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Q122Q4

- SYL_POLSJ

UniProt

Q122Q4 - SYL_POLSJ

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPSP296591:GHI4-5323-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Bpro_4605
OrganismiPolaromonas sp. (strain JS666 / ATCC BAA-500)
Taxonomic identifieri296591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
ProteomesiUP000001983: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 886886Leucine--tRNA ligasePRO_1000009391Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi296591.Bpro_4605.

Structurei

3D structure databases

ProteinModelPortaliQ122Q4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 5611"HIGH" regionAdd
BLAST
Motifi638 – 6425"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q122Q4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQDKYNHLDV ERSAQAQWIA ADAYRVTEDT SGKKPRGKYY ACSMLPYPSG
60 70 80 90 100
KLHMGHVRNY TINDMLTRYL RMKGYNVLMP MGWDAFGLPA ENAAMKNGVP
110 120 130 140 150
PAQWTYDNIA YMKKQMQAMG LAIDWSREVA TCDPSYYKWN QWLFLKMLEK
160 170 180 190 200
GIAYRKTQVV NWDPVDQTVL ANEQVIDGKG WRTGATVEKR EIPGYYLKIT
210 220 230 240 250
DYAEELLGHV QHQLPGWPER VRLMQENWIG KSEGVRFAFT HDIRDASGAL
260 270 280 290 300
IGGGKMYVFT TRADTIMGVT FCAVAPEHPL ALHAAALNPQ LAAFIEECKA
310 320 330 340 350
GGTTEAELAT QEKKGKPTGL FVTHPLTGEQ VEVWVGNYVL MSYGDGAVMG
360 370 380 390 400
VPAHDERDFE FAKKYGLPIK QVTDVKGQAY SLEAWADWYG DKQQGVAINS
410 420 430 440 450
DKYDGLGLKA CVDAVAADLA AKGLGEKKTT WRLRDWGVSR QRYWGTPIPI
460 470 480 490 500
IHCDEHGAVP VPEKDLPVVL PQDCVPDGSG NPLHRHEGFH AGVVCPVCGK
510 520 530 540 550
PARRETDTMD TFVDSSWYYM RYCDPKNDQQ MVAGGADYWM PMDQYIGGIE
560 570 580 590 600
HAILHLLYAR FWTKVMRDLG LVKIDEPFTK LLTQGMVLNH IYSRKGDKGG
610 620 630 640 650
IEYFWPSEVE DIHDAAGKVT GAKRKSDGLL VNYEGVGTMS KSKNNGVDPQ
660 670 680 690 700
DLIERYGADT ARLYTMFTAP PEATLEWNDA AVEGSYRFLR RVWNFGVKLS
710 720 730 740 750
AAKTAAAAAQ AAGFVAEYGK EAKELRREIH TVLKQIDYDY QRMQYNTVVS
760 770 780 790 800
GNMKLLNALE NFTNDGAAGS HKALHESFGI LLRCLYPATP HLAHALWSEL
810 820 830 840 850
GYAAQQGDLL DAPWPEVDSG ALQQDVIELV LQVNGKLRGS VTVPAGADKA
860 870 880
TIEAAALASE AFLKQAAGAP AKKVIVVPGR LVNIVV
Length:886
Mass (Da):98,358
Last modified:August 22, 2006 - v1
Checksum:iEB01FC528E1BC171
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000316 Genomic DNA. Translation: ABE46488.1.
RefSeqiWP_011485475.1. NC_007948.1.
YP_551386.1. NC_007948.1.

Genome annotation databases

EnsemblBacteriaiABE46488; ABE46488; Bpro_4605.
GeneIDi4012724.
KEGGipol:Bpro_4605.
PATRICi22962514. VBIPolSp102244_4702.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000316 Genomic DNA. Translation: ABE46488.1 .
RefSeqi WP_011485475.1. NC_007948.1.
YP_551386.1. NC_007948.1.

3D structure databases

ProteinModelPortali Q122Q4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 296591.Bpro_4605.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE46488 ; ABE46488 ; Bpro_4605 .
GeneIDi 4012724.
KEGGi pol:Bpro_4605.
PATRICi 22962514. VBIPolSp102244_4702.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PSP296591:GHI4-5323-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JS666 / ATCC BAA-500.

Entry informationi

Entry nameiSYL_POLSJ
AccessioniPrimary (citable) accession number: Q122Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3