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Q12286 (SUT2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sterol uptake protein 2
Gene names
Name:SUT2
Ordered Locus Names:YPR009W
ORF Names:LPZ9w
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Putative transcription factor involved in the regulation of the activity of the cAMP/protein kinase A pathway. Involved in sterol uptake. Ref.3 Ref.4

Subcellular location

Nucleus Ref.4.

Sequence similarities

Belongs to the SUT1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Sterol uptake protein 2
PRO_0000115015

Sequences

Sequence LengthMass (Da)Tools
Q12286 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 69B89766F75FDBAE

FASTA26830,258
        10         20         30         40         50         60 
MKPNNRTCDV ITNKDESLPA LLLPALNSYT CDDSLLKGQI SSNGRYQPFG FSDCSLLPKR 

        70         80         90        100        110        120 
LNIQAGQGSM PVSSIQCADH SYSNWQKESE KTKLPKLGCP TEYTEYYKTV SSGETTDSAV 

       130        140        150        160        170        180 
VSSIATNRLK RKRQRDGPSC DSCRIKKIKC NATIIIFLQD RNLISSISSN LHYTLSQDDI 

       190        200        210        220        230        240 
NQFRMKFFRK LPDVMGTYEV IKHLDKIVLF KACTSCSRRN QKNGKCLFSR GFTKSDMNVF 

       250        260 
PKINSKLKDK SIFEMTVDDY VAAGFQTL 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"SUT1 is a putative Zn[II]2Cys6-transcription factor whose upregulation enhances both sterol uptake and synthesis in aerobically growing Saccharomyces cerevisiae cells."
Ness F., Bourot S., Regnacq M., Spagnoli R., Berges T., Karst F.
Eur. J. Biochem. 268:1585-1595(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"SUT2 is a novel multicopy suppressor of low activity of the cAMP/protein kinase A pathway in yeast."
Ruetzler M., Reissaus A., Budzowska M., Bandlow W.
Eur. J. Biochem. 271:1284-1291(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U31900 Genomic DNA. Translation: AAA97588.1.
Z49919 Genomic DNA. Translation: CAA90153.1.
Z71255 Genomic DNA. Translation: CAA95049.1.
BK006949 Genomic DNA. Translation: DAA11436.1.
PIRS57542.
RefSeqNP_015334.1. NM_001184106.1.

3D structure databases

ProteinModelPortalQ12286.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36187. 52 interactions.
STRING4932.YPR009W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYPR009W; YPR009W; YPR009W.
GeneID856118.
KEGGsce:YPR009W.

Organism-specific databases

CYGDYPR009w.
SGDS000006213. SUT2.

Phylogenomic databases

eggNOGNOG45749.
GeneTreeENSGT00530000067177.
OrthoDBEOG74BK3R.

Enzyme and pathway databases

BioCycYEAST:G3O-34171-MONOMER.

Gene expression databases

GenevestigatorQ12286.

Family and domain databases

Gene3D4.10.240.10. 2 hits.
InterProIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
ProtoNetSearch...

Other

NextBio981195.

Entry information

Entry nameSUT2_YEAST
AccessionPrimary (citable) accession number: Q12286
Secondary accession number(s): D6W420
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XVI

Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families