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Q12214

- HOS1_YEAST

UniProt

Q12214 - HOS1_YEAST

Protein

Histone deacetylase HOS1

Gene

HOS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei211 – 2111By similarity

    GO - Molecular functioni

    1. histone deacetylase activity Source: SGD
    2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
    6. protein deacetylase activity Source: SGD

    GO - Biological processi

    1. histone H4 deacetylation Source: SGD
    2. peptidyl-lysine deacetylation Source: SGD
    3. positive regulation of transcription from RNA polymerase II promoter Source: SGD
    4. transcription, DNA-templated Source: UniProtKB-KW
    5. transfer RNA gene-mediated silencing Source: SGD

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34216-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase HOS1 (EC:3.5.1.98)
    Gene namesi
    Name:HOS1
    Ordered Locus Names:YPR068C
    ORF Names:YP9499.23C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    CYGDiYPR068c.
    SGDiS000006272. HOS1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. histone deacetylase complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 470470Histone deacetylase HOS1PRO_0000114726Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei110 – 1101Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ12214.
    PaxDbiQ12214.

    Expressioni

    Gene expression databases

    GenevestigatoriQ12214.

    Interactioni

    Protein-protein interaction databases

    BioGridi36240. 73 interactions.
    DIPiDIP-7974N.
    IntActiQ12214. 3 interactions.
    STRINGi4932.YPR068C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12214.
    SMRiQ12214. Positions 152-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni47 – 392346Histone deacetylaseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    GeneTreeiENSGT00390000003411.
    HOGENOMiHOG000225180.
    KOiK11482.
    OMAiLINDNTE.
    OrthoDBiEOG7J70QM.

    Family and domain databases

    Gene3Di3.40.800.20. 2 hits.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PRINTSiPR01270. HDASUPER.

    Sequencei

    Sequence statusi: Complete.

    Q12214-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKLVISTSI FQSQVADLLP CNNHQKSQLT YSLINAYDLL QHFDEVLTFP    50
    YARKDDLLEF HSKSYIDYLI NGRFNKMMAQ DVNNPMVESK WSELSELADN 100
    WNEKIDYNPS QDLQRFTTRE NLYNYYLNHS QALENNMDCI NNSEVPTNDK 150
    PTDTYILNSE TKQYNLEGDC PIFSYLPMYC QVITGATLNL LDHLSPTERL 200
    IGINWDGGRH HAFKQRASGF CYINDVVLLI QRLRKAKLNK ITYVDFDLHH 250
    GDGVEKAFQY SKQIQTISVH LYEPGFFPGT GSLSDSRKDK NVVNIPLKHG 300
    CDDNYLELIA SKIVNPLIER HEPEALIIEC GGDGLLGDRF NEWQLTIRGL 350
    SRIIINIMKS YPRAHIFLLG GGGYNDLLMS RFYTYLTWCV TKQFSNLRCG 400
    DNNSFQIDPF DVCDGDDSEQ FIREHDLVEM YNEENYQYWI YEMEGSSRMK 450
    MLRNDNKDRD MVELMKFYEL 470
    Length:470
    Mass (Da):54,764
    Last modified:November 1, 1996 - v1
    Checksum:i5DCFF35D8F6AC87D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71255 Genomic DNA. Translation: CAA94976.1.
    Z49219 Genomic DNA. Translation: CAA89185.1.
    BK006949 Genomic DNA. Translation: DAA11488.1.
    PIRiS54089.
    RefSeqiNP_015393.1. NM_001184165.1.

    Genome annotation databases

    EnsemblFungiiYPR068C; YPR068C; YPR068C.
    GeneIDi856181.
    KEGGisce:YPR068C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71255 Genomic DNA. Translation: CAA94976.1 .
    Z49219 Genomic DNA. Translation: CAA89185.1 .
    BK006949 Genomic DNA. Translation: DAA11488.1 .
    PIRi S54089.
    RefSeqi NP_015393.1. NM_001184165.1.

    3D structure databases

    ProteinModelPortali Q12214.
    SMRi Q12214. Positions 152-387.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36240. 73 interactions.
    DIPi DIP-7974N.
    IntActi Q12214. 3 interactions.
    STRINGi 4932.YPR068C.

    Proteomic databases

    MaxQBi Q12214.
    PaxDbi Q12214.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPR068C ; YPR068C ; YPR068C .
    GeneIDi 856181.
    KEGGi sce:YPR068C.

    Organism-specific databases

    CYGDi YPR068c.
    SGDi S000006272. HOS1.

    Phylogenomic databases

    eggNOGi COG0123.
    GeneTreei ENSGT00390000003411.
    HOGENOMi HOG000225180.
    KOi K11482.
    OMAi LINDNTE.
    OrthoDBi EOG7J70QM.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34216-MONOMER.

    Miscellaneous databases

    NextBioi 981352.

    Gene expression databases

    Genevestigatori Q12214.

    Family and domain databases

    Gene3Di 3.40.800.20. 2 hits.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PRINTSi PR01270. HDASUPER.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription."
      Rundlett S.E., Carmen A.A., Kobayashi R., Bavykin S., Turner B.M., Grunstein M.
      Proc. Natl. Acad. Sci. U.S.A. 93:14503-14508(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE NAME.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHOS1_YEAST
    AccessioniPrimary (citable) accession number: Q12214
    Secondary accession number(s): D6W472
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 538 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3