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Q12324

- YVC1_YEAST

UniProt

Q12324 - YVC1_YEAST

Protein

Calcium channel YVC1

Gene

YVC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Required for release of calcium ions from the vacuole in response to hyperosmotic shock.2 Publications

    GO - Molecular functioni

    1. calcium activated cation channel activity Source: SGD
    2. calcium channel activity Source: SGD
    3. potassium channel activity Source: SGD
    4. sodium channel activity Source: SGD
    5. voltage-gated ion channel activity Source: SGD

    GO - Biological processi

    1. cellular cation homeostasis Source: SGD
    2. potassium ion transmembrane transport Source: GOC
    3. regulation of ion transmembrane transport Source: GOC
    4. sodium ion transmembrane transport Source: GOC

    Keywords - Molecular functioni

    Calcium channel, Ion channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33622-MONOMER.

    Protein family/group databases

    TCDBi1.A.4.4.1. the transient receptor potential ca(2+) channel (trp-cc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium channel YVC1
    Alternative name(s):
    TRP homolog
    Yeast vacuolar conductance protein 1
    Gene namesi
    Name:YVC1Imported
    Ordered Locus Names:YOR087W
    ORF Names:YOR088W, YOR3151W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOR087w.
    SGDiS000005613. YVC1.

    Subcellular locationi

    Vacuole membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. fungal-type vacuole Source: SGD
    2. fungal-type vacuole membrane Source: SGD
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 675675Calcium channel YVC1PRO_0000215376Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei636 – 6361Phosphothreonine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ12324.
    PaxDbiQ12324.
    PeptideAtlasiQ12324.
    PRIDEiQ12324.

    Expressioni

    Gene expression databases

    GenevestigatoriQ12324.

    Interactioni

    Protein-protein interaction databases

    BioGridi34486. 32 interactions.
    DIPiDIP-2782N.
    DIP-4157N.
    IntActiQ12324. 2 interactions.
    MINTiMINT-489917.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12324.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 236236CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 29538VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini317 – 33519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini356 – 37621VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini398 – 4058CytoplasmicSequence Analysis
    Topological domaini427 – 43610VacuolarSequence Analysis
    Topological domaini458 – 675218CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei237 – 25721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei296 – 31621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei336 – 35520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei377 – 39721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei406 – 42621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei437 – 45721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi573 – 5764Poly-AspSequence Analysis

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG68558.
    HOGENOMiHOG000199455.
    OMAiRATACEV.
    OrthoDBiEOG7R8397.

    Sequencei

    Sequence statusi: Complete.

    Q12324-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSANGDLHL PISNEQCMPE NNGSLGFEAP TPRQILRVTL NLKYLIDKVV    50
    PIVYDPNDIV CDHSEILSPK VVKLAYEACG GNPKDKANKR KYQSVIIFSL 100
    LKVCEWYSIL ATMEVHNAKL YETRNLASQQ LCKLLIEREE TRDLQFLFMQ 150
    LLLRRYVINE NDEDQEPLNA LELATDMHCT TVIGSSGFQR CLKWIWRGWI 200
    VQNGLDPTTF IKDDSLAEVS LISHFNPVRL KAPVYQNYLQ MIFSFLFLGL 250
    YTLVVNGKDS ERVQSFDLLE SIFYVFNTGF ILDELTKLYY IGYAHLSFWN 300
    LFNDTTYLII TFAMGFRAMS VTPLNAKYSS EDWDKISYRV LSCAAPFVWS 350
    RLLLYLESQR FIGIMLVILK HMMKESIVFF FLLFLIMIGF TQGFLGLDSA 400
    DGKRDITGPI LGNLTITVLG LGSFDVFEEF APPYAAILYY GYYFIVSVIL 450
    LNILIALYST AYQKVIDNAD DEYMALMSQK TLRYIRAPDE DVYVSPLNLI 500
    EVFMTPIFRI LPPKRAKDLS YTVMTIVYSP FLLLISVKET REARRIKYNR 550
    MKRLNDDANE YDTPWDLTDG YLDDDDGLFS DNRNSGMRAT QLKNSRSLKL 600
    QRTAEQEDVH FKVPKKWYKN VKKCSPSFEQ YDNDDTEDDA GEDKDEVKEL 650
    TKKVENLTAV ITDLLEKLDI KDKKE 675
    Length:675
    Mass (Da):77,953
    Last modified:January 24, 2006 - v2
    Checksum:iC8CE3B092A717306
    GO

