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Protein

Ribose-5-phosphate isomerase

Gene

RKI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 5680 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase (RKI1)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

  • ribose-5-phosphate isomerase activity Source: SGD

GO - Biological processi

  • D-ribose metabolic process Source: GO_Central
  • pentose-phosphate shunt Source: SGD
  • pentose-phosphate shunt, non-oxidative branch Source: GO_Central
  • pyridoxine biosynthetic process Source: SGD

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

BioCyciYEAST:YOR095C-MONOMER
ReactomeiR-SCE-71336 Pentose phosphate pathway (hexose monophosphate shunt)
SABIO-RKQ12189
UniPathwayiUPA00115; UER00412

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase (EC:5.3.1.6)
Alternative name(s):
D-ribose-5-phosphate ketol-isomerase
Phosphoriboisomerase
Gene namesi
Name:RKI1
Ordered Locus Names:YOR095C
ORF Names:YOR3174C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR095C
SGDiS000005621 RKI1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001585241 – 258Ribose-5-phosphate isomeraseAdd BLAST258

Proteomic databases

MaxQBiQ12189
PaxDbiQ12189
PRIDEiQ12189

Interactioni

Protein-protein interaction databases

BioGridi34493, 101 interactors
DIPiDIP-4155N
IntActiQ12189, 8 interactors
MINTiQ12189
STRINGi4932.YOR095C

Structurei

Secondary structure

1258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi20 – 33Combined sources14
Turni36 – 38Combined sources3
Beta strandi41 – 44Combined sources4
Helixi51 – 61Combined sources11
Turni64 – 66Combined sources3
Helixi67 – 70Combined sources4
Beta strandi74 – 79Combined sources6
Helixi80 – 88Combined sources9
Turni96 – 98Combined sources3
Beta strandi101 – 107Combined sources7
Beta strandi110 – 112Combined sources3
Helixi126 – 133Combined sources8
Beta strandi136 – 144Combined sources9
Helixi145 – 147Combined sources3
Beta strandi150 – 153Combined sources4
Beta strandi161 – 165Combined sources5
Helixi167 – 169Combined sources3
Helixi170 – 179Combined sources10
Beta strandi184 – 188Combined sources5
Turni192 – 194Combined sources3
Beta strandi195 – 198Combined sources4
Beta strandi206 – 211Combined sources6
Beta strandi213 – 216Combined sources4
Helixi218 – 226Combined sources9
Beta strandi231 – 237Combined sources7
Beta strandi242 – 247Combined sources6
Beta strandi253 – 258Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XTZX-ray2.10A1-258[»]
ProteinModelPortaliQ12189
SMRiQ12189
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12189

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000004352
HOGENOMiHOG000276369
InParanoidiQ12189
KOiK01807
OMAiVAPMAYV
OrthoDBiEOG092C51J9

Family and domain databases

CDDicd01398 RPI_A, 1 hit
InterProiView protein in InterPro
IPR037171 NagB/RpiA_transferase-like
IPR004788 Ribose5P_isomerase_typA
PfamiView protein in Pfam
PF06026 Rib_5-P_isom_A, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00021 rpiA, 1 hit

Sequencei

Sequence statusi: Complete.

Q12189-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGVPKIDA LESLGNPLED AKRAAAYRAV DENLKFDDHK IIGIGSGSTV
60 70 80 90 100
VYVAERIGQY LHDPKFYEVA SKFICIPTGF QSRNLILDNK LQLGSIEQYP
110 120 130 140 150
RIDIAFDGAD EVDENLQLIK GGGACLFQEK LVSTSAKTFI VVADSRKKSP
160 170 180 190 200
KHLGKNWRQG VPIEIVPSSY VRVKNDLLEQ LHAEKVDIRQ GGSAKAGPVV
210 220 230 240 250
TDNNNFIIDA DFGEISDPRK LHREIKLLVG VVETGLFIDN ASKAYFGNSD

GSVEVTEK
Length:258
Mass (Da):28,258
Last modified:November 1, 1996 - v1
Checksum:iE9F72BF2759F4DDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA Translation: CAA64017.1
Z75003 Genomic DNA Translation: CAA99292.1
BK006948 Genomic DNA Translation: DAA10872.1
PIRiS61656
RefSeqiNP_014738.1, NM_001183514.1

Genome annotation databases

EnsemblFungiiYOR095C; YOR095C; YOR095C
GeneIDi854262
KEGGisce:YOR095C

Similar proteinsi

Entry informationi

Entry nameiRPIA_YEAST
AccessioniPrimary (citable) accession number: Q12189
Secondary accession number(s): D6W2F6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health