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Protein

Protein arginine N-methyltransferase SFM1

Gene

SFM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that monomethylates ribosomal protein S3 (RPS3) at 'Arg-146'.1 Publication

GO - Molecular functioni

  1. protein-arginine omega-N monomethyltransferase activity Source: SGD

GO - Biological processi

  1. peptidyl-arginine methylation Source: SGD
  2. peptidyl-arginine omega-N-methylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-33569-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase SFM11 Publication (EC:2.1.1.-1 Publication)
Alternative name(s):
SPOUT family methyltransferase 11 Publication
Gene namesi
Name:SFM11 Publication
Ordered Locus Names:YOR021CImported
ORF Names:OR26.11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR021c.
SGDiS000005547. SFM1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Protein arginine N-methyltransferase SFM1PRO_0000237643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei204 – 2041Phosphoserine1 Publication
Modified residuei207 – 2071Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12314.
PaxDbiQ12314.
PeptideAtlasiQ12314.

Expressioni

Gene expression databases

GenevestigatoriQ12314.

Interactioni

Protein-protein interaction databases

BioGridi34425. 10 interactions.
IntActiQ12314. 3 interactions.
MINTiMINT-2492302.
STRINGi4932.YOR021C.

Structurei

3D structure databases

ProteinModelPortaliQ12314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2428.
HOGENOMiHOG000208878.
InParanoidiQ12314.
OMAiEGFSEWV.
OrthoDBiEOG79932M.

Family and domain databases

InterProiIPR007364. SAM-dep_RNA_MeTrfase_prd.
[Graphical view]
PfamiPF04252. RNA_Me_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12314-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYIIEHMEE GFSEWVILEY SQILREVGAE NLILSSLPES TTEKDIPQRL
60 70 80 90 100
LKLGLRWTTK DLKGINEDFK DLELLKDGRV CLLDPRATID LQPEDATKFD
110 120 130 140 150
YFVFGGILGD HPPRDRTKEL KTAYPNLLIS RRLGDKQMTT DTAIRTTQLI
160 170 180 190 200
IKDRIAFEDI KFIDYPEFRF NKNEATEMPF RYVLDKEGKP ILPEGMLDLI
210
KKDSAQSLDD LLM
Length:213
Mass (Da):24,744
Last modified:November 1, 1996 - v1
Checksum:i11A1FB089B39E7EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87331 Genomic DNA. Translation: CAA60770.1.
Z74929 Genomic DNA. Translation: CAA99211.1.
BK006948 Genomic DNA. Translation: DAA10804.1.
PIRiS54627.
RefSeqiNP_014664.1. NM_001183440.1.

Genome annotation databases

EnsemblFungiiYOR021C; YOR021C; YOR021C.
GeneIDi854186.
KEGGisce:YOR021C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87331 Genomic DNA. Translation: CAA60770.1.
Z74929 Genomic DNA. Translation: CAA99211.1.
BK006948 Genomic DNA. Translation: DAA10804.1.
PIRiS54627.
RefSeqiNP_014664.1. NM_001183440.1.

3D structure databases

ProteinModelPortaliQ12314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34425. 10 interactions.
IntActiQ12314. 3 interactions.
MINTiMINT-2492302.
STRINGi4932.YOR021C.

Proteomic databases

MaxQBiQ12314.
PaxDbiQ12314.
PeptideAtlasiQ12314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR021C; YOR021C; YOR021C.
GeneIDi854186.
KEGGisce:YOR021C.

Organism-specific databases

CYGDiYOR021c.
SGDiS000005547. SFM1.

Phylogenomic databases

eggNOGiCOG2428.
HOGENOMiHOG000208878.
InParanoidiQ12314.
OMAiEGFSEWV.
OrthoDBiEOG79932M.

Enzyme and pathway databases

BioCyciYEAST:G3O-33569-MONOMER.

Miscellaneous databases

NextBioi975999.

Gene expression databases

GenevestigatoriQ12314.

Family and domain databases

InterProiIPR007364. SAM-dep_RNA_MeTrfase_prd.
[Graphical view]
PfamiPF04252. RNA_Me_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204 AND SER-207, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "Identification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation."
    Young B.D., Weiss D.I., Zurita-Lopez C.I., Webb K.J., Clarke S.G., McBride A.E.
    Biochemistry 51:5091-5104(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiSFM1_YEAST
AccessioniPrimary (citable) accession number: Q12314
Secondary accession number(s): D6W288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2520 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.