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Protein

Cell wall integrity and stress response component 3

Gene

WSC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: SGD

GO - Biological processi

  • cell wall organization Source: UniProtKB-KW
  • pexophagy Source: SGD
  • response to heat Source: SGD
  • Rho protein signal transduction Source: SGD

Keywordsi

Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:G3O-33503-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell wall integrity and stress response component 3
Gene namesi
Name:WSC3
Ordered Locus Names:YOL105C
ORF Names:HRE556
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL105C.
SGDiS000005465. WSC3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 384ExtracellularSequence analysisAdd BLAST346
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 556CytoplasmicSequence analysisAdd BLAST151

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000004148539 – 556Cell wall integrity and stress response component 3Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi367N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ12215.

PTM databases

iPTMnetiQ12215.

Interactioni

Protein-protein interaction databases

BioGridi34296. 50 interactors.
DIPiDIP-1748N.
IntActiQ12215. 11 interactors.
MINTiMINT-407097.
STRINGi4932.YOL105C.

Structurei

3D structure databases

ProteinModelPortaliQ12215.
SMRiQ12215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 132WSCPROSITE-ProRule annotationAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi137 – 348Ser/Thr-richAdd BLAST212

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000112583.
InParanoidiQ12215.
KOiK11244.
OMAiPCAIATH.
OrthoDBiEOG092C5SG6.

Family and domain databases

InterProiView protein in InterPro
IPR002889. WSC_carb-bd.
PfamiView protein in Pfam
PF01822. WSC. 1 hit.
SMARTiView protein in SMART
SM00321. WSC. 1 hit.
PROSITEiView protein in PROSITE
PS51212. WSC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12215-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERVWFAKLT NKGTIKIGYI SFILLSLLCQ SLIGLVNADF NYEGCYSAAD
60 70 80 90 100
IQSAGLSLKN SYIYQSVSYC QNQCPESAVV ALFNGSDCYC GNSVSFLTSL
110 120 130 140 150
TKSTDSNCGT KCSGWPYQMC GGSSYMNVYV NAETFVSSVE SSSSKEGSST
160 170 180 190 200
SYMPSTTSSL SSAQISSTTR RTSTDMKSSE MIATTVSTTS TTSSSTSSTT
210 220 230 240 250
SSTTSSTTSS TTSSTTSSST SSTTSSTTSS TTSSTTSSTT SSTTSSTTSS
260 270 280 290 300
TTSSTTSIFS VTSSSSSITL SSSEHTTVDS RTSSPSSTLV PVSSSSSTLS
310 320 330 340 350
TPKVTSMTPS TSSTIPIVTS VELVTSVVTK AIVSTSDQHQ ETIFVTRTSV
360 370 380 390 400
VERSSEVATA TAAASNNRSN STSKQRLSGG AIAGIVIGVV FGVIFIILIL
410 420 430 440 450
LFLIWRRRKS HDQLDLEETK HYQPYSFGDE DANPIGPPPS SGTTNWMRHS
460 470 480 490 500
RGNTAGSIGT SNMYGFSMSN GANYSSPSSN TSGSIINNLA GLQDATVQKQ
510 520 530 540 550
NLPSTVFEEA NTLNSANERF SANSLPDMMM SGPLQVVNPD NPDNPELSST

VSHNRA
Length:556
Mass (Da):58,230
Last modified:November 1, 1996 - v1
Checksum:iDD37E277180001DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48149 Genomic DNA. Translation: CAA88155.1.
Z74847 Genomic DNA. Translation: CAA99123.1.
AY899243 mRNA. Translation: AAX83928.1.
BK006948 Genomic DNA. Translation: DAA10677.1.
PIRiS51892.
RefSeqiNP_014536.1. NM_001183359.1.

Genome annotation databases

EnsemblFungiiYOL105C; YOL105C; YOL105C.
GeneIDi854046.
KEGGisce:YOL105C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiWSC3_YEAST
AccessioniPrimary (citable) accession number: Q12215
Secondary accession number(s): D6W1W1, Q2VQX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names