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Protein

Adrenodoxin homolog, mitochondrial

Gene

YAH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for Fe-S cluster incorporation into mitochondrial and cytosolic apoproteins. May be part of a novel electron transport chain.1 Publication

Cofactori

[2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi98 – 981Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
Metal bindingi104 – 1041Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
Metal bindingi107 – 1071Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
Metal bindingi144 – 1441Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation

GO - Molecular functioni

  • 2 iron, 2 sulfur cluster binding Source: InterPro
  • electron carrier activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor Source: SGD

GO - Biological processi

  • heme a biosynthetic process Source: SGD
  • iron-sulfur cluster assembly Source: UniProtKB
  • ubiquinone biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34137-MONOMER.
ReactomeiR-SCE-1362409. Mitochondrial iron-sulfur cluster biogenesis.
R-SCE-2395516. Electron transport from NADPH to Ferredoxin.

Names & Taxonomyi

Protein namesi
Recommended name:
Adrenodoxin homolog, mitochondrial
Alternative name(s):
Mitochondrial ferredoxin
Gene namesi
Name:YAH1
Ordered Locus Names:YPL252C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL252C.
SGDiS000006173. YAH1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 172Adrenodoxin homolog, mitochondrialPRO_0000000994
Transit peptidei1 – ?Mitochondrion

Proteomic databases

MaxQBiQ12184.

Interactioni

Protein-protein interaction databases

BioGridi35911. 5 interactions.
DIPiDIP-5027N.
IntActiQ12184. 1 interaction.
MINTiMINT-575374.

Structurei

Secondary structure

1
172
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi61 – 666Combined sources
Beta strandi72 – 776Combined sources
Helixi83 – 908Combined sources
Beta strandi101 – 1044Combined sources
Beta strandi108 – 1114Combined sources
Turni113 – 1153Combined sources
Turni124 – 1274Combined sources
Helixi128 – 1314Combined sources
Beta strandi133 – 1353Combined sources
Beta strandi140 – 1423Combined sources
Turni143 – 1453Combined sources
Helixi150 – 1523Combined sources
Beta strandi156 – 1583Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MJDNMR-A58-172[»]
2MJENMR-A58-172[»]
ProteinModelPortaliQ12184.
SMRiQ12184. Positions 58-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 1631032Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adrenodoxin/putidaredoxin family.Curated
Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00530000063577.
HOGENOMiHOG000244518.
InParanoidiQ12184.
OMAiLYVTFID.
OrthoDBiEOG71GB6Z.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR001055. Adrenodoxin.
IPR018298. Adrenodoxin_Fe-S_BS.
IPR012675. Beta-grasp_dom.
[Graphical view]
PfamiPF00111. Fer2. 1 hit.
[Graphical view]
PRINTSiPR00355. ADRENODOXIN.
SUPFAMiSSF54292. SSF54292. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS00814. ADX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12184-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIVTRAGH TARISNIAAH LLRTSPSLLT RTTTTTRFLP FSTSSFLNHG
60 70 80 90 100
HLKKPKPGEE LKITFILKDG SQKTYEVCEG ETILDIAQGH NLDMEGACGG
110 120 130 140 150
SCACSTCHVI VDPDYYDALP EPEDDENDML DLAYGLTETS RLGCQIKMSK
160 170
DIDGIRVALP QMTRNVNNND FS
Length:172
Mass (Da):18,932
Last modified:November 1, 1996 - v1
Checksum:iD7DB9CFACBED1BFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73608 Genomic DNA. Translation: CAA97975.1.
Z67751 Genomic DNA. Translation: CAA91592.1.
BK006949 Genomic DNA. Translation: DAA11185.1.
PIRiS61012.
RefSeqiNP_015071.1. NM_001184066.1.

Genome annotation databases

EnsemblFungiiYPL252C; YPL252C; YPL252C.
GeneIDi855824.
KEGGisce:YPL252C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73608 Genomic DNA. Translation: CAA97975.1.
Z67751 Genomic DNA. Translation: CAA91592.1.
BK006949 Genomic DNA. Translation: DAA11185.1.
PIRiS61012.
RefSeqiNP_015071.1. NM_001184066.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MJDNMR-A58-172[»]
2MJENMR-A58-172[»]
ProteinModelPortaliQ12184.
SMRiQ12184. Positions 58-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35911. 5 interactions.
DIPiDIP-5027N.
IntActiQ12184. 1 interaction.
MINTiMINT-575374.

Proteomic databases

MaxQBiQ12184.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL252C; YPL252C; YPL252C.
GeneIDi855824.
KEGGisce:YPL252C.

Organism-specific databases

EuPathDBiFungiDB:YPL252C.
SGDiS000006173. YAH1.

Phylogenomic databases

GeneTreeiENSGT00530000063577.
HOGENOMiHOG000244518.
InParanoidiQ12184.
OMAiLYVTFID.
OrthoDBiEOG71GB6Z.

Enzyme and pathway databases

BioCyciYEAST:G3O-34137-MONOMER.
ReactomeiR-SCE-1362409. Mitochondrial iron-sulfur cluster biogenesis.
R-SCE-2395516. Electron transport from NADPH to Ferredoxin.

Miscellaneous databases

NextBioi980371.
PROiQ12184.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR001055. Adrenodoxin.
IPR018298. Adrenodoxin_Fe-S_BS.
IPR012675. Beta-grasp_dom.
[Graphical view]
PfamiPF00111. Fer2. 1 hit.
[Graphical view]
PRINTSiPR00355. ADRENODOXIN.
SUPFAMiSSF54292. SSF54292. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS00814. ADX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "YAH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to human adrenodoxin."
    Barros M.H., Nobrega F.G.
    Gene 233:197-203(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.
  4. "A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins."
    Lange H., Kaut A., Kispal G., Lill R.
    Proc. Natl. Acad. Sci. U.S.A. 97:1050-1055(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiADRX_YEAST
AccessioniPrimary (citable) accession number: Q12184
Secondary accession number(s): D6W3B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 14800 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.