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Q12229 (UBX3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UBX domain-containing protein 3
Gene names
Name:UBX3
Ordered Locus Names:YDL091C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway. Involved in delivery of substrates to the 26S proteasome. Also required for membrane fusion By similarity.

Subunit structure

Interacts with CDC48. Ref.6

Subcellular location

Cytoplasm Ref.4.

Miscellaneous

Present with 233 molecules/cell in log phase SD medium. Ref.5

Sequence similarities

Contains 1 UBX domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentCytoplasm
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from direct assay Ref.4. Source: SGD

   Molecular functionprotein binding

Inferred from physical interaction Ref.6. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CDC48P256943EBI-35335,EBI-4308

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 455455UBX domain-containing protein 3
PRO_0000211000

Regions

Domain356 – 455100UBX

Sequences

Sequence LengthMass (Da)Tools
Q12229 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7C565528A9C9D33E

FASTA45552,943
        10         20         30         40         50         60 
MDIFRHTFGN NDDSFIRIPG AFREEPPADL NGRTEDQNSN TNEPTQSRDG RLKSILHFLF 

        70         80         90        100        110        120 
QAPLIVLYYL LNFIVRSSRL LKPLLRLHGF YQRKHNRLLD HSSQLHRLLE NLENEAQAVT 

       130        140        150        160        170        180 
CSEGNGNNDD GSNTDSTSNN ESSGVQFSFG SLYNPENGTF SKSIMQNSYT ELLDACSEQV 

       190        200        210        220        230        240 
KFGVIYLHDP LLDNHMDYVN KILCSEAFVN MIRKYQVLLW YGDVTTSEGL QVSNALKIRQ 

       250        260        270        280        290        300 
YPLLGIISLK AEKKIELIAR VEGSISNYKA QDLEAIFSKN YSRLIQLRQQ RQNIEMQRLI 

       310        320        330        340        350        360 
RQQQDSRYQD SLRRDQQRES ERLEQTQREQ MEREHQRIEN QWLLWRKSQL KPEPSSDKDA 

       370        380        390        400        410        420 
SKVAIRLENG QRLVRKFDAS LPTEEIYAFV ELQLHDMLNS ENDTLPVYQP ANYQHQYSFK 

       430        440        450 
LITPVPRREL DLSTKISDVS GIYPSGNIVM ERLDE

« Hide

References

« Hide 'large scale' references
[1]"The sequence of a 16,691 bp segment of Saccharomyces cerevisiae chromosome IV identifies the DUN1, PMT1, PMT5, SRP14 and DPR1 genes, and five new open reading frames."
Boskovic J., Soler-Mira A., Garcia-Cantalejo J.M., Ballesta J.P.G., Jimenez A., Remacha M.A.
Yeast 12:1377-1384(1996) [PubMed: 8923743] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed: 9169867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation."
Schuberth C., Richly H., Rumpf S., Buchberger A.
EMBO Rep. 5:818-824(2004) [PubMed: 15258615] [Abstract]
Cited for: INTERACTION WITH CDC48.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X95644 Genomic DNA. Translation: CAA64920.1.
Z74139 Genomic DNA. Translation: CAA98657.1.
BK006938 Genomic DNA. Translation: DAA11767.1.
PIRS67627.
RefSeqNP_010192.1. NM_001180150.1.

3D structure databases

ProteinModelPortalQ12229.
SMRQ12229. Positions 357-450.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-5024N.
IntActQ12229. 2 interactions.
MINTMINT-535250.
STRINGQ12229.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDL091C; YDL091C; YDL091C.
GeneID851467.
KEGGsce:YDL091C.
NMPDRfig|4932.3.peg.930.

Organism-specific databases

CYGDYDL091c.
SGDS000002249. UBX3.

Phylogenomic databases

eggNOGfuNOG07429.
GeneTreeEFGT00050000004952.
HOGENOMHBG203080.
OMALLCLTRT.
OrthoDBEOG4N33XD.

Gene expression databases

ArrayExpressQ12229.
GenevestigatorQ12229.
GermOnlineYDL091C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR006577. UAS.
IPR001012. UBX.
[Graphical view]
PfamPF00789. UBX. 1 hit.
[Graphical view]
SMARTSM00594. UAS. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
PROSITEPS50033. UBX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968753.

Entry information

Entry nameUBX3_YEAST
AccessionPrimary (citable) accession number: Q12229
Secondary accession number(s): D6VRQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 1, 1996
Last modified: December 14, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents