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Protein

Malonyl CoA-acyl carrier protein transacylase, mitochondrial

Gene

MCT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in biosynthesis of fatty acids in mitochondria.By similarity

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathway: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei105 – 1051By similarity
Active sitei235 – 2351By similarity

GO - Molecular functioni

  • [acyl-carrier-protein] S-malonyltransferase activity Source: SGD

GO - Biological processi

  • fatty acid biosynthetic process Source: UniProtKB-UniPathway
  • fatty acid metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:YOR221C-MONOMER.
YEAST:YOR221C-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl CoA-acyl carrier protein transacylase, mitochondrial (EC:2.3.1.39)
Short name:
MCT
Alternative name(s):
Malonyl-CoA:ACP transferase
Gene namesi
Name:MCT1
Ordered Locus Names:YOR221C
ORF Names:YOR50-11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XV

Organism-specific databases

CYGDiYOR221c.
EuPathDBiFungiDB:YOR221C.
SGDiS000005747. MCT1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424MitochondrionSequence AnalysisAdd
BLAST
Chaini25 – 360336Malonyl CoA-acyl carrier protein transacylase, mitochondrialPRO_0000257811Add
BLAST

Proteomic databases

MaxQBiQ12283.
PaxDbiQ12283.
PeptideAtlasiQ12283.

Interactioni

Protein-protein interaction databases

BioGridi34615. 107 interactions.
DIPiDIP-4125N.
IntActiQ12283. 5 interactions.
MINTiMINT-564545.
STRINGi4932.YOR221C.

Structurei

3D structure databases

ProteinModelPortaliQ12283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FabD family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0331.
HOGENOMiHOG000066003.
InParanoidiQ12283.
KOiK00645.
OMAiEMWALSS.
OrthoDBiEOG70KH07.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR016035. Acyl_Trfase/lysoPLipase.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLTFPGQG TSISISILKA IIRNKSREFQ TILSQNGKES NDLLQYIFQN
60 70 80 90 100
PSSPGSIAVC SNLFYQLYQI LSNPSDPQDQ APKNMTKIDS PDKKDNEQCY
110 120 130 140 150
LLGHSLGELT CLSVNSLFSL KDLFDIANFR NKLMVTSTEK YLVAHNINRS
160 170 180 190 200
NKFEMWALSS PRATDLPQEV QKLLNSPNLL SSSQNTISVA NANSVKQCVV
210 220 230 240 250
TGLVDDLESL RTELNLRFPR LRITELTNPY NIPFHNSTVL RPVQEPLYDY
260 270 280 290 300
IWDILKKNGT HTLMELNHPI IANLDGNISY YIHHALDRFV KCSSRTVQFT
310 320 330 340 350
MCYDTINSGT PVEIDKSICF GPGNVIYNLI RRNCPQVDTI EYTSLATIDA
360
YHKAAEENKD
Length:360
Mass (Da):40,707
Last modified:October 31, 2006 - v2
Checksum:iF27DC450F367F240
GO

Sequence cautioni

The sequence CAA63184.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAA99439.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92441 Genomic DNA. Translation: CAA63184.1. Sequence problems.
Z75129 Genomic DNA. Translation: CAA99439.1. Sequence problems.
BK006948 Genomic DNA. Translation: DAA10992.1.
PIRiS60948.
RefSeqiNP_014864.4. NM_001183640.3.

Genome annotation databases

EnsemblFungiiYOR221C; YOR221C; YOR221C.
GeneIDi854396.
KEGGisce:YOR221C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92441 Genomic DNA. Translation: CAA63184.1. Sequence problems.
Z75129 Genomic DNA. Translation: CAA99439.1. Sequence problems.
BK006948 Genomic DNA. Translation: DAA10992.1.
PIRiS60948.
RefSeqiNP_014864.4. NM_001183640.3.

3D structure databases

ProteinModelPortaliQ12283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34615. 107 interactions.
DIPiDIP-4125N.
IntActiQ12283. 5 interactions.
MINTiMINT-564545.
STRINGi4932.YOR221C.

Proteomic databases

MaxQBiQ12283.
PaxDbiQ12283.
PeptideAtlasiQ12283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR221C; YOR221C; YOR221C.
GeneIDi854396.
KEGGisce:YOR221C.

Organism-specific databases

CYGDiYOR221c.
EuPathDBiFungiDB:YOR221C.
SGDiS000005747. MCT1.

Phylogenomic databases

eggNOGiCOG0331.
HOGENOMiHOG000066003.
InParanoidiQ12283.
KOiK00645.
OMAiEMWALSS.
OrthoDBiEOG70KH07.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciMetaCyc:YOR221C-MONOMER.
YEAST:YOR221C-MONOMER.

Miscellaneous databases

NextBioi976562.
PROiQ12283.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR016035. Acyl_Trfase/lysoPLipase.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of a 33 kb fragment from the right arm of chromosome XV of the yeast Saccharomyces cerevisiae."
    Galisson F., Dujon B.
    Yeast 12:877-885(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Two genes of the putative mitochondrial fatty acid synthase in the genome of Saccharomyces cerevisiae."
    Schneider R., Brors B., Buerger F., Camrath S., Weiss H.
    Curr. Genet. 32:384-388(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFABD_YEAST
AccessioniPrimary (citable) accession number: Q12283
Secondary accession number(s): D6W2S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 24, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1360 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.