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Protein

Phosphate metabolism protein 7

Gene

PHM7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an osmosensitive calcium-permeable cation channel.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciYEAST:G3O-33487-MONOMER.

Protein family/group databases

TCDBi1.A.17.5.6. the calcium-dependent chloride channel (ca-clc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate metabolism protein 7
Gene namesi
Name:PHM7
Ordered Locus Names:YOL084W
ORF Names:00953
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL084W.
SGDiS000005444. PHM7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 91CytoplasmicSequence analysisAdd BLAST61
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 138ExtracellularSequence analysisAdd BLAST26
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 388CytoplasmicSequence analysisAdd BLAST229
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Topological domaini410 – 437ExtracellularSequence analysisAdd BLAST28
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 471CytoplasmicSequence analysisAdd BLAST13
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493 – 523ExtracellularSequence analysisAdd BLAST31
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 582CytoplasmicSequence analysisAdd BLAST38
Transmembranei583 – 603HelicalSequence analysisAdd BLAST21
Topological domaini604ExtracellularSequence analysis1
Transmembranei605 – 625HelicalSequence analysisAdd BLAST21
Topological domaini626 – 637CytoplasmicSequence analysisAdd BLAST12
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21
Topological domaini659 – 661ExtracellularSequence analysis3
Transmembranei662 – 682HelicalSequence analysisAdd BLAST21
Topological domaini683 – 991CytoplasmicSequence analysisAdd BLAST309

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002627351 – 991Phosphate metabolism protein 7Add BLAST991

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Glycosylationi132N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ12252.

PTM databases

iPTMnetiQ12252.

Expressioni

Inductioni

Regulated by phosphate levels.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi34318. 11 interactors.
IntActiQ12252. 1 interactor.
MINTiMINT-4501935.

Structurei

3D structure databases

ProteinModelPortaliQ12252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000068232.
HOGENOMiHOG000161488.
InParanoidiQ12252.
OMAiENIYWEN.
OrthoDBiEOG092C0KRF.

Family and domain databases

InterProiIPR032880. Csc1_N.
IPR027815. PHM7_cyt.
IPR022257. PHM7_ext.
IPR003864. RSN1_7TM.
[Graphical view]
PfamiPF14703. PHM7_cyt. 1 hit.
PF12621. PHM7_ext. 1 hit.
PF02714. RSN1_7TM. 1 hit.
PF13967. RSN1_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSSSTSAF ISTLIIYGLT AVVFVWLFLL LRPKNRRVYE PRSLKDIQTI
60 70 80 90 100
PEEERTEPVP EGYFGWVEYL LSKPHSFLIQ HTSVDGYFLL RYIGIVGSLS
110 120 130 140 150
FVGCLLLLPI LLPVNATNGN NLQGFELLSF SNVTNKNRFY AHVFLSWIFF
160 170 180 190 200
GLFTYVIYKE LYYYVVFRHA MQTTPLYDGL LSSRTVIVTE LHKSIAQEGE
210 220 230 240 250
MQMRFPKASN VAFAYDLSDL QELCKERAKN AAKYEAALNK VLNKCVKMTR
260 270 280 290 300
NKTQKQLDKL YNNGTKPKDD LETYVPHKKR PKHRLGKLPL CLGGKKVNTL
310 320 330 340 350
SYSSKRIGEL NEEIHEKQAD WASNDRQPAC FIQFETQLEA QRCYQSVEAI
360 370 380 390 400
LGKKNFGKRL IGYSPEDVNW GSMRLSSKER HSRRAVANTI MVLLIIFWAF
410 420 430 440 450
PVAVVGIISN VNFLTDKVPF LRFINNMPTF LMGVITGLLP TIALVVLMSL
460 470 480 490 500
VPPFIVMLGK LSGCVTRQET DLYSQAWYYA FAVIQIFLVV TATSSASSTV
510 520 530 540 550
DSIIDRPRSA MTLLANNLPK ASNFYIMYFI LKGLTGPTWT ILQAVNLLLS
560 570 580 590 600
KVLGRVLDST PRQKWNRYNT LATPRMGIVY PGIEILVCIY ICYSIIAPIL
610 620 630 640 650
LFFSTVMLTL LYVAYLYNLN YVFGFSFDLK GRNYPRALFQ IFVGIYLSEV
660 670 680 690 700
CLLGLFIMAK TWGPLVLEVF WIVVTALAHI YMKRKFIPLF DAVPLSAIRH
710 720 730 740 750
ARGEPGYSYP TSDLGLQEIK DIADEMKGKY EQDNTHGILT PVTKDDLKKA
760 770 780 790 800
NLIPDNDGSS ENGTPSNPFE SGSERASLSG SNAESDSIKK LNDTVIKKSS
810 820 830 840 850
TLSSSTKDNN ESTFVPEGEK FRKFHYSDVE ALRNKRPYDE DDHSKHGPEG
860 870 880 890 900
AVPVNADAGV IYSDPAAVMK EPQAFPPDVL ETNTWTRRIL QFFNPRRSYP
910 920 930 940 950
FDSVRMRFPL VFNTSIEYDE EYLSSAYTDP CVREKDPIVW CCKDPLGVSK
960 970 980 990
QQIQEARSNG LDVRDDFTRY DEKGKVIFTY NPPDYEPEAK K
Length:991
Mass (Da):112,546
Last modified:November 1, 1996 - v1
Checksum:i491FAB0BD143DC5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83121 Genomic DNA. Translation: CAA58195.1.
Z74826 Genomic DNA. Translation: CAA99096.1.
BK006948 Genomic DNA. Translation: DAA10700.1.
PIRiS57385.
RefSeqiNP_014557.1. NM_001183338.1.

Genome annotation databases

EnsemblFungiiYOL084W; YOL084W; YOL084W.
GeneIDi854070.
KEGGisce:YOL084W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83121 Genomic DNA. Translation: CAA58195.1.
Z74826 Genomic DNA. Translation: CAA99096.1.
BK006948 Genomic DNA. Translation: DAA10700.1.
PIRiS57385.
RefSeqiNP_014557.1. NM_001183338.1.

3D structure databases

ProteinModelPortaliQ12252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34318. 11 interactors.
IntActiQ12252. 1 interactor.
MINTiMINT-4501935.

Protein family/group databases

TCDBi1.A.17.5.6. the calcium-dependent chloride channel (ca-clc) family.

PTM databases

iPTMnetiQ12252.

Proteomic databases

PRIDEiQ12252.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL084W; YOL084W; YOL084W.
GeneIDi854070.
KEGGisce:YOL084W.

Organism-specific databases

EuPathDBiFungiDB:YOL084W.
SGDiS000005444. PHM7.

Phylogenomic databases

GeneTreeiENSGT00530000068232.
HOGENOMiHOG000161488.
InParanoidiQ12252.
OMAiENIYWEN.
OrthoDBiEOG092C0KRF.

Enzyme and pathway databases

BioCyciYEAST:G3O-33487-MONOMER.

Miscellaneous databases

PROiQ12252.

Family and domain databases

InterProiIPR032880. Csc1_N.
IPR027815. PHM7_cyt.
IPR022257. PHM7_ext.
IPR003864. RSN1_7TM.
[Graphical view]
PfamiPF14703. PHM7_cyt. 1 hit.
PF12621. PHM7_ext. 1 hit.
PF02714. RSN1_7TM. 1 hit.
PF13967. RSN1_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHM7_YEAST
AccessioniPrimary (citable) accession number: Q12252
Secondary accession number(s): D6W1Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.