Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2-aminoethylphosphonate--pyruvate transaminase 2

Gene

phnW2

Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in phosphonate degradation.UniRule annotation

Catalytic activityi

(2-aminoethyl)phosphonate + pyruvate = 2-phosphonoacetaldehyde + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate, Pyruvate

Names & Taxonomyi

Protein namesi
Recommended name:
2-aminoethylphosphonate--pyruvate transaminase 2UniRule annotation (EC:2.6.1.37UniRule annotation)
Alternative name(s):
2-aminoethylphosphonate aminotransferase 2UniRule annotation
AEP transaminase 2UniRule annotation
Short name:
AEPT 2UniRule annotation
Gene namesi
Name:phnW2UniRule annotation
Ordered Locus Names:Bpro_4697
OrganismiPolaromonas sp. (strain JS666 / ATCC BAA-500)
Taxonomic identifieri296591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
Proteomesi
  • UP000001983 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002867721 – 3722-aminoethylphosphonate--pyruvate transaminase 2Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei192N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi296591.Bpro_4697.

Structurei

3D structure databases

ProteinModelPortaliQ122G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107THD. Bacteria.
COG0075. LUCA.
HOGENOMiHOG000171816.
KOiK03430.
OMAiNIMLPIT.
OrthoDBiPOG091H03C8.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01376. PhnW_aminotrans_5. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR012703. NH2EtPonate_pyrv_transaminase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR024169. SP_NH2Trfase/AEP_transaminase.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000524. SPT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03301. PhnW-AepZ. 1 hit.
TIGR02326. transamin_PhnW. 1 hit.

Sequencei

Sequence statusi: Complete.

Q122G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRDKILLTP GPLTTTLRTK LAMLKDWGSW DTDFNAVTAS VRRSLLDIIH
60 70 80 90 100
GHDSHVVVPL QGSGTFSVEA AVATLVPHDG HVLVLDNGAY CKRAVRLTQL
110 120 130 140 150
MGRRCTVLPF DEAAPVSAAA LADQLKADAS ISHVILIHCE TGAGVLNPLQ
160 170 180 190 200
EVADVCAAHG KGLIVDAMSS FAALEIDARK VRFDALVAAS GKCLEGVPGM
210 220 230 240 250
GFVFIRKAIL EGCAGRSQSL AMDLYDQYIY MEKTTQWRFT PPTHVVVALA
260 270 280 290 300
EAIAQFEEEG GQPARLARYQ RNYSTLITGM ARLGFRPFLD PAIQAPIIVT
310 320 330 340 350
FHAPADSRYE FKRFYASARE RGFVLYPGKL TQVETFRVGC IGAIGPREME
360 370
QAVHAIAGAL QDMGISSAAP AH
Length:372
Mass (Da):40,231
Last modified:August 22, 2006 - v1
Checksum:iDF816A21C65F933E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000316 Genomic DNA. Translation: ABE46580.1.
RefSeqiWP_011485567.1. NC_007948.1.

Genome annotation databases

EnsemblBacteriaiABE46580; ABE46580; Bpro_4697.
KEGGipol:Bpro_4697.
PATRICi22962704. VBIPolSp102244_4797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000316 Genomic DNA. Translation: ABE46580.1.
RefSeqiWP_011485567.1. NC_007948.1.

3D structure databases

ProteinModelPortaliQ122G2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi296591.Bpro_4697.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE46580; ABE46580; Bpro_4697.
KEGGipol:Bpro_4697.
PATRICi22962704. VBIPolSp102244_4797.

Phylogenomic databases

eggNOGiENOG4107THD. Bacteria.
COG0075. LUCA.
HOGENOMiHOG000171816.
KOiK03430.
OMAiNIMLPIT.
OrthoDBiPOG091H03C8.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01376. PhnW_aminotrans_5. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR012703. NH2EtPonate_pyrv_transaminase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR024169. SP_NH2Trfase/AEP_transaminase.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000524. SPT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03301. PhnW-AepZ. 1 hit.
TIGR02326. transamin_PhnW. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHNW2_POLSJ
AccessioniPrimary (citable) accession number: Q122G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: August 22, 2006
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

The second enzyme involved in phosphonate degradation (PhnX, EC 3.11.1.1) is not found in this organism. The function of this enzyme is therefore uncertain.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.