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Reviewed, UniProtKB/Swiss-Prot Q12184 (ADRX_YEAST)

Last modified November 24, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Adrenodoxin homolog, mitochondrial
Alternative name(s):
    Mitochondrial ferredoxin
Gene names
Name: YAH1
Ordered Locus Names: YPL252C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length172 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Required for Fe-S cluster incorporation into mitochondrial and cytosolic apoproteins. May be part of a novel electron transport chain. Ref.3

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Subcellular location

Mitochondrion matrix.

Miscellaneous

Present with 14800 molecules/cell in log phase SD medium. Ref.4

Sequence similarities

Belongs to the adrenodoxin/putidaredoxin family.

Contains 1 2Fe-2S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion
Chain? – 172Adrenodoxin homolog, mitochondrialPRO_0000000994

Regions

Domain61 – 1631032Fe-2S ferredoxin-type

Sites

Metal binding981Iron-sulfur (2Fe-2S) By similarity
Metal binding1041Iron-sulfur (2Fe-2S) By similarity
Metal binding1071Iron-sulfur (2Fe-2S) By similarity
Metal binding1441Iron-sulfur (2Fe-2S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q12184-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D7DB9CFACBED1BFC

FASTA17218,932
        10         20         30         40         50         60 
MLKIVTRAGH TARISNIAAH LLRTSPSLLT RTTTTTRFLP FSTSSFLNHG HLKKPKPGEE 

        70         80         90        100        110        120 
LKITFILKDG SQKTYEVCEG ETILDIAQGH NLDMEGACGG SCACSTCHVI VDPDYYDALP 

       130        140        150        160        170 
EPEDDENDML DLAYGLTETS RLGCQIKMSK DIDGIRVALP QMTRNVNNND FS 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed: 9169875] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"YAH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to human adrenodoxin."
Barros M.H., Nobrega F.G.
Gene 233:197-203(1999) [PubMed: 10375636] [Abstract]
Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.
[3]"A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins."
Lange H., Kaut A., Kispal G., Lill R.
Proc. Natl. Acad. Sci. U.S.A. 97:1050-1055(2000) [PubMed: 10655482] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

Z73608 Genomic DNA. Translation: CAA97975.1.
Z67751 Genomic DNA. Translation: CAA91592.1.
PIRS61012.
RefSeqNP_015071.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:5027N.
IntActQ12184. 2 interactions.
STRINGQ12184.

Genome annotation databases

EnsemblYPL252C; YPL252C; YPL252C; Saccharomyces cerevisiae. [Genome view]
GeneID855824.
KEGGsce:YPL252C.
NMPDRfig|4932.3.peg.6197.

Organism-specific databases

CYGDYPL252c.
SGDS000006173. YAH1.

Phylogenomic databases

HOGENOMQ12184.
OMALGCQVKM
OrthoDBEOG9K9CW3

Gene expression databases

ArrayExpressQ12184.
GenevestigatorQ12184.
GermOnlineYPL252C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR001055. Adrenodoxin.
IPR018298. Adrenodoxin_Fe-S_BS.
IPR012675. b-grasp_ferredoxin-like.
IPR001041. Ferredoxin.
[Graphical view]
Gene3DG3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
PfamPF00111. Fer2. 1 hit.
[Graphical view]
PRINTSPR00355. ADRENODOXIN.
PROSITEPS51085. 2FE2S_FER_2. 1 hit.
PS00814. ADX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio980371.

Entry information

Entry nameADRX_YEAST
AccessionPrimary (citable) accession number: Q12184
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: November 24, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents