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Q12220

- UTP12_YEAST

UniProt

Q12220 - UTP12_YEAST

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Protein

U3 small nucleolar RNA-associated protein 12

Gene

DIP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA.1 Publication

GO - Molecular functioni

  1. snoRNA binding Source: SGD

GO - Biological processi

  1. endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  2. endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  3. endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  4. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-32271-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 12
Short name:
U3 snoRNA-associated protein 12
Alternative name(s):
DOM34-interacting protein 2
U three protein 12
Gene namesi
Name:DIP2
Synonyms:UTP12
Ordered Locus Names:YLR129W
ORF Names:L3116, L9233.1
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLR129w.
SGDiS000004119. DIP2.

Subcellular locationi

Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. nucleolus Source: SGD
  2. Pwp2p-containing subcomplex of 90S preribosome Source: SGD
  3. small-subunit processome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 943943U3 small nucleolar RNA-associated protein 12PRO_0000050955Add
BLAST

Proteomic databases

MaxQBiQ12220.
PaxDbiQ12220.
PeptideAtlasiQ12220.

Expressioni

Gene expression databases

GenevestigatoriQ12220.

Interactioni

Subunit structurei

Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PWP2P256356EBI-5896,EBI-14332

Protein-protein interaction databases

BioGridi31398. 47 interactions.
DIPiDIP-6494N.
IntActiQ12220. 13 interactions.
MINTiMINT-620162.
STRINGi4932.YLR129W.

Structurei

3D structure databases

ProteinModelPortaliQ12220.
SMRiQ12220. Positions 20-799.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati77 – 10731WD 1Add
BLAST
Repeati119 – 14931WD 2Add
BLAST
Repeati161 – 19030WD 3Add
BLAST
Repeati202 – 23029WD 4Add
BLAST
Repeati389 – 41830WD 5Add
BLAST
Repeati428 – 45831WD 6Add
BLAST
Repeati471 – 50131WD 7Add
BLAST
Repeati571 – 60131WD 8Add
BLAST
Repeati613 – 64331WD 9Add
BLAST
Repeati655 – 68531WD 10Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat WDR3/UTP12 family.Curated
Contains 10 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00760000119320.
HOGENOMiHOG000212524.
InParanoidiQ12220.
KOiK14556.
OMAiFECGYAL.
OrthoDBiEOG77WWN8.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR007148. SSU_processome_Utp12.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04003. Utp12. 1 hit.
PF00400. WD40. 9 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 8 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12220-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKSYQRFEQ AAAFGVIASN ANCVWIPASS GNSNGSGPGQ LITSALEDVN
60 70 80 90 100
IWDIKTGDLV SKLSDGLPPG ASDARGAKPA ECTYLEAHKD TDLLAVGYAD
110 120 130 140 150
GVIKVWDLMS KTVLLNFNGH KAAITLLQFD GTGTRLISGS KDSNIIVWDL
160 170 180 190 200
VGEVGLYKLR SHKDSITGFW CQGEDWLIST SKDGMIKLWD LKTHQCIETH
210 220 230 240 250
IAHTGECWGL AVKDDLLITT GTDSQVKIWK LDIENDKMGG KLTEMGIFEK
260 270 280 290 300
QSKQRGLKIE FITNSSDKTS FFYIQNADKT IETFRIRKEE EIARGLKKRE
310 320 330 340 350
KRLKEKGLTE EEIAKSIKES YSSFILHPFQ TIRSLYKIKS ASWTTVSSSK
360 370 380 390 400
LELVLTTSSN TIEYYSIPYE KRDPTSPAPL KTHTIELQGQ RTDVRSIDIS
410 420 430 440 450
DDNKLLATAS NGSLKIWNIK THKCIRTFEC GYALTCKFLP GGLLVILGTR
460 470 480 490 500
NGELQLFDLA SSSLLDTIED AHDAAIWSLD LTSDGKRLVT GSADKTVKFW
510 520 530 540 550
DFKVENSLVP GTKNKFLPVL KLHHDTTLEL TDDILCVRVS PDDRYLAISL
560 570 580 590 600
LDNTVKVFFL DSMKFYLSLY GHKLPVLSID ISFDSKMIIT SSADKNIKIW
610 620 630 640 650
GLDFGDCHKS LFAHQDSIMN VKFLPQSHNF FSCSKDAVVK YWDGEKFECI
660 670 680 690 700
QKLYAHQSEV WALAVATDGG FVVSSSHDHS IRIWEETEDQ VFLEEEKEKE
710 720 730 740 750
LEEQYEDTLL TSLEEGNGDD AFKADASGEG VEDEASGVHK QTLESLKAGE
760 770 780 790 800
RLMEALDLGI AEIEGLEAYN RDMKLWQRKK LGEAPIKPQG NAVLIAVNKT
810 820 830 840 850
PEQYIMDTLL RIRMSQLEDA LMVMPFSYVL KFLKFIDTVM QNKTLLHSHL
860 870 880 890 900
PLICKNLFFI IKFNHKELVS QKNEELKLQI NRVKTELRSA LKSTEDDLGF
910 920 930 940
NVQGLKFVKQ QWNLRHNYEF VDEYDQQEKE SNSARKRVFG TVI
Length:943
Mass (Da):106,342
Last modified:November 1, 1996 - v1
Checksum:i7D9AEC7AF6A9C740
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53877 Genomic DNA. Translation: AAB82375.1.
U53881 Genomic DNA. Translation: AAB82402.1.
X91258 Genomic DNA. Translation: CAA62640.1.
Z73301 Genomic DNA. Translation: CAA97699.1.
Z73302 Genomic DNA. Translation: CAA97700.1.
X89514 Genomic DNA. Translation: CAA61707.1.
BK006945 Genomic DNA. Translation: DAA09440.1.
PIRiS59317.
RefSeqiNP_013230.1. NM_001182016.1.

