Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

U3 small nucleolar RNA-associated protein 12

Gene

DIP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA.1 Publication

Miscellaneous

Present with 9620 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • snoRNA binding Source: SGD

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-32271-MONOMER
ReactomeiR-SCE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 12
Short name:
U3 snoRNA-associated protein 12
Alternative name(s):
DOM34-interacting protein 2
U three protein 12
Gene namesi
Name:DIP2
Synonyms:UTP12
Ordered Locus Names:YLR129W
ORF Names:L3116, L9233.1
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR129W
SGDiS000004119 DIP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509551 – 943U3 small nucleolar RNA-associated protein 12Add BLAST943

Proteomic databases

MaxQBiQ12220
PaxDbiQ12220
PRIDEiQ12220

PTM databases

iPTMnetiQ12220

Interactioni

Subunit structurei

Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31398, 87 interactors
DIPiDIP-6494N
IntActiQ12220, 19 interactors
MINTiQ12220
STRINGi4932.YLR129W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WLCelectron microscopy3.80LQ1-943[»]
5WYJelectron microscopy8.70BB1-943[»]
5WYKelectron microscopy4.50BB1-943[»]
ProteinModelPortaliQ12220
SMRiQ12220
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati77 – 107WD 1Add BLAST31
Repeati119 – 149WD 2Add BLAST31
Repeati161 – 190WD 3Add BLAST30
Repeati202 – 230WD 4Add BLAST29
Repeati389 – 418WD 5Add BLAST30
Repeati428 – 458WD 6Add BLAST31
Repeati471 – 501WD 7Add BLAST31
Repeati571 – 601WD 8Add BLAST31
Repeati613 – 643WD 9Add BLAST31
Repeati655 – 685WD 10Add BLAST31

Sequence similaritiesi

Belongs to the WD repeat WDR3/UTP12 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00910000144238
HOGENOMiHOG000212524
InParanoidiQ12220
KOiK14556
OMAiDTMVKWW
OrthoDBiEOG092C0EL4

Family and domain databases

Gene3Di2.130.10.10, 4 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR007148 SSU_processome_Utp12
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF04003 Utp12, 1 hit
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 11 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 4 hits
PS50082 WD_REPEATS_2, 8 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q12220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKSYQRFEQ AAAFGVIASN ANCVWIPASS GNSNGSGPGQ LITSALEDVN
60 70 80 90 100
IWDIKTGDLV SKLSDGLPPG ASDARGAKPA ECTYLEAHKD TDLLAVGYAD
110 120 130 140 150
GVIKVWDLMS KTVLLNFNGH KAAITLLQFD GTGTRLISGS KDSNIIVWDL
160 170 180 190 200
VGEVGLYKLR SHKDSITGFW CQGEDWLIST SKDGMIKLWD LKTHQCIETH
210 220 230 240 250
IAHTGECWGL AVKDDLLITT GTDSQVKIWK LDIENDKMGG KLTEMGIFEK
260 270 280 290 300
QSKQRGLKIE FITNSSDKTS FFYIQNADKT IETFRIRKEE EIARGLKKRE
310 320 330 340 350
KRLKEKGLTE EEIAKSIKES YSSFILHPFQ TIRSLYKIKS ASWTTVSSSK
360 370 380 390 400
LELVLTTSSN TIEYYSIPYE KRDPTSPAPL KTHTIELQGQ RTDVRSIDIS
410 420 430 440 450
DDNKLLATAS NGSLKIWNIK THKCIRTFEC GYALTCKFLP GGLLVILGTR
460 470 480 490 500
NGELQLFDLA SSSLLDTIED AHDAAIWSLD LTSDGKRLVT GSADKTVKFW
510 520 530 540 550
DFKVENSLVP GTKNKFLPVL KLHHDTTLEL TDDILCVRVS PDDRYLAISL
560 570 580 590 600
LDNTVKVFFL DSMKFYLSLY GHKLPVLSID ISFDSKMIIT SSADKNIKIW
610 620 630 640 650
GLDFGDCHKS LFAHQDSIMN VKFLPQSHNF FSCSKDAVVK YWDGEKFECI
660 670 680 690 700
QKLYAHQSEV WALAVATDGG FVVSSSHDHS IRIWEETEDQ VFLEEEKEKE
710 720 730 740 750
LEEQYEDTLL TSLEEGNGDD AFKADASGEG VEDEASGVHK QTLESLKAGE
760 770 780 790 800
RLMEALDLGI AEIEGLEAYN RDMKLWQRKK LGEAPIKPQG NAVLIAVNKT
810 820 830 840 850
PEQYIMDTLL RIRMSQLEDA LMVMPFSYVL KFLKFIDTVM QNKTLLHSHL
860 870 880 890 900
PLICKNLFFI IKFNHKELVS QKNEELKLQI NRVKTELRSA LKSTEDDLGF
910 920 930 940
NVQGLKFVKQ QWNLRHNYEF VDEYDQQEKE SNSARKRVFG TVI
Length:943
Mass (Da):106,342
Last modified:November 1, 1996 - v1
Checksum:i7D9AEC7AF6A9C740
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53877 Genomic DNA Translation: AAB82375.1
U53881 Genomic DNA Translation: AAB82402.1
X91258 Genomic DNA Translation: CAA62640.1
Z73301 Genomic DNA Translation: CAA97699.1
Z73302 Genomic DNA Translation: CAA97700.1
X89514 Genomic DNA Translation: CAA61707.1
BK006945 Genomic DNA Translation: DAA09440.1
PIRiS59317
RefSeqiNP_013230.1, NM_001182016.1

Genome annotation databases

EnsemblFungiiYLR129W; YLR129W; YLR129W
GeneIDi850820
KEGGisce:YLR129W

Similar proteinsi

Entry informationi

Entry nameiUTP12_YEAST
AccessioniPrimary (citable) accession number: Q12220
Secondary accession number(s): D6VYC4, Q05386
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health