Q12184 (ADRX_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adrenodoxin homolog, mitochondrial

Alternative name(s):
Mitochondrial ferredoxin

Gene names

Name:	YAH1
Ordered Locus Names:	YPL252C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for Fe-S cluster incorporation into mitochondrial and cytosolic apoproteins. May be part of a novel electron transport chain. Ref.4
Cofactor	Binds 1 2Fe-2S cluster By similarity.
Subcellular location	Mitochondrion matrix Ref.3 Ref.4.
Miscellaneous	Present with 14800 molecules/cell in log phase SD medium. Ref.5
Sequence similarities	Belongs to the adrenodoxin/putidaredoxin family. Contains 1 2Fe-2S ferredoxin-type domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Iron Iron-sulfur Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW heme a biosynthetic process Inferred from mutant phenotype. Source: SGD iron-sulfur cluster assembly Inferred from direct assay Ref.4. Source: UniProtKB transport Inferred from electronic annotation. Source: UniProtKB-KW ubiquinone biosynthetic process Inferred from mutant phenotype. Source: SGD
Cellular component	mitochondrial matrix Inferred from direct assay Ref.3. Source: UniProtKB
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: InterPro electron carrier activity Non-traceable author statement Ref.3. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion
	Chain	? – 172		Adrenodoxin homolog, mitochondrial		PRO_0000000994
Regions
	Domain	61 – 163	103	2Fe-2S ferredoxin-type
Sites
	Metal binding	98	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	104	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	107	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	144	1	Iron-sulfur (2Fe-2S) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q12184 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: D7DB9CFACBED1BFC	FASTA	172	18,932
	10 20 30 40 50 60 MLKIVTRAGH TARISNIAAH LLRTSPSLLT RTTTTTRFLP FSTSSFLNHG HLKKPKPGEE 70 80 90 100 110 120 LKITFILKDG SQKTYEVCEG ETILDIAQGH NLDMEGACGG SCACSTCHVI VDPDYYDALP 130 140 150 160 170 EPEDDENDML DLAYGLTETS RLGCQIKMSK DIDGIRVALP QMTRNVNNND FS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J. Nature 387:103-105(1997) [PubMed: 9169875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"YAH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to human adrenodoxin." Barros M.H., Nobrega F.G. Gene 233:197-203(1999) [PubMed: 10375636] [Abstract] Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.
[4]	"A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins." Lange H., Kaut A., Kispal G., Lill R. Proc. Natl. Acad. Sci. U.S.A. 97:1050-1055(2000) [PubMed: 10655482] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z73608 Genomic DNA. Translation: CAA97975.1. Z67751 Genomic DNA. Translation: CAA91592.1. BK006949 Genomic DNA. Translation: DAA11185.1.
PIR	S61012.
RefSeq	NP_015071.1. NM_001184066.1.
3D structure databases
ProteinModelPortal	Q12184.
SMR	Q12184. Positions 58-160.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5027N.
IntAct	Q12184. 1 interaction.
MINT	MINT-575374.
STRING	Q12184.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YPL252C; YPL252C; YPL252C.
GeneID	855824.
KEGG	sce:YPL252C.
NMPDR	fig|4932.3.peg.6197.
Organism-specific databases
CYGD	YPL252c.
SGD	S000006173. YAH1.
Phylogenomic databases
eggNOG	fuNOG10342.
GeneTree	EFGT00050000004063.
HOGENOM	HBG524254.
OMA	DMEGACG.
OrthoDB	EOG44N22Q.
Gene expression databases
ArrayExpress	Q12184.
Genevestigator	Q12184.
GermOnline	YPL252C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001055. Adrenodoxin. IPR018298. Adrenodoxin_Fe-S_BS. IPR012675. Beta-grasp_ferredoxin-type. IPR001041. Ferredoxin. [Graphical view]
Gene3D	G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
Pfam	PF00111. Fer2. 1 hit. [Graphical view]
PRINTS	PR00355. ADRENODOXIN.
SUPFAM	SSF54292. Ferredoxin. 1 hit.
PROSITE	PS51085. 2FE2S_FER_2. 1 hit. PS00814. ADX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	980371.

Entry information

Entry name

ADRX_YEAST

Accession

Primary (citable) accession number: Q12184
Secondary accession number(s): D6W3B9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program