    Sequence cautioni

    The sequence CAA64009.1 differs from that shown. Reason: Frameshift at position 245.
    The sequence CAA99282.1 differs from that shown. Reason: Frameshift at position 245.
    The sequence CAA99283.1 differs from that shown. Reason: Frameshift at position 245.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94335 Genomic DNA. Translation: CAA64009.1. Frameshift.
    Z74995 Genomic DNA. Translation: CAA99282.1. Frameshift.
    Z74995 Genomic DNA. Translation: CAA99283.1. Frameshift.
    Z74997 Genomic DNA. Translation: CAA99286.1.
    BK006948 Genomic DNA. Translation: DAA10865.1.
    PIRiS61648.
    S66972.
    RefSeqiNP_014730.2. NM_001183506.1.

    Genome annotation databases

    EnsemblFungiiYOR087W; YOR087W; YOR087W.
    GeneIDi854255.
    KEGGisce:YOR087W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94335 Genomic DNA. Translation: CAA64009.1 . Frameshift.
    Z74995 Genomic DNA. Translation: CAA99282.1 . Frameshift.
    Z74995 Genomic DNA. Translation: CAA99283.1 . Frameshift.
    Z74997 Genomic DNA. Translation: CAA99286.1 .
    BK006948 Genomic DNA. Translation: DAA10865.1 .
    PIRi S61648.
    S66972.
    RefSeqi NP_014730.2. NM_001183506.1.

    3D structure databases

    ProteinModelPortali Q12324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34486. 32 interactions.
    DIPi DIP-2782N.
    DIP-4157N.
    IntActi Q12324. 2 interactions.
    MINTi MINT-489917.

    Protein family/group databases

    TCDBi 1.A.4.4.1. the transient receptor potential ca(2+) channel (trp-cc) family.

    Proteomic databases

    MaxQBi Q12324.
    PaxDbi Q12324.
    PeptideAtlasi Q12324.
    PRIDEi Q12324.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOR087W ; YOR087W ; YOR087W .
    GeneIDi 854255.
    KEGGi sce:YOR087W.

    Organism-specific databases

    CYGDi YOR087w.
    SGDi S000005613. YVC1.

    Phylogenomic databases

    eggNOGi NOG68558.
    HOGENOMi HOG000199455.
    OMAi RATACEV.
    OrthoDBi EOG7R8397.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33622-MONOMER.

    Miscellaneous databases

    NextBioi 976179.

    Gene expression databases

    Genevestigatori Q12324.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "A TRP homolog in Saccharomyces cerevisiae forms an intracellular Ca(2+)-permeable channel in the yeast vacuolar membrane."
      Palmer C.P., Zhou X.-L., Lin J., Loukin S.H., Kung C., Saimi Y.
      Proc. Natl. Acad. Sci. U.S.A. 98:7801-7805(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, IDENTIFICATION OF FRAMESHIFT.
      Strain: ATCC 201389 / BY4742.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "Internal Ca(2+) release in yeast is triggered by hypertonic shock and mediated by a TRP channel homologue."
      Denis V., Cyert M.S.
      J. Cell Biol. 156:29-34(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
      Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
      Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF FRAMESHIFT.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-636, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-636, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYVC1_YEAST
    AccessioniPrimary (citable) accession number: Q12324
    Secondary accession number(s): D6W2E9, Q08500, Q7LGN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1310 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3