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Q12226

- AYT1_YEAST

UniProt

Q12226 - AYT1_YEAST

Protein

Trichothecene 3-O-acetyltransferase

Gene

AYT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Trichothecene 3-O-acetyltransferase involved in self-protection against trichothecenes, mycotoxins acting as eukaryotic protein synthesis inhibitors. Its existence is surprising in a non-trichothecene producer organism which needs no self-protection again endogenic trichothecenes. The persistence of this non-essential gene may be due to a selective advantage that it may confer, like a resistance to exogenic trichothecenes.2 Publications

    GO - Molecular functioni

    1. trichothecene 3-O-acetyltransferase activity Source: SGD

    GO - Biological processi

    1. mycotoxin catabolic process Source: SGD

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciYEAST:YLL063C-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trichothecene 3-O-acetyltransferase (EC:2.3.1.-)
    Gene namesi
    Name:AYT1
    Ordered Locus Names:YLL063C
    ORF Names:L0549
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    CYGDiYLL063c.
    SGDiS000003986. AYT1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 474474Trichothecene 3-O-acetyltransferasePRO_0000076181Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ12226.

    Interactioni

    Protein-protein interaction databases

    BioGridi31253. 9 interactions.
    IntActiQ12226. 1 interaction.
    MINTiMINT-2732466.
    STRINGi4932.YLL063C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12226.
    SMRiQ12226. Positions 22-474.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG84518.
    HOGENOMiHOG000206827.
    OMAiHNIMDIT.
    OrthoDBiEOG780RWP.

    Family and domain databases

    Gene3Di3.30.559.10. 2 hits.
    InterProiIPR023213. CAT-like_dom.
    IPR003480. Transferase.
    [Graphical view]
    PfamiPF02458. Transferase. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12226-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFRVKIISQK RTKSVQMLEN DQLDILGQQP SLYKLYTQIC SIYRVPDPSA    50
    HDHIVNTLTR GLETLAKNFQ WLAGNVVNEG ADEGNTGTYR IVPSDKIPLI 100
    VQDLREDLSA PTMDSLEKAD FPIYMLDEKT FAPCMTINPP GNTIGMAAKS 150
    GPVFAVQANF ISGGLVLTIV GQHNIMDITG QESIINLLNK SCHQKPFSDE 200
    ELLIGNIDKS KSIPLFDETW EPDTTLVHEI VETSRNTSGE EKEQSCSSNS 250
    TWAYVEFSAI SLQNLRILAM QTCTSGTKFV STDDIVTAFI WKSVSRARLS 300
    RLKPETKSNL GRAVDVRKRL GLPETYPGLL VNMTFNTGSL KSLDHKSLGV 350
    LASQIRRKLD PKVFDLAYNT CALATLLSRC PDKTKVSIPQ PIDTLSGIMV 400
    SSWAKVSLYD VDFNLGLGKP KSVRRPRFIS LESLIYFMPR SSRGEMVVAL 450
    CLRDKDWECL NADKEWTNYA THIG 474
    Length:474
    Mass (Da):52,837
    Last modified:November 1, 1996 - v1
    Checksum:i0576D77357607F5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z47973 Genomic DNA. Translation: CAA87994.1.
    Z73168 Genomic DNA. Translation: CAA97516.1.
    BK006945 Genomic DNA. Translation: DAA09262.1.
    PIRiS50957.
    RefSeqiNP_013037.1. NM_001181883.1.

    Genome annotation databases

    EnsemblFungiiYLL063C; YLL063C; YLL063C.
    GeneIDi850663.
    KEGGisce:YLL063C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z47973 Genomic DNA. Translation: CAA87994.1 .
    Z73168 Genomic DNA. Translation: CAA97516.1 .
    BK006945 Genomic DNA. Translation: DAA09262.1 .
    PIRi S50957.
    RefSeqi NP_013037.1. NM_001181883.1.

    3D structure databases

    ProteinModelPortali Q12226.
    SMRi Q12226. Positions 22-474.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31253. 9 interactions.
    IntActi Q12226. 1 interaction.
    MINTi MINT-2732466.
    STRINGi 4932.YLL063C.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLL063C ; YLL063C ; YLL063C .
    GeneIDi 850663.
    KEGGi sce:YLL063C.

    Organism-specific databases

    CYGDi YLL063c.
    SGDi S000003986. AYT1.

    Phylogenomic databases

    eggNOGi NOG84518.
    HOGENOMi HOG000206827.
    OMAi HNIMDIT.
    OrthoDBi EOG780RWP.

    Enzyme and pathway databases

    BioCyci YEAST:YLL063C-MONOMER.

    Miscellaneous databases

    NextBioi 966635.

    Gene expression databases

    Genevestigatori Q12226.

    Family and domain databases

    Gene3Di 3.30.559.10. 2 hits.
    InterProi IPR023213. CAT-like_dom.
    IPR003480. Transferase.
    [Graphical view ]
    Pfami PF02458. Transferase. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a 37 kb DNA fragment from chromosome XII of Saccharomyces cerevisiae including the subtelomeric region of the left arm."
      Wedler H., Wambutt R.
      Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204511 / S288c / AB972.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "The identification of the Saccharomyces cerevisiae gene AYT1(ORF-YLL063c) encoding an acetyltransferase."
      Alexander N.J., McCormick S.P., Hohn T.M.
      Yeast 19:1425-1430(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Concordant evolution of trichothecene 3-O-acetyltransferase and an rDNA species phylogeny of trichothecene-producing and non-producing fusaria and other ascomycetous fungi."
      Tokai T., Fujimura M., Inoue H., Aoki T., Ohta K., Shibata T., Yamaguchi I., Kimura M.
      Microbiology 151:509-519(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiAYT1_YEAST
    AccessioniPrimary (citable) accession number: Q12226
    Secondary accession number(s): D6VXU6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3