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Protein

Cell wall protein TIR4

Gene

TIR4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the cell wall. Required for anaerobic growth.1 Publication

GO - Biological processi

Keywordsi

Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:G3O-33559-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell wall protein TIR4
Alternative name(s):
TIP1-related protein 4
Gene namesi
Name:TIR4
Ordered Locus Names:YOR009W
ORF Names:UNB487
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR009W
SGDiS000005535 TIR4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell wall, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000026764023 – 465Cell wall protein TIR4Add BLAST443
PropeptideiPRO_0000267641466 – 487Removed in mature formSequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi403N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi404N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi465GPI-anchor amidated asparagineSequence analysis1

Post-translational modificationi

The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).By similarity

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ12218
TopDownProteomicsiQ12218

Expressioni

Inductioni

Induced during anaerobic growth. Induced by cold shock.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi34414, 70 interactors
DIPiDIP-5194N
IntActiQ12218, 2 interactors
MINTiQ12218
STRINGi4932.YOR009W

Structurei

3D structure databases

ProteinModelPortaliQ12218
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati137 – 14811 PublicationAdd BLAST12
Repeati149 – 16021 PublicationAdd BLAST12
Repeati161 – 17231 PublicationAdd BLAST12
Repeati173 – 18441 PublicationAdd BLAST12
Repeati185 – 19651 PublicationAdd BLAST12
Repeati197 – 20861 PublicationAdd BLAST12
Repeati209 – 22071 PublicationAdd BLAST12
Repeati221 – 23281 PublicationAdd BLAST12
Repeati233 – 24491 PublicationAdd BLAST12
Repeati245 – 256101 PublicationAdd BLAST12
Repeati257 – 268111 PublicationAdd BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni137 – 26811 X 12 AA approximate tandem repeats, Ser-richAdd BLAST132

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi113 – 365Ser-richAdd BLAST253

Domaini

The number of the intragenic tandem repeats varies between different S.cerevisiae strains.

Sequence similaritiesi

Belongs to the SRP1/TIP1 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00700000104882
InParanoidiQ12218
OMAiQTTTIYG
OrthoDBiEOG092C5NOA

Family and domain databases

InterProiView protein in InterPro
IPR000992 SRP1_TIP1
PfamiView protein in Pfam
PF00660 SRP1_TIP1, 1 hit
PROSITEiView protein in PROSITE
PS00724 SRP1_TIP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYSKITLLA ALAAIAYAQT QAQINELNVV LDDVKTNIAD YITLSYTPNS
60 70 80 90 100
GFSLDQMPAG IMDIAAQLVA NPSDDSYTTL YSEVDFSAVE HMLTMVPWYS
110 120 130 140 150
SRLLPELEAM DASLTTSSSA ATSSSEVASS SIASSTSSSV APSSSEVVSS
160 170 180 190 200
SVAPSSSEVV SSSVAPSSSE VVSSSVASSS SEVASSSVAP SSSEVVSSSV
210 220 230 240 250
ASSSSEVASS SVAPSSSEVV SSSVAPSSSE VVSSSVASSS SEVASSSVAP
260 270 280 290 300
SSSEVVSSSV ASSTSEATSS SAVTSSSAVS SSTESVSSSS VSSSSAVSSS
310 320 330 340 350
EAVSSSPVSS VVSSSAGPAS SSVAPYNSTI ASSSSTAQTS ISTIAPYNST
360 370 380 390 400
TTTTPASSAS SVIISTRNGT TVTETDNTLV TKETTVCDYS STSAVPASTT
410 420 430 440 450
GYNNSTKVST ATICSTCKEG TSTATDFSTL KTTVTVCDSA CQAKKSATVV
460 470 480
SVQSKTTGIV EQTENGAAKA VIGMGAGALA AVAAMLL
Length:487
Mass (Da):47,849
Last modified:November 1, 1996 - v1
Checksum:iBA12415C400FAD65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43491 Genomic DNA Translation: AAC49489.1
Z74917 Genomic DNA Translation: CAA99197.1
BK006948 Genomic DNA Translation: DAA10792.1
PIRiS61993
RefSeqiNP_014652.1, NM_001183428.1

Genome annotation databases

EnsemblFungiiYOR009W; YOR009W; YOR009W
GeneIDi854173
KEGGisce:YOR009W

Similar proteinsi

Entry informationi

Entry nameiTIR4_YEAST
AccessioniPrimary (citable) accession number: Q12218
Secondary accession number(s): D6W276
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
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