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Protein

NPC intracellular cholesterol transporter 1-related protein 1

Gene

NCR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in sphingolipid trafficking. May recycle sphingolipids between cellular membranous compartments.2 Publications

Miscellaneous

Present with 521 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • sphingolipid transporter activity Source: SGD

GO - Biological processi

  • sphingolipid metabolic process Source: SGD

Keywordsi

Biological processLipid metabolism, Lipid transport, Sphingolipid metabolism, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33925-MONOMER
ReactomeiR-SCE-5632684 Hedgehog 'on' state
R-SCE-8963678 Intestinal lipid absorption
R-SCE-8964038 LDL clearance

Protein family/group databases

TCDBi2.A.6.6.3 the resistance-nodulation-cell division (rnd) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
NPC intracellular cholesterol transporter 1-related protein 1Curated
Alternative name(s):
Niemann-Pick type C-related protein 1Imported
Gene namesi
Name:NCR1Imported
Ordered Locus Names:YPL006W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL006W
SGDiS000005927 NCR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Transmembranei556 – 576HelicalSequence analysisAdd BLAST21
Transmembranei585 – 605HelicalSequence analysisAdd BLAST21
Transmembranei616 – 636HelicalSequence analysisAdd BLAST21
Transmembranei667 – 687HelicalSequence analysisAdd BLAST21
Transmembranei698 – 718HelicalSequence analysisAdd BLAST21
Transmembranei752 – 772HelicalSequence analysisAdd BLAST21
Transmembranei1000 – 1020HelicalSequence analysisAdd BLAST21
Transmembranei1027 – 1047HelicalSequence analysisAdd BLAST21
Transmembranei1054 – 1074HelicalSequence analysisAdd BLAST21
Transmembranei1099 – 1119HelicalSequence analysisAdd BLAST21
Transmembranei1133 – 1153HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Vacuole

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi718Y → D: Sphingolipids mislocalization and no growth at 38 degrees Celsius. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000026868520 – 1170NPC intracellular cholesterol transporter 1-related protein 1Add BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi513N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi900N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi940N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ12200
PaxDbiQ12200
PRIDEiQ12200

Interactioni

Protein-protein interaction databases

BioGridi36171, 201 interactors
IntActiQ12200, 5 interactors
MINTiQ12200
STRINGi4932.YPL006W

Structurei

3D structure databases

ProteinModelPortaliQ12200
SMRiQ12200
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini557 – 717SSDPROSITE-ProRule annotationAdd BLAST161

Sequence similaritiesi

Belongs to the patched family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00900000140845
HOGENOMiHOG000036674
InParanoidiQ12200
KOiK12385
OMAiMYNACRD
OrthoDBiEOG092C063K

Family and domain databases

InterProiView protein in InterPro
IPR032190 NPC1_N
IPR003392 Ptc/Disp
IPR000731 SSD
PfamiView protein in Pfam
PF16414 NPC1_N, 1 hit
PF02460 Patched, 1 hit
PROSITEiView protein in PROSITE
PS50156 SSD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12200-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVLWIIALV GQLMRLVQGT ATCAMYGNCG KKSVFGNELP CPVPRSFEPP
60 70 80 90 100
VLSDETSKLL VEVCGEEWKE VRYACCTKDQ VVALRDNLQK AQPLISSCPA
110 120 130 140 150
CLKNFNNLFC HFTCAADQGR FVNITKVEKS KEDKDIVAEL DVFMNSSWAS
160 170 180 190 200
EFYDSCKNIK FSATNGYAMD LIGGGAKNYS QFLKFLGDAK PMLGGSPFQI
210 220 230 240 250
NYKYDLANEE KEWQEFNDEV YACDDAQYKC ACSDCQESCP HLKPLKDGVC
260 270 280 290 300
KVGPLPCFSL SVLIFYTICA LFAFMWYYLC KRKKNGAMIV DDDIVPESGS
310 320 330 340 350
LDESETNVFE SFNNETNFFN GKLANLFTKV GQFSVENPYK ILITTVFSIF
360 370 380 390 400
VFSFIIFQYA TLETDPINLW VSKNSEKFKE KEYFDDNFGP FYRTEQIFVV
410 420 430 440 450
NETGPVLSYE TLHWWFDVEN FITEELQSSE NIGYQDLCFR PTEDSTCVIE
460 470 480 490 500
SFTQYFQGAL PNKDSWKREL QECGKFPVNC LPTFQQPLKT NLLFSDDDIL
510 520 530 540 550
NAHAFVVTLL LTNHTQSANR WEERLEEYLL DLKVPEGLRI SFNTEISLEK
560 570 580 590 600
ELNNNNDIST VAISYLMMFL YATWALRRKD GKTRLLLGIS GLLIVLASIV
610 620 630 640 650
CAAGFLTLFG LKSTLIIAEV IPFLILAIGI DNIFLITHEY DRNCEQKPEY
660 670 680 690 700
SIDQKIISAI GRMSPSILMS LLCQTGCFLI AAFVTMPAVH NFAIYSTVSV
710 720 730 740 750
IFNGVLQLTA YVSILSLYEK RSNYKQITGN EETKESFLKT FYFKMLTQKR
760 770 780 790 800
LIIIIFSAWF FTSLVFLPEI QFGLDQTLAV PQDSYLVDYF KDVYSFLNVG
810 820 830 840 850
PPVYMVVKNL DLTKRQNQQK ICGKFTTCER DSLANVLEQE RHRSTITEPL
860 870 880 890 900
ANWLDDYFMF LNPQNDQCCR LKKGTDEVCP PSFPSRRCET CFQQGSWNYN
910 920 930 940 950
MSGFPEGKDF MEYLSIWINA PSDPCPLGGR APYSTALVYN ETSVSASVFR
960 970 980 990 1000
TAHHPLRSQK DFIQAYSDGV RISSSFPELD MFAYSPFYIF FVQYQTLGPL
1010 1020 1030 1040 1050
TLKLIGSAII LIFFISSVFL QNIRSSFLLA LVVTMIIVDI GALMALLGIS
1060 1070 1080 1090 1100
LNAVSLVNLI ICVGLGVEFC VHIVRSFTVV PSETKKDANS RVLYSLNTIG
1110 1120 1130 1140 1150
ESVIKGITLT KFIGVCVLAF AQSKIFDVFY FRMWFTLIIV AALHALLFLP
1160 1170
ALLSLFGGES YRDDSIEAED
Length:1,170
Mass (Da):132,645
Last modified:November 1, 1996 - v1
Checksum:iF976EBDB36C36C92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33335 Genomic DNA Translation: AAB68099.1
Z48483 Genomic DNA Translation: CAA88380.1
Z71255 Genomic DNA Translation: CAA95035.1
BK006949 Genomic DNA Translation: DAA11422.1
PIRiS52525
RefSeqiNP_015319.1, NM_001183820.1

Genome annotation databases

EnsemblFungiiYPL006W; YPL006W; YPL006W
GeneIDi856101
KEGGisce:YPL006W

Similar proteinsi

Entry informationi

Entry nameiNPC1_YEAST
AccessioniPrimary (citable) accession number: Q12200
Secondary accession number(s): D6W406
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

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