Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L7-B

Gene

RPL7B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 7080 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for uL30 in yeast.Curated

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: GO_Central
  • maturation of LSU-rRNA Source: SGD
  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
  • ribosomal large subunit biogenesis Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-34090-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7-B1 Publication
Alternative name(s):
L6
Large ribosomal subunit protein uL30-B1 Publication
RP11
YL8
Gene namesi
Name:RPL7B1 Publication
Synonyms:RPL6B, YL8B
Ordered Locus Names:YPL198W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL198W.
SGDiS000006119. RPL7B.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • cytosolic large ribosomal subunit Source: SGD
  • nucleolus Source: SGD

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001046522 – 24460S ribosomal protein L7-BAdd BLAST243

Proteomic databases

MaxQBiQ12213.
PRIDEiQ12213.

PTM databases

iPTMnetiQ12213.

Interactioni

Subunit structurei

Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi35986. 107 interactors.
IntActiQ12213. 108 interactors.
MINTiMINT-8285476.

Structurei

3D structure databases

ProteinModelPortaliQ12213.
SMRiQ12213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000006213.
HOGENOMiHOG000170917.
InParanoidiQ12213.
KOiK02937.
OMAiFGNREDN.
OrthoDBiEOG092C4MAX.

Family and domain databases

Gene3Di3.30.1390.20. 2 hits.
InterProiView protein in InterPro
IPR018038. Ribosomal_L30_CS.
IPR016082. Ribosomal_L30_ferredoxin-like.
IPR012988. Ribosomal_L30_N.
IPR005998. Ribosomal_L7_euk.
PfamiView protein in Pfam
PF00327. Ribosomal_L30. 1 hit.
PF08079. Ribosomal_L30_N. 1 hit.
SUPFAMiSSF55129. SSF55129. 1 hit.
TIGRFAMsiTIGR01310. uL30_euk. 1 hit.
PROSITEiView protein in PROSITE
PS00634. RIBOSOMAL_L30. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEKILTPE SQLKKTKAQQ KTAEQIAAER AARKAANKEK RAIILERNAA
60 70 80 90 100
YQKEYETAER NIIQAKRDAK AAGSYYVEAQ HKLVFVVRIK GINKIPPKPR
110 120 130 140 150
KVLQLLRLTR INSGTFVKVT KATLELLKLI EPYVAYGYPS YSTIRQLVYK
160 170 180 190 200
RGFGKINKQR VPLSDNAIIE ANLGKYGILS IDDLIHEIIT VGPHFKQANN
210 220 230 240
FLWPFKLSNP SGGWGVPRKF KHFIQGGSFG NREEFINKLV KAMN
Length:244
Mass (Da):27,696
Last modified:January 23, 2007 - v3
Checksum:i27F8FC0EE61EC266
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25232 Genomic DNA. Translation: BAA04957.1.
Z73554 Genomic DNA. Translation: CAA97911.1.
BK006949 Genomic DNA. Translation: DAA11237.1.
PIRiS55910.
RefSeqiNP_015126.1. NM_001184012.1.

Genome annotation databases

EnsemblFungiiYPL198W; YPL198W; YPL198W.
GeneIDi855903.
KEGGisce:YPL198W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25232 Genomic DNA. Translation: BAA04957.1.
Z73554 Genomic DNA. Translation: CAA97911.1.
BK006949 Genomic DNA. Translation: DAA11237.1.
PIRiS55910.
RefSeqiNP_015126.1. NM_001184012.1.

3D structure databases

ProteinModelPortaliQ12213.
SMRiQ12213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35986. 107 interactors.
IntActiQ12213. 108 interactors.
MINTiMINT-8285476.

PTM databases

iPTMnetiQ12213.

Proteomic databases

MaxQBiQ12213.
PRIDEiQ12213.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL198W; YPL198W; YPL198W.
GeneIDi855903.
KEGGisce:YPL198W.

Organism-specific databases

EuPathDBiFungiDB:YPL198W.
SGDiS000006119. RPL7B.

Phylogenomic databases

GeneTreeiENSGT00390000006213.
HOGENOMiHOG000170917.
InParanoidiQ12213.
KOiK02937.
OMAiFGNREDN.
OrthoDBiEOG092C4MAX.

Enzyme and pathway databases

BioCyciYEAST:G3O-34090-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiPR:Q12213.

Family and domain databases

Gene3Di3.30.1390.20. 2 hits.
InterProiView protein in InterPro
IPR018038. Ribosomal_L30_CS.
IPR016082. Ribosomal_L30_ferredoxin-like.
IPR012988. Ribosomal_L30_N.
IPR005998. Ribosomal_L7_euk.
PfamiView protein in Pfam
PF00327. Ribosomal_L30. 1 hit.
PF08079. Ribosomal_L30_N. 1 hit.
SUPFAMiSSF55129. SSF55129. 1 hit.
TIGRFAMsiTIGR01310. uL30_euk. 1 hit.
PROSITEiView protein in PROSITE
PS00634. RIBOSOMAL_L30. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRL7B_YEAST
AccessioniPrimary (citable) accession number: Q12213
Secondary accession number(s): D6W3H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.