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Protein

Ribosome biogenesis protein MAK21

Gene

MAK21

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for 60S ribosomal subunit synthesis.1 Publication

Miscellaneous

Present with 15000 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • ribosomal large subunit assembly Source: SGD
  • ribosomal large subunit biogenesis Source: SGD

Keywordsi

Biological processRibosome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-29668-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein MAK21
Alternative name(s):
Maintenance of killer protein 21
Nucleolar complex protein 1
Gene namesi
Name:MAK21
Synonyms:NOC1
Ordered Locus Names:YDR060W
ORF Names:D4237, YD9609.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR060W
SGDiS000002467 MAK21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001734722 – 1025Ribosome biogenesis protein MAK21Add BLAST1024

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei62PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1
Modified residuei80PhosphoserineCombined sources1
Modified residuei275PhosphoserineCombined sources1
Modified residuei708PhosphotyrosineCombined sources1
Modified residuei710PhosphoserineCombined sources1
Modified residuei874PhosphoserineCombined sources1
Modified residuei878PhosphoserineCombined sources1
Modified residuei977PhosphoserineCombined sources1
Modified residuei978PhosphoserineCombined sources1
Modified residuei1024PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ12176
PaxDbiQ12176
PRIDEiQ12176

PTM databases

iPTMnetiQ12176

Interactioni

Subunit structurei

Interacts with NOC2. Forms a nucleolar complex with NOC2 that binds to 90S and 66S pre-ribosomes.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi32115443 interactors.
DIPiDIP-4040N
IntActiQ12176 116 interactors.
MINTiQ12176
STRINGi4932.YDR060W

Structurei

3D structure databases

ProteinModelPortaliQ12176
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 77Poly-Asp4
Compositional biasi117 – 122Poly-Asp6
Compositional biasi979 – 986Poly-Glu8

Sequence similaritiesi

Belongs to the CBF/MAK21 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000006395
HOGENOMiHOG000207540
InParanoidiQ12176
KOiK14832
OMAiFQGPRKK
OrthoDBiEOG092C13JZ

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR005612 CCAAT-binding_factor
PfamiView protein in Pfam
PF03914 CBF, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENNGNPLD LSSLRNKISS KLRDNNSKKA KKTHKGKDVK ASSNSKKVNE
60 70 80 90 100
DIRREALALG ASEEDLKLIQ GLSDDDDAKS EQEFDAVADE DADDKGFKND
110 120 130 140 150
LQNFMKNVGF DQHKLEDVDD DDIEEESTSS KESKIPAQEK EHAQSNIASS
160 170 180 190 200
TIEKTSQESI DNGSEQEENT VEEANLSSDQ EPESESAEKE KKEEKDGGLI
210 220 230 240 250
TQTTIISSDK LIIPYDKPWY EIPLDPQVGQ NDDVEELSKE QIEKLFERGK
260 270 280 290 300
QTLEADNQTY YEEFTKDSSQ AKFMSQILSD GTLNDKISAV TLLIQDSPLH
310 320 330 340 350
NTKSLETLVS YCGKKSRNSA LQSLNALKDL FLNGLLPNRK LRYFKNQPGL
360 370 380 390 400
SMMLNKKTLA IFYFEDYLKK LFFRVLEVLE VLSHDPIIHV RLQILNHVFD
410 420 430 440 450
LLTNQPEQEF NLLRLGVNKI GDIDSKVSSK ASYLLLKLEQ AHPNMKSIVI
460 470 480 490 500
DAIVDIALRP NADYHTTYYS VITLNQTILK RSEDSVANKL VKTYFTLFEK
510 520 530 540 550
FLINTDKDNT NGVVKSNSKS YEEKRKKNFK KGKHGGKSVK IEKTENEVLD
560 570 580 590 600
EKNSKLFSAL LTGINRAFPF AQIPASVYEV HMETLFKITH SSNFNTSIQA
610 620 630 640 650
LVLINQVTVK AKLNSDRYYR TLYESLFDPR LVNSSKQGIY LNLLYKSLKQ
660 670 680 690 700
DALNVERVEA FVKRILQVCS HWLNVGTITG FFFLLIQLAK TVPQIKNLLT
710 720 730 740 750
NTPVDYEYES DAEEEQGDKD IKRKEYDGRK RDPKFANAEK SSLWEINNFI
760 770 780 790 800
NHFHPTVKTY ANAYVTGETE QIAKPDLGLF TLSHFLDRFV YRSAKQTNTA
810 820 830 840 850
RGTSIMQPLF SGSRVNDSVL VKASDIMHDQ GPVNTEDWLT KKVEDIKPED
860 870 880 890 900
KFFYQYFTTK KTADGKGKKS NKASNFDSDD EMDENEIWSA LVKSRPDVED
910 920 930 940 950
DSDDSELDFA EDDFSDSTSD DEPKLDAIDD EDAKSEGSQE SDQEEGLDED
960 970 980 990 1000
IFYSFDGEQD NSDKKRSFAE SSEEDESSEE EKEEEENKEV SAKRAKKKQR
1010 1020
KNMLKSLPVF ASADDYAQYL DQDSD
Length:1,025
Mass (Da):116,677
Last modified:November 1, 1996 - v1
Checksum:iFB80378727ED71D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84162 Genomic DNA Translation: CAA58976.1
Z74356 Genomic DNA Translation: CAA98878.1
Z49209 Genomic DNA Translation: CAA89089.1
BK006938 Genomic DNA Translation: DAA11906.1
PIRiS54044
RefSeqiNP_010345.3, NM_001180368.3

Genome annotation databases

EnsemblFungiiYDR060W; YDR060W; YDR060W
GeneIDi851632
KEGGisce:YDR060W

Similar proteinsi

Entry informationi

Entry nameiMAK21_YEAST
AccessioniPrimary (citable) accession number: Q12176
Secondary accession number(s): D6VS46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome