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Protein

Transmembrane protein 115 homolog

Gene

YOL107W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum.By similarity

Enzyme and pathway databases

BioCyciYEAST:G3O-33504-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 115 homologCurated
Gene namesi
Ordered Locus Names:YOL107W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XV

Organism-specific databases

CYGDiYOL107w.
EuPathDBiFungiDB:YOL107W.
SGDiS000005467. YOL107W.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121CytoplasmicCuratedAdd
BLAST
Transmembranei22 – 4221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini43 – 12179LumenalCuratedAdd
BLAST
Transmembranei122 – 14221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini143 – 15917CytoplasmicCuratedAdd
BLAST
Transmembranei160 – 18021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini181 – 20727LumenalCuratedAdd
BLAST
Transmembranei208 – 22821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini229 – 342114CytoplasmicCuratedAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Transmembrane protein 115 homologPRO_0000235931Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ12239.

Interactioni

Subunit structurei

Homooligomer.By similarity

Protein-protein interaction databases

BioGridi34294. 15 interactions.
DIPiDIP-4218N.
IntActiQ12239. 2 interactions.
MINTiMINT-554964.

Structurei

3D structure databases

ProteinModelPortaliQ12239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM115 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251000.
GeneTreeiENSGT00390000002470.
HOGENOMiHOG000065992.
InParanoidiQ12239.
OMAiPEHNIVL.
OrthoDBiEOG72RN8C.

Family and domain databases

InterProiIPR013861. DUF1751_Mem_euk.
[Graphical view]
PfamiPF08551. DUF1751. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12239-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQYSSRFLEL NIPDSFLNIN KIPDATKFIT VTYICLTATL FCIRRSLYNK
60 70 80 90 100
LVLEDPNLDY NLITSPLLQM VPSQIWRYPT SLVLSNFIDT KAWKVVVNLL
110 120 130 140 150
NLIIGGSFIE RNWNSSKEMF KFIIVLGSLT NVLIIMLTLL VSFFSNKVRL
160 170 180 190 200
DIPLDGNYTI LIGFPIIYRQ LLPETTIIHL KTPQFLAKNF RFKLLPIFVM
210 220 230 240 250
FTMTVTQIIW FHHFAQLFSI WVTFFASWSY LRFFQKLAPL NCPSLPTTNS
260 270 280 290 300
QGGQEILVGD ASDTFQLIYF FPDLIKPILR PIFNFIYNVV VVKFKVIKPF
310 320 330 340
HDIDIDIGNT IAESRGAKKI MTVEERRRQL ALQVLEERMV NP
Length:342
Mass (Da):39,742
Last modified:November 1, 1996 - v1
Checksum:i75C352C4CE35DC57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48149 Genomic DNA. Translation: CAA88154.1.
Z74849 Genomic DNA. Translation: CAA99126.1.
BK006948 Genomic DNA. Translation: DAA10676.1.
PIRiS51891.
RefSeqiNP_014534.1. NM_001183361.1.

Genome annotation databases

EnsemblFungiiYOL107W; YOL107W; YOL107W.
GeneIDi854043.
KEGGisce:YOL107W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48149 Genomic DNA. Translation: CAA88154.1.
Z74849 Genomic DNA. Translation: CAA99126.1.
BK006948 Genomic DNA. Translation: DAA10676.1.
PIRiS51891.
RefSeqiNP_014534.1. NM_001183361.1.

3D structure databases

ProteinModelPortaliQ12239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34294. 15 interactions.
DIPiDIP-4218N.
IntActiQ12239. 2 interactions.
MINTiMINT-554964.

Proteomic databases

PaxDbiQ12239.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL107W; YOL107W; YOL107W.
GeneIDi854043.
KEGGisce:YOL107W.

Organism-specific databases

CYGDiYOL107w.
EuPathDBiFungiDB:YOL107W.
SGDiS000005467. YOL107W.

Phylogenomic databases

eggNOGiNOG251000.
GeneTreeiENSGT00390000002470.
HOGENOMiHOG000065992.
InParanoidiQ12239.
OMAiPEHNIVL.
OrthoDBiEOG72RN8C.

Enzyme and pathway databases

BioCyciYEAST:G3O-33504-MONOMER.

Miscellaneous databases

NextBioi975615.
PROiQ12239.

Family and domain databases

InterProiIPR013861. DUF1751_Mem_euk.
[Graphical view]
PfamiPF08551. DUF1751. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a 44 kb DNA fragment of yeast chromosome XV including the Ty1-H3 retrotransposon, the suf1(+) frameshift suppressor gene for tRNA-Gly, the yeast transfer RNA-Thr-1a and a delta element."
    Vandenbol M., Durand P., Portetelle D., Hilger F.
    Yeast 11:1069-1075(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiTM115_YEAST
AccessioniPrimary (citable) accession number: Q12239
Secondary accession number(s): D6W1W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 1, 1996
Last modified: July 22, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1630 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.