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Protein

Phosphate metabolism protein 7

Gene

PHM7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an osmosensitive calcium-permeable cation channel.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciYEAST:G3O-33487-MONOMER.

Protein family/group databases

TCDBi1.A.17.5.6. the calcium-dependent chloride channel (ca-clc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate metabolism protein 7
Gene namesi
Name:PHM7
Ordered Locus Names:YOL084W
ORF Names:00953
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL084W.
SGDiS000005444. PHM7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99ExtracellularSequence analysis
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Topological domaini31 – 9161CytoplasmicSequence analysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence analysisAdd
BLAST
Topological domaini113 – 13826ExtracellularSequence analysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST
Topological domaini160 – 388229CytoplasmicSequence analysisAdd
BLAST
Transmembranei389 – 40921HelicalSequence analysisAdd
BLAST
Topological domaini410 – 43728ExtracellularSequence analysisAdd
BLAST
Transmembranei438 – 45821HelicalSequence analysisAdd
BLAST
Topological domaini459 – 47113CytoplasmicSequence analysisAdd
BLAST
Transmembranei472 – 49221HelicalSequence analysisAdd
BLAST
Topological domaini493 – 52331ExtracellularSequence analysisAdd
BLAST
Transmembranei524 – 54421HelicalSequence analysisAdd
BLAST
Topological domaini545 – 58238CytoplasmicSequence analysisAdd
BLAST
Transmembranei583 – 60321HelicalSequence analysisAdd
BLAST
Topological domaini604 – 6041ExtracellularSequence analysis
Transmembranei605 – 62521HelicalSequence analysisAdd
BLAST
Topological domaini626 – 63712CytoplasmicSequence analysisAdd
BLAST
Transmembranei638 – 65821HelicalSequence analysisAdd
BLAST
Topological domaini659 – 6613ExtracellularSequence analysis
Transmembranei662 – 68221HelicalSequence analysisAdd
BLAST
Topological domaini683 – 991309CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 991991Phosphate metabolism protein 7PRO_0000262735Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence analysis
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

PTM databases

iPTMnetiQ12252.

Expressioni

Inductioni

Regulated by phosphate levels.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi34318. 11 interactions.
IntActiQ12252. 1 interaction.
MINTiMINT-4501935.

Structurei

3D structure databases

ProteinModelPortaliQ12252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000068232.
HOGENOMiHOG000161488.
InParanoidiQ12252.
OMAiENIYWEN.
OrthoDBiEOG092C0KRF.

