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Protein

Calcium channel YVC1

Gene

YVC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for release of calcium ions from the vacuole in response to hyperosmotic shock.2 Publications

Miscellaneous

Present with 1310 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • calcium activated cation channel activity Source: SGD
  • calcium channel activity Source: SGD
  • potassium channel activity Source: SGD
  • sodium channel activity Source: SGD
  • voltage-gated ion channel activity Source: SGD

GO - Biological processi

  • calcium ion transmembrane import into cytosol Source: SGD
  • cellular cation homeostasis Source: SGD

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

BioCyciYEAST:G3O-33622-MONOMER

Protein family/group databases

TCDBi1.A.4.4.1 the transient receptor potential ca(2+) channel (trp-cc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium channel YVC1
Alternative name(s):
TRP homolog
Yeast vacuolar conductance protein 1
Gene namesi
Name:YVC1Imported
Ordered Locus Names:YOR087W
ORF Names:YOR088W, YOR3151W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR087W
SGDiS000005613 YVC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 236CytoplasmicSequence analysisAdd BLAST236
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 295VacuolarSequence analysisAdd BLAST38
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 335CytoplasmicSequence analysisAdd BLAST19
Transmembranei336 – 355HelicalSequence analysisAdd BLAST20
Topological domaini356 – 376VacuolarSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 405CytoplasmicSequence analysis8
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 436VacuolarSequence analysis10
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Topological domaini458 – 675CytoplasmicSequence analysisAdd BLAST218

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153761 – 675Calcium channel YVC1Add BLAST675

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei636PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12324
PaxDbiQ12324
PRIDEiQ12324

PTM databases

iPTMnetiQ12324

Interactioni

Protein-protein interaction databases

BioGridi34486, 137 interactors
DIPiDIP-4157N
IntActiQ12324, 2 interactors
MINTiQ12324
STRINGi4932.YOR087W

Structurei

3D structure databases

ProteinModelPortaliQ12324
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi573 – 576Poly-AspSequence analysis4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000199455
InParanoidiQ12324
OMAiRATACEV
OrthoDBiEOG092C1F4Q

Family and domain databases

InterProiView protein in InterPro
IPR024862 TRPV
PANTHERiPTHR10582 PTHR10582, 1 hit

Sequencei

Sequence statusi: Complete.

Q12324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSANGDLHL PISNEQCMPE NNGSLGFEAP TPRQILRVTL NLKYLIDKVV
60 70 80 90 100
PIVYDPNDIV CDHSEILSPK VVKLAYEACG GNPKDKANKR KYQSVIIFSL
110 120 130 140 150
LKVCEWYSIL ATMEVHNAKL YETRNLASQQ LCKLLIEREE TRDLQFLFMQ
160 170 180 190 200
LLLRRYVINE NDEDQEPLNA LELATDMHCT TVIGSSGFQR CLKWIWRGWI
210 220 230 240 250
VQNGLDPTTF IKDDSLAEVS LISHFNPVRL KAPVYQNYLQ MIFSFLFLGL
260 270 280 290 300
YTLVVNGKDS ERVQSFDLLE SIFYVFNTGF ILDELTKLYY IGYAHLSFWN
310 320 330 340 350
LFNDTTYLII TFAMGFRAMS VTPLNAKYSS EDWDKISYRV LSCAAPFVWS
360 370 380 390 400
RLLLYLESQR FIGIMLVILK HMMKESIVFF FLLFLIMIGF TQGFLGLDSA
410 420 430 440 450
DGKRDITGPI LGNLTITVLG LGSFDVFEEF APPYAAILYY GYYFIVSVIL
460 470 480 490 500
LNILIALYST AYQKVIDNAD DEYMALMSQK TLRYIRAPDE DVYVSPLNLI
510 520 530 540 550
EVFMTPIFRI LPPKRAKDLS YTVMTIVYSP FLLLISVKET REARRIKYNR
560 570 580 590 600
MKRLNDDANE YDTPWDLTDG YLDDDDGLFS DNRNSGMRAT QLKNSRSLKL
610 620 630 640 650
QRTAEQEDVH FKVPKKWYKN VKKCSPSFEQ YDNDDTEDDA GEDKDEVKEL
660 670
TKKVENLTAV ITDLLEKLDI KDKKE
Length:675
Mass (Da):77,953
Last modified:January 24, 2006 - v2
Checksum:iC8CE3B092A717306
GO

Sequence cautioni

The sequence CAA64009 differs from that shown. Reason: Frameshift at position 245.Curated
The sequence CAA99282 differs from that shown. Reason: Frameshift at position 245.Curated
The sequence CAA99283 differs from that shown. Reason: Frameshift at position 245.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA Translation: CAA64009.1 Frameshift.
Z74995 Genomic DNA Translation: CAA99282.1 Frameshift.
Z74995 Genomic DNA Translation: CAA99283.1 Frameshift.
Z74997 Genomic DNA Translation: CAA99286.1
BK006948 Genomic DNA Translation: DAA10865.1
PIRiS61648
S66972
RefSeqiNP_014730.2, NM_001183506.1

Genome annotation databases

EnsemblFungiiYOR087W; YOR087W; YOR087W
GeneIDi854255
KEGGisce:YOR087W

Similar proteinsi

Entry informationi

Entry nameiYVC1_YEAST
AccessioniPrimary (citable) accession number: Q12324
Secondary accession number(s): D6W2E9, Q08500, Q7LGN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

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