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Q12283 (FABD_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malonyl CoA-acyl carrier protein transacylase, mitochondrial

Short name=MCT
EC=2.3.1.39
Alternative name(s):
Malonyl-CoA:ACP transferase
Gene names
Name:MCT1
Ordered Locus Names:YOR221C
ORF Names:YOR50-11
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in biosynthesis of fatty acids in mitochondria By similarity. Ref.4

Catalytic activity

Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subcellular location

Mitochondrion Ref.5.

Miscellaneous

Present with 1360 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the FabD family.

Sequence caution

The sequence CAA63184.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAA99439.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2424Mitochondrion Potential
Chain25 – 360336Malonyl CoA-acyl carrier protein transacylase, mitochondrial
PRO_0000257811

Sites

Active site1051 By similarity
Active site2351 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q12283 [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: F27DC450F367F240

FASTA36040,707
        10         20         30         40         50         60 
MKLLTFPGQG TSISISILKA IIRNKSREFQ TILSQNGKES NDLLQYIFQN PSSPGSIAVC 

        70         80         90        100        110        120 
SNLFYQLYQI LSNPSDPQDQ APKNMTKIDS PDKKDNEQCY LLGHSLGELT CLSVNSLFSL 

       130        140        150        160        170        180 
KDLFDIANFR NKLMVTSTEK YLVAHNINRS NKFEMWALSS PRATDLPQEV QKLLNSPNLL 

       190        200        210        220        230        240 
SSSQNTISVA NANSVKQCVV TGLVDDLESL RTELNLRFPR LRITELTNPY NIPFHNSTVL 

       250        260        270        280        290        300 
RPVQEPLYDY IWDILKKNGT HTLMELNHPI IANLDGNISY YIHHALDRFV KCSSRTVQFT 

       310        320        330        340        350        360 
MCYDTINSGT PVEIDKSICF GPGNVIYNLI RRNCPQVDTI EYTSLATIDA YHKAAEENKD 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of a 33 kb fragment from the right arm of chromosome XV of the yeast Saccharomyces cerevisiae."
Galisson F., Dujon B.
Yeast 12:877-885(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. expand/collapse author list , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Two genes of the putative mitochondrial fatty acid synthase in the genome of Saccharomyces cerevisiae."
Schneider R., Brors B., Buerger F., Camrath S., Weiss H.
Curr. Genet. 32:384-388(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X92441 Genomic DNA. Translation: CAA63184.1. Sequence problems.
Z75129 Genomic DNA. Translation: CAA99439.1. Sequence problems.
BK006948 Genomic DNA. Translation: DAA10992.1.
PIRS60948.
RefSeqNP_014864.4. NM_001183640.3.

3D structure databases

ProteinModelPortalQ12283.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34615. 107 interactions.
DIPDIP-4125N.
IntActQ12283. 5 interactions.
MINTMINT-564545.
STRING4932.YOR221C.

Proteomic databases

MaxQBQ12283.
PaxDbQ12283.
PeptideAtlasQ12283.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYOR221C; YOR221C; YOR221C.
GeneID854396.
KEGGsce:YOR221C.

Organism-specific databases

CYGDYOR221c.
SGDS000005747. MCT1.

Phylogenomic databases

eggNOGCOG0331.
HOGENOMHOG000066003.
KOK00645.
OMAEMWALSS.
OrthoDBEOG70KH07.

Enzyme and pathway databases

BioCycMetaCyc:YOR221C-MONOMER.
YEAST:YOR221C-MONOMER.
UniPathwayUPA00094.

Gene expression databases

GenevestigatorQ12283.

Family and domain databases

Gene3D3.40.366.10. 2 hits.
InterProIPR001227. Ac_transferase_dom.
IPR016035. Acyl_Trfase/lysoPLipase.
[Graphical view]
SUPFAMSSF52151. SSF52151. 3 hits.
ProtoNetSearch...

Other

NextBio976562.
PROQ12283.

Entry information

Entry nameFABD_YEAST
AccessionPrimary (citable) accession number: Q12283
Secondary accession number(s): D6W2S6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: May 14, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XV

Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways