Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial carnitine carrier

Gene

CRC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transports carnitine, acetylcarnitine, propionylcarnitine and to a much lower extent medium- and long-chain acylcarnitines.2 Publications

GO - Molecular functioni

  • carnitine:acyl carnitine antiporter activity Source: SGD

GO - Biological processi

  • fatty acid metabolic process Source: SGD
  • transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33633-MONOMER.
ReactomeiR-SCE-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Protein family/group databases

TCDBi2.A.29.8.4. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carnitine carrier
Gene namesi
Name:CRC1
Ordered Locus Names:YOR100C
ORF Names:YOR3193C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR100C.
SGDiS000005626. CRC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 4917Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei107 – 12317Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei141 – 16222Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei196 – 21217Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei244 – 26017Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei293 – 31321Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Mitochondrial carnitine carrierPRO_0000090681Add
BLAST

Proteomic databases

MaxQBiQ12289.
PeptideAtlasiQ12289.

2D gel databases

UCD-2DPAGEQ12289.

Interactioni

Protein-protein interaction databases

BioGridi34498. 20 interactions.
DIPiDIP-4154N.
IntActiQ12289. 2 interactions.
MINTiMINT-555330.

Structurei

3D structure databases

ProteinModelPortaliQ12289.
SMRiQ12289. Positions 39-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati33 – 12694Solcar 1Add
BLAST
Repeati139 – 22183Solcar 2Add
BLAST
Repeati237 – 32185Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
InParanoidiQ12289.
KOiK15109.
OMAiIAGMSMW.
OrthoDBiEOG7Z69MP.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDTSLSES SLLKEESGSL TKSRPPIKSN PVRENIKSFV AGGVGGVCAV
60 70 80 90 100
FTGHPFDLIK VRCQNGQANS TVHAITNIIK EAKTQVKGTL FTNSVKGFYK
110 120 130 140 150
GVIPPLLGVT PIFAVSFWGY DVGKKLVTFN NKQGGSNELT MGQMAAAGFI
160 170 180 190 200
SAIPTTLVTA PTERVKVVLQ TSSKGSFIQA AKTIVKEGGI ASLFKGSLAT
210 220 230 240 250
LARDGPGSAL YFASYEISKN YLNSRQPRQD AGKDEPVNIL NVCLAGGIAG
260 270 280 290 300
MSMWLAVFPI DTIKTKLQAS STRQNMLSAT KEIYLQRGGI KGFFPGLGPA
310 320
LLRSFPANAA TFLGVEMTHS LFKKYGI
Length:327
Mass (Da):34,754
Last modified:November 1, 1996 - v1
Checksum:i0CF982E858BD1EA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250124 Genomic DNA. Translation: CAB64359.1.
X94335 Genomic DNA. Translation: CAA64022.1.
Z75008 Genomic DNA. Translation: CAA99297.1.
AY693195 Genomic DNA. Translation: AAT93214.1.
BK006948 Genomic DNA. Translation: DAA10877.1.
PIRiS61660.
RefSeqiNP_014743.1. NM_001183519.1.

Genome annotation databases

EnsemblFungiiYOR100C; YOR100C; YOR100C.
GeneIDi854267.
KEGGisce:YOR100C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250124 Genomic DNA. Translation: CAB64359.1.
X94335 Genomic DNA. Translation: CAA64022.1.
Z75008 Genomic DNA. Translation: CAA99297.1.
AY693195 Genomic DNA. Translation: AAT93214.1.
BK006948 Genomic DNA. Translation: DAA10877.1.
PIRiS61660.
RefSeqiNP_014743.1. NM_001183519.1.

3D structure databases

ProteinModelPortaliQ12289.
SMRiQ12289. Positions 39-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34498. 20 interactions.
DIPiDIP-4154N.
IntActiQ12289. 2 interactions.
MINTiMINT-555330.

Protein family/group databases

TCDBi2.A.29.8.4. the mitochondrial carrier (mc) family.

2D gel databases

UCD-2DPAGEQ12289.

Proteomic databases

MaxQBiQ12289.
PeptideAtlasiQ12289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR100C; YOR100C; YOR100C.
GeneIDi854267.
KEGGisce:YOR100C.

Organism-specific databases

EuPathDBiFungiDB:YOR100C.
SGDiS000005626. CRC1.

Phylogenomic databases

GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
InParanoidiQ12289.
KOiK15109.
OMAiIAGMSMW.
OrthoDBiEOG7Z69MP.

Enzyme and pathway databases

BioCyciYEAST:G3O-33633-MONOMER.
ReactomeiR-SCE-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Miscellaneous databases

PROiQ12289.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae."
    Palmieri L., Lasorsa F.M., Iacobazzi V., Runswick M.J., Palmieri F., Walker J.E.
    FEBS Lett. 462:472-476(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: ATCC 96099 / S288c / SEY6210.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. "Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p."
    van Roermund C.W., Hettema E.H., van den Berg M., Tabak H.F., Wanders R.J.
    EMBO J. 18:5843-5852(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CARNITINE TRANSPORT.

Entry informationi

Entry nameiCRC1_YEAST
AccessioniPrimary (citable) accession number: Q12289
Secondary accession number(s): D6W2G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.