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Protein

Protein MAM3

Gene

MAM3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in metal homeostasis and more specially in manganese sensitivity.1 Publication

Miscellaneous

Present with 2270 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • cellular manganese ion homeostasis Source: SGD
  • mitochondrion organization Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-33469-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MAM3
Gene namesi
Name:MAM3
Ordered Locus Names:YOL060C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL060C
SGDiS000005421 MAM3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16VacuolarSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 65CytoplasmicSequence analysisAdd BLAST28
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 120VacuolarSequence analysisAdd BLAST34
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 145CytoplasmicSequence analysis4
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 177VacuolarSequence analysisAdd BLAST11
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 706CytoplasmicSequence analysisAdd BLAST508

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002559601 – 706Protein MAM3Add BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei439PhosphoserineCombined sources1
Modified residuei447PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1
Modified residuei604PhosphotyrosineCombined sources1
Modified residuei607PhosphothreonineCombined sources1
Modified residuei614PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12296
PaxDbiQ12296
PRIDEiQ12296
TopDownProteomicsiQ12296

PTM databases

iPTMnetiQ12296

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SSB1P114843EBI-33338,EBI-8627

Protein-protein interaction databases

BioGridi34341, 62 interactors
IntActiQ12296, 26 interactors
STRINGi4932.YOL060C

Structurei

3D structure databases

ProteinModelPortaliQ12296
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 240CNNM transmembranePROSITE-ProRule annotationAdd BLAST184
Domaini259 – 320CBS 1PROSITE-ProRule annotationAdd BLAST62
Domaini321 – 386CBS 2PROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Belongs to the ACDP family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002383
HOGENOMiHOG000183089
InParanoidiQ12296
KOiK16302
OMAiDVFVDIH
OrthoDBiEOG092C1Z0E

Family and domain databases

InterProiView protein in InterPro
IPR000644 CBS_dom
IPR002550 DUF21
PfamiView protein in Pfam
PF01595 DUF21, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits
PS51846 CNNM, 1 hit

Sequencei

Sequence statusi: Complete.

Q12296-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLPLRSRS RSGAPHWVYI ILYHIFTIPK IYSLPLLSGS HVLNSRDVAD
60 70 80 90 100
SGHSVGDEAS VTTYYIISII LVLLGGVFAG LTLGLMGQDE VYLKVISTSG
110 120 130 140 150
SNSEKKLAKR VLDLISRGKH WVLVTLLLSN VITNETLPIV LDRCLGGGWQ
160 170 180 190 200
AVVSSTILIV IFGEIIPQSV CVKYGLQVGA FFCPFVLVLM YLMYPVAYPI
210 220 230 240 250
ATLLDYMLGE DHGTMYKKSG LKTLVTLHRT MGVERLTKDE VTIISAVLDL
260 270 280 290 300
KAKRVEEIMT PIENVFTMSA DTILDDKTVE KIFNSGFSRI PIFLPNEPNN
310 320 330 340 350
FIGMLLVRVL ISYDPDDCLP ISHFPLATLP ETSPNTSCLN ILNYFQEGKA
360 370 380 390 400
HMCVVSKEPG SSHGAIGVLT LEDVIEELIG EEIVDESDVF VDMHQHIMRQ
410 420 430 440 450
QPGPLSKRHI TSYLHHLYTS SHKEHKAADQ ADESSPLLSP SNSNHPSEHP
460 470 480 490 500
QQDLNNKSWK QKSNDGYDRS NAVLSPTPQV TEHGTIIPSN LASNPLNVNK
510 520 530 540 550
SFVTIKKPAN VPKIITTHTP HSSKEPSPAP HSNDKSLSAE EQQLLSDHAE
560 570 580 590 600
LSRQAVLHTQ RSGQPTQVTT STKTTRNSPD SISIPNSGAN HGNENQNVTI
610 620 630 640 650
STSYQNTKNG IVESVITVKG VPKTIIGPAK DWDESKSEYG NENINQENSN
660 670 680 690 700
RSDDRESSSS NASLFSSIKN KFKNENANNN DRSNFTDSLS RTSNYDANGS

SSTIKR
Length:706
Mass (Da):77,712
Last modified:November 1, 1996 - v1
Checksum:iAAB3EA4CAD8E5F53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91067 Genomic DNA Translation: CAA62524.1
Z74802 Genomic DNA Translation: CAA99069.1
AY692822 Genomic DNA Translation: AAT92841.1
BK006948 Genomic DNA Translation: DAA10723.1
PIRiS61717
RefSeqiNP_014581.1, NM_001183315.1

Genome annotation databases

EnsemblFungiiYOL060C; YOL060C; YOL060C
GeneIDi854094
KEGGisce:YOL060C

Similar proteinsi

Entry informationi

Entry nameiMAM3_YEAST
AccessioniPrimary (citable) accession number: Q12296
Secondary accession number(s): D6W207
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health