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Q12300

- RGT2_YEAST

UniProt

Q12300 - RGT2_YEAST

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Protein

High-affinity glucose transporter RGT2

Gene
RGT2, YDL138W, D2160
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Low-affinity glucose transporter. Can function as a sensor that generates an intracellular signal in the presence of high level of glucose. Required for maximal expression of the high glucose-induced HXT1 protein.

GO - Molecular functioni

  1. glucose binding Source: SGD
  2. receptor activity Source: SGD
  3. substrate-specific transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. carbohydrate transport Source: UniProtKB-KW
  2. detection of glucose Source: SGD
  3. signal transduction Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29537-MONOMER.

Protein family/group databases

TCDBi2.A.1.1.19. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity glucose transporter RGT2
Gene namesi
Name:RGT2
Ordered Locus Names:YDL138W
ORF Names:D2160
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDL138w.
SGDiS000002297. RGT2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9999Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei100 – 12021Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini121 – 14424Extracellular Reviewed predictionAdd
BLAST
Transmembranei145 – 16521Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini166 – 17510Cytoplasmic Reviewed prediction
Transmembranei176 – 19621Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini197 – 1971Extracellular Reviewed prediction
Transmembranei198 – 21821Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini219 – 23113Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei232 – 25221Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini253 – 26614Extracellular Reviewed predictionAdd
BLAST
Transmembranei267 – 28721Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini288 – 35770Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei358 – 37821Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini379 – 39315Extracellular Reviewed predictionAdd
BLAST
Transmembranei394 – 41421Helical; Name=8; Reviewed predictionAdd
BLAST
Topological domaini415 – 4217Cytoplasmic Reviewed prediction
Transmembranei422 – 44221Helical; Name=9; Reviewed predictionAdd
BLAST
Topological domaini443 – 45210Extracellular Reviewed prediction
Transmembranei453 – 47321Helical; Name=10; Reviewed predictionAdd
BLAST
Topological domaini474 – 49118Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei492 – 51221Helical; Name=11; Reviewed predictionAdd
BLAST
Topological domaini513 – 52412Extracellular Reviewed predictionAdd
BLAST
Transmembranei525 – 54521Helical; Name=12; Reviewed predictionAdd
BLAST
Topological domaini546 – 763218Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi231 – 2311R → K in RGT2-1; constitutively signaling glucose receptor.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763High-affinity glucose transporter RGT2PRO_0000050389Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi136 – 1361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi385 – 3851N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

GenevestigatoriQ12300.

Interactioni

Protein-protein interaction databases

BioGridi31923. 13 interactions.
DIPiDIP-2865N.
IntActiQ12300. 15 interactions.
MINTiMINT-508420.
STRINGi4932.YDL138W.

Structurei

3D structure databases

ProteinModelPortaliQ12300.
SMRiQ12300. Positions 102-559.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202870.
KOiK08139.
OMAiWLVNFVC.
OrthoDBiEOG73JM4H.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12300-1 [UniParc]FASTAAdd to Basket

« Hide

MNDSQNCLRQ REENSHLNPG NDFGHHQGAE CTINHNNMPH RNAYTESTND    50
TEAKSIVMCD DPNAYQISYT NNEPAGDGAI ETTSILLSQP LPLRSNVMSV 100
LVGIFVAVGG FLFGYDTGLI NSITDMPYVK TYIAPNHSYF TTSQIAILVS 150
FLSLGTFFGA LIAPYISDSY GRKPTIMFST AVIFSIGNSL QVASGGLVLL 200
IVGRVISGIG IGIISAVVPL YQAEAAQKNL RGAIISSYQW AITIGLLVSS 250
AVSQGTHSKN GPSSYRIPIG LQYVWSSILA VGMIFLPESP RYYVLKDELN 300
KAAKSLSFLR GLPIEDPRLL EELVEIKATY DYEASFGPST LLDCFKTSEN 350
RPKQILRIFT GIAIQAFQQA SGINFIFYYG VNFFNNTGVD NSYLVSFISY 400
AVNVAFSIPG MYLVDRIGRR PVLLAGGVIM AIANLVIAIV GVSEGKTVVA 450
SKIMIAFICL FIAAFSATWG GVVWVVSAEL YPLGVRSKCT AICAAANWLV 500
NFTCALITPY IVDVGSHTSS MGPKIFFIWG GLNVVAVIVV YFAVYETRGL 550
TLEEIDELFR KAPNSVISSK WNKKIRKRCL AFPISQQIEM KTNIKNAGKL 600
DNNNSPIVQD DSHNIIDVDG FLENQIQSND HMIAADKGSG SLVNIIDTAP 650
LTSTEFKPVE HPPVNYVDLG NGLGLNTYNR GPPSIISDST DEFYEENDSS 700
YYNNNTERNG ANSVNTYMAQ LINSSSTTSN DTSFSPSHNS NARTSSNWTS 750
DLASKHSQYT SPQ 763
Length:763
Mass (Da):83,159
Last modified:November 1, 1997 - v1
Checksum:iDF6E2F1C337F106E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96876 Genomic DNA. Translation: CAA65621.1.
Z74186 Genomic DNA. Translation: CAA98711.1.
BK006938 Genomic DNA. Translation: DAA11720.1.
PIRiS67684.
RefSeqiNP_010143.1. NM_001180198.1.

Genome annotation databases

EnsemblFungiiYDL138W; YDL138W; YDL138W.
GeneIDi851417.
KEGGisce:YDL138W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96876 Genomic DNA. Translation: CAA65621.1 .
Z74186 Genomic DNA. Translation: CAA98711.1 .
BK006938 Genomic DNA. Translation: DAA11720.1 .
PIRi S67684.
RefSeqi NP_010143.1. NM_001180198.1.

3D structure databases

ProteinModelPortali Q12300.
SMRi Q12300. Positions 102-559.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31923. 13 interactions.
DIPi DIP-2865N.
IntActi Q12300. 15 interactions.
MINTi MINT-508420.
STRINGi 4932.YDL138W.

Protein family/group databases

TCDBi 2.A.1.1.19. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDL138W ; YDL138W ; YDL138W .
GeneIDi 851417.
KEGGi sce:YDL138W.

Organism-specific databases

CYGDi YDL138w.
SGDi S000002297. RGT2.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00720000108754.
HOGENOMi HOG000202870.
KOi K08139.
OMAi WLVNFVC.
OrthoDBi EOG73JM4H.

Enzyme and pathway databases

BioCyci YEAST:G3O-29537-MONOMER.

Miscellaneous databases

NextBioi 968612.
PROi Q12300.

Gene expression databases

Genevestigatori Q12300.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
PRINTSi PR00171. SUGRTRNSPORT.
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00879. SP. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a 26,756 bp segment from the left arm of yeast chromosome IV."
    Woelfl S., Haneman V., Saluz H.P.
    Yeast 12:1549-1554(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression."
    Oezcan S., Dover J., Rosenwald A.G., Woelfl S., Johnston M.
    Proc. Natl. Acad. Sci. U.S.A. 93:12428-12432(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiRGT2_YEAST
AccessioniPrimary (citable) accession number: Q12300
Secondary accession number(s): D6VRL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

Similar proteinsi