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Q12226

- AYT1_YEAST

UniProt

Q12226 - AYT1_YEAST

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Protein

Trichothecene 3-O-acetyltransferase

Gene

AYT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Trichothecene 3-O-acetyltransferase involved in self-protection against trichothecenes, mycotoxins acting as eukaryotic protein synthesis inhibitors. Its existence is surprising in a non-trichothecene producer organism which needs no self-protection again endogenic trichothecenes. The persistence of this non-essential gene may be due to a selective advantage that it may confer, like a resistance to exogenic trichothecenes.2 Publications

GO - Molecular functioni

  1. trichothecene 3-O-acetyltransferase activity Source: SGD

GO - Biological processi

  1. mycotoxin catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:YLL063C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trichothecene 3-O-acetyltransferase (EC:2.3.1.-)
Gene namesi
Name:AYT1
Ordered Locus Names:YLL063C
ORF Names:L0549
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLL063c.
SGDiS000003986. AYT1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Trichothecene 3-O-acetyltransferasePRO_0000076181Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ12226.

Interactioni

Protein-protein interaction databases

BioGridi31253. 9 interactions.
IntActiQ12226. 1 interaction.
MINTiMINT-2732466.
STRINGi4932.YLL063C.

Structurei

3D structure databases

ProteinModelPortaliQ12226.
SMRiQ12226. Positions 22-474.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG84518.
HOGENOMiHOG000206827.
InParanoidiQ12226.
OMAiHNIMDIT.
OrthoDBiEOG780RWP.

Family and domain databases

Gene3Di3.30.559.10. 2 hits.
InterProiIPR023213. CAT-like_dom.
IPR003480. Transferase.
[Graphical view]
PfamiPF02458. Transferase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12226-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRVKIISQK RTKSVQMLEN DQLDILGQQP SLYKLYTQIC SIYRVPDPSA
60 70 80 90 100
HDHIVNTLTR GLETLAKNFQ WLAGNVVNEG ADEGNTGTYR IVPSDKIPLI
110 120 130 140 150
VQDLREDLSA PTMDSLEKAD FPIYMLDEKT FAPCMTINPP GNTIGMAAKS
160 170 180 190 200
GPVFAVQANF ISGGLVLTIV GQHNIMDITG QESIINLLNK SCHQKPFSDE
210 220 230 240 250
ELLIGNIDKS KSIPLFDETW EPDTTLVHEI VETSRNTSGE EKEQSCSSNS
260 270 280 290 300
TWAYVEFSAI SLQNLRILAM QTCTSGTKFV STDDIVTAFI WKSVSRARLS
310 320 330 340 350
RLKPETKSNL GRAVDVRKRL GLPETYPGLL VNMTFNTGSL KSLDHKSLGV
360 370 380 390 400
LASQIRRKLD PKVFDLAYNT CALATLLSRC PDKTKVSIPQ PIDTLSGIMV
410 420 430 440 450
SSWAKVSLYD VDFNLGLGKP KSVRRPRFIS LESLIYFMPR SSRGEMVVAL
460 470
CLRDKDWECL NADKEWTNYA THIG
Length:474
Mass (Da):52,837
Last modified:November 1, 1996 - v1
Checksum:i0576D77357607F5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47973 Genomic DNA. Translation: CAA87994.1.
Z73168 Genomic DNA. Translation: CAA97516.1.
BK006945 Genomic DNA. Translation: DAA09262.1.
PIRiS50957.
RefSeqiNP_013037.1. NM_001181883.1.

Genome annotation databases

EnsemblFungiiYLL063C; YLL063C; YLL063C.
GeneIDi850663.
KEGGisce:YLL063C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47973 Genomic DNA. Translation: CAA87994.1 .
Z73168 Genomic DNA. Translation: CAA97516.1 .
BK006945 Genomic DNA. Translation: DAA09262.1 .
PIRi S50957.
RefSeqi NP_013037.1. NM_001181883.1.

3D structure databases

ProteinModelPortali Q12226.
SMRi Q12226. Positions 22-474.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31253. 9 interactions.
IntActi Q12226. 1 interaction.
MINTi MINT-2732466.
STRINGi 4932.YLL063C.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLL063C ; YLL063C ; YLL063C .
GeneIDi 850663.
KEGGi sce:YLL063C.

Organism-specific databases

CYGDi YLL063c.
SGDi S000003986. AYT1.

Phylogenomic databases

eggNOGi NOG84518.
HOGENOMi HOG000206827.
InParanoidi Q12226.
OMAi HNIMDIT.
OrthoDBi EOG780RWP.

Enzyme and pathway databases

BioCyci YEAST:YLL063C-MONOMER.

Miscellaneous databases

NextBioi 966635.

Gene expression databases

Genevestigatori Q12226.

Family and domain databases

Gene3Di 3.30.559.10. 2 hits.
InterProi IPR023213. CAT-like_dom.
IPR003480. Transferase.
[Graphical view ]
Pfami PF02458. Transferase. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a 37 kb DNA fragment from chromosome XII of Saccharomyces cerevisiae including the subtelomeric region of the left arm."
    Wedler H., Wambutt R.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The identification of the Saccharomyces cerevisiae gene AYT1(ORF-YLL063c) encoding an acetyltransferase."
    Alexander N.J., McCormick S.P., Hohn T.M.
    Yeast 19:1425-1430(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Concordant evolution of trichothecene 3-O-acetyltransferase and an rDNA species phylogeny of trichothecene-producing and non-producing fusaria and other ascomycetous fungi."
    Tokai T., Fujimura M., Inoue H., Aoki T., Ohta K., Shibata T., Yamaguchi I., Kimura M.
    Microbiology 151:509-519(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiAYT1_YEAST
AccessioniPrimary (citable) accession number: Q12226
Secondary accession number(s): D6VXU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3