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Protein

Ubiquitin-like protein MDY2

Gene

MDY2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for efficient mating. Involved in the production of alpha-factor, the KAR9 and TUB1 location to the shmoo tip and nuclear migration into pheromone-induced shmoos.2 Publications

Miscellaneous

Present with 6510 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • cell morphogenesis involved in conjugation with cellular fusion Source: SGD
  • posttranslational protein targeting to endoplasmic reticulum membrane Source: SGD
  • protein insertion into ER membrane Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-33508-MONOMER

Protein family/group databases

TCDBi3.A.21.1.1 the c-terminal tail-anchored membrane protein biogenesis/ insertion complex (tamp-b) family

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein MDY2
Alternative name(s):
Golgi to ER traffic protein 5
Mating-deficient protein 2
Translation machinery-associated protein 24
Gene namesi
Name:MDY2
Synonyms:GET5, TMA24
Ordered Locus Names:YOL111C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL111C
SGDiS000005471 MDY2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002359171 – 212Ubiquitin-like protein MDY2Add BLAST212

Proteomic databases

MaxQBiQ12285
PaxDbiQ12285
PRIDEiQ12285

Interactioni

Subunit structurei

Interacts with GET4.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34289, 177 interactors
ComplexPortaliCPX-1861 GET4-GET5 transmembrane domain recognition complex
DIPiDIP-1982N
IntActiQ12285, 9 interactors
MINTiQ12285
STRINGi4932.YOL111C

Structurei

Secondary structure

1212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Helixi8 – 20Combined sources13
Helixi35 – 37Combined sources3
Beta strandi74 – 80Combined sources7
Beta strandi82 – 84Combined sources3
Beta strandi86 – 92Combined sources7
Helixi98 – 107Combined sources10
Helixi114 – 116Combined sources3
Beta strandi117 – 121Combined sources5
Beta strandi124 – 126Combined sources3
Helixi132 – 134Combined sources3
Beta strandi139 – 141Combined sources3
Beta strandi143 – 148Combined sources6
Helixi179 – 189Combined sources11
Turni190 – 192Combined sources3
Helixi194 – 210Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LNZNMR-A/B152-212[»]
2LXANMR-A74-151[»]
2LXCNMR-A74-151[»]
2WPVX-ray1.99B/D/F/H1-59[»]
3LKUX-ray2.80B/D/F3-56[»]
3VEJX-ray1.23A/B175-212[»]
3ZDMX-ray1.80C/F71-151[»]
4A20X-ray1.78A70-152[»]
4ASWNMR-C70-152[»]
4GOCX-ray2.40A/B/C74-148[»]
4PWXX-ray5.40D/F1-54[»]
5BW8X-ray2.80D1-54[»]
5BWKX-ray6.00F/H/J/L/R/T/V/X1-56[»]
ProteinModelPortaliQ12285
SMRiQ12285
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12285

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 152Ubiquitin-likePROSITE-ProRule annotationAdd BLAST79

Phylogenomic databases

HOGENOMiHOG000113515
InParanoidiQ12285
OMAiPEHEFVS
OrthoDBiEOG092C4PDD

Family and domain databases

InterProiView protein in InterPro
IPR031765 Mdy2_get4-bd
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF16843 Get5_bdg, 1 hit
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q12285-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSASGPEH EFVSKFLTLA TLTEPKLPKS YTKPLKDVTN LGVPLPTLKY
60 70 80 90 100
KYKQNRAKKL KLHQDQQGQD NAAVHLTLKK IQAPKFSIEH DFSPSDTILQ
110 120 130 140 150
IKQHLISEEK ASHISEIKLL LKGKVLHDNL FLSDLKVTPA NSTITVMIKP
160 170 180 190 200
NPTISKEPEA EKSTNSPAPA PPQELTVPWD DIEALLKNNF ENDQAAVRQV
210
MERLQKGWSL AK
Length:212
Mass (Da):23,732
Last modified:November 1, 1996 - v1
Checksum:iCE6FC4282E0E472C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48149 Genomic DNA Translation: CAA88151.1
Z74853 Genomic DNA Translation: CAA99130.1
BK006948 Genomic DNA Translation: DAA10672.1
PIRiS51888
RefSeqiNP_014530.1, NM_001183365.1

Genome annotation databases

EnsemblFungiiYOL111C; YOL111C; YOL111C
GeneIDi854038
KEGGisce:YOL111C

Similar proteinsi

Entry informationi

Entry nameiMDY2_YEAST
AccessioniPrimary (citable) accession number: Q12285
Secondary accession number(s): D6W1V6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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