Q12229 (UBX3_YEAST) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 73.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: UBX domain-containing protein 3 | ||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ||||
| Taxonomic identifier | 559292 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 455 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway. Involved in delivery of substrates to the 26S proteasome. Also required for membrane fusion By similarity. |
| Subunit structure | Interacts with CDC48. Ref.6 |
| Subcellular location | |
| Miscellaneous | Present with 233 molecules/cell in log phase SD medium. Ref.5 |
| Sequence similarities | Contains 1 UBX domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ubl conjugation pathway |
| Cellular component | Cytoplasm |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from direct assay Ref.4. Source: SGD |
| Molecular function | protein binding Inferred from physical interaction Ref.6. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CDC48 | P25694 | 3 | EBI-35335,EBI-4308 |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The sequence of a 16,691 bp segment of Saccharomyces cerevisiae chromosome IV identifies the DUN1, PMT1, PMT5, SRP14 and DPR1 genes, and five new open reading frames." Boskovic J., Soler-Mira A., Garcia-Cantalejo J.M., Ballesta J.P.G., Jimenez A., Remacha M.A. Yeast 12:1377-1384(1996) [PubMed: 8923743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679. |
| [2] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. Zaccaria P.Nature 387:75-78(1997) [PubMed: 9169867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [3] | Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c. |
| [4] | "Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
| [5] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| [6] | "Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation." Schuberth C., Richly H., Rumpf S., Buchberger A. EMBO Rep. 5:818-824(2004) [PubMed: 15258615] [Abstract] Cited for: INTERACTION WITH CDC48. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X95644 Genomic DNA. Translation: CAA64920.1. Z74139 Genomic DNA. Translation: CAA98657.1. BK006938 Genomic DNA. Translation: DAA11767.1. |
| PIR | S67627. |
| RefSeq | NP_010192.1. NM_001180150.1. |
3D structure databases | |
| ProteinModelPortal | Q12229. |
| SMR | Q12229. Positions 357-450. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-5024N. |
| IntAct | Q12229. 2 interactions. |
| MINT | MINT-535250. |
| STRING | Q12229. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | YDL091C; YDL091C; YDL091C. |
| GeneID | 851467. |
| KEGG | sce:YDL091C. |
| NMPDR | fig|4932.3.peg.930. |
Organism-specific databases | |
| CYGD | YDL091c. |
| SGD | S000002249. UBX3. |
Phylogenomic databases | |
| eggNOG | fuNOG07429. |
| GeneTree | EFGT00050000004952. |
| HOGENOM | HBG203080. |
| OMA | LLCLTRT. |
| OrthoDB | EOG4N33XD. |
Gene expression databases | |
| ArrayExpress | Q12229. |
| Genevestigator | Q12229. |
| GermOnline | YDL091C. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR006577. UAS. IPR001012. UBX. [Graphical view] |
| Pfam | PF00789. UBX. 1 hit. [Graphical view] |
| SMART | SM00594. UAS. 1 hit. SM00166. UBX. 1 hit. [Graphical view] |
| PROSITE | PS50033. UBX. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 968753. |
Entry information
| Entry name | UBX3_YEAST | ||||||||
| Accession | Primary (citable) accession number: Q12229 Secondary accession number(s): D6VRQ7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| SIMILARITY comments Index of protein domains and families |

Clusters with