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Q12324 (YVC1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcium channel YVC1
Alternative name(s):
TRP homolog
Yeast vacuolar conductance protein 1
Gene names
Name:YVC1
Ordered Locus Names:YOR087W
ORF Names:YOR088W, YOR3151W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length675 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for release of calcium ions from the vacuole in response to hyperosmotic shock. Ref.1 Ref.5

Subcellular location

Vacuole membrane; Multi-pass membrane protein Ref.1 Ref.5.

Miscellaneous

Present with 1310 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the transient receptor (TC 1.A.4) family. [View classification]

Sequence caution

The sequence CAA64009.1 differs from that shown. Reason: Frameshift at position 245.

The sequence CAA99282.1 differs from that shown. Reason: Frameshift at position 245.

The sequence CAA99283.1 differs from that shown. Reason: Frameshift at position 245.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 675675Calcium channel YVC1
PRO_0000215376

Regions

Topological domain1 – 236236Cytoplasmic Potential
Transmembrane237 – 25721Helical; Potential
Topological domain258 – 29538Vacuolar Potential
Transmembrane296 – 31621Helical; Potential
Topological domain317 – 33519Cytoplasmic Potential
Transmembrane336 – 35520Helical; Potential
Topological domain356 – 37621Vacuolar Potential
Transmembrane377 – 39721Helical; Potential
Topological domain398 – 4058Cytoplasmic Potential
Transmembrane406 – 42621Helical; Potential
Topological domain427 – 43610Vacuolar Potential
Transmembrane437 – 45721Helical; Potential
Topological domain458 – 675218Cytoplasmic Potential
Compositional bias573 – 5764Poly-Asp

Amino acid modifications

Modified residue6361Phosphothreonine Ref.9 Ref.10

Sequences

Sequence LengthMass (Da)Tools
Q12324 [UniParc].

Last modified January 24, 2006. Version 2.
Checksum: C8CE3B092A717306

FASTA67577,953
        10         20         30         40         50         60 
MVSANGDLHL PISNEQCMPE NNGSLGFEAP TPRQILRVTL NLKYLIDKVV PIVYDPNDIV 

        70         80         90        100        110        120 
CDHSEILSPK VVKLAYEACG GNPKDKANKR KYQSVIIFSL LKVCEWYSIL ATMEVHNAKL 

       130        140        150        160        170        180 
YETRNLASQQ LCKLLIEREE TRDLQFLFMQ LLLRRYVINE NDEDQEPLNA LELATDMHCT 

       190        200        210        220        230        240 
TVIGSSGFQR CLKWIWRGWI VQNGLDPTTF IKDDSLAEVS LISHFNPVRL KAPVYQNYLQ 

       250        260        270        280        290        300 
MIFSFLFLGL YTLVVNGKDS ERVQSFDLLE SIFYVFNTGF ILDELTKLYY IGYAHLSFWN 

       310        320        330        340        350        360 
LFNDTTYLII TFAMGFRAMS VTPLNAKYSS EDWDKISYRV LSCAAPFVWS RLLLYLESQR 

       370        380        390        400        410        420 
FIGIMLVILK HMMKESIVFF FLLFLIMIGF TQGFLGLDSA DGKRDITGPI LGNLTITVLG 

       430        440        450        460        470        480 
LGSFDVFEEF APPYAAILYY GYYFIVSVIL LNILIALYST AYQKVIDNAD DEYMALMSQK 

       490        500        510        520        530        540 
TLRYIRAPDE DVYVSPLNLI EVFMTPIFRI LPPKRAKDLS YTVMTIVYSP FLLLISVKET 

       550        560        570        580        590        600 
REARRIKYNR MKRLNDDANE YDTPWDLTDG YLDDDDGLFS DNRNSGMRAT QLKNSRSLKL 

       610        620        630        640        650        660 
QRTAEQEDVH FKVPKKWYKN VKKCSPSFEQ YDNDDTEDDA GEDKDEVKEL TKKVENLTAV 

       670 
ITDLLEKLDI KDKKE 

« Hide

References

« Hide 'large scale' references
[1]"A TRP homolog in Saccharomyces cerevisiae forms an intracellular Ca(2+)-permeable channel in the yeast vacuolar membrane."
Palmer C.P., Zhou X.-L., Lin J., Loukin S.H., Kung C., Saimi Y.
Proc. Natl. Acad. Sci. U.S.A. 98:7801-7805(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, IDENTIFICATION OF FRAMESHIFT.
Strain: ATCC 201389 / BY4742.
[2]"DNA sequencing and analysis of 130 kb from yeast chromosome XV."
Voss H., Benes V., Andrade M.A., Valencia A., Rechmann S., Teodoru C., Schwager C., Paces V., Sander C., Ansorge W.
Yeast 13:655-672(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. expand/collapse author list , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Internal Ca(2+) release in yeast is triggered by hypertonic shock and mediated by a TRP channel homologue."
Denis V., Cyert M.S.
J. Cell Biol. 156:29-34(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]"Sequencing and comparison of yeast species to identify genes and regulatory elements."
Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF FRAMESHIFT.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[9]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-636, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-636, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X94335 Genomic DNA. Translation: CAA64009.1. Frameshift.
Z74995 Genomic DNA. Translation: CAA99282.1. Frameshift.
Z74995 Genomic DNA. Translation: CAA99283.1. Frameshift.
Z74997 Genomic DNA. Translation: CAA99286.1.
BK006948 Genomic DNA. Translation: DAA10865.1.
PIRS61648.
S66972.
RefSeqNP_014730.2. NM_001183506.1.

3D structure databases

ProteinModelPortalQ12324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34486. 32 interactions.
DIPDIP-2782N.
DIP-4157N.
IntActQ12324. 2 interactions.
MINTMINT-489917.

Protein family/group databases

TCDB1.A.4.4.1. the transient receptor potential ca(2+) channel (trp-cc) family.

Proteomic databases

PaxDbQ12324.
PeptideAtlasQ12324.
PRIDEQ12324.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYOR087W; YOR087W; YOR087W.
GeneID854255.
KEGGsce:YOR087W.

Organism-specific databases

CYGDYOR087w.
SGDS000005613. YVC1.

Phylogenomic databases

eggNOGNOG68558.
HOGENOMHOG000199455.
OMARATACEV.
OrthoDBEOG7R8397.

Enzyme and pathway databases

BioCycYEAST:G3O-33622-MONOMER.

Gene expression databases

GenevestigatorQ12324.

Family and domain databases

ProtoNetSearch...

Other

NextBio976179.

Entry information

Entry nameYVC1_YEAST
AccessionPrimary (citable) accession number: Q12324
Secondary accession number(s): D6W2E9, Q08500, Q7LGN3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XV

Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families