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Q12189 (RPIA_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribose-5-phosphate isomerase
EC=5.3.1.6
Alternative name(s):
D-ribose-5-phosphate ketol-isomerase
Phosphoriboisomerase
Gene names
Name:RKI1
Ordered Locus Names:YOR095C
ORF Names:YOR3174C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

D-ribose 5-phosphate = D-ribulose 5-phosphate.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.

Miscellaneous

Present with 5680 molecules/cell in log phase SD medium. Ref.5

Sequence similarities

Belongs to the ribose 5-phosphate isomerase family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself2EBI-15898,EBI-15898

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Ribose-5-phosphate isomerase
PRO_0000158524

Secondary structure

1 ................................................ 258
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q12189 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: E9F72BF2759F4DDD

FASTA25828,258
        10         20         30         40         50         60 
MAAGVPKIDA LESLGNPLED AKRAAAYRAV DENLKFDDHK IIGIGSGSTV VYVAERIGQY 

        70         80         90        100        110        120 
LHDPKFYEVA SKFICIPTGF QSRNLILDNK LQLGSIEQYP RIDIAFDGAD EVDENLQLIK 

       130        140        150        160        170        180 
GGGACLFQEK LVSTSAKTFI VVADSRKKSP KHLGKNWRQG VPIEIVPSSY VRVKNDLLEQ 

       190        200        210        220        230        240 
LHAEKVDIRQ GGSAKAGPVV TDNNNFIIDA DFGEISDPRK LHREIKLLVG VVETGLFIDN 

       250 
ASKAYFGNSD GSVEVTEK

« Hide

References

« Hide 'large scale' references
[1]"DNA sequencing and analysis of 130 kb from yeast chromosome XV."
Voss H., Benes V., Andrade M.A., Valencia A., Rechmann S., Teodoru C., Schwager C., Paces V., Sander C., Ansorge W.
Yeast 13:655-672(1997) [PubMed: 9200815] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. expand/collapse author list , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
Nature 387:98-102(1997) [PubMed: 9169874] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Cloning and characterization of the first two genes of the non-oxidative part of the Saccharomyces cerevisiae pentose-phosphate pathway."
Miosga T., Zimmermann F.K.
Curr. Genet. 30:404-409(1996) [PubMed: 8929392] [Abstract]
Cited for: CHARACTERIZATION.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X94335 Genomic DNA. Translation: CAA64017.1.
Z75003 Genomic DNA. Translation: CAA99292.1.
BK006948 Genomic DNA. Translation: DAA10872.1.
PIRS61656.
RefSeqNP_014738.1. NM_001183514.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1XTZX-ray2.10A1-258[»]
ProteinModelPortalQ12189.
SMRQ12189. Positions 19-258.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4155N.
IntActQ12189. 10 interactions.
MINTMINT-544335.
STRINGQ12189.

Proteomic databases

PeptideAtlasQ12189.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYOR095C; YOR095C; YOR095C.
GeneID854262.
KEGGsce:YOR095C.
NMPDRfig|4932.3.peg.5840.

Organism-specific databases

CYGDYOR095c.
SGDS000005621. RKI1.

Phylogenomic databases

eggNOGfuNOG05297.
GeneTreeEFGT00050000003430.
HOGENOMHBG515603.
OMAGGAQKPV.
OrthoDBEOG4M68SS.

Gene expression databases

ArrayExpressQ12189.
GenevestigatorQ12189.
GermOnlineYOR095C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR004788. Ribose5P_isomerase_typA.
[Graphical view]
KOK01807.
PANTHERPTHR11934. RpiA. 1 hit.
PfamPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsTIGR00021. RpiA. 1 hit.
ProtoNetSearch...

Other

NextBio976200.

Entry information

Entry nameRPIA_YEAST
AccessionPrimary (citable) accession number: Q12189
Secondary accession number(s): D6W2F6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: December 14, 2011
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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