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Protein

Mitochondrial carnitine carrier

Gene

CRC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transports carnitine, acetylcarnitine, propionylcarnitine and to a much lower extent medium- and long-chain acylcarnitines.2 Publications

GO - Molecular functioni

  • carnitine:acyl carnitine antiporter activity Source: SGD

GO - Biological processi

  • fatty acid metabolic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33633-MONOMER.
ReactomeiR-SCE-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Protein family/group databases

TCDBi2.A.29.8.4. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carnitine carrier
Gene namesi
Name:CRC1
Ordered Locus Names:YOR100C
ORF Names:YOR3193C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR100C.
SGDiS000005626. CRC1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 49Helical; Name=1Sequence analysisAdd BLAST17
Transmembranei107 – 123Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei141 – 162Helical; Name=3Sequence analysisAdd BLAST22
Transmembranei196 – 212Helical; Name=4Sequence analysisAdd BLAST17
Transmembranei244 – 260Helical; Name=5Sequence analysisAdd BLAST17
Transmembranei293 – 313Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906811 – 327Mitochondrial carnitine carrierAdd BLAST327

Proteomic databases

MaxQBiQ12289.
PRIDEiQ12289.

2D gel databases

UCD-2DPAGEQ12289.

Interactioni

Protein-protein interaction databases

BioGridi34498. 22 interactors.
DIPiDIP-4154N.
IntActiQ12289. 2 interactors.
MINTiMINT-555330.

Structurei

3D structure databases

ProteinModelPortaliQ12289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati33 – 126Solcar 1Add BLAST94
Repeati139 – 221Solcar 2Add BLAST83
Repeati237 – 321Solcar 3Add BLAST85

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
InParanoidiQ12289.
KOiK15109.
OMAiFASYEIS.
OrthoDBiEOG092C3ESU.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDTSLSES SLLKEESGSL TKSRPPIKSN PVRENIKSFV AGGVGGVCAV
60 70 80 90 100
FTGHPFDLIK VRCQNGQANS TVHAITNIIK EAKTQVKGTL FTNSVKGFYK
110 120 130 140 150
GVIPPLLGVT PIFAVSFWGY DVGKKLVTFN NKQGGSNELT MGQMAAAGFI
160 170 180 190 200
SAIPTTLVTA PTERVKVVLQ TSSKGSFIQA AKTIVKEGGI ASLFKGSLAT
210 220 230 240 250
LARDGPGSAL YFASYEISKN YLNSRQPRQD AGKDEPVNIL NVCLAGGIAG
260 270 280 290 300
MSMWLAVFPI DTIKTKLQAS STRQNMLSAT KEIYLQRGGI KGFFPGLGPA
310 320
LLRSFPANAA TFLGVEMTHS LFKKYGI
Length:327
Mass (Da):34,754
Last modified:November 1, 1996 - v1
Checksum:i0CF982E858BD1EA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250124 Genomic DNA. Translation: CAB64359.1.
X94335 Genomic DNA. Translation: CAA64022.1.
Z75008 Genomic DNA. Translation: CAA99297.1.
AY693195 Genomic DNA. Translation: AAT93214.1.
BK006948 Genomic DNA. Translation: DAA10877.1.
PIRiS61660.
RefSeqiNP_014743.1. NM_001183519.1.

Genome annotation databases

EnsemblFungiiYOR100C; YOR100C; YOR100C.
GeneIDi854267.
KEGGisce:YOR100C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250124 Genomic DNA. Translation: CAB64359.1.
X94335 Genomic DNA. Translation: CAA64022.1.
Z75008 Genomic DNA. Translation: CAA99297.1.
AY693195 Genomic DNA. Translation: AAT93214.1.
BK006948 Genomic DNA. Translation: DAA10877.1.
PIRiS61660.
RefSeqiNP_014743.1. NM_001183519.1.

3D structure databases

ProteinModelPortaliQ12289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34498. 22 interactors.
DIPiDIP-4154N.
IntActiQ12289. 2 interactors.
MINTiMINT-555330.

Protein family/group databases

TCDBi2.A.29.8.4. the mitochondrial carrier (mc) family.

2D gel databases

UCD-2DPAGEQ12289.

Proteomic databases

MaxQBiQ12289.
PRIDEiQ12289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR100C; YOR100C; YOR100C.
GeneIDi854267.
KEGGisce:YOR100C.

Organism-specific databases

EuPathDBiFungiDB:YOR100C.
SGDiS000005626. CRC1.

Phylogenomic databases

GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
InParanoidiQ12289.
KOiK15109.
OMAiFASYEIS.
OrthoDBiEOG092C3ESU.

Enzyme and pathway databases

BioCyciYEAST:G3O-33633-MONOMER.
ReactomeiR-SCE-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Miscellaneous databases

PROiQ12289.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRC1_YEAST
AccessioniPrimary (citable) accession number: Q12289
Secondary accession number(s): D6W2G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.