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Q12314

- SFM1_YEAST

UniProt

Q12314 - SFM1_YEAST

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Protein

Protein arginine N-methyltransferase SFM1

Gene

SFM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that monomethylates ribosomal protein S3 (RPS3) at 'Arg-146'.1 Publication

GO - Molecular functioni

  1. protein-arginine omega-N monomethyltransferase activity Source: SGD

GO - Biological processi

  1. peptidyl-arginine methylation Source: SGD
  2. peptidyl-arginine omega-N-methylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-33569-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase SFM11 Publication (EC:2.1.1.-1 Publication)
Alternative name(s):
SPOUT family methyltransferase 11 Publication
Gene namesi
Name:SFM11 Publication
Ordered Locus Names:YOR021CImported
ORF Names:OR26.11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR021c.
SGDiS000005547. SFM1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Protein arginine N-methyltransferase SFM1PRO_0000237643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei204 – 2041Phosphoserine1 Publication
Modified residuei207 – 2071Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12314.
PaxDbiQ12314.
PeptideAtlasiQ12314.

Expressioni

Gene expression databases

GenevestigatoriQ12314.

Interactioni

Protein-protein interaction databases

BioGridi34425. 10 interactions.
IntActiQ12314. 3 interactions.
MINTiMINT-2492302.
STRINGi4932.YOR021C.

Structurei

3D structure databases

ProteinModelPortaliQ12314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2428.
HOGENOMiHOG000208878.
InParanoidiQ12314.
OMAiEGFSEWV.
OrthoDBiEOG79932M.

Family and domain databases

InterProiIPR007364. SAM-dep_RNA_MeTrfase_prd.
[Graphical view]
PfamiPF04252. RNA_Me_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12314-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYIIEHMEE GFSEWVILEY SQILREVGAE NLILSSLPES TTEKDIPQRL
60 70 80 90 100
LKLGLRWTTK DLKGINEDFK DLELLKDGRV CLLDPRATID LQPEDATKFD
110 120 130 140 150
YFVFGGILGD HPPRDRTKEL KTAYPNLLIS RRLGDKQMTT DTAIRTTQLI
160 170 180 190 200
IKDRIAFEDI KFIDYPEFRF NKNEATEMPF RYVLDKEGKP ILPEGMLDLI
210
KKDSAQSLDD LLM
Length:213
Mass (Da):24,744
Last modified:November 1, 1996 - v1
Checksum:i11A1FB089B39E7EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87331 Genomic DNA. Translation: CAA60770.1.
Z74929 Genomic DNA. Translation: CAA99211.1.
BK006948 Genomic DNA. Translation: DAA10804.1.
PIRiS54627.
RefSeqiNP_014664.1. NM_001183440.1.

Genome annotation databases

EnsemblFungiiYOR021C; YOR021C; YOR021C.
GeneIDi854186.
KEGGisce:YOR021C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87331 Genomic DNA. Translation: CAA60770.1 .
Z74929 Genomic DNA. Translation: CAA99211.1 .
BK006948 Genomic DNA. Translation: DAA10804.1 .
PIRi S54627.
RefSeqi NP_014664.1. NM_001183440.1.

3D structure databases

ProteinModelPortali Q12314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34425. 10 interactions.
IntActi Q12314. 3 interactions.
MINTi MINT-2492302.
STRINGi 4932.YOR021C.

Proteomic databases

MaxQBi Q12314.
PaxDbi Q12314.
PeptideAtlasi Q12314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR021C ; YOR021C ; YOR021C .
GeneIDi 854186.
KEGGi sce:YOR021C.

Organism-specific databases

CYGDi YOR021c.
SGDi S000005547. SFM1.

Phylogenomic databases

eggNOGi COG2428.
HOGENOMi HOG000208878.
InParanoidi Q12314.
OMAi EGFSEWV.
OrthoDBi EOG79932M.

Enzyme and pathway databases

BioCyci YEAST:G3O-33569-MONOMER.

Miscellaneous databases

NextBioi 975999.

Gene expression databases

Genevestigatori Q12314.

Family and domain databases

InterProi IPR007364. SAM-dep_RNA_MeTrfase_prd.
[Graphical view ]
Pfami PF04252. RNA_Me_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204 AND SER-207, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "Identification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation."
    Young B.D., Weiss D.I., Zurita-Lopez C.I., Webb K.J., Clarke S.G., McBride A.E.
    Biochemistry 51:5091-5104(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiSFM1_YEAST
AccessioniPrimary (citable) accession number: Q12314
Secondary accession number(s): D6W288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2520 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3