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Protein

Sulfate permease 2

Gene

SUL2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High affinity uptake of sulfate into the cell.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32242-MONOMER.
ReactomeiR-SCE-427601. Multifunctional anion exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate permease 2
Alternative name(s):
High-affinity sulfate transporter 2
Gene namesi
Name:SUL2
Synonyms:SEL2
Ordered Locus Names:YLR092W
ORF Names:L9449.1
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR092W.
SGDiS000004082. SUL2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 131CytoplasmicSequence analysisAdd BLAST131
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 163ExtracellularSequence analysisAdd BLAST11
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 188CytoplasmicSequence analysis4
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 221ExtracellularSequence analysisAdd BLAST12
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 244CytoplasmicSequence analysis2
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 305ExtracellularSequence analysisAdd BLAST40
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 350CytoplasmicSequence analysisAdd BLAST24
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Topological domaini372 – 399ExtracellularSequence analysisAdd BLAST28
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Topological domaini421 – 443CytoplasmicSequence analysisAdd BLAST23
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Topological domaini465 – 483ExtracellularSequence analysisAdd BLAST19
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 532CytoplasmicSequence analysisAdd BLAST28
Transmembranei533 – 551HelicalSequence analysisAdd BLAST19
Topological domaini552 – 559ExtracellularSequence analysis8
Transmembranei560 – 580HelicalSequence analysisAdd BLAST21
Topological domaini581 – 893CytoplasmicSequence analysisAdd BLAST313

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000801851 – 893Sulfate permease 2Add BLAST893

Proteomic databases

PRIDEiQ12325.
TopDownProteomicsiQ12325.

Interactioni

Protein-protein interaction databases

BioGridi31365. 24 interactors.
DIPiDIP-5082N.
IntActiQ12325. 3 interactors.
MINTiMINT-575339.

Structurei

3D structure databases

ProteinModelPortaliQ12325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini676 – 854STASPROSITE-ProRule annotationAdd BLAST179

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00850000132388.
HOGENOMiHOG000210988.
InParanoidiQ12325.
KOiK14708.
OMAiPLAGCIT.
OrthoDBiEOG092C0HLP.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 3 hits.
PfamiPF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSREGYPNFE EVEIPDFQET NNTVPDLDDL ELEYDQYKNN ENNDTFNDKD
60 70 80 90 100
LESNSVAKHN AVNSSKGVKG SKIDYFNPSD VSLYDNSVSQ FEETTVSLKE
110 120 130 140 150
YYDHSIRSHL TVKGACSYLK SVFPIINWLP HYNFSWFTAD LIAGITIGCV
160 170 180 190 200
LVPQSMSYAQ VATLPAQYGL YSSFIGAYSY SFFATSKDVC IGPVAVMSLQ
210 220 230 240 250
TAKVIADVTA KYPDGDSAIT GPVIATTLAL LCGIISAAVG FLRLGFLVEL
260 270 280 290 300
ISLNAVAGFM TGSAFNILWG QVPALMGYNS LVNTRAATYK VVIETLKHLP
310 320 330 340 350
DTKLDAVFGL IPLFLLYVWK WWCGTYGPRL NDRYNSKNPR LHKIIKWTYF
360 370 380 390 400
YAQASRNGII IIVFTCIGWA ITRGKSKSER PISILGSVPS GLKEVGVFHV
410 420 430 440 450
PPGLMSKLGP NLPASIIVLL LEHIAISKSF GRINDYKVVP DQELIAIGVS
460 470 480 490 500
NLLGTFFNAY PATGSFSRSA LKAKCNVRTP LSGLFSGSCV LLALYCLTGA
510 520 530 540 550
FFYIPKATLS AVIIHAVSDL LASYQTTWNF WKMNPLDFIC FIVTVLITVF
560 570 580 590 600
ASIEDGIYFA MCWSCAMLIL KVAFPAGKFL GRVEVAEVTD AYVRPDSDVV
610 620 630 640 650
SYVSENNNGI STLEDGGEDD KESSTKYVTN SSKKIETNVQ TKGFDSPSSS
660 670 680 690 700
ISQPRIKYHT KWIPFDHKYT RELNPDVQIL PPPDGVLVYR LSESYTYLNC
710 720 730 740 750
SRHYNIITEE VKKVTRRGQL IRHRKKSDRP WNDPGPWEAP AFLKNLKFWK
760 770 780 790 800
KRENDPESME NAPSTSVDVE RDDRPLLKIL CLDFSQVAQT DATALQSLVD
810 820 830 840 850
LRKAINQYAD RQVEFHFVGI ISPWVKRGLI SRGFGTLNEE YSDESIVAGH
860 870 880 890
TSYHVARVPQ GEENPEKYSV YTASGTNLPF FHIDIPDFAK WDI
Length:893
Mass (Da):99,651
Last modified:November 1, 1996 - v1
Checksum:i67826955AC7C0BF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53880 Genomic DNA. Translation: AAB67596.1.
Z73264 Genomic DNA. Translation: CAA97653.1.
Z73265 Genomic DNA. Translation: CAA97655.1.
U53876 Genomic DNA. Translation: AAB67550.1.
BK006945 Genomic DNA. Translation: DAA09408.1.
PIRiS64926.
RefSeqiNP_013193.1. NM_001181979.1.

Genome annotation databases

EnsemblFungiiYLR092W; YLR092W; YLR092W.
GeneIDi850781.
KEGGisce:YLR092W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53880 Genomic DNA. Translation: AAB67596.1.
Z73264 Genomic DNA. Translation: CAA97653.1.
Z73265 Genomic DNA. Translation: CAA97655.1.
U53876 Genomic DNA. Translation: AAB67550.1.
BK006945 Genomic DNA. Translation: DAA09408.1.
PIRiS64926.
RefSeqiNP_013193.1. NM_001181979.1.

3D structure databases

ProteinModelPortaliQ12325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31365. 24 interactors.
DIPiDIP-5082N.
IntActiQ12325. 3 interactors.
MINTiMINT-575339.

Proteomic databases

PRIDEiQ12325.
TopDownProteomicsiQ12325.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR092W; YLR092W; YLR092W.
GeneIDi850781.
KEGGisce:YLR092W.

Organism-specific databases

EuPathDBiFungiDB:YLR092W.
SGDiS000004082. SUL2.

Phylogenomic databases

GeneTreeiENSGT00850000132388.
HOGENOMiHOG000210988.
InParanoidiQ12325.
KOiK14708.
OMAiPLAGCIT.
OrthoDBiEOG092C0HLP.

Enzyme and pathway databases

BioCyciYEAST:G3O-32242-MONOMER.
ReactomeiR-SCE-427601. Multifunctional anion exchangers.

Miscellaneous databases

PROiQ12325.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 3 hits.
PfamiPF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUL2_YEAST
AccessioniPrimary (citable) accession number: Q12325
Secondary accession number(s): D6VY92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.