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Protein

Adrenodoxin homolog, mitochondrial

Gene

YAH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for Fe-S cluster incorporation into mitochondrial and cytosolic apoproteins. May be part of a novel electron transport chain.1 Publication

Miscellaneous

Present with 14800 molecules/cell in log phase SD medium.1 Publication

Cofactori

[2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi98Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi104Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi107Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi144Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1

GO - Molecular functioni

  • 2 iron, 2 sulfur cluster binding Source: InterPro
  • electron transfer activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor Source: SGD

GO - Biological processi

  • heme a biosynthetic process Source: SGD
  • iron-sulfur cluster assembly Source: UniProtKB
  • ubiquinone biosynthetic process Source: SGD

Keywordsi

Biological processElectron transport, Transport
LigandIron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:G3O-34137-MONOMER
YEAST:G3O-34137-MONOMER
ReactomeiR-SCE-1362409 Mitochondrial iron-sulfur cluster biogenesis
R-SCE-2395516 Electron transport from NADPH to Ferredoxin

Names & Taxonomyi

Protein namesi
Recommended name:
Adrenodoxin homolog, mitochondrial
Alternative name(s):
Mitochondrial ferredoxin
Gene namesi
Name:YAH1
Ordered Locus Names:YPL252C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL252C
SGDiS000006173 YAH1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000000994? – 172Adrenodoxin homolog, mitochondrial
Transit peptidei1 – ?Mitochondrion

Proteomic databases

MaxQBiQ12184
PaxDbiQ12184
PRIDEiQ12184

Interactioni

Protein-protein interaction databases

BioGridi35911, 7 interactors
DIPiDIP-5027N
IntActiQ12184, 2 interactors
STRINGi4932.YPL252C

Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi61 – 66Combined sources6
Beta strandi72 – 77Combined sources6
Helixi83 – 90Combined sources8
Beta strandi101 – 104Combined sources4
Beta strandi108 – 111Combined sources4
Turni113 – 115Combined sources3
Turni124 – 127Combined sources4
Helixi128 – 131Combined sources4
Beta strandi133 – 135Combined sources3
Beta strandi140 – 142Combined sources3
Turni143 – 145Combined sources3
Helixi150 – 152Combined sources3
Beta strandi156 – 158Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MJDNMR-A58-172[»]
2MJENMR-A58-172[»]
ProteinModelPortaliQ12184
SMRiQ12184
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 1632Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST103

Sequence similaritiesi

Belongs to the adrenodoxin/putidaredoxin family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00530000063577
HOGENOMiHOG000244518
InParanoidiQ12184
KOiK22071
OMAiWQDPKSP
OrthoDBiEOG092C5GZH

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR001055 Adrenodoxin
IPR018298 Adrenodoxin_Fe-S_BS
IPR012675 Beta-grasp_dom_sf
PfamiView protein in Pfam
PF00111 Fer2, 1 hit
PRINTSiPR00355 ADRENODOXIN
SUPFAMiSSF54292 SSF54292, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS00814 ADX, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12184-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIVTRAGH TARISNIAAH LLRTSPSLLT RTTTTTRFLP FSTSSFLNHG
60 70 80 90 100
HLKKPKPGEE LKITFILKDG SQKTYEVCEG ETILDIAQGH NLDMEGACGG
110 120 130 140 150
SCACSTCHVI VDPDYYDALP EPEDDENDML DLAYGLTETS RLGCQIKMSK
160 170
DIDGIRVALP QMTRNVNNND FS
Length:172
Mass (Da):18,932
Last modified:November 1, 1996 - v1
Checksum:iD7DB9CFACBED1BFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73608 Genomic DNA Translation: CAA97975.1
Z67751 Genomic DNA Translation: CAA91592.1
BK006949 Genomic DNA Translation: DAA11185.1
PIRiS61012
RefSeqiNP_015071.1, NM_001184066.1

Genome annotation databases

EnsemblFungiiYPL252C; YPL252C; YPL252C
GeneIDi855824
KEGGisce:YPL252C

Similar proteinsi

Entry informationi

Entry nameiADRX_YEAST
AccessioniPrimary (citable) accession number: Q12184
Secondary accession number(s): D6W3B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

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