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Q12324

- YVC1_YEAST

UniProt

Q12324 - YVC1_YEAST

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Protein

Calcium channel YVC1

Gene

YVC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for release of calcium ions from the vacuole in response to hyperosmotic shock.2 Publications

GO - Molecular functioni

  1. calcium activated cation channel activity Source: SGD
  2. calcium channel activity Source: SGD
  3. potassium channel activity Source: SGD
  4. sodium channel activity Source: SGD
  5. voltage-gated ion channel activity Source: SGD

GO - Biological processi

  1. cellular cation homeostasis Source: SGD
  2. potassium ion transmembrane transport Source: GOC
  3. regulation of ion transmembrane transport Source: GOC
  4. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciYEAST:G3O-33622-MONOMER.

Protein family/group databases

TCDBi1.A.4.4.1. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium channel YVC1
Alternative name(s):
TRP homolog
Yeast vacuolar conductance protein 1
Gene namesi
Name:YVC1Imported
Ordered Locus Names:YOR087W
ORF Names:YOR088W, YOR3151W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR087w.
SGDiS000005613. YVC1.

Subcellular locationi

Vacuole membrane 2 Publications; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 236236CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence AnalysisAdd
BLAST
Topological domaini258 – 29538VacuolarSequence AnalysisAdd
BLAST
Transmembranei296 – 31621HelicalSequence AnalysisAdd
BLAST
Topological domaini317 – 33519CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei336 – 35520HelicalSequence AnalysisAdd
BLAST
Topological domaini356 – 37621VacuolarSequence AnalysisAdd
BLAST
Transmembranei377 – 39721HelicalSequence AnalysisAdd
BLAST
Topological domaini398 – 4058CytoplasmicSequence Analysis
Transmembranei406 – 42621HelicalSequence AnalysisAdd
BLAST
Topological domaini427 – 43610VacuolarSequence Analysis
Transmembranei437 – 45721HelicalSequence AnalysisAdd
BLAST
Topological domaini458 – 675218CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. fungal-type vacuole Source: SGD
  2. fungal-type vacuole membrane Source: SGD
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 675675Calcium channel YVC1PRO_0000215376Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei636 – 6361Phosphothreonine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12324.
PaxDbiQ12324.
PeptideAtlasiQ12324.
PRIDEiQ12324.

Expressioni

Gene expression databases

GenevestigatoriQ12324.

Interactioni

Protein-protein interaction databases

BioGridi34486. 33 interactions.
DIPiDIP-2782N.
DIP-4157N.
IntActiQ12324. 2 interactions.
MINTiMINT-489917.

Structurei

3D structure databases

ProteinModelPortaliQ12324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi573 – 5764Poly-AspSequence Analysis

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG68558.
HOGENOMiHOG000199455.
InParanoidiQ12324.
OMAiRATACEV.
OrthoDBiEOG7R8397.

Sequencei

Sequence statusi: Complete.

Q12324-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSANGDLHL PISNEQCMPE NNGSLGFEAP TPRQILRVTL NLKYLIDKVV
60 70 80 90 100
PIVYDPNDIV CDHSEILSPK VVKLAYEACG GNPKDKANKR KYQSVIIFSL
110 120 130 140 150
LKVCEWYSIL ATMEVHNAKL YETRNLASQQ LCKLLIEREE TRDLQFLFMQ
160 170 180 190 200
LLLRRYVINE NDEDQEPLNA LELATDMHCT TVIGSSGFQR CLKWIWRGWI
210 220 230 240 250
VQNGLDPTTF IKDDSLAEVS LISHFNPVRL KAPVYQNYLQ MIFSFLFLGL
260 270 280 290 300
YTLVVNGKDS ERVQSFDLLE SIFYVFNTGF ILDELTKLYY IGYAHLSFWN
310 320 330 340 350
LFNDTTYLII TFAMGFRAMS VTPLNAKYSS EDWDKISYRV LSCAAPFVWS
360 370 380 390 400
RLLLYLESQR FIGIMLVILK HMMKESIVFF FLLFLIMIGF TQGFLGLDSA
410 420 430 440 450
DGKRDITGPI LGNLTITVLG LGSFDVFEEF APPYAAILYY GYYFIVSVIL
460 470 480 490 500
LNILIALYST AYQKVIDNAD DEYMALMSQK TLRYIRAPDE DVYVSPLNLI
510 520 530 540 550
EVFMTPIFRI LPPKRAKDLS YTVMTIVYSP FLLLISVKET REARRIKYNR
560 570 580 590 600
MKRLNDDANE YDTPWDLTDG YLDDDDGLFS DNRNSGMRAT QLKNSRSLKL
610 620 630 640 650
QRTAEQEDVH FKVPKKWYKN VKKCSPSFEQ YDNDDTEDDA GEDKDEVKEL
660 670
TKKVENLTAV ITDLLEKLDI KDKKE
Length:675
Mass (Da):77,953
Last modified:January 24, 2006 - v2
Checksum:iC8CE3B092A717306
GO

