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Protein

Protein arginine N-methyltransferase SFM1

Gene

SFM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that monomethylates ribosomal protein S3 (RPS3) at 'Arg-146'.1 Publication

GO - Molecular functioni

  • protein-arginine omega-N monomethyltransferase activity Source: SGD

GO - Biological processi

  • peptidyl-arginine methylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-33569-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase SFM11 Publication (EC:2.1.1.-1 Publication)
Alternative name(s):
SPOUT family methyltransferase 11 Publication
Gene namesi
Name:SFM11 Publication
Ordered Locus Names:YOR021CImported
ORF Names:OR26.11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR021C.
SGDiS000005547. SFM1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002376431 – 213Protein arginine N-methyltransferase SFM1Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei204PhosphoserineCombined sources1
Modified residuei207PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12314.
PRIDEiQ12314.

PTM databases

iPTMnetiQ12314.

Interactioni

Protein-protein interaction databases

BioGridi34425. 9 interactors.
IntActiQ12314. 4 interactors.
MINTiMINT-2492302.

Structurei

Secondary structure

1213
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Beta strandi9 – 11Combined sources3
Helixi14 – 27Combined sources14
Helixi29 – 31Combined sources3
Beta strandi32 – 36Combined sources5
Helixi43 – 45Combined sources3
Helixi48 – 52Combined sources5
Helixi62 – 64Combined sources3
Helixi65 – 68Combined sources4
Beta strandi80 – 83Combined sources4
Beta strandi88 – 90Combined sources3
Helixi93 – 97Combined sources5
Beta strandi100 – 104Combined sources5
Turni110 – 113Combined sources4
Helixi116 – 123Combined sources8
Turni125 – 127Combined sources3
Beta strandi128 – 132Combined sources5
Helixi140 – 151Combined sources12
Helixi157 – 159Combined sources3
Beta strandi162 – 165Combined sources4
Beta strandi167 – 171Combined sources5
Beta strandi174 – 177Combined sources4
Beta strandi180 – 184Combined sources5
Helixi196 – 204Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5C74X-ray1.90A/B1-204[»]
5C77X-ray2.50A/B1-213[»]
ProteinModelPortaliQ12314.
SMRiQ12314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000208878.
InParanoidiQ12314.
OMAiEGFSEWV.
OrthoDBiEOG092C4JOB.

Family and domain databases

InterProiIPR007364. RNA_MeTrfase_TK0422/Sfm1.
[Graphical view]
PfamiPF04252. RNA_Me_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12314-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYIIEHMEE GFSEWVILEY SQILREVGAE NLILSSLPES TTEKDIPQRL
60 70 80 90 100
LKLGLRWTTK DLKGINEDFK DLELLKDGRV CLLDPRATID LQPEDATKFD
110 120 130 140 150
YFVFGGILGD HPPRDRTKEL KTAYPNLLIS RRLGDKQMTT DTAIRTTQLI
160 170 180 190 200
IKDRIAFEDI KFIDYPEFRF NKNEATEMPF RYVLDKEGKP ILPEGMLDLI
210
KKDSAQSLDD LLM
Length:213
Mass (Da):24,744
Last modified:November 1, 1996 - v1
Checksum:i11A1FB089B39E7EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87331 Genomic DNA. Translation: CAA60770.1.
Z74929 Genomic DNA. Translation: CAA99211.1.
BK006948 Genomic DNA. Translation: DAA10804.1.
PIRiS54627.
RefSeqiNP_014664.1. NM_001183440.1.

Genome annotation databases

EnsemblFungiiYOR021C; YOR021C; YOR021C.
GeneIDi854186.
KEGGisce:YOR021C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87331 Genomic DNA. Translation: CAA60770.1.
Z74929 Genomic DNA. Translation: CAA99211.1.
BK006948 Genomic DNA. Translation: DAA10804.1.
PIRiS54627.
RefSeqiNP_014664.1. NM_001183440.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5C74X-ray1.90A/B1-204[»]
5C77X-ray2.50A/B1-213[»]
ProteinModelPortaliQ12314.
SMRiQ12314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34425. 9 interactors.
IntActiQ12314. 4 interactors.
MINTiMINT-2492302.

PTM databases

iPTMnetiQ12314.

Proteomic databases

MaxQBiQ12314.
PRIDEiQ12314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR021C; YOR021C; YOR021C.
GeneIDi854186.
KEGGisce:YOR021C.

Organism-specific databases

EuPathDBiFungiDB:YOR021C.
SGDiS000005547. SFM1.

Phylogenomic databases

HOGENOMiHOG000208878.
InParanoidiQ12314.
OMAiEGFSEWV.
OrthoDBiEOG092C4JOB.

Enzyme and pathway databases

BioCyciYEAST:G3O-33569-MONOMER.

Miscellaneous databases

PROiQ12314.

Family and domain databases

InterProiIPR007364. RNA_MeTrfase_TK0422/Sfm1.
[Graphical view]
PfamiPF04252. RNA_Me_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSFM1_YEAST
AccessioniPrimary (citable) accession number: Q12314
Secondary accession number(s): D6W288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2520 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.