Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

High-affinity glucose transporter RGT2

Gene

RGT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Low-affinity glucose transporter. Can function as a sensor that generates an intracellular signal in the presence of high level of glucose. Required for maximal expression of the high glucose-induced HXT1 protein.

GO - Molecular functioni

GO - Biological processi

  • detection of glucose Source: SGD
  • glucose mediated signaling pathway Source: SGD
  • hexose transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29537-MONOMER.

Protein family/group databases

TCDBi2.A.1.1.19. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity glucose transporter RGT2
Gene namesi
Name:RGT2
Ordered Locus Names:YDL138W
ORF Names:D2160
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL138W.
SGDiS000002297. RGT2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 99CytoplasmicSequence analysisAdd BLAST99
Transmembranei100 – 120Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini121 – 144ExtracellularSequence analysisAdd BLAST24
Transmembranei145 – 165Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini166 – 175CytoplasmicSequence analysis10
Transmembranei176 – 196Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini197ExtracellularSequence analysis1
Transmembranei198 – 218Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini219 – 231CytoplasmicSequence analysisAdd BLAST13
Transmembranei232 – 252Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini253 – 266ExtracellularSequence analysisAdd BLAST14
Transmembranei267 – 287Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini288 – 357CytoplasmicSequence analysisAdd BLAST70
Transmembranei358 – 378Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini379 – 393ExtracellularSequence analysisAdd BLAST15
Transmembranei394 – 414Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini415 – 421CytoplasmicSequence analysis7
Transmembranei422 – 442Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini443 – 452ExtracellularSequence analysis10
Transmembranei453 – 473Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini474 – 491CytoplasmicSequence analysisAdd BLAST18
Transmembranei492 – 512Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini513 – 524ExtracellularSequence analysisAdd BLAST12
Transmembranei525 – 545Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini546 – 763CytoplasmicSequence analysisAdd BLAST218

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi231R → K in RGT2-1; constitutively signaling glucose receptor. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503891 – 763High-affinity glucose transporter RGT2Add BLAST763

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi136N-linked (GlcNAc...)Sequence analysis1
Glycosylationi385N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ12300.

Interactioni

Protein-protein interaction databases

BioGridi31923. 14 interactors.
DIPiDIP-2865N.
IntActiQ12300. 15 interactors.
MINTiMINT-508420.

Structurei

3D structure databases

ProteinModelPortaliQ12300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000202870.
InParanoidiQ12300.
KOiK08139.
OMAiSVSNYCK.
OrthoDBiEOG092C1Q5W.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12300-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDSQNCLRQ REENSHLNPG NDFGHHQGAE CTINHNNMPH RNAYTESTND
60 70 80 90 100
TEAKSIVMCD DPNAYQISYT NNEPAGDGAI ETTSILLSQP LPLRSNVMSV
110 120 130 140 150
LVGIFVAVGG FLFGYDTGLI NSITDMPYVK TYIAPNHSYF TTSQIAILVS
160 170 180 190 200
FLSLGTFFGA LIAPYISDSY GRKPTIMFST AVIFSIGNSL QVASGGLVLL
210 220 230 240 250
IVGRVISGIG IGIISAVVPL YQAEAAQKNL RGAIISSYQW AITIGLLVSS
260 270 280 290 300
AVSQGTHSKN GPSSYRIPIG LQYVWSSILA VGMIFLPESP RYYVLKDELN
310 320 330 340 350
KAAKSLSFLR GLPIEDPRLL EELVEIKATY DYEASFGPST LLDCFKTSEN
360 370 380 390 400
RPKQILRIFT GIAIQAFQQA SGINFIFYYG VNFFNNTGVD NSYLVSFISY
410 420 430 440 450
AVNVAFSIPG MYLVDRIGRR PVLLAGGVIM AIANLVIAIV GVSEGKTVVA
460 470 480 490 500
SKIMIAFICL FIAAFSATWG GVVWVVSAEL YPLGVRSKCT AICAAANWLV
510 520 530 540 550
NFTCALITPY IVDVGSHTSS MGPKIFFIWG GLNVVAVIVV YFAVYETRGL
560 570 580 590 600
TLEEIDELFR KAPNSVISSK WNKKIRKRCL AFPISQQIEM KTNIKNAGKL
610 620 630 640 650
DNNNSPIVQD DSHNIIDVDG FLENQIQSND HMIAADKGSG SLVNIIDTAP
660 670 680 690 700
LTSTEFKPVE HPPVNYVDLG NGLGLNTYNR GPPSIISDST DEFYEENDSS
710 720 730 740 750
YYNNNTERNG ANSVNTYMAQ LINSSSTTSN DTSFSPSHNS NARTSSNWTS
760
DLASKHSQYT SPQ
Length:763
Mass (Da):83,159
Last modified:November 1, 1997 - v1
Checksum:iDF6E2F1C337F106E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96876 Genomic DNA. Translation: CAA65621.1.
Z74186 Genomic DNA. Translation: CAA98711.1.
BK006938 Genomic DNA. Translation: DAA11720.1.
PIRiS67684.
RefSeqiNP_010143.1. NM_001180198.1.

Genome annotation databases

EnsemblFungiiYDL138W; YDL138W; YDL138W.
GeneIDi851417.
KEGGisce:YDL138W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96876 Genomic DNA. Translation: CAA65621.1.
Z74186 Genomic DNA. Translation: CAA98711.1.
BK006938 Genomic DNA. Translation: DAA11720.1.
PIRiS67684.
RefSeqiNP_010143.1. NM_001180198.1.

3D structure databases

ProteinModelPortaliQ12300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31923. 14 interactors.
DIPiDIP-2865N.
IntActiQ12300. 15 interactors.
MINTiMINT-508420.

Protein family/group databases

TCDBi2.A.1.1.19. the major facilitator superfamily (mfs).

Proteomic databases

PRIDEiQ12300.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL138W; YDL138W; YDL138W.
GeneIDi851417.
KEGGisce:YDL138W.

Organism-specific databases

EuPathDBiFungiDB:YDL138W.
SGDiS000002297. RGT2.

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000202870.
InParanoidiQ12300.
KOiK08139.
OMAiSVSNYCK.
OrthoDBiEOG092C1Q5W.

Enzyme and pathway databases

BioCyciYEAST:G3O-29537-MONOMER.

Miscellaneous databases

PROiQ12300.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGT2_YEAST
AccessioniPrimary (citable) accession number: Q12300
Secondary accession number(s): D6VRL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.