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Protein

Type 2A phosphatase activator TIP41

Gene

TIP41

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source. Indirectly activates the PP2A phosphatase SIT4 via interaction with its suppressor TAP42. This interaction is enhanced under nitrogen limitation conditions. Also has a role in regulation of NPR1 in response to nitrogen limitation.2 Publications

GO - Biological processi

  • negative regulation of signal transduction Source: UniProtKB-KW
  • signal transduction Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

BioCyciYEAST:G3O-34196-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type 2A phosphatase activator TIP41
Alternative name(s):
PP2A phosphatase activator TIP41
TAP42-interacting protein 1
Gene namesi
Name:TIP41
Ordered Locus Names:YPR040W
ORF Names:YP3085.04
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR040W.
SGDiS000006244. TIP41.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Type 2A phosphatase activator TIP41PRO_0000247903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551PhosphothreonineCombined sources

Post-translational modificationi

Phosphorylation. Dephosphorylated by SIT4.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12199.
PeptideAtlasiQ12199.

PTM databases

iPTMnetiQ12199.

Interactioni

Subunit structurei

Interacts with TAP42 and NPR1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPH22P235953EBI-38123,EBI-12752

Protein-protein interaction databases

BioGridi36217. 49 interactions.
DIPiDIP-1609N.
IntActiQ12199. 19 interactions.
MINTiMINT-397219.

Structurei

3D structure databases

ProteinModelPortaliQ12199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TIP41 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000006659.
HOGENOMiHOG000213547.
InParanoidiQ12199.
KOiK17607.
OMAiFPLPEMI.
OrthoDBiEOG7SN8P3.

Family and domain databases

InterProiIPR007303. TIP41-like.
[Graphical view]
PfamiPF04176. TIP41. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRNTPPLR SSGINTIQIN AAREMHAQTV RARRMPMPTS GITTPSVQPT
60 70 80 90 100
AAPATPPRHI CNNPNNPQCL HCGSVIIPSP RATLPLEDNP SISINDWTIS
110 120 130 140 150
SRKKPILNSQ ELDIWENEKL KGLTLPEMIF GNNYIRIENS KQHWSIEFNA
160 170 180 190 200
LDALKEVQLQ DSGIRVAYSN DWINSKKRQN STNGAQRFTN DVNDDSLNII
210 220 230 240 250
HKYDWTYTTR YKGTESSPES KFRLDNDQKL PLDKLAVHDK ILFYDDMILF
260 270 280 290 300
EDELADNGIS ILNVKIRVMN ERLLLLSRFF LRVDDVLVRV YDTRIYVEFD
310 320 330 340 350
ENVVIRESKE FEGKYQDVLA KHRLSQSHDP KAALRDSNWV AQNTPMIKRQ

CEIIQF
Length:356
Mass (Da):41,020
Last modified:November 1, 1996 - v1
Checksum:i7E5E31189983EE9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71255 Genomic DNA. Translation: CAA94988.1.
Z68111 Genomic DNA. Translation: CAA92144.1.
BK006949 Genomic DNA. Translation: DAA11465.1.
PIRiS61061.
RefSeqiNP_015365.1. NM_001184137.1.

Genome annotation databases

EnsemblFungiiYPR040W; YPR040W; YPR040W.
GeneIDi856153.
KEGGisce:YPR040W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71255 Genomic DNA. Translation: CAA94988.1.
Z68111 Genomic DNA. Translation: CAA92144.1.
BK006949 Genomic DNA. Translation: DAA11465.1.
PIRiS61061.
RefSeqiNP_015365.1. NM_001184137.1.

3D structure databases

ProteinModelPortaliQ12199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36217. 49 interactions.
DIPiDIP-1609N.
IntActiQ12199. 19 interactions.
MINTiMINT-397219.

PTM databases

iPTMnetiQ12199.

Proteomic databases

MaxQBiQ12199.
PeptideAtlasiQ12199.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR040W; YPR040W; YPR040W.
GeneIDi856153.
KEGGisce:YPR040W.

Organism-specific databases

EuPathDBiFungiDB:YPR040W.
SGDiS000006244. TIP41.

Phylogenomic databases

GeneTreeiENSGT00390000006659.
HOGENOMiHOG000213547.
InParanoidiQ12199.
KOiK17607.
OMAiFPLPEMI.
OrthoDBiEOG7SN8P3.

Enzyme and pathway databases

BioCyciYEAST:G3O-34196-MONOMER.

Miscellaneous databases

PROiQ12199.

Family and domain databases

InterProiIPR007303. TIP41-like.
[Graphical view]
PfamiPF04176. TIP41. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Removal of an intron with unique 3' branch site creates an amino-terminal protein sequence directing the scERV1 gene product to mitochondria."
    Lisowsky T.
    Yeast 12:1501-1510(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL.
    Strain: ATCC 204511 / S288c / AB972.
  4. "TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway."
    Jacinto E., Guo B., Arndt K.T., Schmelzle T., Hall M.N.
    Mol. Cell 8:1017-1026(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TAP42 AND NPR1, PHOSPHORYLATION.
  5. "Suppression of a defect in mitochondrial protein import identifies cytosolic proteins required for viability of yeast cells lacking mitochondrial DNA."
    Dunn C.D., Jensen R.E.
    Genetics 165:35-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. "PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p."
    Santhanam A., Hartley A., Duevel K., Broach J.R., Garrett S.
    Eukaryot. Cell 3:1261-1271(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-55, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-55, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTIP41_YEAST
AccessioniPrimary (citable) accession number: Q12199
Secondary accession number(s): D6W449
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.