Reviewed,
UniProtKB/Swiss-Prot Q12229 (UBX3_YEAST)
Last modified
June 16, 2009.
Version 53.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: UBX domain-containing protein 3 | ||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4932 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 455 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway. Involved in delivery of substrates to the 26S proteasome. Also required for membrane fusion By similarity. |
| Subunit structure | Interacts with CDC48. Ref.5 |
| Subcellular location | |
| Miscellaneous | Present with 233 molecules/cell in log phase SD medium. Ref.4 |
| Sequence similarities | Contains 1 UBX domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ubl conjugation pathway |
| Cellular component | Cytoplasm |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Ref.3 Inferred from direct assay. Source: SGD |
| Molecular function | protein binding Ref.5 Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CDC48 | P25694 | 1 | EBI-35335,EBI-4308 | |
| RSP5 | P39940 | 1 | EBI-35335,EBI-16219 |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The sequence of a 16,691 bp segment of Saccharomyces cerevisiae chromosome IV identifies the DUN1, PMT1, PMT5, SRP14 and DPR1 genes, and five new open reading frames." Boskovic J., Soler-Mira A., Garcia-Cantalejo J.M., Ballesta J.P.G., Jimenez A., Remacha M.A. Yeast 12:1377-1384(1996) [PubMed: 8923743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679. |
| [2] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. Zaccaria P.Nature 387:75-78(1997) [PubMed: 9169867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [3] | "Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
| [4] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| [5] | "Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation." Schuberth C., Richly H., Rumpf S., Buchberger A. EMBO Rep. 5:818-824(2004) [PubMed: 15258615] [Abstract] Cited for: INTERACTION WITH CDC48. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X95644 Genomic DNA. Translation: CAA64920.1. Z74139 Genomic DNA. Translation: CAA98657.1. | |
| PIR | S67627. |
| RefSeq | NP_010192.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:5024N. |
| IntAct | Q12229. 3 interactions. |
Genome annotation databases | |
| Ensembl | YDL091C. Saccharomyces cerevisiae. [Contig view] |
| GeneID | 851467. |
| GenomeReviews | Gene locus YDL091C in contig Z71256_GR. |
| KEGG | sce:YDL091C. |
| NMPDR | fig|4932.3.peg.930. |
Organism-specific databases | |
| CYGD | YDL091c. |
| SGD | S000002249. UBX3. |
| Yeast-GFP | Search... |
Phylogenomic databases | |
| HOGENOM | Q12229. |
| OMA | Q12229. DSLRRDQ. |
Gene expression databases | |
| GermOnline | YDL091C. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR006577. UAS. IPR001012. UBX. [Graphical view] |
| Pfam | PF00789. UBX. 1 hit. [Graphical view] |
| SMART | SM00594. UAS. 1 hit. SM00166. UBX. 1 hit. [Graphical view] |
| PROSITE | PS50033. UBX. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 968753. |
Entry information
| Entry name | UBX3_YEAST | ||||||||
| Accession | Primary (citable) accession number: Q12229 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |

Clusters with


