Reviewed, UniProtKB/Swiss-Prot Q12298 (YD061_YEAST)

Names and origin

Protein names

Recommended name:
    Uncharacterized ABC transporter ATP-binding protein YDR061W

Gene names

Ordered Locus Names:	YDR061W
ORF Names:	D4241

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	539 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Mitochondrion. Ref.4
Induction	Induced by transcription factor YRM1. Ref.3
Miscellaneous	Present with 1580 molecules/cell in log phase SD medium. Ref.5
Sequence similarities	Belongs to the ABC transporter family. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Mitochondrion
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Ref.4 Inferred from direct assay. Source: SGD
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	P43582	1	EBI-34580,EBI-22766
ADH1	P00330	1	EBI-34580,EBI-2218
ESS1	P22696	1	EBI-34580,EBI-6679
PRP40	P33203	1	EBI-34580,EBI-701
RSP5	P39940	1	EBI-34580,EBI-16219
URN1	Q06525	1	EBI-34580,EBI-35138

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 539	539	Uncharacterized ABC transporter ATP-binding protein YDR061W		PRO_0000244440
Regions
	Domain	8 – 265	258	ABC transporter 1
	Domain	307 – 537	231	ABC transporter 2
	Nucleotide binding	339 – 346	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q12298-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3F27AF363EBED838	FASTA	539	61,191
	10 20 30 40 50 60 MSTNKFVVRI TNALFKSSLA SNSPPVYPKR IRHFEILPNE KWVIWGPGKG KFLDVLNNKY 70 80 90 100 110 120 ICEPPLSLRF GFLKESSNIL PRIEQVAFKG VMPTAHLSAR YEYFKDDYDQ TCKQFIFDKA 130 140 150 160 170 180 SGSNAVSYKV ETNNRQINME LYNALVENLN LSSLQDRWVM GLSNGQMRRA RLARSILKEP 190 200 210 220 230 240 DLLLIDDPFL GLDPAAIATI SQFLAKYDSI EVSGGCPIVI GLRYQDTIPA WCTHICCVDE 250 260 270 280 290 300 KNGILFEGPI EKLQSKMDET RSRALKELEQ LKKASNSKED ISINDLICIH PMYGKKEHEI 310 320 330 340 350 360 IKMPHLIELD GLSVSYKGEA VLENLHWKVQ PGSKWHIRGD NGSGKSTLLS LLTAEHPQSW 370 380 390 400 410 420 NSRVIDNGVP RRTGKTNYFD LNSKIGMSSP ELHAIFLKNA GGRLNIRESV ATGYHEASSN 430 440 450 460 470 480 NYLPIWKRLD KNSQEIVNMY LKYFGLDKDA DSVLFEQLSV SDQKLVLFVR SLIKMPQILI 490 500 510 520 530 LDEAFSGMEV EPMMRCHEFL EEWPGTVLVV AHVAEETPKC AHYLRLISPG EYEIGDMEN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence analysis of a 32,500 bp region of the right arm of Saccharomyces cerevisiae chromosome IV." Brandt P., Ramlow S., Otto B., Bloecker H. Yeast 12:85-90(1996) [PubMed: 8789263] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P. Nature 387:75-78(1997) [PubMed: 9169867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon." Lucau-Danila A., Delaveau T., Lelandais G., Devaux F., Jacq C. J. Biol. Chem. 278:52641-52650(2003) [PubMed: 14512416] [Abstract] Cited for: INDUCTION.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X84162 Genomic DNA. Translation: CAA58977.1. Z49209 Genomic DNA. Translation: CAA89090.1. Z74357 Genomic DNA. Translation: CAA98879.1.
PIR	S54045.
RefSeq	NP_010346.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:1817N.
IntAct	Q12298. 9 interactions.
Proteomic databases
PeptideAtlas	Q12298.
Genome annotation databases
Ensembl	YDR061W. Saccharomyces cerevisiae. [Contig view]
GeneID	851633.
GenomeReviews	Gene locus YDR061W in contig Z71256_GR.
KEGG	sce:YDR061W.
NMPDR	fig|4932.3.peg.1091.
Organism-specific databases
CYGD	YDR061w.
SGD	S000002468. YDR061W.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	Q12298.
OMA	Q12298. WINSLSN.
Gene expression databases
GermOnline	YDR061W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
ProDom	PD000006. ABC_transporter. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. False negative. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	969185.

Entry information

Entry name

YD061_YEAST

Accession

Primary (citable) accession number: Q12298

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)