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Protein

Histone deacetylase HOS1

Gene

HOS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei211By similarity1

GO - Molecular functioni

GO - Biological processi

  • histone H4 deacetylation Source: SGD
  • peptidyl-lysine deacetylation Source: SGD
  • positive regulation of transcription by RNA polymerase II Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
  • transfer RNA gene-mediated silencing Source: SGD

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-34216-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase HOS1 (EC:3.5.1.98)
Gene namesi
Name:HOS1
Ordered Locus Names:YPR068C
ORF Names:YP9499.23C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR068C
SGDiS000006272 HOS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147261 – 470Histone deacetylase HOS1Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12214
PaxDbiQ12214
PRIDEiQ12214

PTM databases

iPTMnetiQ12214

Interactioni

Protein-protein interaction databases

BioGridi36240, 96 interactors
DIPiDIP-7974N
IntActiQ12214, 4 interactors
STRINGi4932.YPR068C

Structurei

3D structure databases

ProteinModelPortaliQ12214
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni47 – 392Histone deacetylaseAdd BLAST346

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000225180
InParanoidiQ12214
KOiK11482
OMAiRIIINIM
OrthoDBiEOG092C386A

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 2 hits

Sequencei

Sequence statusi: Complete.

Q12214-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLVISTSI FQSQVADLLP CNNHQKSQLT YSLINAYDLL QHFDEVLTFP
60 70 80 90 100
YARKDDLLEF HSKSYIDYLI NGRFNKMMAQ DVNNPMVESK WSELSELADN
110 120 130 140 150
WNEKIDYNPS QDLQRFTTRE NLYNYYLNHS QALENNMDCI NNSEVPTNDK
160 170 180 190 200
PTDTYILNSE TKQYNLEGDC PIFSYLPMYC QVITGATLNL LDHLSPTERL
210 220 230 240 250
IGINWDGGRH HAFKQRASGF CYINDVVLLI QRLRKAKLNK ITYVDFDLHH
260 270 280 290 300
GDGVEKAFQY SKQIQTISVH LYEPGFFPGT GSLSDSRKDK NVVNIPLKHG
310 320 330 340 350
CDDNYLELIA SKIVNPLIER HEPEALIIEC GGDGLLGDRF NEWQLTIRGL
360 370 380 390 400
SRIIINIMKS YPRAHIFLLG GGGYNDLLMS RFYTYLTWCV TKQFSNLRCG
410 420 430 440 450
DNNSFQIDPF DVCDGDDSEQ FIREHDLVEM YNEENYQYWI YEMEGSSRMK
460 470
MLRNDNKDRD MVELMKFYEL
Length:470
Mass (Da):54,764
Last modified:November 1, 1996 - v1
Checksum:i5DCFF35D8F6AC87D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71255 Genomic DNA Translation: CAA94976.1
Z49219 Genomic DNA Translation: CAA89185.1
BK006949 Genomic DNA Translation: DAA11488.1
PIRiS54089
RefSeqiNP_015393.1, NM_001184165.1

Genome annotation databases

EnsemblFungiiYPR068C; YPR068C; YPR068C
GeneIDi856181
KEGGisce:YPR068C

Similar proteinsi

Entry informationi

Entry nameiHOS1_YEAST
AccessioniPrimary (citable) accession number: Q12214
Secondary accession number(s): D6W472
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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