Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NuA3 HAT complex component NTO1

Gene

NTO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation.1 Publication

Miscellaneous

Present with 172 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri263 – 313PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri317 – 350C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri374 – 439PHD-type 2PROSITE-ProRule annotationAdd BLAST66

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • methylated histone binding Source: SGD

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-34190-MONOMER.
ReactomeiR-SCE-114608. Platelet degranulation.
R-SCE-3214847. HATs acetylate histones.
R-SCE-6804758. Regulation of TP53 Activity through Acetylation.

Names & Taxonomyi

Protein namesi
Recommended name:
NuA3 HAT complex component NTO1
Gene namesi
Name:NTO1
Ordered Locus Names:YPR031W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR031W.
SGDiS000006235. NTO1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • NuA3a histone acetyltransferase complex Source: SGD
  • NuA3b histone acetyltransferase complex Source: SGD
  • NuA3 histone acetyltransferase complex Source: SGD

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686921 – 748NuA3 HAT complex component NTO1Add BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei728PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12311.
PRIDEiQ12311.

PTM databases

iPTMnetiQ12311.

Interactioni

Subunit structurei

Component of the NuA3 complex, which consists of at least NTO1, SAS3, TAF14, YNG1 and EAF6.1 Publication

GO - Molecular functioni

  • methylated histone binding Source: SGD

Protein-protein interaction databases

BioGridi36209. 128 interactors.
DIPiDIP-4956N.
IntActiQ12311. 10 interactors.
MINTiMINT-510213.
STRINGi4932.YPR031W.

Structurei

3D structure databases

ProteinModelPortaliQ12311.
SMRiQ12311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Residues 156 to 543 compose a region conserved in chromatin associated proteins.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri263 – 313PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri317 – 350C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri374 – 439PHD-type 2PROSITE-ProRule annotationAdd BLAST66

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00740000114866.
HOGENOMiHOG000246761.
InParanoidiQ12311.
KOiK11380.
OMAiHYMEPIE.
OrthoDBiEOG092C3HLI.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR019542. Enhancer_polycomb-like_N.
IPR034732. EPHD.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF10513. EPL1. 1 hit.
SMARTiView protein in SMART
SM00249. PHD. 2 hits.
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiView protein in PROSITE
PS51805. EPHD. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRGSLDDGP KLREEKHFQD FYPDLNADTL LPFIVPLVET KDNSTDTDSD
60 70 80 90 100
DISNRNNREI GSVKSVQTKE LIFKGRVTTE PLVLKKNEVE FQKCKITTNE
110 120 130 140 150
LKGKKNPYCV RFNESFISRY YHINKVRNRK SYKQQQKEFD GVEAPYFTKF
160 170 180 190 200
SSKEAPNITI STSTKSAIQK FASISPNLVN FKPQYDMDEQ DELYLHYLNK
210 220 230 240 250
RYFKDQMSHE IFEILMTTLE TEWFHIEKHI PSTNSLIARH NILRDCKNYE
260 270 280 290 300
LYGSDDGTGL SMDQACAVCL GTDSDNLNTI VFCDGCDIAV HQECYGIIFI
310 320 330 340 350
PEGKWLCRRC MISKNNFATC LMCPSHTGAF KQTDTGSWVH NICALWLPEL
360 370 380 390 400
YFSNLHYMEP IEGVQNVSVS RWKLNCYICK KKMGACIQCF QRNCFTAYHV
410 420 430 440 450
TCARRAGLYM SKGKCTIQEL ASNQFSQKYS VESFCHKHAP RGWQTSIEGI
460 470 480 490 500
NKARKYFSLL STLQTETPQH NEANDRTNSK FNKTIWKTPN QTPVAPHVFA
510 520 530 540 550
EILQKVVDFF GLANPPAGAF DICKYWSMKR ELTGGTPLTA CFENNSLGSL
560 570 580 590 600
TEEQVQTRID FANDQLEDLY RLKELTTLVK KRTQASNSLS RSRKKVFDIV
610 620 630 640 650
KSPQKYLLKI NVLDIFIKSE QFKALERLVT EPKLLVILEK CKHCDFDTVQ
660 670 680 690 700
IFKEEIMHFF EVLETLPGAS RILQTVSSKA KEQVTNLIGL IEHVDIKKLL
710 720 730 740
SRDFIINDDK IEERPWSGPV IMEEEGLSDA EELSAGEHRM LKLILNSG
Length:748
Mass (Da):86,029
Last modified:November 1, 1996 - v1
Checksum:i7D6796553BCFA06D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49274 Genomic DNA. Translation: CAA89285.1.
Z71255 Genomic DNA. Translation: CAA95027.1.
BK006949 Genomic DNA. Translation: DAA11457.1.
PIRiS54505.
RefSeqiNP_015356.1. NM_001184128.1.

Genome annotation databases

EnsemblFungiiYPR031W; YPR031W; YPR031W.
GeneIDi856143.
KEGGisce:YPR031W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNTO1_YEAST
AccessioniPrimary (citable) accession number: Q12311
Secondary accession number(s): D6W441
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names