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Q12220 (UTP12_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
U3 small nucleolar RNA-associated protein 12

Short name=U3 snoRNA-associated protein 12
Alternative name(s):
DOM34-interacting protein 2
U three protein 12
Gene names
Name:DIP2
Synonyms:UTP12
Ordered Locus Names:YLR129W
ORF Names:L3116, L9233.1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length943 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in nucleolar processing of pre-18S ribosomal RNA. Ref.3

Subunit structure

Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Ref.3

Subcellular location

Nucleusnucleolus Ref.3.

Miscellaneous

Present with 9620 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the WD repeat WDR3/UTP12 family.

Contains 10 WD repeats.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PWP2P256356EBI-5896,EBI-14332

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 943943U3 small nucleolar RNA-associated protein 12
PRO_0000050955

Regions

Repeat77 – 10731WD 1
Repeat119 – 14931WD 2
Repeat161 – 19030WD 3
Repeat202 – 23029WD 4
Repeat389 – 41830WD 5
Repeat428 – 45831WD 6
Repeat471 – 50131WD 7
Repeat571 – 60131WD 8
Repeat613 – 64331WD 9
Repeat655 – 68531WD 10

Sequences

Sequence LengthMass (Da)Tools
Q12220 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7D9AEC7AF6A9C740

FASTA943106,342
        10         20         30         40         50         60 
MVKSYQRFEQ AAAFGVIASN ANCVWIPASS GNSNGSGPGQ LITSALEDVN IWDIKTGDLV 

        70         80         90        100        110        120 
SKLSDGLPPG ASDARGAKPA ECTYLEAHKD TDLLAVGYAD GVIKVWDLMS KTVLLNFNGH 

       130        140        150        160        170        180 
KAAITLLQFD GTGTRLISGS KDSNIIVWDL VGEVGLYKLR SHKDSITGFW CQGEDWLIST 

       190        200        210        220        230        240 
SKDGMIKLWD LKTHQCIETH IAHTGECWGL AVKDDLLITT GTDSQVKIWK LDIENDKMGG 

       250        260        270        280        290        300 
KLTEMGIFEK QSKQRGLKIE FITNSSDKTS FFYIQNADKT IETFRIRKEE EIARGLKKRE 

       310        320        330        340        350        360 
KRLKEKGLTE EEIAKSIKES YSSFILHPFQ TIRSLYKIKS ASWTTVSSSK LELVLTTSSN 

       370        380        390        400        410        420 
TIEYYSIPYE KRDPTSPAPL KTHTIELQGQ RTDVRSIDIS DDNKLLATAS NGSLKIWNIK 

       430        440        450        460        470        480 
THKCIRTFEC GYALTCKFLP GGLLVILGTR NGELQLFDLA SSSLLDTIED AHDAAIWSLD 

       490        500        510        520        530        540 
LTSDGKRLVT GSADKTVKFW DFKVENSLVP GTKNKFLPVL KLHHDTTLEL TDDILCVRVS 

       550        560        570        580        590        600 
PDDRYLAISL LDNTVKVFFL DSMKFYLSLY GHKLPVLSID ISFDSKMIIT SSADKNIKIW 

       610        620        630        640        650        660 
GLDFGDCHKS LFAHQDSIMN VKFLPQSHNF FSCSKDAVVK YWDGEKFECI QKLYAHQSEV 

       670        680        690        700        710        720 
WALAVATDGG FVVSSSHDHS IRIWEETEDQ VFLEEEKEKE LEEQYEDTLL TSLEEGNGDD 

       730        740        750        760        770        780 
AFKADASGEG VEDEASGVHK QTLESLKAGE RLMEALDLGI AEIEGLEAYN RDMKLWQRKK 

       790        800        810        820        830        840 
LGEAPIKPQG NAVLIAVNKT PEQYIMDTLL RIRMSQLEDA LMVMPFSYVL KFLKFIDTVM 

       850        860        870        880        890        900 
QNKTLLHSHL PLICKNLFFI IKFNHKELVS QKNEELKLQI NRVKTELRSA LKSTEDDLGF 

       910        920        930        940 
NVQGLKFVKQ QWNLRHNYEF VDEYDQQEKE SNSARKRVFG TVI 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis."
Dragon F., Gallagher J.E.G., Compagnone-Post P.A., Mitchell B.M., Porwancher K.A., Wehner K.A., Wormsley S., Settlage R.E., Shabanowitz J., Osheim Y., Beyer A.L., Hunt D.F., Baserga S.J.
Nature 417:967-970(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U53877 Genomic DNA. Translation: AAB82375.1.
U53881 Genomic DNA. Translation: AAB82402.1.
X91258 Genomic DNA. Translation: CAA62640.1.
Z73301 Genomic DNA. Translation: CAA97699.1.
Z73302 Genomic DNA. Translation: CAA97700.1.
X89514 Genomic DNA. Translation: CAA61707.1.
BK006945 Genomic DNA. Translation: DAA09440.1.
PIRS59317.
RefSeqNP_013230.1. NM_001182016.1.

3D structure databases

ProteinModelPortalQ12220.
SMRQ12220. Positions 20-799.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31398. 46 interactions.
DIPDIP-6494N.
IntActQ12220. 13 interactions.
MINTMINT-620162.
STRING4932.YLR129W.

Proteomic databases

MaxQBQ12220.
PaxDbQ12220.
PeptideAtlasQ12220.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR129W; YLR129W; YLR129W.
GeneID850820.
KEGGsce:YLR129W.

Organism-specific databases

CYGDYLR129w.
SGDS000004119. DIP2.

Phylogenomic databases

eggNOGCOG2319.
GeneTreeENSGT00750000117677.
HOGENOMHOG000212524.
KOK14556.
OMAFECGYAL.
OrthoDBEOG77WWN8.

Enzyme and pathway databases

BioCycYEAST:G3O-32271-MONOMER.

Gene expression databases

GenevestigatorQ12220.

Family and domain databases

Gene3D2.130.10.10. 3 hits.
InterProIPR020472. G-protein_beta_WD-40_rep.
IPR007148. SSU_processome_Utp12.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF04003. Utp12. 1 hit.
PF00400. WD40. 9 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 8 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio967067.
PROQ12220.

Entry information

Entry nameUTP12_YEAST
AccessionPrimary (citable) accession number: Q12220
Secondary accession number(s): D6VYC4, Q05386
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families