Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NuA3 HAT complex component NTO1

Gene

NTO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation.1 Publication

Miscellaneous

Present with 172 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri263 – 313PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri317 – 350C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri374 – 439PHD-type 2PROSITE-ProRule annotationAdd BLAST66

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • methylated histone binding Source: SGD

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-34190-MONOMER
ReactomeiR-SCE-114608 Platelet degranulation
R-SCE-3214847 HATs acetylate histones
R-SCE-6804758 Regulation of TP53 Activity through Acetylation

Names & Taxonomyi

Protein namesi
Recommended name:
NuA3 HAT complex component NTO1
Gene namesi
Name:NTO1
Ordered Locus Names:YPR031W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR031W
SGDiS000006235 NTO1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686921 – 748NuA3 HAT complex component NTO1Add BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei728PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12311
PaxDbiQ12311
PRIDEiQ12311

PTM databases

iPTMnetiQ12311

Interactioni

Subunit structurei

Component of the NuA3 complex, which consists of at least NTO1, SAS3, TAF14, YNG1 and EAF6.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • methylated histone binding Source: SGD

Protein-protein interaction databases

BioGridi36209, 130 interactors
DIPiDIP-4956N
IntActiQ12311, 23 interactors
MINTiQ12311
STRINGi4932.YPR031W

Structurei

3D structure databases

ProteinModelPortaliQ12311
SMRiQ12311
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Residues 156 to 543 compose a region conserved in chromatin associated proteins.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri263 – 313PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri317 – 350C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri374 – 439PHD-type 2PROSITE-ProRule annotationAdd BLAST66

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00740000114866
HOGENOMiHOG000246761
InParanoidiQ12311
KOiK11380
OMAiHYMEPIE
OrthoDBiEOG092C3HLI

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF10513 EPL1, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51805 EPHD, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q12311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRGSLDDGP KLREEKHFQD FYPDLNADTL LPFIVPLVET KDNSTDTDSD
60 70 80 90 100
DISNRNNREI GSVKSVQTKE LIFKGRVTTE PLVLKKNEVE FQKCKITTNE
110 120 130 140 150
LKGKKNPYCV RFNESFISRY YHINKVRNRK SYKQQQKEFD GVEAPYFTKF
160 170 180 190 200
SSKEAPNITI STSTKSAIQK FASISPNLVN FKPQYDMDEQ DELYLHYLNK
210 220 230 240 250
RYFKDQMSHE IFEILMTTLE TEWFHIEKHI PSTNSLIARH NILRDCKNYE
260 270 280 290 300
LYGSDDGTGL SMDQACAVCL GTDSDNLNTI VFCDGCDIAV HQECYGIIFI
310 320 330 340 350
PEGKWLCRRC MISKNNFATC LMCPSHTGAF KQTDTGSWVH NICALWLPEL
360 370 380 390 400
YFSNLHYMEP IEGVQNVSVS RWKLNCYICK KKMGACIQCF QRNCFTAYHV
410 420 430 440 450
TCARRAGLYM SKGKCTIQEL ASNQFSQKYS VESFCHKHAP RGWQTSIEGI
460 470 480 490 500
NKARKYFSLL STLQTETPQH NEANDRTNSK FNKTIWKTPN QTPVAPHVFA
510 520 530 540 550
EILQKVVDFF GLANPPAGAF DICKYWSMKR ELTGGTPLTA CFENNSLGSL
560 570 580 590 600
TEEQVQTRID FANDQLEDLY RLKELTTLVK KRTQASNSLS RSRKKVFDIV
610 620 630 640 650
KSPQKYLLKI NVLDIFIKSE QFKALERLVT EPKLLVILEK CKHCDFDTVQ
660 670 680 690 700
IFKEEIMHFF EVLETLPGAS RILQTVSSKA KEQVTNLIGL IEHVDIKKLL
710 720 730 740
SRDFIINDDK IEERPWSGPV IMEEEGLSDA EELSAGEHRM LKLILNSG
Length:748
Mass (Da):86,029
Last modified:November 1, 1996 - v1
Checksum:i7D6796553BCFA06D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49274 Genomic DNA Translation: CAA89285.1
Z71255 Genomic DNA Translation: CAA95027.1
BK006949 Genomic DNA Translation: DAA11457.1
PIRiS54505
RefSeqiNP_015356.1, NM_001184128.1

Genome annotation databases

EnsemblFungiiYPR031W; YPR031W; YPR031W
GeneIDi856143
KEGGisce:YPR031W

Similar proteinsi

Entry informationi

Entry nameiNTO1_YEAST
AccessioniPrimary (citable) accession number: Q12311
Secondary accession number(s): D6W441
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health