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Protein

Rhomboid protein 2

Gene

RBD2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable serine protease.By similarity

Miscellaneous

Present with 7850 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei124NucleophileBy similarity1
Active sitei179By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciYEAST:G3O-34132-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Rhomboid protein 2 (EC:3.4.21.-)
Gene namesi
Name:RBD2
Ordered Locus Names:YPL246C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL246C
SGDiS000006167 RBD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 57LumenalSequence analysisAdd BLAST20
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 89CytoplasmicSequence analysisAdd BLAST11
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111 – 112LumenalSequence analysis2
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 151CytoplasmicSequence analysisAdd BLAST18
Transmembranei152 – 168HelicalSequence analysisAdd BLAST17
Topological domaini169 – 174LumenalSequence analysis6
Transmembranei175 – 191HelicalSequence analysisAdd BLAST17
Topological domaini192 – 262CytoplasmicSequence analysisAdd BLAST71

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002061931 – 262Rhomboid protein 2Add BLAST262

Proteomic databases

MaxQBiQ12270
PaxDbiQ12270
PRIDEiQ12270
TopDownProteomicsiQ12270

Interactioni

Subunit structurei

Interacts with SNX3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
VAM7P329123EBI-31471,EBI-20232

Protein-protein interaction databases

BioGridi35917, 121 interactors
DIPiDIP-1734N
IntActiQ12270, 47 interactors
MINTiQ12270
STRINGi4932.YPL246C

Structurei

3D structure databases

ProteinModelPortaliQ12270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000111157
InParanoidiQ12270
OMAiPHYVSID
OrthoDBiEOG092C49RT

Family and domain databases

Gene3Di1.20.1540.10, 1 hit
InterProiView protein in InterPro
IPR022764 Peptidase_S54_rhomboid_dom
IPR035952 Rhomboid-like_sf
PfamiView protein in Pfam
PF01694 Rhomboid, 1 hit

Sequencei

Sequence statusi: Complete.

Q12270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWKSYVFPG GHPPAALTTG LVVFLTAIYL LSFIFALRED LSLAPESLFK
60 70 80 90 100
LQMSRLSLYP LIHLSLPHLL FNVLAIWAPL NLFEETHGTV YTGVFLNLSA
110 120 130 140 150
LFAGILYCLL GKLLYPEALV AGASGWCFTL FAYYSFKESQ IRPRTRIFRT
160 170 180 190 200
DYSIPTLYTP LVLLVAIAVV IPGSSFWGHF FGLCVGYAIG YKESWFNKIT
210 220 230 240 250
PPGWIITKIE KSLDGLIRLI PWGIKYYRDE DIDRTKDYEP LMSTETPLPL
260
HNDNSGTVLG TA
Length:262
Mass (Da):29,500
Last modified:November 1, 1996 - v1
Checksum:i3A436E3FEAB7FD35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73602 Genomic DNA Translation: CAA97967.1
Z67751 Genomic DNA Translation: CAA91598.1
BK006949 Genomic DNA Translation: DAA11191.1
PIRiS61018
RefSeqiNP_015078.1, NM_001184060.1

Genome annotation databases

EnsemblFungiiYPL246C; YPL246C; YPL246C
GeneIDi855830
KEGGisce:YPL246C

Similar proteinsi

Entry informationi

Entry nameiRBD2_YEAST
AccessioniPrimary (citable) accession number: Q12270
Secondary accession number(s): D6W3C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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