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Protein

Transcription initiation factor TFIID subunit 3

Gene

TAF3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.6 Publications

GO - Molecular functioni

  • chromatin binding Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33930-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 3
Alternative name(s):
TAFII-47
Short name:
TAFII47
TBP-associated factor 3
TBP-associated factor 47 kDa
Gene namesi
Name:TAF3
Synonyms:TAF47
Ordered Locus Names:YPL011C
ORF Names:LPA6C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL011C.
SGDiS000005932. TAF3.

Subcellular locationi

GO - Cellular componenti

  • transcription factor TFIID complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188681 – 353Transcription initiation factor TFIID subunit 3Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei237PhosphothreonineCombined sources1
Modified residuei310PhosphoserineCombined sources1
Modified residuei346PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12297.
PRIDEiQ12297.

PTM databases

iPTMnetiQ12297.

Interactioni

Subunit structurei

TAF3 heterodimerizes with TAF10. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14.1 Publication

Protein-protein interaction databases

BioGridi36166. 26 interactors.
DIPiDIP-5328N.
IntActiQ12297. 18 interactors.
MINTiMINT-545815.

Structurei

3D structure databases

ProteinModelPortaliQ12297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 78Histone-foldAdd BLAST68

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili289 – 309Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the TAF3 family.Curated
Contains 1 histone-fold domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000141699.
InParanoidiQ12297.
KOiK14650.
OMAiIPEYINQ.
OrthoDBiEOG092C2WCV.

Family and domain databases

InterProiIPR006565. BTP.
[Graphical view]
PfamiPF07524. Bromo_TP. 1 hit.
[Graphical view]
SMARTiSM00576. BTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTNNDFYFA LLRISILQLL KAQGFDRARP SLVDVMTDLY AKFLSLLASE
60 70 80 90 100
VSSIAQARCD QDDTIALQDI TLALENLGIV KPTNVLDVYD ENSELSSSRG
110 120 130 140 150
MEKFKDWCIY STQLTDARIT ALPTVELLQS EEKESDPLSA IPDYLNQLLQ
160 170 180 190 200
NKGAKQKLET KNRKTELIED LINNNGLDDW IKLVIARQRI NMIERASKKE
210 220 230 240 250
SQNVPALPHI AGYKSSILSR HHHTTITNED RMPSAMTPRD EDALTEIQEN
260 270 280 290 300
PFVTSKLPIM RKENRLENIT LSFEDEELES LGEVEGPNQK SQENNNEESF
310 320 330 340 350
KENNKSLTES PHGDDRDISM FQFDSNVDTK WAEQEDMDST FQRRTSLDYG

GYF
Length:353
Mass (Da):40,296
Last modified:November 1, 1996 - v1
Checksum:i98A6B7813A29978F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33335 Genomic DNA. Translation: AAB68094.1.
Z71255 Genomic DNA. Translation: CAA95030.1.
Z48483 Genomic DNA. Translation: CAA88375.1.
BK006949 Genomic DNA. Translation: DAA11417.1.
PIRiS52520.
RefSeqiNP_015314.1. NM_001183825.1.

Genome annotation databases

EnsemblFungiiYPL011C; YPL011C; YPL011C.
GeneIDi856096.
KEGGisce:YPL011C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33335 Genomic DNA. Translation: AAB68094.1.
Z71255 Genomic DNA. Translation: CAA95030.1.
Z48483 Genomic DNA. Translation: CAA88375.1.
BK006949 Genomic DNA. Translation: DAA11417.1.
PIRiS52520.
RefSeqiNP_015314.1. NM_001183825.1.

3D structure databases

ProteinModelPortaliQ12297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36166. 26 interactors.
DIPiDIP-5328N.
IntActiQ12297. 18 interactors.
MINTiMINT-545815.

PTM databases

iPTMnetiQ12297.

Proteomic databases

MaxQBiQ12297.
PRIDEiQ12297.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL011C; YPL011C; YPL011C.
GeneIDi856096.
KEGGisce:YPL011C.

Organism-specific databases

EuPathDBiFungiDB:YPL011C.
SGDiS000005932. TAF3.

Phylogenomic databases

HOGENOMiHOG000141699.
InParanoidiQ12297.
KOiK14650.
OMAiIPEYINQ.
OrthoDBiEOG092C2WCV.

Enzyme and pathway databases

BioCyciYEAST:G3O-33930-MONOMER.

Miscellaneous databases

PROiQ12297.

Family and domain databases

InterProiIPR006565. BTP.
[Graphical view]
PfamiPF07524. Bromo_TP. 1 hit.
[Graphical view]
SMARTiSM00576. BTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAF3_YEAST
AccessioniPrimary (citable) accession number: Q12297
Secondary accession number(s): D6W401
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.