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Q12226 (AYT1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trichothecene 3-O-acetyltransferase

EC=2.3.1.-
Gene names
Name:AYT1
Ordered Locus Names:YLL063C
ORF Names:L0549
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Trichothecene 3-O-acetyltransferase involved in self-protection against trichothecenes, mycotoxins acting as eukaryotic protein synthesis inhibitors. Its existence is surprising in a non-trichothecene producer organism which needs no self-protection again endogenic trichothecenes. The persistence of this non-essential gene may be due to a selective advantage that it may confer, like a resistance to exogenic trichothecenes. Ref.4 Ref.5

Sequence similarities

Belongs to the trichothecene 3-O-acetyltransferase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474Trichothecene 3-O-acetyltransferase
PRO_0000076181

Sequences

Sequence LengthMass (Da)Tools
Q12226 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 0576D77357607F5C

FASTA47452,837
        10         20         30         40         50         60 
MFRVKIISQK RTKSVQMLEN DQLDILGQQP SLYKLYTQIC SIYRVPDPSA HDHIVNTLTR 

        70         80         90        100        110        120 
GLETLAKNFQ WLAGNVVNEG ADEGNTGTYR IVPSDKIPLI VQDLREDLSA PTMDSLEKAD 

       130        140        150        160        170        180 
FPIYMLDEKT FAPCMTINPP GNTIGMAAKS GPVFAVQANF ISGGLVLTIV GQHNIMDITG 

       190        200        210        220        230        240 
QESIINLLNK SCHQKPFSDE ELLIGNIDKS KSIPLFDETW EPDTTLVHEI VETSRNTSGE 

       250        260        270        280        290        300 
EKEQSCSSNS TWAYVEFSAI SLQNLRILAM QTCTSGTKFV STDDIVTAFI WKSVSRARLS 

       310        320        330        340        350        360 
RLKPETKSNL GRAVDVRKRL GLPETYPGLL VNMTFNTGSL KSLDHKSLGV LASQIRRKLD 

       370        380        390        400        410        420 
PKVFDLAYNT CALATLLSRC PDKTKVSIPQ PIDTLSGIMV SSWAKVSLYD VDFNLGLGKP 

       430        440        450        460        470 
KSVRRPRFIS LESLIYFMPR SSRGEMVVAL CLRDKDWECL NADKEWTNYA THIG 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of a 37 kb DNA fragment from chromosome XII of Saccharomyces cerevisiae including the subtelomeric region of the left arm."
Wedler H., Wambutt R.
Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"The identification of the Saccharomyces cerevisiae gene AYT1(ORF-YLL063c) encoding an acetyltransferase."
Alexander N.J., McCormick S.P., Hohn T.M.
Yeast 19:1425-1430(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Concordant evolution of trichothecene 3-O-acetyltransferase and an rDNA species phylogeny of trichothecene-producing and non-producing fusaria and other ascomycetous fungi."
Tokai T., Fujimura M., Inoue H., Aoki T., Ohta K., Shibata T., Yamaguchi I., Kimura M.
Microbiology 151:509-519(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z47973 Genomic DNA. Translation: CAA87994.1.
Z73168 Genomic DNA. Translation: CAA97516.1.
BK006945 Genomic DNA. Translation: DAA09262.1.
PIRS50957.
RefSeqNP_013037.1. NM_001181883.1.

3D structure databases

ProteinModelPortalQ12226.
SMRQ12226. Positions 22-474.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31253. 9 interactions.
IntActQ12226. 1 interaction.
MINTMINT-2732466.
STRING4932.YLL063C.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLL063C; YLL063C; YLL063C.
GeneID850663.
KEGGsce:YLL063C.

Organism-specific databases

CYGDYLL063c.
SGDS000003986. AYT1.

Phylogenomic databases

eggNOGNOG84518.
HOGENOMHOG000206827.
OMAHNIMDIT.
OrthoDBEOG780RWP.

Enzyme and pathway databases

BioCycYEAST:YLL063C-MONOMER.

Gene expression databases

GenevestigatorQ12226.

Family and domain databases

Gene3D3.30.559.10. 2 hits.
InterProIPR023213. CAT-like_dom.
IPR003480. Transferase.
[Graphical view]
PfamPF02458. Transferase. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio966635.

Entry information

Entry nameAYT1_YEAST
AccessionPrimary (citable) accession number: Q12226
Secondary accession number(s): D6VXU6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families