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Protein

Cytochrome c oxidase copper chaperone

Gene

COX17

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23CopperBy similarity1
Metal bindingi24CopperBy similarity1

GO - Molecular functioni

  • copper chaperone activity Source: SGD
  • cuprous ion binding Source: CAFA

GO - Biological processi

  • aerobic respiration Source: SGD
  • intracellular copper ion transport Source: SGD
  • mitochondrial respiratory chain complex IV assembly Source: SGD
  • protein farnesylation Source: MGI

Keywordsi

Molecular functionChaperone
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32114-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase copper chaperone
Gene namesi
Name:COX17
Ordered Locus Names:YLL009C
ORF Names:L1343
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL009C
SGDiS000003932 COX17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002135412 – 69Cytochrome c oxidase copper chaperoneAdd BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 57PROSITE-ProRule annotation
Disulfide bondi36 ↔ 47PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ12287
PaxDbiQ12287
PRIDEiQ12287

Interactioni

Protein-protein interaction databases

BioGridi31242, 213 interactors
DIPiDIP-2915N
IntActiQ12287, 7 interactors
MINTiQ12287
STRINGi4932.YLL009C

Structurei

Secondary structure

169
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Beta strandi13 – 15Combined sources3
Beta strandi23 – 25Combined sources3
Helixi28 – 39Combined sources12
Helixi45 – 47Combined sources3
Helixi48 – 59Combined sources12
Turni60 – 62Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U96NMR-A1-69[»]
1U97NMR-A1-69[»]
1Z2GNMR-A1-69[»]
DisProtiDP00277
ProteinModelPortaliQ12287
SMRiQ12287
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12287

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 65CHCHPROSITE-ProRule annotationAdd BLAST43

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi26 – 36Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi47 – 57Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the COX17 family.Curated

Phylogenomic databases

HOGENOMiHOG000195037
InParanoidiQ12287
KOiK02260
OMAiCCACPQT
OrthoDBiEOG092C5YRF

Family and domain databases

InterProiView protein in InterPro
IPR009069 Cys_alpha_HP_mot_SF
IPR007745 Cyt_c_oxidase_Cu-chaperone
PANTHERiPTHR16719 PTHR16719, 1 hit
PfamiView protein in Pfam
PF05051 COX17, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014904 Cyt_c_oxidase_Cu-chaperone, 1 hit
SUPFAMiSSF47072 SSF47072, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTETDKKQEQ ENHAECEDKP KPCCVCKPEK EERDTCILFN GQDSEKCKEF
60
IEKYKECMKG YGFEVPSAN
Length:69
Mass (Da):8,056
Last modified:January 23, 2007 - v3
Checksum:i7DA9A5F97C8A3F78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L75948 Genomic DNA Translation: AAA85477.1
Z73114 Genomic DNA Translation: CAA97453.1
BK006945 Genomic DNA Translation: DAA09309.1
PIRiS62056
RefSeqiNP_013092.1, NM_001181829.1

Genome annotation databases

EnsemblFungiiYLL009C; YLL009C; YLL009C
GeneIDi850651
KEGGisce:YLL009C

Similar proteinsi

Entry informationi

Entry nameiCOX17_YEAST
AccessioniPrimary (citable) accession number: Q12287
Secondary accession number(s): D6VXZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

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