Genome annotation databases

EnsemblFungiiYLR129W; YLR129W; YLR129W.
GeneIDi850820.
KEGGisce:YLR129W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53877 Genomic DNA. Translation: AAB82375.1 .
U53881 Genomic DNA. Translation: AAB82402.1 .
X91258 Genomic DNA. Translation: CAA62640.1 .
Z73301 Genomic DNA. Translation: CAA97699.1 .
Z73302 Genomic DNA. Translation: CAA97700.1 .
X89514 Genomic DNA. Translation: CAA61707.1 .
BK006945 Genomic DNA. Translation: DAA09440.1 .
PIRi S59317.
RefSeqi NP_013230.1. NM_001182016.1.

3D structure databases

ProteinModelPortali Q12220.
SMRi Q12220. Positions 20-799.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31398. 47 interactions.
DIPi DIP-6494N.
IntActi Q12220. 13 interactions.
MINTi MINT-620162.
STRINGi 4932.YLR129W.

Proteomic databases

MaxQBi Q12220.
PaxDbi Q12220.
PeptideAtlasi Q12220.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR129W ; YLR129W ; YLR129W .
GeneIDi 850820.
KEGGi sce:YLR129W.

Organism-specific databases

CYGDi YLR129w.
SGDi S000004119. DIP2.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00760000119320.
HOGENOMi HOG000212524.
InParanoidi Q12220.
KOi K14556.
OMAi FECGYAL.
OrthoDBi EOG77WWN8.

Enzyme and pathway databases

BioCyci YEAST:G3O-32271-MONOMER.

Miscellaneous databases

NextBioi 967067.
PROi Q12220.

Gene expression databases

Genevestigatori Q12220.

Family and domain databases

Gene3Di 2.130.10.10. 3 hits.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR007148. SSU_processome_Utp12.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF04003. Utp12. 1 hit.
PF00400. WD40. 9 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 11 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 8 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUTP12_YEAST
AccessioniPrimary (citable) accession number: Q12220
Secondary accession number(s): D6VYC4, Q05386
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 9620 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3