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Q12220

- UTP12_YEAST

UniProt

Q12220 - UTP12_YEAST

Protein

U3 small nucleolar RNA-associated protein 12

Gene

DIP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Involved in nucleolar processing of pre-18S ribosomal RNA.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. snoRNA binding Source: SGD

    GO - Biological processi

    1. endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    2. endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    3. endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    4. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32271-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U3 small nucleolar RNA-associated protein 12
    Short name:
    U3 snoRNA-associated protein 12
    Alternative name(s):
    DOM34-interacting protein 2
    U three protein 12
    Gene namesi
    Name:DIP2
    Synonyms:UTP12
    Ordered Locus Names:YLR129W
    ORF Names:L3116, L9233.1
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    CYGDiYLR129w.
    SGDiS000004119. DIP2.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: SGD
    2. Pwp2p-containing subcomplex of 90S preribosome Source: SGD
    3. small-subunit processome Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 943943U3 small nucleolar RNA-associated protein 12PRO_0000050955Add
    BLAST

    Proteomic databases

    MaxQBiQ12220.
    PaxDbiQ12220.
    PeptideAtlasiQ12220.

    Expressioni

    Gene expression databases

    GenevestigatoriQ12220.

    Interactioni

    Subunit structurei

    Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PWP2P256356EBI-5896,EBI-14332

    Protein-protein interaction databases

    BioGridi31398. 46 interactions.
    DIPiDIP-6494N.
    IntActiQ12220. 13 interactions.
    MINTiMINT-620162.
    STRINGi4932.YLR129W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12220.
    SMRiQ12220. Positions 20-799.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati77 – 10731WD 1Add
    BLAST
    Repeati119 – 14931WD 2Add
    BLAST
    Repeati161 – 19030WD 3Add
    BLAST
    Repeati202 – 23029WD 4Add
    BLAST
    Repeati389 – 41830WD 5Add
    BLAST
    Repeati428 – 45831WD 6Add
    BLAST
    Repeati471 – 50131WD 7Add
    BLAST
    Repeati571 – 60131WD 8Add
    BLAST
    Repeati613 – 64331WD 9Add
    BLAST
    Repeati655 – 68531WD 10Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat WDR3/UTP12 family.Curated
    Contains 10 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00750000117677.
    HOGENOMiHOG000212524.
    KOiK14556.
    OMAiFECGYAL.
    OrthoDBiEOG77WWN8.

