OrthoDBiEOG7HXD07.

Family and domain databases

InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 3 hits.
PfamiPF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSREGYPNFE EVEIPDFQET NNTVPDLDDL ELEYDQYKNN ENNDTFNDKD
60 70 80 90 100
LESNSVAKHN AVNSSKGVKG SKIDYFNPSD VSLYDNSVSQ FEETTVSLKE
110 120 130 140 150
YYDHSIRSHL TVKGACSYLK SVFPIINWLP HYNFSWFTAD LIAGITIGCV
160 170 180 190 200
LVPQSMSYAQ VATLPAQYGL YSSFIGAYSY SFFATSKDVC IGPVAVMSLQ
210 220 230 240 250
TAKVIADVTA KYPDGDSAIT GPVIATTLAL LCGIISAAVG FLRLGFLVEL
260 270 280 290 300
ISLNAVAGFM TGSAFNILWG QVPALMGYNS LVNTRAATYK VVIETLKHLP
310 320 330 340 350
DTKLDAVFGL IPLFLLYVWK WWCGTYGPRL NDRYNSKNPR LHKIIKWTYF
360 370 380 390 400
YAQASRNGII IIVFTCIGWA ITRGKSKSER PISILGSVPS GLKEVGVFHV
410 420 430 440 450
PPGLMSKLGP NLPASIIVLL LEHIAISKSF GRINDYKVVP DQELIAIGVS
460 470 480 490 500
NLLGTFFNAY PATGSFSRSA LKAKCNVRTP LSGLFSGSCV LLALYCLTGA
510 520 530 540 550
FFYIPKATLS AVIIHAVSDL LASYQTTWNF WKMNPLDFIC FIVTVLITVF
560 570 580 590 600
ASIEDGIYFA MCWSCAMLIL KVAFPAGKFL GRVEVAEVTD AYVRPDSDVV
610 620 630 640 650
SYVSENNNGI STLEDGGEDD KESSTKYVTN SSKKIETNVQ TKGFDSPSSS
660 670 680 690 700
ISQPRIKYHT KWIPFDHKYT RELNPDVQIL PPPDGVLVYR LSESYTYLNC
710 720 730 740 750
SRHYNIITEE VKKVTRRGQL IRHRKKSDRP WNDPGPWEAP AFLKNLKFWK
760 770 780 790 800
KRENDPESME NAPSTSVDVE RDDRPLLKIL CLDFSQVAQT DATALQSLVD
810 820 830 840 850
LRKAINQYAD RQVEFHFVGI ISPWVKRGLI SRGFGTLNEE YSDESIVAGH
860 870 880 890
TSYHVARVPQ GEENPEKYSV YTASGTNLPF FHIDIPDFAK WDI
Length:893
Mass (Da):99,651
Last modified:November 1, 1996 - v1
Checksum:i67826955AC7C0BF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53880 Genomic DNA. Translation: AAB67596.1.
Z73264 Genomic DNA. Translation: CAA97653.1.
Z73265 Genomic DNA. Translation: CAA97655.1.
U53876 Genomic DNA. Translation: AAB67550.1.
BK006945 Genomic DNA. Translation: DAA09408.1.
PIRiS64926.
RefSeqiNP_013193.1. NM_001181979.1.

Genome annotation databases

EnsemblFungiiYLR092W; YLR092W; YLR092W.
GeneIDi850781.
KEGGisce:YLR092W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53880 Genomic DNA. Translation: AAB67596.1.
Z73264 Genomic DNA. Translation: CAA97653.1.
Z73265 Genomic DNA. Translation: CAA97655.1.
U53876 Genomic DNA. Translation: AAB67550.1.
BK006945 Genomic DNA. Translation: DAA09408.1.
PIRiS64926.
RefSeqiNP_013193.1. NM_001181979.1.

3D structure databases

ProteinModelPortaliQ12325.
SMRiQ12325. Positions 136-279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31365. 24 interactions.
DIPiDIP-5082N.
IntActiQ12325. 3 interactions.
MINTiMINT-575339.

Proteomic databases

TopDownProteomicsiQ12325.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR092W; YLR092W; YLR092W.
GeneIDi850781.
KEGGisce:YLR092W.

Organism-specific databases

EuPathDBiFungiDB:YLR092W.
SGDiS000004082. SUL2.

Phylogenomic databases

GeneTreeiENSGT00760000119026.
HOGENOMiHOG000210988.
InParanoidiQ12325.
KOiK14708.
OMAiNTRAATY.
OrthoDBiEOG7HXD07.

Enzyme and pathway databases

BioCyciYEAST:G3O-32242-MONOMER.

Miscellaneous databases

PROiQ12325.

Family and domain databases

InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 3 hits.
PfamiPF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Molecular characterization of two high affinity sulfate transporters in Saccharomyces cerevisiae."
    Cherest H., Davidian J.C., Thomas D., Benes V., Ansorge W., Surdin-Kerjan Y.
    Genetics 145:627-635(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiSUL2_YEAST
AccessioniPrimary (citable) accession number: Q12325
Secondary accession number(s): D6VY92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.