Sequence cautioni

The sequence CAA64009.1 differs from that shown. Reason: Frameshift at position 245. Curated
The sequence CAA99282.1 differs from that shown. Reason: Frameshift at position 245. Curated
The sequence CAA99283.1 differs from that shown. Reason: Frameshift at position 245. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA. Translation: CAA64009.1. Frameshift.
Z74995 Genomic DNA. Translation: CAA99282.1. Frameshift.
Z74995 Genomic DNA. Translation: CAA99283.1. Frameshift.
Z74997 Genomic DNA. Translation: CAA99286.1.
BK006948 Genomic DNA. Translation: DAA10865.1.
PIRiS61648.
S66972.
RefSeqiNP_014730.2. NM_001183506.1.

Genome annotation databases

EnsemblFungiiYOR087W; YOR087W; YOR087W.
GeneIDi854255.
KEGGisce:YOR087W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA. Translation: CAA64009.1 . Frameshift.
Z74995 Genomic DNA. Translation: CAA99282.1 . Frameshift.
Z74995 Genomic DNA. Translation: CAA99283.1 . Frameshift.
Z74997 Genomic DNA. Translation: CAA99286.1 .
BK006948 Genomic DNA. Translation: DAA10865.1 .
PIRi S61648.
S66972.
RefSeqi NP_014730.2. NM_001183506.1.

3D structure databases

ProteinModelPortali Q12324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34486. 33 interactions.
DIPi DIP-2782N.
DIP-4157N.
IntActi Q12324. 2 interactions.
MINTi MINT-489917.

Protein family/group databases

TCDBi 1.A.4.4.1. the transient receptor potential ca(2+) channel (trp-cc) family.

Proteomic databases

MaxQBi Q12324.
PaxDbi Q12324.
PeptideAtlasi Q12324.
PRIDEi Q12324.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR087W ; YOR087W ; YOR087W .
GeneIDi 854255.
KEGGi sce:YOR087W.

Organism-specific databases

CYGDi YOR087w.
SGDi S000005613. YVC1.

Phylogenomic databases

eggNOGi NOG68558.
HOGENOMi HOG000199455.
InParanoidi Q12324.
OMAi RATACEV.
OrthoDBi EOG7R8397.

Enzyme and pathway databases

BioCyci YEAST:G3O-33622-MONOMER.

Miscellaneous databases

NextBioi 976179.

Gene expression databases

Genevestigatori Q12324.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A TRP homolog in Saccharomyces cerevisiae forms an intracellular Ca(2+)-permeable channel in the yeast vacuolar membrane."
    Palmer C.P., Zhou X.-L., Lin J., Loukin S.H., Kung C., Saimi Y.
    Proc. Natl. Acad. Sci. U.S.A. 98:7801-7805(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, IDENTIFICATION OF FRAMESHIFT.
    Strain: ATCC 201389 / BY4742.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Internal Ca(2+) release in yeast is triggered by hypertonic shock and mediated by a TRP channel homologue."
    Denis V., Cyert M.S.
    J. Cell Biol. 156:29-34(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF FRAMESHIFT.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-636, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-636, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYVC1_YEAST
AccessioniPrimary (citable) accession number: Q12324
Secondary accession number(s): D6W2E9, Q08500, Q7LGN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1310 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3