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Q12184 (ADRX_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adrenodoxin homolog, mitochondrial
Alternative name(s):
Mitochondrial ferredoxin
Gene names
Name:YAH1
Ordered Locus Names:YPL252C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length172 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for Fe-S cluster incorporation into mitochondrial and cytosolic apoproteins. May be part of a novel electron transport chain. Ref.4

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Subcellular location

Mitochondrion matrix Ref.3 Ref.4.

Miscellaneous

Present with 14800 molecules/cell in log phase SD medium. Ref.5

Sequence similarities

Belongs to the adrenodoxin/putidaredoxin family.

Contains 1 2Fe-2S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion
Chain? – 172Adrenodoxin homolog, mitochondrialPRO_0000000994

Regions

Domain61 – 1631032Fe-2S ferredoxin-type

Sites

Metal binding981Iron-sulfur (2Fe-2S) By similarity
Metal binding1041Iron-sulfur (2Fe-2S) By similarity
Metal binding1071Iron-sulfur (2Fe-2S) By similarity
Metal binding1441Iron-sulfur (2Fe-2S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q12184 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D7DB9CFACBED1BFC

FASTA17218,932
        10         20         30         40         50         60 
MLKIVTRAGH TARISNIAAH LLRTSPSLLT RTTTTTRFLP FSTSSFLNHG HLKKPKPGEE 

        70         80         90        100        110        120 
LKITFILKDG SQKTYEVCEG ETILDIAQGH NLDMEGACGG SCACSTCHVI VDPDYYDALP 

       130        140        150        160        170 
EPEDDENDML DLAYGLTETS RLGCQIKMSK DIDGIRVALP QMTRNVNNND FS 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed: 9169875] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"YAH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to human adrenodoxin."
Barros M.H., Nobrega F.G.
Gene 233:197-203(1999) [PubMed: 10375636] [Abstract]
Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.
[4]"A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins."
Lange H., Kaut A., Kispal G., Lill R.
Proc. Natl. Acad. Sci. U.S.A. 97:1050-1055(2000) [PubMed: 10655482] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z73608 Genomic DNA. Translation: CAA97975.1.
Z67751 Genomic DNA. Translation: CAA91592.1.
BK006949 Genomic DNA. Translation: DAA11185.1.
PIRS61012.
RefSeqNP_015071.1. NM_001184066.1.

3D structure databases

ProteinModelPortalQ12184.
SMRQ12184. Positions 58-160.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-5027N.
IntActQ12184. 1 interaction.
MINTMINT-575374.
STRINGQ12184.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYPL252C; YPL252C; YPL252C.
GeneID855824.
KEGGsce:YPL252C.
NMPDRfig|4932.3.peg.6197.

Organism-specific databases

CYGDYPL252c.
SGDS000006173. YAH1.

Phylogenomic databases

eggNOGfuNOG10342.
GeneTreeEFGT00050000004063.
HOGENOMHBG524254.
OMADMEGACG.
OrthoDBEOG44N22Q.

Gene expression databases

ArrayExpressQ12184.
GenevestigatorQ12184.
GermOnlineYPL252C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR001055. Adrenodoxin.
IPR018298. Adrenodoxin_Fe-S_BS.
IPR012675. Beta-grasp_ferredoxin-type.
IPR001041. Ferredoxin.
[Graphical view]
Gene3DG3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
PfamPF00111. Fer2. 1 hit.
[Graphical view]
PRINTSPR00355. ADRENODOXIN.
SUPFAMSSF54292. Ferredoxin. 1 hit.
PROSITEPS51085. 2FE2S_FER_2. 1 hit.
PS00814. ADX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio980371.

Entry information

Entry nameADRX_YEAST
AccessionPrimary (citable) accession number: Q12184
Secondary accession number(s): D6W3B9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: January 25, 2012
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families