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Protein

Trichothecene 3-O-acetyltransferase

Gene

AYT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Trichothecene 3-O-acetyltransferase involved in self-protection against trichothecenes, mycotoxins acting as eukaryotic protein synthesis inhibitors. Its existence is surprising in a non-trichothecene producer organism which needs no self-protection again endogenic trichothecenes. The persistence of this non-essential gene may be due to a selective advantage that it may confer, like a resistance to exogenic trichothecenes.2 Publications

GO - Molecular functioni

  • trichothecene 3-O-acetyltransferase activity Source: SGD

GO - Biological processi

  • mycotoxin catabolic process Source: SGD

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:YLL063C-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Trichothecene 3-O-acetyltransferase (EC:2.3.1.-)
Gene namesi
Name:AYT1
Ordered Locus Names:YLL063C
ORF Names:L0549
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL063C
SGDiS000003986 AYT1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000761811 – 474Trichothecene 3-O-acetyltransferaseAdd BLAST474

Proteomic databases

PaxDbiQ12226
PRIDEiQ12226

PTM databases

CarbonylDBiQ12226

Interactioni

Protein-protein interaction databases

BioGridi31253, 32 interactors
IntActiQ12226, 1 interactor
MINTiQ12226
STRINGi4932.YLL063C

Structurei

3D structure databases

ProteinModelPortaliQ12226
SMRiQ12226
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000206827
InParanoidiQ12226
OMAiESLMYIM
OrthoDBiEOG092C1UXI

Family and domain databases

Gene3Di3.30.559.10, 4 hits
InterProiView protein in InterPro
IPR023213 CAT-like_dom_sf
IPR003480 Transferase
PfamiView protein in Pfam
PF02458 Transferase, 1 hit

Sequencei

Sequence statusi: Complete.

Q12226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRVKIISQK RTKSVQMLEN DQLDILGQQP SLYKLYTQIC SIYRVPDPSA
60 70 80 90 100
HDHIVNTLTR GLETLAKNFQ WLAGNVVNEG ADEGNTGTYR IVPSDKIPLI
110 120 130 140 150
VQDLREDLSA PTMDSLEKAD FPIYMLDEKT FAPCMTINPP GNTIGMAAKS
160 170 180 190 200
GPVFAVQANF ISGGLVLTIV GQHNIMDITG QESIINLLNK SCHQKPFSDE
210 220 230 240 250
ELLIGNIDKS KSIPLFDETW EPDTTLVHEI VETSRNTSGE EKEQSCSSNS
260 270 280 290 300
TWAYVEFSAI SLQNLRILAM QTCTSGTKFV STDDIVTAFI WKSVSRARLS
310 320 330 340 350
RLKPETKSNL GRAVDVRKRL GLPETYPGLL VNMTFNTGSL KSLDHKSLGV
360 370 380 390 400
LASQIRRKLD PKVFDLAYNT CALATLLSRC PDKTKVSIPQ PIDTLSGIMV
410 420 430 440 450
SSWAKVSLYD VDFNLGLGKP KSVRRPRFIS LESLIYFMPR SSRGEMVVAL
460 470
CLRDKDWECL NADKEWTNYA THIG
Length:474
Mass (Da):52,837
Last modified:November 1, 1996 - v1
Checksum:i0576D77357607F5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47973 Genomic DNA Translation: CAA87994.1
Z73168 Genomic DNA Translation: CAA97516.1
BK006945 Genomic DNA Translation: DAA09262.1
PIRiS50957
RefSeqiNP_013037.1, NM_001181883.1

Genome annotation databases

EnsemblFungiiYLL063C; YLL063C; YLL063C
GeneIDi850663
KEGGisce:YLL063C

Similar proteinsi

Entry informationi

Entry nameiAYT1_YEAST
AccessioniPrimary (citable) accession number: Q12226
Secondary accession number(s): D6VXU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. Protein nomenclature information
    List of publications dealing with protein nomenclature and links to specialized websites

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