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Q12286

- SUT2_YEAST

UniProt

Q12286 - SUT2_YEAST

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Protein

Sterol uptake protein 2

Gene
SUT2, YPR009W, LPZ9w
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Putative transcription factor involved in the regulation of the activity of the cAMP/protein kinase A pathway. Involved in sterol uptake.2 Publications

GO - Molecular functioni

  1. RNA polymerase II repressing transcription factor binding Source: SGD
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. positive regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones Source: SGD
  2. positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-34171-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol uptake protein 2
Gene namesi
Name:SUT2
Ordered Locus Names:YPR009W
ORF Names:LPZ9w
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR009w.
SGDiS000006213. SUT2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Sterol uptake protein 2PRO_0000115015Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ12286.

Interactioni

Protein-protein interaction databases

BioGridi36187. 52 interactions.
STRINGi4932.YPR009W.

Structurei

3D structure databases

ProteinModelPortaliQ12286.

Family & Domainsi

Sequence similaritiesi

Belongs to the SUT1 family.

Phylogenomic databases

eggNOGiNOG45749.
GeneTreeiENSGT00530000067177.
OMAiPTEYTEY.
OrthoDBiEOG74BK3R.

Family and domain databases

Gene3Di4.10.240.10. 2 hits.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12286-1 [UniParc]FASTAAdd to Basket

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MKPNNRTCDV ITNKDESLPA LLLPALNSYT CDDSLLKGQI SSNGRYQPFG    50
FSDCSLLPKR LNIQAGQGSM PVSSIQCADH SYSNWQKESE KTKLPKLGCP 100
TEYTEYYKTV SSGETTDSAV VSSIATNRLK RKRQRDGPSC DSCRIKKIKC 150
NATIIIFLQD RNLISSISSN LHYTLSQDDI NQFRMKFFRK LPDVMGTYEV 200
IKHLDKIVLF KACTSCSRRN QKNGKCLFSR GFTKSDMNVF PKINSKLKDK 250
SIFEMTVDDY VAAGFQTL 268
Length:268
Mass (Da):30,258
Last modified:November 1, 1996 - v1
Checksum:i69B89766F75FDBAE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31900 Genomic DNA. Translation: AAA97588.1.
Z49919 Genomic DNA. Translation: CAA90153.1.
Z71255 Genomic DNA. Translation: CAA95049.1.
BK006949 Genomic DNA. Translation: DAA11436.1.
PIRiS57542.
RefSeqiNP_015334.1. NM_001184106.1.

Genome annotation databases

EnsemblFungiiYPR009W; YPR009W; YPR009W.
GeneIDi856118.
KEGGisce:YPR009W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31900 Genomic DNA. Translation: AAA97588.1 .
Z49919 Genomic DNA. Translation: CAA90153.1 .
Z71255 Genomic DNA. Translation: CAA95049.1 .
BK006949 Genomic DNA. Translation: DAA11436.1 .
PIRi S57542.
RefSeqi NP_015334.1. NM_001184106.1.

3D structure databases

ProteinModelPortali Q12286.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36187. 52 interactions.
STRINGi 4932.YPR009W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR009W ; YPR009W ; YPR009W .
GeneIDi 856118.
KEGGi sce:YPR009W.

Organism-specific databases

CYGDi YPR009w.
SGDi S000006213. SUT2.

Phylogenomic databases

eggNOGi NOG45749.
GeneTreei ENSGT00530000067177.
OMAi PTEYTEY.
OrthoDBi EOG74BK3R.

Enzyme and pathway databases

BioCyci YEAST:G3O-34171-MONOMER.

Miscellaneous databases

NextBioi 981195.

Gene expression databases

Genevestigatori Q12286.

Family and domain databases

Gene3Di 4.10.240.10. 2 hits.
InterProi IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "SUT1 is a putative Zn[II]2Cys6-transcription factor whose upregulation enhances both sterol uptake and synthesis in aerobically growing Saccharomyces cerevisiae cells."
    Ness F., Bourot S., Regnacq M., Spagnoli R., Berges T., Karst F.
    Eur. J. Biochem. 268:1585-1595(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "SUT2 is a novel multicopy suppressor of low activity of the cAMP/protein kinase A pathway in yeast."
    Ruetzler M., Reissaus A., Budzowska M., Bandlow W.
    Eur. J. Biochem. 271:1284-1291(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSUT2_YEAST
AccessioniPrimary (citable) accession number: Q12286
Secondary accession number(s): D6W420
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

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