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Q12214

- HOS1_YEAST

UniProt

Q12214 - HOS1_YEAST

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Protein

Histone deacetylase HOS1

Gene

HOS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei211 – 2111By similarity

GO - Molecular functioni

  1. histone deacetylase activity Source: SGD
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  6. protein deacetylase activity Source: SGD

GO - Biological processi

  1. histone H4 deacetylation Source: SGD
  2. peptidyl-lysine deacetylation Source: SGD
  3. positive regulation of transcription from RNA polymerase II promoter Source: SGD
  4. transcription, DNA-templated Source: UniProtKB-KW
  5. transfer RNA gene-mediated silencing Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-34216-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase HOS1 (EC:3.5.1.98)
Gene namesi
Name:HOS1
Ordered Locus Names:YPR068C
ORF Names:YP9499.23C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR068c.
SGDiS000006272. HOS1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. histone deacetylase complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Histone deacetylase HOS1PRO_0000114726Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei110 – 1101Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12214.
PaxDbiQ12214.

Expressioni

Gene expression databases

GenevestigatoriQ12214.

Interactioni

Protein-protein interaction databases

BioGridi36240. 73 interactions.
DIPiDIP-7974N.
IntActiQ12214. 3 interactions.
STRINGi4932.YPR068C.

Structurei

3D structure databases

ProteinModelPortaliQ12214.
SMRiQ12214. Positions 152-387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni47 – 392346Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00390000003411.
HOGENOMiHOG000225180.
InParanoidiQ12214.
KOiK11482.
OMAiLINDNTE.
OrthoDBiEOG7J70QM.

Family and domain databases

Gene3Di3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q12214-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKLVISTSI FQSQVADLLP CNNHQKSQLT YSLINAYDLL QHFDEVLTFP
60 70 80 90 100
YARKDDLLEF HSKSYIDYLI NGRFNKMMAQ DVNNPMVESK WSELSELADN
110 120 130 140 150
WNEKIDYNPS QDLQRFTTRE NLYNYYLNHS QALENNMDCI NNSEVPTNDK
160 170 180 190 200
PTDTYILNSE TKQYNLEGDC PIFSYLPMYC QVITGATLNL LDHLSPTERL
210 220 230 240 250
IGINWDGGRH HAFKQRASGF CYINDVVLLI QRLRKAKLNK ITYVDFDLHH
260 270 280 290 300
GDGVEKAFQY SKQIQTISVH LYEPGFFPGT GSLSDSRKDK NVVNIPLKHG
310 320 330 340 350
CDDNYLELIA SKIVNPLIER HEPEALIIEC GGDGLLGDRF NEWQLTIRGL
360 370 380 390 400
SRIIINIMKS YPRAHIFLLG GGGYNDLLMS RFYTYLTWCV TKQFSNLRCG
410 420 430 440 450
DNNSFQIDPF DVCDGDDSEQ FIREHDLVEM YNEENYQYWI YEMEGSSRMK
460 470
MLRNDNKDRD MVELMKFYEL
Length:470
Mass (Da):54,764
Last modified:November 1, 1996 - v1
Checksum:i5DCFF35D8F6AC87D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71255 Genomic DNA. Translation: CAA94976.1.
Z49219 Genomic DNA. Translation: CAA89185.1.
BK006949 Genomic DNA. Translation: DAA11488.1.
PIRiS54089.
RefSeqiNP_015393.1. NM_001184165.1.

Genome annotation databases

EnsemblFungiiYPR068C; YPR068C; YPR068C.
GeneIDi856181.
KEGGisce:YPR068C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71255 Genomic DNA. Translation: CAA94976.1 .
Z49219 Genomic DNA. Translation: CAA89185.1 .
BK006949 Genomic DNA. Translation: DAA11488.1 .
PIRi S54089.
RefSeqi NP_015393.1. NM_001184165.1.

3D structure databases

ProteinModelPortali Q12214.
SMRi Q12214. Positions 152-387.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36240. 73 interactions.
DIPi DIP-7974N.
IntActi Q12214. 3 interactions.
STRINGi 4932.YPR068C.

Proteomic databases

MaxQBi Q12214.
PaxDbi Q12214.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR068C ; YPR068C ; YPR068C .
GeneIDi 856181.
KEGGi sce:YPR068C.

Organism-specific databases

CYGDi YPR068c.
SGDi S000006272. HOS1.

Phylogenomic databases

eggNOGi COG0123.
GeneTreei ENSGT00390000003411.
HOGENOMi HOG000225180.
InParanoidi Q12214.
KOi K11482.
OMAi LINDNTE.
OrthoDBi EOG7J70QM.

Enzyme and pathway databases

BioCyci YEAST:G3O-34216-MONOMER.

Miscellaneous databases

NextBioi 981352.

Gene expression databases

Genevestigatori Q12214.

Family and domain databases

Gene3Di 3.40.800.20. 2 hits.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription."
    Rundlett S.E., Carmen A.A., Kobayashi R., Bavykin S., Turner B.M., Grunstein M.
    Proc. Natl. Acad. Sci. U.S.A. 93:14503-14508(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE NAME.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHOS1_YEAST
AccessioniPrimary (citable) accession number: Q12214
Secondary accession number(s): D6W472
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3