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Protein

Malonyl CoA-acyl carrier protein transacylase, mitochondrial

Gene

MCT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in biosynthesis of fatty acids in mitochondria.By similarity1 Publication

Miscellaneous

Present with 1360 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei105By similarity1
Active sitei235By similarity1

GO - Molecular functioni

  • [acyl-carrier-protein] S-malonyltransferase activity Source: SGD

GO - Biological processi

  • fatty acid biosynthetic process Source: UniProtKB-UniPathway
  • fatty acid metabolic process Source: SGD

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:YOR221C-MONOMER.
YEAST:YOR221C-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl CoA-acyl carrier protein transacylase, mitochondrial (EC:2.3.1.39)
Short name:
MCT
Alternative name(s):
Malonyl-CoA:ACP transferase
Gene namesi
Name:MCT1
Ordered Locus Names:YOR221C
ORF Names:YOR50-11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR221C.
SGDiS000005747. MCT1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionSequence analysisAdd BLAST24
ChainiPRO_000025781125 – 360Malonyl CoA-acyl carrier protein transacylase, mitochondrialAdd BLAST336

Proteomic databases

MaxQBiQ12283.
PRIDEiQ12283.

Interactioni

Protein-protein interaction databases

BioGridi34615. 294 interactors.
DIPiDIP-4125N.
IntActiQ12283. 5 interactors.
MINTiMINT-564545.
STRINGi4932.YOR221C.

Structurei

3D structure databases

ProteinModelPortaliQ12283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FabD family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000066003.
InParanoidiQ12283.
KOiK00645.
OMAiANSVKQC.
OrthoDBiEOG092C2WRY.

Family and domain databases

InterProiView protein in InterPro
IPR016035. Acyl_Trfase/lysoPLipase.
SUPFAMiSSF52151. SSF52151. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLTFPGQG TSISISILKA IIRNKSREFQ TILSQNGKES NDLLQYIFQN
60 70 80 90 100
PSSPGSIAVC SNLFYQLYQI LSNPSDPQDQ APKNMTKIDS PDKKDNEQCY
110 120 130 140 150
LLGHSLGELT CLSVNSLFSL KDLFDIANFR NKLMVTSTEK YLVAHNINRS
160 170 180 190 200
NKFEMWALSS PRATDLPQEV QKLLNSPNLL SSSQNTISVA NANSVKQCVV
210 220 230 240 250
TGLVDDLESL RTELNLRFPR LRITELTNPY NIPFHNSTVL RPVQEPLYDY
260 270 280 290 300
IWDILKKNGT HTLMELNHPI IANLDGNISY YIHHALDRFV KCSSRTVQFT
310 320 330 340 350
MCYDTINSGT PVEIDKSICF GPGNVIYNLI RRNCPQVDTI EYTSLATIDA
360
YHKAAEENKD
Length:360
Mass (Da):40,707
Last modified:October 31, 2006 - v2
Checksum:iF27DC450F367F240
GO

Sequence cautioni

The sequence CAA63184 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA99439 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92441 Genomic DNA. Translation: CAA63184.1. Sequence problems.
Z75129 Genomic DNA. Translation: CAA99439.1. Sequence problems.
BK006948 Genomic DNA. Translation: DAA10992.1.
PIRiS60948.
RefSeqiNP_014864.4. NM_001183640.3.

Genome annotation databases

EnsemblFungiiYOR221C; YOR221C; YOR221C.
GeneIDi854396.
KEGGisce:YOR221C.

Similar proteinsi

Entry informationi

Entry nameiFABD_YEAST
AccessioniPrimary (citable) accession number: Q12283
Secondary accession number(s): D6W2S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: October 25, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names