ID   UBX3_YEAST              Reviewed;         455 AA.
AC   Q12229;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 53.
DE   RecName: Full=UBX domain-containing protein 3;
GN   Name=UBX3; OrderedLocusNames=YDL091C;
OS   Saccharomyces cerevisiae (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 96604 / S288c / FY1679;
RX   MEDLINE=97082507; PubMed=8923743;
RX   DOI=10.1002/(SICI)1097-0061(199610)12:13<1377::AID-YEA35>3.0.CO;2-R;
RA   Boskovic J., Soler-Mira A., Garcia-Cantalejo J.M., Ballesta J.P.G.,
RA   Jimenez A., Remacha M.A.;
RT   "The sequence of a 16,691 bp segment of Saccharomyces cerevisiae
RT   chromosome IV identifies the DUN1, PMT1, PMT5, SRP14 and DPR1 genes,
RT   and five new open reading frames.";
RL   Yeast 12:1377-1384(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   MEDLINE=97313263; PubMed=9169867;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N.,
RA   Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M.,
RA   Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L.,
RA   Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M.,
RA   Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S.,
RA   Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M.,
RA   Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S.,
RA   Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K.,
RA   Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D.,
RA   Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C.,
RA   Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T.,
RA   Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W.,
RA   Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K.,
RA   Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S.,
RA   Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A.,
RA   Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S.,
RA   Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M.,
RA   Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y.,
RA   Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M.,
RA   Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E.,
RA   Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R.,
RA   Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   MEDLINE=22923954; PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   MEDLINE=22923965; PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
RA   Dephoure N., O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   INTERACTION WITH CDC48.
RX   PubMed=15258615; DOI=10.1038/sj.embor.7400203;
RA   Schuberth C., Richly H., Rumpf S., Buchberger A.;
RT   "Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent
RT   protein degradation.";
RL   EMBO Rep. 5:818-824(2004).
CC   -!- FUNCTION: Involved in CDC48-dependent protein degradation through
CC       the ubiquitin/proteasome pathway. Involved in delivery of
CC       substrates to the 26S proteasome. Also required for membrane
CC       fusion (By similarity).
CC   -!- SUBUNIT: Interacts with CDC48.
CC   -!- INTERACTION:
CC       P25694:CDC48; NbExp=1; IntAct=EBI-35335, EBI-4308;
CC       P39940:RSP5; NbExp=1; IntAct=EBI-35335, EBI-16219;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- MISCELLANEOUS: Present with 233 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Contains 1 UBX domain.
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DR   EMBL; X95644; CAA64920.1; -; Genomic_DNA.
DR   EMBL; Z74139; CAA98657.1; -; Genomic_DNA.
DR   PIR; S67627; S67627.
DR   RefSeq; NP_010192.1; -.
DR   DIP; DIP:5024N; -.
DR   IntAct; Q12229; 3.
DR   Ensembl; YDL091C; Saccharomyces cerevisiae.
DR   GeneID; 851467; -.
DR   GenomeReviews; Z71256_GR; YDL091C.
DR   KEGG; sce:YDL091C; -.
DR   NMPDR; fig|4932.3.peg.930; -.
DR   CYGD; YDL091c; -.
DR   SGD; S000002249; UBX3.
DR   HOGENOM; Q12229; -.
DR   OMA; Q12229; DSLRRDQ.
DR   NextBio; 968753; -.
DR   GermOnline; YDL091C; Saccharomyces cerevisiae.
DR   GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0019941; P:modification-dependent protein catabolic pr...; IEA:UniProtKB-KW.
DR   InterPro; IPR006577; UAS.
DR   InterPro; IPR001012; UBX.
DR   Pfam; PF00789; UBX; 1.
DR   SMART; SM00594; UAS; 1.
DR   SMART; SM00166; UBX; 1.
DR   PROSITE; PS50033; UBX; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasm; Ubl conjugation pathway.
FT   CHAIN         1    455       UBX domain-containing protein 3.
FT                                /FTId=PRO_0000211000.
FT   DOMAIN      356    455       UBX.
SQ   SEQUENCE   455 AA;  52943 MW;  7C565528A9C9D33E CRC64;
     MDIFRHTFGN NDDSFIRIPG AFREEPPADL NGRTEDQNSN TNEPTQSRDG RLKSILHFLF
     QAPLIVLYYL LNFIVRSSRL LKPLLRLHGF YQRKHNRLLD HSSQLHRLLE NLENEAQAVT
     CSEGNGNNDD GSNTDSTSNN ESSGVQFSFG SLYNPENGTF SKSIMQNSYT ELLDACSEQV
     KFGVIYLHDP LLDNHMDYVN KILCSEAFVN MIRKYQVLLW YGDVTTSEGL QVSNALKIRQ
     YPLLGIISLK AEKKIELIAR VEGSISNYKA QDLEAIFSKN YSRLIQLRQQ RQNIEMQRLI
     RQQQDSRYQD SLRRDQQRES ERLEQTQREQ MEREHQRIEN QWLLWRKSQL KPEPSSDKDA
     SKVAIRLENG QRLVRKFDAS LPTEEIYAFV ELQLHDMLNS ENDTLPVYQP ANYQHQYSFK
     LITPVPRREL DLSTKISDVS GIYPSGNIVM ERLDE
//