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Q12286

- SUT2_YEAST

UniProt

Q12286 - SUT2_YEAST

Protein

Sterol uptake protein 2

Gene

SUT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Putative transcription factor involved in the regulation of the activity of the cAMP/protein kinase A pathway. Involved in sterol uptake.2 Publications

    GO - Molecular functioni

    1. RNA polymerase II repressing transcription factor binding Source: SGD
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones Source: SGD
    2. positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter Source: SGD

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34171-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sterol uptake protein 2
    Gene namesi
    Name:SUT2
    Ordered Locus Names:YPR009W
    ORF Names:LPZ9w
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    CYGDiYPR009w.
    SGDiS000006213. SUT2.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Sterol uptake protein 2PRO_0000115015Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ12286.

    Interactioni

    Protein-protein interaction databases

    BioGridi36187. 52 interactions.
    STRINGi4932.YPR009W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12286.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SUT1 family.Curated

    Phylogenomic databases

    eggNOGiNOG45749.
    GeneTreeiENSGT00530000067177.
    OMAiPTEYTEY.
    OrthoDBiEOG74BK3R.

    Family and domain databases

    Gene3Di4.10.240.10. 2 hits.
    InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12286-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPNNRTCDV ITNKDESLPA LLLPALNSYT CDDSLLKGQI SSNGRYQPFG    50
    FSDCSLLPKR LNIQAGQGSM PVSSIQCADH SYSNWQKESE KTKLPKLGCP 100
    TEYTEYYKTV SSGETTDSAV VSSIATNRLK RKRQRDGPSC DSCRIKKIKC 150
    NATIIIFLQD RNLISSISSN LHYTLSQDDI NQFRMKFFRK LPDVMGTYEV 200
    IKHLDKIVLF KACTSCSRRN QKNGKCLFSR GFTKSDMNVF PKINSKLKDK 250
    SIFEMTVDDY VAAGFQTL 268
    Length:268
    Mass (Da):30,258
    Last modified:November 1, 1996 - v1
    Checksum:i69B89766F75FDBAE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31900 Genomic DNA. Translation: AAA97588.1.
    Z49919 Genomic DNA. Translation: CAA90153.1.
    Z71255 Genomic DNA. Translation: CAA95049.1.
    BK006949 Genomic DNA. Translation: DAA11436.1.
    PIRiS57542.
    RefSeqiNP_015334.1. NM_001184106.1.

    Genome annotation databases

    EnsemblFungiiYPR009W; YPR009W; YPR009W.
    GeneIDi856118.
    KEGGisce:YPR009W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31900 Genomic DNA. Translation: AAA97588.1 .
    Z49919 Genomic DNA. Translation: CAA90153.1 .
    Z71255 Genomic DNA. Translation: CAA95049.1 .
    BK006949 Genomic DNA. Translation: DAA11436.1 .
    PIRi S57542.
    RefSeqi NP_015334.1. NM_001184106.1.

    3D structure databases

    ProteinModelPortali Q12286.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36187. 52 interactions.
    STRINGi 4932.YPR009W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPR009W ; YPR009W ; YPR009W .
    GeneIDi 856118.
    KEGGi sce:YPR009W.

    Organism-specific databases

    CYGDi YPR009w.
    SGDi S000006213. SUT2.

    Phylogenomic databases

    eggNOGi NOG45749.
    GeneTreei ENSGT00530000067177.
    OMAi PTEYTEY.
    OrthoDBi EOG74BK3R.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34171-MONOMER.

    Miscellaneous databases

    NextBioi 981195.

    Gene expression databases

    Genevestigatori Q12286.

    Family and domain databases

    Gene3Di 4.10.240.10. 2 hits.
    InterProi IPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "SUT1 is a putative Zn[II]2Cys6-transcription factor whose upregulation enhances both sterol uptake and synthesis in aerobically growing Saccharomyces cerevisiae cells."
      Ness F., Bourot S., Regnacq M., Spagnoli R., Berges T., Karst F.
      Eur. J. Biochem. 268:1585-1595(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "SUT2 is a novel multicopy suppressor of low activity of the cAMP/protein kinase A pathway in yeast."
      Ruetzler M., Reissaus A., Budzowska M., Bandlow W.
      Eur. J. Biochem. 271:1284-1291(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSUT2_YEAST
    AccessioniPrimary (citable) accession number: Q12286
    Secondary accession number(s): D6W420
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3