Reviewed, UniProtKB/Swiss-Prot Q12214 (HOS1_YEAST)

Names and origin

Protein names

Recommended name:
    Histone deacetylase HOS1
    EC=3.5.1.98

Gene names

Name:	HOS1
Ordered Locus Names:	YPR068C
ORF Names:	YP9499.23C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subcellular location	Nucleus By similarity.
Miscellaneous	Present with 538 molecules/cell in log phase SD medium. Ref.3
Sequence similarities	Belongs to the histone deacetylase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Chromatin regulator Hydrolase Repressor
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of specific transcription from RNA polymerase II promoter Inferred from mutant phenotype. Source: SGD transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	histone deacetylase complex Traceable author statement. Source: SGD
Molecular function	histone deacetylase activity Traceable author statement. Source: SGD protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CYC8	P14922	1	EBI-8471,EBI-18215
TUP1	P16649	1	EBI-8471,EBI-19654

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 470	470	Histone deacetylase HOS1		PRO_0000114726
Regions
	Region	47 – 392	346	Histone deacetylase
Sites
	Active site	211	1	By similarity
Amino acid modifications
	Modified residue	110	1	Phosphoserine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q12214-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 5DCFF35D8F6AC87D	FASTA	470	54,764
	10 20 30 40 50 60 MSKLVISTSI FQSQVADLLP CNNHQKSQLT YSLINAYDLL QHFDEVLTFP YARKDDLLEF 70 80 90 100 110 120 HSKSYIDYLI NGRFNKMMAQ DVNNPMVESK WSELSELADN WNEKIDYNPS QDLQRFTTRE 130 140 150 160 170 180 NLYNYYLNHS QALENNMDCI NNSEVPTNDK PTDTYILNSE TKQYNLEGDC PIFSYLPMYC 190 200 210 220 230 240 QVITGATLNL LDHLSPTERL IGINWDGGRH HAFKQRASGF CYINDVVLLI QRLRKAKLNK 250 260 270 280 290 300 ITYVDFDLHH GDGVEKAFQY SKQIQTISVH LYEPGFFPGT GSLSDSRKDK NVVNIPLKHG 310 320 330 340 350 360 CDDNYLELIA SKIVNPLIER HEPEALIIEC GGDGLLGDRF NEWQLTIRGL SRIIINIMKS 370 380 390 400 410 420 YPRAHIFLLG GGGYNDLLMS RFYTYLTWCV TKQFSNLRCG DNNSFQIDPF DVCDGDDSEQ 430 440 450 460 470 FIREHDLVEM YNEENYQYWI YEMEGSSRMK MLRNDNKDRD MVELMKFYEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J. Nature 387:103-105(1997) [PubMed: 9169875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription." Rundlett S.E., Carmen A.A., Kobayashi R., Bavykin S., Turner B.M., Grunstein M. Proc. Natl. Acad. Sci. U.S.A. 93:14503-14508(1996) [PubMed: 8962081] [Abstract] Cited for: GENE NAME.
[3]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z71255 Genomic DNA. Translation: CAA94976.1. Z49219 Genomic DNA. Translation: CAA89185.1.
PIR	S54089.
RefSeq	NP_015393.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q12214. 2 interactions.
Genome annotation databases
Ensembl	YPR068C. Saccharomyces cerevisiae. [Contig view]
GeneID	856181.
GenomeReviews	Gene locus YPR068C in contig U00094_GR.
KEGG	sce:YPR068C.
NMPDR	fig|4932.3.peg.6529.
Organism-specific databases
CYGD	YPR068c.
SGD	S000006272. HOS1.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	Q12214.
OMA	Q12214. NWDGGRH.
Gene expression databases
GermOnline	YPR068C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR000286. His_deacetylse. [Graphical view]
Gene3D	G3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHER	PTHR10625. His_deacetylse. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PRINTS	PR01270. HDASUPER.
ProtoNet	Search...
Other Resources
NextBio	981352.

Entry information

Entry name

HOS1_YEAST

Accession

Primary (citable) accession number: Q12214

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)