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Protein

Probable phospholipase YOR022C, mitochondrial

Gene

YOR022C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable phospholipase that hydrolyzes phosphatidic acid.By similarity

Miscellaneous

Present with 736 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei501By similarity1

GO - Molecular functioni

  • metal ion binding Source: InterPro
  • phospholipase activity Source: SGD

GO - Biological processi

  • cardiolipin metabolic process Source: SGD
  • lipid catabolic process Source: UniProtKB-KW
  • phosphatidylethanolamine metabolic process Source: SGD
  • phospholipid metabolic process Source: SGD

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciYEAST:G3O-33570-MONOMER.
ReactomeiR-SCE-1483166. Synthesis of PA.
R-SCE-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipase YOR022C, mitochondrial (EC:3.1.1.-)
Gene namesi
Ordered Locus Names:YOR022C
ORF Names:OR26.12
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR022C.
SGDiS000005548. YOR022C.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: SGD

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 22MitochondrionSequence analysisAdd BLAST22
ChainiPRO_000023764423 – 715Probable phospholipase YOR022C, mitochondrialAdd BLAST693

Proteomic databases

MaxQBiQ12204.
PRIDEiQ12204.

PTM databases

iPTMnetiQ12204.

Interactioni

Protein-protein interaction databases

BioGridi34426. 49 interactors.
MINTiMINT-4502424.
STRINGi4932.YOR022C.

Structurei

3D structure databases

ProteinModelPortaliQ12204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini519 – 700DDHDPROSITE-ProRule annotationAdd BLAST182

Sequence similaritiesi

Belongs to the PA-PLA1 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00530000063155.
HOGENOMiHOG000093626.
InParanoidiQ12204.
OMAiWEGPIYE.
OrthoDBiEOG092C0QYG.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR004177. DDHD_dom.
PfamiView protein in Pfam
PF02862. DDHD. 2 hits.
SMARTiView protein in SMART
SM01127. DDHD. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiView protein in PROSITE
PS51043. DDHD. 1 hit.
PS00120. LIPASE_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12204-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRFTHRGLP SSTRFRNIFV RLNHIYVPWF YAIDVPNSKP YLPTYQTLHS
60 70 80 90 100
PKKFKPFSVD DSNRLEKASK RQERRPVLVN EDYLFKVDLS HMELSPTYWE
110 120 130 140 150
GPTYQVRRGV WFDSSNQPLS SDLTSEIEGL YKQLKFDDSN DDPTTTPPAE
160 170 180 190 200
SQDIFRLKGK YPVDKENEGE QKNGSSNKDE NESTFKFILF ANKQTAFLLS
210 220 230 240 250
DLDGGKLQLA FLRSNLAQSL PINATMITRS YKYSSSATTK QTSTSFKAAK
260 270 280 290 300
TPQTEVADGS NSSKSRSIET KLEKKVSNLF NLSDFLQLFN GNASKDQDDA
310 320 330 340 350
QSLEKQMETD YNNADNSQGA NASSKIEDGK NSGASDRQIR SNRRDVDNLI
360 370 380 390 400
LCVHGIGQTL GKKYEYVNFA HTVNLLRSNM KKIYNNSEKL QSLNTAPDYK
410 420 430 440 450
SNCNVQVLPI TWRHSISFQT DAKEENIENP DLPTLSQVTV NGVLPLRKLL
460 470 480 490 500
ADGLLDILLY VEPYYQDMIL QQVTSQLNKT YRIFKEFNPE FDGKVHLVGH
510 520 530 540 550
SLGSMILFDI LSKQKKYELE FQVDNLFFIG SPIGLLKLIQ RTKIGDRPEF
560 570 580 590 600
PNDLERKLTV QRPQCKDIYN VYHVCDPISY RMEPLVSKEM AHYEQTYLPH
610 620 630 640 650
CSEAYGLTSK VLEFGENIWK DLPGTDENNL QSKKTSPEKK EVKLSENLTR
660 670 680 690 700
MLTGLNYTGR LDYAMSPSLL EVDFISAIKS HVSYFEEPDI AAFILKEILS
710
KHENASEIYV KRKTG
Length:715
Mass (Da):81,769
Last modified:November 1, 1996 - v1
Checksum:iDE3982A606E4BD9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87331 Genomic DNA. Translation: CAA60771.1.
Z74930 Genomic DNA. Translation: CAA99212.1.
BK006948 Genomic DNA. Translation: DAA10805.1.
PIRiS54628.
RefSeqiNP_014665.1. NM_001183441.1.

Genome annotation databases

EnsemblFungiiYOR022C; YOR022C; YOR022C.
GeneIDi854187.
KEGGisce:YOR022C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiYOR22_YEAST
AccessioniPrimary (citable) accession number: Q12204
Secondary accession number(s): D6W289
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names