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Protein

Mitochondrial carnitine carrier

Gene

CRC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports carnitine, acetylcarnitine, propionylcarnitine and to a much lower extent medium- and long-chain acylcarnitines.2 Publications

GO - Molecular functioni

GO - Biological processi

  • carnitine transport Source: GO_Central
  • fatty acid metabolic process Source: SGD
  • mitochondrial transport Source: GO_Central

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-33633-MONOMER
ReactomeiR-SCE-200425 Import of palmitoyl-CoA into the mitochondrial matrix

Protein family/group databases

TCDBi2.A.29.8.4 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carnitine carrier
Gene namesi
Name:CRC1
Ordered Locus Names:YOR100C
ORF Names:YOR3193C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR100C
SGDiS000005626 CRC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 49Helical; Name=1Sequence analysisAdd BLAST17
Transmembranei107 – 123Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei141 – 162Helical; Name=3Sequence analysisAdd BLAST22
Transmembranei196 – 212Helical; Name=4Sequence analysisAdd BLAST17
Transmembranei244 – 260Helical; Name=5Sequence analysisAdd BLAST17
Transmembranei293 – 313Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906811 – 327Mitochondrial carnitine carrierAdd BLAST327

Proteomic databases

MaxQBiQ12289
PaxDbiQ12289
PRIDEiQ12289

2D gel databases

UCD-2DPAGEiQ12289

Interactioni

Protein-protein interaction databases

BioGridi34498, 100 interactors
DIPiDIP-4154N
IntActiQ12289, 3 interactors
MINTiQ12289
STRINGi4932.YOR100C

Structurei

3D structure databases

ProteinModelPortaliQ12289
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati33 – 126Solcar 1Add BLAST94
Repeati139 – 221Solcar 2Add BLAST83
Repeati237 – 321Solcar 3Add BLAST85

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00700000104295
HOGENOMiHOG000168307
InParanoidiQ12289
KOiK15109
OMAiNIVAPNF
OrthoDBiEOG092C3ESU

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q12289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDTSLSES SLLKEESGSL TKSRPPIKSN PVRENIKSFV AGGVGGVCAV
60 70 80 90 100
FTGHPFDLIK VRCQNGQANS TVHAITNIIK EAKTQVKGTL FTNSVKGFYK
110 120 130 140 150
GVIPPLLGVT PIFAVSFWGY DVGKKLVTFN NKQGGSNELT MGQMAAAGFI
160 170 180 190 200
SAIPTTLVTA PTERVKVVLQ TSSKGSFIQA AKTIVKEGGI ASLFKGSLAT
210 220 230 240 250
LARDGPGSAL YFASYEISKN YLNSRQPRQD AGKDEPVNIL NVCLAGGIAG
260 270 280 290 300
MSMWLAVFPI DTIKTKLQAS STRQNMLSAT KEIYLQRGGI KGFFPGLGPA
310 320
LLRSFPANAA TFLGVEMTHS LFKKYGI
Length:327
Mass (Da):34,754
Last modified:November 1, 1996 - v1
Checksum:i0CF982E858BD1EA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250124 Genomic DNA Translation: CAB64359.1
X94335 Genomic DNA Translation: CAA64022.1
Z75008 Genomic DNA Translation: CAA99297.1
AY693195 Genomic DNA Translation: AAT93214.1
BK006948 Genomic DNA Translation: DAA10877.1
PIRiS61660
RefSeqiNP_014743.1, NM_001183519.1

Genome annotation databases

EnsemblFungiiYOR100C; YOR100C; YOR100C
GeneIDi854267
KEGGisce:YOR100C

Similar proteinsi

Entry informationi

Entry nameiCRC1_YEAST
AccessioniPrimary (citable) accession number: Q12289
Secondary accession number(s): D6W2G1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

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