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Protein

Cytochrome c oxidase copper chaperone

Gene

COX17

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231CopperBy similarity
Metal bindingi24 – 241CopperBy similarity

GO - Molecular functioni

  • copper chaperone activity Source: SGD

GO - Biological processi

  • intracellular copper ion transport Source: SGD
  • mitochondrial respiratory chain complex IV assembly Source: SGD
  • protein farnesylation Source: MGI
  • protein targeting to mitochondrion Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32114-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase copper chaperone
Gene namesi
Name:COX17
Ordered Locus Names:YLL009C
ORF Names:L1343
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL009C.
SGDiS000003932. COX17.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • mitochondrial intermembrane space Source: SGD
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 6968Cytochrome c oxidase copper chaperonePRO_0000213541Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 57By similarity
Disulfide bondi36 ↔ 47By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ12287.

Interactioni

Protein-protein interaction databases

BioGridi31242. 19 interactions.
DIPiDIP-2915N.
IntActiQ12287. 7 interactions.
MINTiMINT-517429.

Structurei

Secondary structure

1
69
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 75Combined sources
Beta strandi13 – 153Combined sources
Beta strandi23 – 253Combined sources
Helixi28 – 3912Combined sources
Helixi45 – 473Combined sources
Helixi48 – 5912Combined sources
Turni60 – 623Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U96NMR-A1-69[»]
1U97NMR-A1-69[»]
1Z2GNMR-A1-69[»]
DisProtiDP00277.
ProteinModelPortaliQ12287.
SMRiQ12287. Positions 1-69.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12287.

Family & Domainsi

Sequence similaritiesi

Belongs to the COX17 family.Curated

Phylogenomic databases

HOGENOMiHOG000195037.
InParanoidiQ12287.
KOiK02260.
OMAiTEKPKPC.
OrthoDBiEOG092C5YRF.

Family and domain databases

Gene3Di1.10.810.10. 1 hit.
InterProiIPR009069. Cys_alpha_HP_mot_SF.
IPR007745. Cyt_c_oxidase_Cu-chaperone.
[Graphical view]
PANTHERiPTHR16719. PTHR16719. 1 hit.
PfamiPF05051. COX17. 1 hit.
[Graphical view]
ProDomiPD014904. Cyt_c_oxidase_Cu-chaperone. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47072. SSF47072. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTETDKKQEQ ENHAECEDKP KPCCVCKPEK EERDTCILFN GQDSEKCKEF
60
IEKYKECMKG YGFEVPSAN
Length:69
Mass (Da):8,056
Last modified:January 23, 2007 - v3
Checksum:i7DA9A5F97C8A3F78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L75948 Genomic DNA. Translation: AAA85477.1.
Z73114 Genomic DNA. Translation: CAA97453.1.
BK006945 Genomic DNA. Translation: DAA09309.1.
PIRiS62056.
RefSeqiNP_013092.1. NM_001181829.1.

Genome annotation databases

EnsemblFungiiYLL009C; YLL009C; YLL009C.
GeneIDi850651.
KEGGisce:YLL009C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L75948 Genomic DNA. Translation: AAA85477.1.
Z73114 Genomic DNA. Translation: CAA97453.1.
BK006945 Genomic DNA. Translation: DAA09309.1.
PIRiS62056.
RefSeqiNP_013092.1. NM_001181829.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U96NMR-A1-69[»]
1U97NMR-A1-69[»]
1Z2GNMR-A1-69[»]
DisProtiDP00277.
ProteinModelPortaliQ12287.
SMRiQ12287. Positions 1-69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31242. 19 interactions.
DIPiDIP-2915N.
IntActiQ12287. 7 interactions.
MINTiMINT-517429.

Proteomic databases

MaxQBiQ12287.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLL009C; YLL009C; YLL009C.
GeneIDi850651.
KEGGisce:YLL009C.

Organism-specific databases

EuPathDBiFungiDB:YLL009C.
SGDiS000003932. COX17.

Phylogenomic databases

HOGENOMiHOG000195037.
InParanoidiQ12287.
KOiK02260.
OMAiTEKPKPC.
OrthoDBiEOG092C5YRF.

Enzyme and pathway databases

BioCyciYEAST:G3O-32114-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Miscellaneous databases

EvolutionaryTraceiQ12287.
PROiQ12287.

Family and domain databases

Gene3Di1.10.810.10. 1 hit.
InterProiIPR009069. Cys_alpha_HP_mot_SF.
IPR007745. Cyt_c_oxidase_Cu-chaperone.
[Graphical view]
PANTHERiPTHR16719. PTHR16719. 1 hit.
PfamiPF05051. COX17. 1 hit.
[Graphical view]
ProDomiPD014904. Cyt_c_oxidase_Cu-chaperone. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47072. SSF47072. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX17_YEAST
AccessioniPrimary (citable) accession number: Q12287
Secondary accession number(s): D6VXZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.