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Q122Q4

- SYL_POLSJ

UniProt

Q122Q4 - SYL_POLSJ

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei641 – 6411ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPSP296591:GHI4-5323-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Bpro_4605
    OrganismiPolaromonas sp. (strain JS666 / ATCC BAA-500)
    Taxonomic identifieri296591 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
    ProteomesiUP000001983: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 886886Leucine--tRNA ligasePRO_1000009391Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi296591.Bpro_4605.

    Structurei

    3D structure databases

    ProteinModelPortaliQ122Q4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi46 – 5611"HIGH" regionAdd
    BLAST
    Motifi638 – 6425"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiVVHCDAC.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q122Q4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQDKYNHLDV ERSAQAQWIA ADAYRVTEDT SGKKPRGKYY ACSMLPYPSG    50
    KLHMGHVRNY TINDMLTRYL RMKGYNVLMP MGWDAFGLPA ENAAMKNGVP 100
    PAQWTYDNIA YMKKQMQAMG LAIDWSREVA TCDPSYYKWN QWLFLKMLEK 150
    GIAYRKTQVV NWDPVDQTVL ANEQVIDGKG WRTGATVEKR EIPGYYLKIT 200
    DYAEELLGHV QHQLPGWPER VRLMQENWIG KSEGVRFAFT HDIRDASGAL 250
    IGGGKMYVFT TRADTIMGVT FCAVAPEHPL ALHAAALNPQ LAAFIEECKA 300
    GGTTEAELAT QEKKGKPTGL FVTHPLTGEQ VEVWVGNYVL MSYGDGAVMG 350
    VPAHDERDFE FAKKYGLPIK QVTDVKGQAY SLEAWADWYG DKQQGVAINS 400
    DKYDGLGLKA CVDAVAADLA AKGLGEKKTT WRLRDWGVSR QRYWGTPIPI 450
    IHCDEHGAVP VPEKDLPVVL PQDCVPDGSG NPLHRHEGFH AGVVCPVCGK 500
    PARRETDTMD TFVDSSWYYM RYCDPKNDQQ MVAGGADYWM PMDQYIGGIE 550
    HAILHLLYAR FWTKVMRDLG LVKIDEPFTK LLTQGMVLNH IYSRKGDKGG 600
    IEYFWPSEVE DIHDAAGKVT GAKRKSDGLL VNYEGVGTMS KSKNNGVDPQ 650
    DLIERYGADT ARLYTMFTAP PEATLEWNDA AVEGSYRFLR RVWNFGVKLS 700
    AAKTAAAAAQ AAGFVAEYGK EAKELRREIH TVLKQIDYDY QRMQYNTVVS 750
    GNMKLLNALE NFTNDGAAGS HKALHESFGI LLRCLYPATP HLAHALWSEL 800
    GYAAQQGDLL DAPWPEVDSG ALQQDVIELV LQVNGKLRGS VTVPAGADKA 850
    TIEAAALASE AFLKQAAGAP AKKVIVVPGR LVNIVV 886
    Length:886
    Mass (Da):98,358
    Last modified:August 22, 2006 - v1
    Checksum:iEB01FC528E1BC171
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000316 Genomic DNA. Translation: ABE46488.1.
    RefSeqiWP_011485475.1. NC_007948.1.
    YP_551386.1. NC_007948.1.

    Genome annotation databases

    EnsemblBacteriaiABE46488; ABE46488; Bpro_4605.
    GeneIDi4012724.
    KEGGipol:Bpro_4605.
    PATRICi22962514. VBIPolSp102244_4702.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000316 Genomic DNA. Translation: ABE46488.1 .
    RefSeqi WP_011485475.1. NC_007948.1.
    YP_551386.1. NC_007948.1.

    3D structure databases

    ProteinModelPortali Q122Q4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 296591.Bpro_4605.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE46488 ; ABE46488 ; Bpro_4605 .
    GeneIDi 4012724.
    KEGGi pol:Bpro_4605.
    PATRICi 22962514. VBIPolSp102244_4702.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi VVHCDAC.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PSP296591:GHI4-5323-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JS666 / ATCC BAA-500.

    Entry informationi

    Entry nameiSYL_POLSJ
    AccessioniPrimary (citable) accession number: Q122Q4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3