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Protein

Proteasome chaperone 4

Gene

POC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in 20S proteasome assembly, facilitating the alpha-ring formation. Involved in maintenance of telomere length.3 Publications

GO - Biological processi

  • chaperone-mediated protein complex assembly Source: SGD
  • proteasome assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-34041-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome chaperone 4
Gene namesi
Name:POC4
Synonyms:DMP1
Ordered Locus Names:YPL144W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL144W.
SGDiS000006065. POC4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • intracellular Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148Proteasome chaperone 4PRO_0000238635Add
BLAST

Proteomic databases

MaxQBiQ12245.

Interactioni

Subunit structurei

Component of the 20S proteasome chaperone. Forms a heterodimer with IRC25 that binds to proteasome precursors. Interacts with POP2.2 Publications

Protein-protein interaction databases

BioGridi36039. 74 interactions.
DIPiDIP-8930N.
IntActiQ12245. 3 interactions.
MINTiMINT-2492870.

Structurei

Secondary structure

1
148
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 108Combined sources
Beta strandi21 – 3010Combined sources
Beta strandi32 – 365Combined sources
Beta strandi38 – 447Combined sources
Beta strandi55 – 6511Combined sources
Beta strandi80 – 867Combined sources
Helixi91 – 10818Combined sources
Beta strandi112 – 1187Combined sources
Helixi125 – 1295Combined sources
Helixi131 – 14616Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z5BX-ray1.96A1-148[»]
2Z5CX-ray2.90A/D1-148[»]
ProteinModelPortaliQ12245.
SMRiQ12245. Positions 1-147.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12245.

Family & Domainsi

Sequence similaritiesi

Belongs to the PSMG4 family.Curated

Phylogenomic databases

HOGENOMiHOG000115600.
InParanoidiQ12245.
KOiK11882.
OMAiHMATIIS.
OrthoDBiEOG092C5PA4.

Family and domain databases

InterProiIPR018854. Psome_chaperone_3/4.
[Graphical view]
PfamiPF10448. POC3_POC4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12245-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVKTISRTI ESESGFLQPT LDVIATLPAD DRSKKIPISL VVGFKQEASL
60 70 80 90 100
NSSSSLSCYY YAIPLMRDRH INLKSGGSNV VGIPLLDTKD DRIRDMARHM
110 120 130 140
ATIISERFNR PCYVTWSSLP SEDPSMLVAN HLYILKKCLD LLKTELGE
Length:148
Mass (Da):16,573
Last modified:November 1, 1996 - v1
Checksum:i1CC7C6074CF4AC08
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91T → P in AAS56461 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96770 Genomic DNA. Translation: CAA65549.1.
U43703 Genomic DNA. Translation: AAB68232.1.
Z73500 Genomic DNA. Translation: CAA97848.1.
AY558135 Genomic DNA. Translation: AAS56461.1.
BK006949 Genomic DNA. Translation: DAA11291.1.
PIRiS65155.
RefSeqiNP_015181.1. NM_001183958.1.

Genome annotation databases

EnsemblFungiiYPL144W; YPL144W; YPL144W.
GeneIDi855959.
KEGGisce:YPL144W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96770 Genomic DNA. Translation: CAA65549.1.
U43703 Genomic DNA. Translation: AAB68232.1.
Z73500 Genomic DNA. Translation: CAA97848.1.
AY558135 Genomic DNA. Translation: AAS56461.1.
BK006949 Genomic DNA. Translation: DAA11291.1.
PIRiS65155.
RefSeqiNP_015181.1. NM_001183958.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z5BX-ray1.96A1-148[»]
2Z5CX-ray2.90A/D1-148[»]
ProteinModelPortaliQ12245.
SMRiQ12245. Positions 1-147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36039. 74 interactions.
DIPiDIP-8930N.
IntActiQ12245. 3 interactions.
MINTiMINT-2492870.

Proteomic databases

MaxQBiQ12245.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL144W; YPL144W; YPL144W.
GeneIDi855959.
KEGGisce:YPL144W.

Organism-specific databases

EuPathDBiFungiDB:YPL144W.
SGDiS000006065. POC4.

Phylogenomic databases

HOGENOMiHOG000115600.
InParanoidiQ12245.
KOiK11882.
OMAiHMATIIS.
OrthoDBiEOG092C5PA4.

Enzyme and pathway databases

BioCyciYEAST:G3O-34041-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ12245.
PROiQ12245.

Family and domain databases

InterProiIPR018854. Psome_chaperone_3/4.
[Graphical view]
PfamiPF10448. POC3_POC4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOC4_YEAST
AccessioniPrimary (citable) accession number: Q12245
Secondary accession number(s): D6W3M5, Q6Q5F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2210 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.