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Q12283

- FABD_YEAST

UniProt

Q12283 - FABD_YEAST

Protein

Malonyl CoA-acyl carrier protein transacylase, mitochondrial

Gene

MCT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Involved in biosynthesis of fatty acids in mitochondria.By similarity

    Catalytic activityi

    Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei105 – 1051By similarity
    Active sitei235 – 2351By similarity

    GO - Molecular functioni

    1. [acyl-carrier-protein] S-malonyltransferase activity Source: SGD

    GO - Biological processi

    1. aerobic respiration Source: SGD
    2. fatty acid biosynthetic process Source: UniProtKB-UniPathway
    3. fatty acid metabolic process Source: SGD

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciMetaCyc:YOR221C-MONOMER.
    YEAST:YOR221C-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malonyl CoA-acyl carrier protein transacylase, mitochondrial (EC:2.3.1.39)
    Short name:
    MCT
    Alternative name(s):
    Malonyl-CoA:ACP transferase
    Gene namesi
    Name:MCT1
    Ordered Locus Names:YOR221C
    ORF Names:YOR50-11
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOR221c.
    SGDiS000005747. MCT1.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: SGD

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2424MitochondrionSequence AnalysisAdd
    BLAST
    Chaini25 – 360336Malonyl CoA-acyl carrier protein transacylase, mitochondrialPRO_0000257811Add
    BLAST

    Proteomic databases

    MaxQBiQ12283.
    PaxDbiQ12283.
    PeptideAtlasiQ12283.

    Expressioni

    Gene expression databases

    GenevestigatoriQ12283.

    Interactioni

    Protein-protein interaction databases

    BioGridi34615. 107 interactions.
    DIPiDIP-4125N.
    IntActiQ12283. 5 interactions.
    MINTiMINT-564545.
    STRINGi4932.YOR221C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FabD family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0331.
    HOGENOMiHOG000066003.
    KOiK00645.
    OMAiEMWALSS.
    OrthoDBiEOG70KH07.

    Family and domain databases

    Gene3Di3.40.366.10. 2 hits.
    InterProiIPR001227. Ac_transferase_dom.
    IPR016035. Acyl_Trfase/lysoPLipase.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q12283-1 [UniParc]FASTAAdd to Basket

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    MKLLTFPGQG TSISISILKA IIRNKSREFQ TILSQNGKES NDLLQYIFQN    50
    PSSPGSIAVC SNLFYQLYQI LSNPSDPQDQ APKNMTKIDS PDKKDNEQCY 100
    LLGHSLGELT CLSVNSLFSL KDLFDIANFR NKLMVTSTEK YLVAHNINRS 150
    NKFEMWALSS PRATDLPQEV QKLLNSPNLL SSSQNTISVA NANSVKQCVV 200
    TGLVDDLESL RTELNLRFPR LRITELTNPY NIPFHNSTVL RPVQEPLYDY 250
    IWDILKKNGT HTLMELNHPI IANLDGNISY YIHHALDRFV KCSSRTVQFT 300
    MCYDTINSGT PVEIDKSICF GPGNVIYNLI RRNCPQVDTI EYTSLATIDA 350
    YHKAAEENKD 360
    Length:360
    Mass (Da):40,707
    Last modified:October 31, 2006 - v2
    Checksum:iF27DC450F367F240
    GO

    Sequence cautioni

    The sequence CAA63184.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAA99439.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92441 Genomic DNA. Translation: CAA63184.1. Sequence problems.
    Z75129 Genomic DNA. Translation: CAA99439.1. Sequence problems.
    BK006948 Genomic DNA. Translation: DAA10992.1.
    PIRiS60948.
    RefSeqiNP_014864.4. NM_001183640.3.

    Genome annotation databases

    EnsemblFungiiYOR221C; YOR221C; YOR221C.
    GeneIDi854396.
    KEGGisce:YOR221C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92441 Genomic DNA. Translation: CAA63184.1 . Sequence problems.
    Z75129 Genomic DNA. Translation: CAA99439.1 . Sequence problems.
    BK006948 Genomic DNA. Translation: DAA10992.1 .
    PIRi S60948.
    RefSeqi NP_014864.4. NM_001183640.3.

    3D structure databases

    ProteinModelPortali Q12283.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34615. 107 interactions.
    DIPi DIP-4125N.
    IntActi Q12283. 5 interactions.
    MINTi MINT-564545.
    STRINGi 4932.YOR221C.

    Proteomic databases

    MaxQBi Q12283.
    PaxDbi Q12283.
    PeptideAtlasi Q12283.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOR221C ; YOR221C ; YOR221C .
    GeneIDi 854396.
    KEGGi sce:YOR221C.

    Organism-specific databases

    CYGDi YOR221c.
    SGDi S000005747. MCT1.

    Phylogenomic databases

    eggNOGi COG0331.
    HOGENOMi HOG000066003.
    KOi K00645.
    OMAi EMWALSS.
    OrthoDBi EOG70KH07.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci MetaCyc:YOR221C-MONOMER.
    YEAST:YOR221C-MONOMER.

    Miscellaneous databases

    NextBioi 976562.
    PROi Q12283.

    Gene expression databases

    Genevestigatori Q12283.

    Family and domain databases

    Gene3Di 3.40.366.10. 2 hits.
    InterProi IPR001227. Ac_transferase_dom.
    IPR016035. Acyl_Trfase/lysoPLipase.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of a 33 kb fragment from the right arm of chromosome XV of the yeast Saccharomyces cerevisiae."
      Galisson F., Dujon B.
      Yeast 12:877-885(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Two genes of the putative mitochondrial fatty acid synthase in the genome of Saccharomyces cerevisiae."
      Schneider R., Brors B., Buerger F., Camrath S., Weiss H.
      Curr. Genet. 32:384-388(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFABD_YEAST
    AccessioniPrimary (citable) accession number: Q12283
    Secondary accession number(s): D6W2S6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1360 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3