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Protein

Serine/threonine-protein kinase PRR2

Gene

PRR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein kinase that functions as regulator in the pheromone-induced mating pathway downstream of mitogen-activated protein kinase (MAPK) FUS3. Diminishes transcriptional induction of genes in response to pheromone signaling.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei390ATPPROSITE-ProRule annotation1
Active sitei484Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi367 – 375ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • negative regulation of conjugation with cellular fusion Source: SGD
  • negative regulation of transcription from RNA polymerase II promoter by pheromones Source: SGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processPheromone response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29596-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PRR2 (EC:2.7.11.1)
Alternative name(s):
Pheromone response regulator 2
Gene namesi
Name:PRR2
Ordered Locus Names:YDL214C
ORF Names:D1014
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL214C
SGDiS000002373 PRR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi390K → R: Abolishes kinase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002627521 – 699Serine/threonine-protein kinase PRR2Add BLAST699

Proteomic databases

PaxDbiQ12310
PRIDEiQ12310

PTM databases

iPTMnetiQ12310

Expressioni

Inductioni

By the macrolide rapamycin in a TOR-dependent manner.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi31831, 84 interactors
DIPiDIP-1640N
IntActiQ12310, 9 interactors
MINTiQ12310
STRINGi4932.YDL214C

Structurei

3D structure databases

ProteinModelPortaliQ12310
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini361 – 653Protein kinasePROSITE-ProRule annotationAdd BLAST293

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000075309
HOGENOMiHOG000093332
InParanoidiQ12310
OrthoDBiEOG092C0ZCR

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q12310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSRILRYN QRNNKTTASL TAEHAYSDNW AYSVSLGDPT SVGVNMAAKT
60 70 80 90 100
GEALNKSYDS VFSSLPVADS VPRTDFTASS RDDENTDVQK LTTSWMEKID
110 120 130 140 150
TKMPENISKI DSNIISSPMV SKVEARFIVP KGRLRKNSTD FTSSFSNSLS
160 170 180 190 200
LPKSYGKLIF FTSKKNSSST KKNLANDISD NKHNNNSSNT IGHNIPVTTA
210 220 230 240 250
TATCDEIACT STEHEYNVYE EERMFTTRVY SLEDSVSSLS TNPLDDTYSE
260 270 280 290 300
AVQVNTRHIE DTESTAHIRK HSYTTSLSSI KRLFKITSFS NNNSNSCDHQ
310 320 330 340 350
ESTVADDCAI SSSLKETTSS PVSTGSFSLM IENEDSDRDQ IIQALYSNIE
360 370 380 390 400
ASTDLVSRKY RDLDVVLGEG SGGKVKLVQR VLDNKVFALK EYRSKKKRES
410 420 430 440 450
ERKYIKNIIS EYCIASTLKN PNICETLEIL YEKGKIFQIL EYCEYDLFSL
460 470 480 490 500
VMSEKMHYEE ICCLFKQLIN GVKYLHDIGL SHRDLKLDNC VVTRRGILKL
510 520 530 540 550
IDFGASSVFH YPLSSQMIEA NGIVGSDPYL SPEVFYFNEY DPRALDVWSV
560 570 580 590 600
GIIFFCMITR RFPWKYPKVK DVQFKAFCSG RGVSSFKDLV TRPATDDSNN
610 620 630 640 650
YDNDGYEEGV IDMGPNFILH RLPEETHKIM RRILEVSPFR RITINGILQD
660 670 680 690
GWIKEIETCQ VVGAASPNEA SLRIINKGNH IHTNIDQRYA HIGGLHQRT
Length:699
Mass (Da):78,939
Last modified:November 1, 1996 - v1
Checksum:iBB178BCE735D6086
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99000 Genomic DNA Translation: CAA67476.1
Z74262 Genomic DNA Translation: CAA98792.1
BK006938 Genomic DNA Translation: DAA11650.1
PIRiS67773
RefSeqiNP_010067.1, NM_001180274.1

Genome annotation databases

EnsemblFungiiYDL214C; YDL214C; YDL214C
GeneIDi851312
KEGGisce:YDL214C

Similar proteinsi

Entry informationi

Entry nameiPRR2_YEAST
AccessioniPrimary (citable) accession number: Q12310
Secondary accession number(s): D6VRE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health