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Protein

Protein arginine N-methyltransferase SFM1

Gene

SFM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that monomethylates ribosomal protein S3 (RPS3) at 'Arg-146'.1 Publication

Miscellaneous

Present with 2520 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein-arginine omega-N monomethyltransferase activity Source: SGD

GO - Biological processi

  • peptidyl-arginine methylation Source: SGD

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-33569-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase SFM11 Publication (EC:2.1.1.-1 Publication)
Alternative name(s):
SPOUT family methyltransferase 11 Publication
Gene namesi
Name:SFM11 Publication
Ordered Locus Names:YOR021CImported
ORF Names:OR26.11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR021C
SGDiS000005547 SFM1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002376431 – 213Protein arginine N-methyltransferase SFM1Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei204PhosphoserineCombined sources1
Modified residuei207PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12314
PaxDbiQ12314
PRIDEiQ12314

PTM databases

iPTMnetiQ12314

Interactioni

Protein-protein interaction databases

BioGridi34425, 45 interactors
IntActiQ12314, 4 interactors
MINTiQ12314
STRINGi4932.YOR021C

Structurei

Secondary structure

1213
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Beta strandi9 – 11Combined sources3
Helixi14 – 27Combined sources14
Helixi29 – 31Combined sources3
Beta strandi32 – 35Combined sources4
Helixi43 – 45Combined sources3
Helixi48 – 52Combined sources5
Helixi62 – 64Combined sources3
Helixi65 – 68Combined sources4
Beta strandi79 – 83Combined sources5
Beta strandi88 – 90Combined sources3
Helixi93 – 97Combined sources5
Beta strandi100 – 106Combined sources7
Turni110 – 113Combined sources4
Helixi118 – 123Combined sources6
Turni125 – 127Combined sources3
Beta strandi128 – 132Combined sources5
Helixi140 – 151Combined sources12
Helixi157 – 159Combined sources3
Beta strandi162 – 165Combined sources4
Beta strandi167 – 171Combined sources5
Beta strandi174 – 177Combined sources4
Beta strandi180 – 184Combined sources5
Helixi196 – 204Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5C74X-ray1.90A/B1-204[»]
5C77X-ray2.50A/B1-213[»]
5H5DX-ray2.70A2-213[»]
5H5EX-ray2.09A2-213[»]
5H5FX-ray1.70A2-213[»]
ProteinModelPortaliQ12314
SMRiQ12314
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000208878
InParanoidiQ12314
OMAiELGPWSE
OrthoDBiEOG092C4JOB

Family and domain databases

InterProiView protein in InterPro
IPR007364 RNA_MeTrfase_TK0422/Sfm1
PfamiView protein in Pfam
PF04252 RNA_Me_trans, 1 hit

Sequencei

Sequence statusi: Complete.

Q12314-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYIIEHMEE GFSEWVILEY SQILREVGAE NLILSSLPES TTEKDIPQRL
60 70 80 90 100
LKLGLRWTTK DLKGINEDFK DLELLKDGRV CLLDPRATID LQPEDATKFD
110 120 130 140 150
YFVFGGILGD HPPRDRTKEL KTAYPNLLIS RRLGDKQMTT DTAIRTTQLI
160 170 180 190 200
IKDRIAFEDI KFIDYPEFRF NKNEATEMPF RYVLDKEGKP ILPEGMLDLI
210
KKDSAQSLDD LLM
Length:213
Mass (Da):24,744
Last modified:November 1, 1996 - v1
Checksum:i11A1FB089B39E7EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87331 Genomic DNA Translation: CAA60770.1
Z74929 Genomic DNA Translation: CAA99211.1
BK006948 Genomic DNA Translation: DAA10804.1
PIRiS54627
RefSeqiNP_014664.1, NM_001183440.1

Genome annotation databases

EnsemblFungiiYOR021C; YOR021C; YOR021C
GeneIDi854186
KEGGisce:YOR021C

Similar proteinsi

Entry informationi

Entry nameiSFM1_YEAST
AccessioniPrimary (citable) accession number: Q12314
Secondary accession number(s): D6W288
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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