Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Type 2A phosphatase activator TIP41

Gene

TIP41

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source. Indirectly activates the PP2A phosphatase SIT4 via interaction with its suppressor TAP42. This interaction is enhanced under nitrogen limitation conditions. Also has a role in regulation of NPR1 in response to nitrogen limitation.2 Publications

GO - Biological processi

  • negative regulation of signal transduction Source: UniProtKB-KW
  • signal transduction Source: SGD

Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

BioCyciYEAST:G3O-34196-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Type 2A phosphatase activator TIP41
Alternative name(s):
PP2A phosphatase activator TIP41
TAP42-interacting protein 1
Gene namesi
Name:TIP41
Ordered Locus Names:YPR040W
ORF Names:YP3085.04
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR040W
SGDiS000006244 TIP41

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002479031 – 356Type 2A phosphatase activator TIP41Add BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylation. Dephosphorylated by SIT4.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12199
PaxDbiQ12199
PRIDEiQ12199

PTM databases

iPTMnetiQ12199

Interactioni

Subunit structurei

Interacts with TAP42 and NPR1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SAP155P436123EBI-38123,EBI-16370

Protein-protein interaction databases

BioGridi36217, 89 interactors
DIPiDIP-1609N
IntActiQ12199, 18 interactors
MINTiQ12199
STRINGi4932.YPR040W

Structurei

3D structure databases

ProteinModelPortaliQ12199
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TIP41 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000006659
HOGENOMiHOG000213547
InParanoidiQ12199
KOiK17607
OMAiKIANLMH
OrthoDBiEOG092C4CEK

Family and domain databases

InterProiView protein in InterPro
IPR007303 TIP41-like
PANTHERiPTHR21021:SF16 PTHR21021:SF16, 1 hit
PfamiView protein in Pfam
PF04176 TIP41, 1 hit

Sequencei

Sequence statusi: Complete.

Q12199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRNTPPLR SSGINTIQIN AAREMHAQTV RARRMPMPTS GITTPSVQPT
60 70 80 90 100
AAPATPPRHI CNNPNNPQCL HCGSVIIPSP RATLPLEDNP SISINDWTIS
110 120 130 140 150
SRKKPILNSQ ELDIWENEKL KGLTLPEMIF GNNYIRIENS KQHWSIEFNA
160 170 180 190 200
LDALKEVQLQ DSGIRVAYSN DWINSKKRQN STNGAQRFTN DVNDDSLNII
210 220 230 240 250
HKYDWTYTTR YKGTESSPES KFRLDNDQKL PLDKLAVHDK ILFYDDMILF
260 270 280 290 300
EDELADNGIS ILNVKIRVMN ERLLLLSRFF LRVDDVLVRV YDTRIYVEFD
310 320 330 340 350
ENVVIRESKE FEGKYQDVLA KHRLSQSHDP KAALRDSNWV AQNTPMIKRQ

CEIIQF
Length:356
Mass (Da):41,020
Last modified:November 1, 1996 - v1
Checksum:i7E5E31189983EE9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71255 Genomic DNA Translation: CAA94988.1
Z68111 Genomic DNA Translation: CAA92144.1
BK006949 Genomic DNA Translation: DAA11465.1
PIRiS61061
RefSeqiNP_015365.1, NM_001184137.1

Genome annotation databases

EnsemblFungiiYPR040W; YPR040W; YPR040W
GeneIDi856153
KEGGisce:YPR040W

Similar proteinsi

Entry informationi

Entry nameiTIP41_YEAST
AccessioniPrimary (citable) accession number: Q12199
Secondary accession number(s): D6W449
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health