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Protein

Calcium channel YVC1

Gene

YVC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for release of calcium ions from the vacuole in response to hyperosmotic shock.2 Publications

GO - Molecular functioni

  • calcium activated cation channel activity Source: SGD
  • calcium channel activity Source: SGD
  • potassium channel activity Source: SGD
  • sodium channel activity Source: SGD
  • voltage-gated ion channel activity Source: SGD

GO - Biological processi

  • cellular cation homeostasis Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciYEAST:G3O-33622-MONOMER.

Protein family/group databases

TCDBi1.A.4.4.1. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium channel YVC1
Alternative name(s):
TRP homolog
Yeast vacuolar conductance protein 1
Gene namesi
Name:YVC1Imported
Ordered Locus Names:YOR087W
ORF Names:YOR088W, YOR3151W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR087W.
SGDiS000005613. YVC1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 236CytoplasmicSequence analysisAdd BLAST236
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 295VacuolarSequence analysisAdd BLAST38
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 335CytoplasmicSequence analysisAdd BLAST19
Transmembranei336 – 355HelicalSequence analysisAdd BLAST20
Topological domaini356 – 376VacuolarSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 405CytoplasmicSequence analysis8
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 436VacuolarSequence analysis10
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Topological domaini458 – 675CytoplasmicSequence analysisAdd BLAST218

GO - Cellular componenti

  • fungal-type vacuole Source: SGD
  • fungal-type vacuole membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
  • vacuole-mitochondrion membrane contact site Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153761 – 675Calcium channel YVC1Add BLAST675

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei636PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12324.
PRIDEiQ12324.

PTM databases

iPTMnetiQ12324.

Interactioni

Protein-protein interaction databases

BioGridi34486. 33 interactors.
DIPiDIP-2782N.
DIP-4157N.
IntActiQ12324. 2 interactors.
MINTiMINT-489917.

Structurei

3D structure databases

ProteinModelPortaliQ12324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi573 – 576Poly-AspSequence analysis4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000199455.
InParanoidiQ12324.
OMAiMMKESII.
OrthoDBiEOG092C1F4Q.

Sequencei

Sequence statusi: Complete.

Q12324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSANGDLHL PISNEQCMPE NNGSLGFEAP TPRQILRVTL NLKYLIDKVV
60 70 80 90 100
PIVYDPNDIV CDHSEILSPK VVKLAYEACG GNPKDKANKR KYQSVIIFSL
110 120 130 140 150
LKVCEWYSIL ATMEVHNAKL YETRNLASQQ LCKLLIEREE TRDLQFLFMQ
160 170 180 190 200
LLLRRYVINE NDEDQEPLNA LELATDMHCT TVIGSSGFQR CLKWIWRGWI
210 220 230 240 250
VQNGLDPTTF IKDDSLAEVS LISHFNPVRL KAPVYQNYLQ MIFSFLFLGL
260 270 280 290 300
YTLVVNGKDS ERVQSFDLLE SIFYVFNTGF ILDELTKLYY IGYAHLSFWN
310 320 330 340 350
LFNDTTYLII TFAMGFRAMS VTPLNAKYSS EDWDKISYRV LSCAAPFVWS
360 370 380 390 400
RLLLYLESQR FIGIMLVILK HMMKESIVFF FLLFLIMIGF TQGFLGLDSA
410 420 430 440 450
DGKRDITGPI LGNLTITVLG LGSFDVFEEF APPYAAILYY GYYFIVSVIL
460 470 480 490 500
LNILIALYST AYQKVIDNAD DEYMALMSQK TLRYIRAPDE DVYVSPLNLI
510 520 530 540 550
EVFMTPIFRI LPPKRAKDLS YTVMTIVYSP FLLLISVKET REARRIKYNR
560 570 580 590 600
MKRLNDDANE YDTPWDLTDG YLDDDDGLFS DNRNSGMRAT QLKNSRSLKL
610 620 630 640 650
QRTAEQEDVH FKVPKKWYKN VKKCSPSFEQ YDNDDTEDDA GEDKDEVKEL
660 670
TKKVENLTAV ITDLLEKLDI KDKKE
Length:675
Mass (Da):77,953
Last modified:January 24, 2006 - v2
Checksum:iC8CE3B092A717306
GO

Sequence cautioni

The sequence CAA64009 differs from that shown. Reason: Frameshift at position 245.Curated
The sequence CAA99282 differs from that shown. Reason: Frameshift at position 245.Curated
The sequence CAA99283 differs from that shown. Reason: Frameshift at position 245.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA. Translation: CAA64009.1. Frameshift.
Z74995 Genomic DNA. Translation: CAA99282.1. Frameshift.
Z74995 Genomic DNA. Translation: CAA99283.1. Frameshift.
Z74997 Genomic DNA. Translation: CAA99286.1.
BK006948 Genomic DNA. Translation: DAA10865.1.
PIRiS61648.
S66972.
RefSeqiNP_014730.2. NM_001183506.1.

Genome annotation databases

EnsemblFungiiYOR087W; YOR087W; YOR087W.
GeneIDi854255.
KEGGisce:YOR087W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA. Translation: CAA64009.1. Frameshift.
Z74995 Genomic DNA. Translation: CAA99282.1. Frameshift.
Z74995 Genomic DNA. Translation: CAA99283.1. Frameshift.
Z74997 Genomic DNA. Translation: CAA99286.1.
BK006948 Genomic DNA. Translation: DAA10865.1.
PIRiS61648.
S66972.
RefSeqiNP_014730.2. NM_001183506.1.

3D structure databases

ProteinModelPortaliQ12324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34486. 33 interactors.
DIPiDIP-2782N.
DIP-4157N.
IntActiQ12324. 2 interactors.
MINTiMINT-489917.

Protein family/group databases

TCDBi1.A.4.4.1. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

iPTMnetiQ12324.

Proteomic databases

MaxQBiQ12324.
PRIDEiQ12324.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR087W; YOR087W; YOR087W.
GeneIDi854255.
KEGGisce:YOR087W.

Organism-specific databases

EuPathDBiFungiDB:YOR087W.
SGDiS000005613. YVC1.

Phylogenomic databases

HOGENOMiHOG000199455.
InParanoidiQ12324.
OMAiMMKESII.
OrthoDBiEOG092C1F4Q.

Enzyme and pathway databases

BioCyciYEAST:G3O-33622-MONOMER.

Miscellaneous databases

PROiQ12324.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiYVC1_YEAST
AccessioniPrimary (citable) accession number: Q12324
Secondary accession number(s): D6W2E9, Q08500, Q7LGN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1310 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.