    Family and domain databases

    Gene3Di2.130.10.10. 3 hits.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR007148. SSU_processome_Utp12.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF04003. Utp12. 1 hit.
    PF00400. WD40. 9 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00320. WD40. 11 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 4 hits.
    PS50082. WD_REPEATS_2. 8 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12220-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKSYQRFEQ AAAFGVIASN ANCVWIPASS GNSNGSGPGQ LITSALEDVN    50
    IWDIKTGDLV SKLSDGLPPG ASDARGAKPA ECTYLEAHKD TDLLAVGYAD 100
    GVIKVWDLMS KTVLLNFNGH KAAITLLQFD GTGTRLISGS KDSNIIVWDL 150
    VGEVGLYKLR SHKDSITGFW CQGEDWLIST SKDGMIKLWD LKTHQCIETH 200
    IAHTGECWGL AVKDDLLITT GTDSQVKIWK LDIENDKMGG KLTEMGIFEK 250
    QSKQRGLKIE FITNSSDKTS FFYIQNADKT IETFRIRKEE EIARGLKKRE 300
    KRLKEKGLTE EEIAKSIKES YSSFILHPFQ TIRSLYKIKS ASWTTVSSSK 350
    LELVLTTSSN TIEYYSIPYE KRDPTSPAPL KTHTIELQGQ RTDVRSIDIS 400
    DDNKLLATAS NGSLKIWNIK THKCIRTFEC GYALTCKFLP GGLLVILGTR 450
    NGELQLFDLA SSSLLDTIED AHDAAIWSLD LTSDGKRLVT GSADKTVKFW 500
    DFKVENSLVP GTKNKFLPVL KLHHDTTLEL TDDILCVRVS PDDRYLAISL 550
    LDNTVKVFFL DSMKFYLSLY GHKLPVLSID ISFDSKMIIT SSADKNIKIW 600
    GLDFGDCHKS LFAHQDSIMN VKFLPQSHNF FSCSKDAVVK YWDGEKFECI 650
    QKLYAHQSEV WALAVATDGG FVVSSSHDHS IRIWEETEDQ VFLEEEKEKE 700
    LEEQYEDTLL TSLEEGNGDD AFKADASGEG VEDEASGVHK QTLESLKAGE 750
    RLMEALDLGI AEIEGLEAYN RDMKLWQRKK LGEAPIKPQG NAVLIAVNKT 800
    PEQYIMDTLL RIRMSQLEDA LMVMPFSYVL KFLKFIDTVM QNKTLLHSHL 850
    PLICKNLFFI IKFNHKELVS QKNEELKLQI NRVKTELRSA LKSTEDDLGF 900
    NVQGLKFVKQ QWNLRHNYEF VDEYDQQEKE SNSARKRVFG TVI 943
    Length:943
    Mass (Da):106,342
    Last modified:November 1, 1996 - v1
    Checksum:i7D9AEC7AF6A9C740
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53877 Genomic DNA. Translation: AAB82375.1.
    U53881 Genomic DNA. Translation: AAB82402.1.
    X91258 Genomic DNA. Translation: CAA62640.1.
    Z73301 Genomic DNA. Translation: CAA97699.1.
    Z73302 Genomic DNA. Translation: CAA97700.1.
    X89514 Genomic DNA. Translation: CAA61707.1.
    BK006945 Genomic DNA. Translation: DAA09440.1.
    PIRiS59317.
    RefSeqiNP_013230.1. NM_001182016.1.

    Genome annotation databases

    EnsemblFungiiYLR129W; YLR129W; YLR129W.
    GeneIDi850820.
    KEGGisce:YLR129W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53877 Genomic DNA. Translation: AAB82375.1 .
    U53881 Genomic DNA. Translation: AAB82402.1 .
    X91258 Genomic DNA. Translation: CAA62640.1 .
    Z73301 Genomic DNA. Translation: CAA97699.1 .
    Z73302 Genomic DNA. Translation: CAA97700.1 .
    X89514 Genomic DNA. Translation: CAA61707.1 .
    BK006945 Genomic DNA. Translation: DAA09440.1 .
    PIRi S59317.
    RefSeqi NP_013230.1. NM_001182016.1.

    3D structure databases

    ProteinModelPortali Q12220.
    SMRi Q12220. Positions 20-799.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31398. 46 interactions.
    DIPi DIP-6494N.
    IntActi Q12220. 13 interactions.
    MINTi MINT-620162.
    STRINGi 4932.YLR129W.

    Proteomic databases

    MaxQBi Q12220.
    PaxDbi Q12220.
    PeptideAtlasi Q12220.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR129W ; YLR129W ; YLR129W .
    GeneIDi 850820.
    KEGGi sce:YLR129W.

    Organism-specific databases

    CYGDi YLR129w.
    SGDi S000004119. DIP2.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00750000117677.
    HOGENOMi HOG000212524.
    KOi K14556.
    OMAi FECGYAL.
    OrthoDBi EOG77WWN8.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32271-MONOMER.

    Miscellaneous databases

    NextBioi 967067.
    PROi Q12220.

    Gene expression databases

    Genevestigatori Q12220.

    Family and domain databases

    Gene3Di 2.130.10.10. 3 hits.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR007148. SSU_processome_Utp12.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF04003. Utp12. 1 hit.
    PF00400. WD40. 9 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00320. WD40. 11 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 4 hits.
    PS50082. WD_REPEATS_2. 8 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiUTP12_YEAST
    AccessioniPrimary (citable) accession number: Q12220
    Secondary accession number(s): D6VYC4, Q05386
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 9620 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3