Family and domain databases

InterProiIPR032880. Csc1_N.
IPR027815. PHM7_cyt.
IPR022257. PHM7_ext.
IPR003864. RSN1_7TM.
[Graphical view]
PfamiPF14703. PHM7_cyt. 1 hit.
PF12621. PHM7_ext. 1 hit.
PF02714. RSN1_7TM. 1 hit.
PF13967. RSN1_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSSSTSAF ISTLIIYGLT AVVFVWLFLL LRPKNRRVYE PRSLKDIQTI
60 70 80 90 100
PEEERTEPVP EGYFGWVEYL LSKPHSFLIQ HTSVDGYFLL RYIGIVGSLS
110 120 130 140 150
FVGCLLLLPI LLPVNATNGN NLQGFELLSF SNVTNKNRFY AHVFLSWIFF
160 170 180 190 200
GLFTYVIYKE LYYYVVFRHA MQTTPLYDGL LSSRTVIVTE LHKSIAQEGE
210 220 230 240 250
MQMRFPKASN VAFAYDLSDL QELCKERAKN AAKYEAALNK VLNKCVKMTR
260 270 280 290 300
NKTQKQLDKL YNNGTKPKDD LETYVPHKKR PKHRLGKLPL CLGGKKVNTL
310 320 330 340 350
SYSSKRIGEL NEEIHEKQAD WASNDRQPAC FIQFETQLEA QRCYQSVEAI
360 370 380 390 400
LGKKNFGKRL IGYSPEDVNW GSMRLSSKER HSRRAVANTI MVLLIIFWAF
410 420 430 440 450
PVAVVGIISN VNFLTDKVPF LRFINNMPTF LMGVITGLLP TIALVVLMSL
460 470 480 490 500
VPPFIVMLGK LSGCVTRQET DLYSQAWYYA FAVIQIFLVV TATSSASSTV
510 520 530 540 550
DSIIDRPRSA MTLLANNLPK ASNFYIMYFI LKGLTGPTWT ILQAVNLLLS
560 570 580 590 600
KVLGRVLDST PRQKWNRYNT LATPRMGIVY PGIEILVCIY ICYSIIAPIL
610 620 630 640 650
LFFSTVMLTL LYVAYLYNLN YVFGFSFDLK GRNYPRALFQ IFVGIYLSEV
660 670 680 690 700
CLLGLFIMAK TWGPLVLEVF WIVVTALAHI YMKRKFIPLF DAVPLSAIRH
710 720 730 740 750
ARGEPGYSYP TSDLGLQEIK DIADEMKGKY EQDNTHGILT PVTKDDLKKA
760 770 780 790 800
NLIPDNDGSS ENGTPSNPFE SGSERASLSG SNAESDSIKK LNDTVIKKSS
810 820 830 840 850
TLSSSTKDNN ESTFVPEGEK FRKFHYSDVE ALRNKRPYDE DDHSKHGPEG
860 870 880 890 900
AVPVNADAGV IYSDPAAVMK EPQAFPPDVL ETNTWTRRIL QFFNPRRSYP
910 920 930 940 950
FDSVRMRFPL VFNTSIEYDE EYLSSAYTDP CVREKDPIVW CCKDPLGVSK
960 970 980 990
QQIQEARSNG LDVRDDFTRY DEKGKVIFTY NPPDYEPEAK K
Length:991
Mass (Da):112,546
Last modified:November 1, 1996 - v1
Checksum:i491FAB0BD143DC5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83121 Genomic DNA. Translation: CAA58195.1.
Z74826 Genomic DNA. Translation: CAA99096.1.
BK006948 Genomic DNA. Translation: DAA10700.1.
PIRiS57385.
RefSeqiNP_014557.1. NM_001183338.1.

Genome annotation databases

EnsemblFungiiYOL084W; YOL084W; YOL084W.
GeneIDi854070.
KEGGisce:YOL084W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83121 Genomic DNA. Translation: CAA58195.1.
Z74826 Genomic DNA. Translation: CAA99096.1.
BK006948 Genomic DNA. Translation: DAA10700.1.
PIRiS57385.
RefSeqiNP_014557.1. NM_001183338.1.

3D structure databases

ProteinModelPortaliQ12252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34318. 11 interactions.
IntActiQ12252. 1 interaction.
MINTiMINT-4501935.

Protein family/group databases

TCDBi1.A.17.5.6. the calcium-dependent chloride channel (ca-clc) family.

PTM databases

iPTMnetiQ12252.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL084W; YOL084W; YOL084W.
GeneIDi854070.
KEGGisce:YOL084W.

Organism-specific databases

EuPathDBiFungiDB:YOL084W.
SGDiS000005444. PHM7.

Phylogenomic databases

GeneTreeiENSGT00530000068232.
HOGENOMiHOG000161488.
InParanoidiQ12252.
OMAiENIYWEN.
OrthoDBiEOG092C0KRF.

Enzyme and pathway databases

BioCyciYEAST:G3O-33487-MONOMER.

Miscellaneous databases

PROiQ12252.

Family and domain databases

InterProiIPR032880. Csc1_N.
IPR027815. PHM7_cyt.
IPR022257. PHM7_ext.
IPR003864. RSN1_7TM.
[Graphical view]
PfamiPF14703. PHM7_cyt. 1 hit.
PF12621. PHM7_ext. 1 hit.
PF02714. RSN1_7TM. 1 hit.
PF13967. RSN1_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHM7_YEAST
AccessioniPrimary (citable) accession number: Q12252
Secondary accession number(s): D6W1Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.