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Protein

Zinc finger transcription factor YRR1

Gene

YRR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor involved in the regulation of multidrug resistance genes. Acts in concert with YRR1.5 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi54 – 8229Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33679-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger transcription factor YRR1
Alternative name(s):
Pleiotropic drug-resistance protein 2
Gene namesi
Name:YRR1
Synonyms:PDR2
Ordered Locus Names:YOR162C
ORF Names:O3571
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR162C.
SGDiS000005688. YRR1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 810810Zinc finger transcription factor YRR1PRO_0000269651Add
BLAST

Proteomic databases

MaxQBiQ12172.

PTM databases

iPTMnetiQ12172.

Interactioni

Protein-protein interaction databases

BioGridi34558. 25 interactions.
DIPiDIP-5493N.
IntActiQ12172. 5 interactions.
MINTiMINT-540074.

Structurei

3D structure databases

ProteinModelPortaliQ12172.
SMRiQ12172. Positions 45-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000010685.
HOGENOMiHOG000155687.
InParanoidiQ12172.
OMAiLVNINEC.
OrthoDBiEOG7RJQ0S.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRRSDALLG SFQATNVTPP SDNSNSTAGG ANGSNSGTPT STSGKKRNKL
60 70 80 90 100
IKSCGFCRRR KLRCDQQKPM CSTCISRNLT TCQYAEEFNK NIEKKATYGP
110 120 130 140 150
YPNADLLKKV EELENKIRIL EAEKNTNSSA SSMYTSPNFP PLGTSVGRGS
160 170 180 190 200
TETSSPLPDG VINPYADRYY LQSKHSGRST LYGPTSMRTQ IANSNWGFIE
210 220 230 240 250
KYKQLWAKVK VERNKWKQNN QKTMCRELGL LDESDWQPDP LIKQICRFLP
260 270 280 290 300
SYNKALSILD DFFNDGACNE INVILDKAKV RRDFLDYFMP EKEVKAEGDR
310 320 330 340 350
SIVYILSNPK KNYYKAAVIL LILCLKYFHT DVPTPIEKFF TLLKGASTAK
360 370 380 390 400
VFYIERAQML ILFYYHRETY SFGGDGSDLV NINECLVTTV TTIGLHLNIR
410 420 430 440 450
ETFKEHEVFM GSIESLENVW LMAIFIDYNI SCNVGRPLLI NKFYLDENQD
460 470 480 490 500
HCILNSKSKT YEGKLKRYLK LTRPMLLTLY DRDKFPDLKA YSKRIINFVE
510 520 530 540 550
EELGPLGHYT GENISEEVPL RESRILSMAV GLLLSFYALI HSVLKVRNIE
560 570 580 590 600
SKNNTFQLVL INFSIIVNTT IRCYRIDKAL YPEKFEASNP HLPPHMALSM
610 620 630 640 650
SLTAGLFSKT LVFFCSLIYF KLTLFENGLC LSNDMEVGWS DLTKLTVPLD
660 670 680 690 700
KDLSLGTAMS LYSSIFDRLF TVGNKELIRT MHRSSQFVIE LAIERTYRTI
710 720 730 740 750
LGNVIEFRKL TEETWLAQIK QELDPQSDNP SSEAKIVSDR QRDLSLAVPT
760 770 780 790 800
PTPSIIPMLP SPGETKNHAK SQSEIIQMLT DEFWANYNSG WEELINQSEF
810
STLFDDYKDN
Length:810
Mass (Da):92,468
Last modified:November 1, 1996 - v1
Checksum:i1B4A32A91CFF2515
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55021 Genomic DNA. Translation: AAB47409.1.
Z75070 Genomic DNA. Translation: CAA99368.1.
AY692760 Genomic DNA. Translation: AAT92779.1.
BK006948 Genomic DNA. Translation: DAA10936.1.
PIRiS67050.
RefSeqiNP_014805.3. NM_001183581.3.

Genome annotation databases

EnsemblFungiiYOR162C; YOR162C; YOR162C.
GeneIDi854333.
KEGGisce:YOR162C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55021 Genomic DNA. Translation: AAB47409.1.
Z75070 Genomic DNA. Translation: CAA99368.1.
AY692760 Genomic DNA. Translation: AAT92779.1.
BK006948 Genomic DNA. Translation: DAA10936.1.
PIRiS67050.
RefSeqiNP_014805.3. NM_001183581.3.

3D structure databases

ProteinModelPortaliQ12172.
SMRiQ12172. Positions 45-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34558. 25 interactions.
DIPiDIP-5493N.
IntActiQ12172. 5 interactions.
MINTiMINT-540074.

PTM databases

iPTMnetiQ12172.

Proteomic databases

MaxQBiQ12172.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR162C; YOR162C; YOR162C.
GeneIDi854333.
KEGGisce:YOR162C.

Organism-specific databases

EuPathDBiFungiDB:YOR162C.
SGDiS000005688. YRR1.

Phylogenomic databases

GeneTreeiENSGT00390000010685.
HOGENOMiHOG000155687.
InParanoidiQ12172.
OMAiLVNINEC.
OrthoDBiEOG7RJQ0S.

Enzyme and pathway databases

BioCyciYEAST:G3O-33679-MONOMER.

Miscellaneous databases

NextBioi976393.
PROiQ12172.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a 22,956 bp region on the right arm of Saccharomyces cerevisiae chromosome XV."
    Madania A., Poch O., Tarassov I.A., Winsor B., Martin R.P.
    Yeast 12:1563-1573(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2."
    Cui Z., Shiraki T., Hirata D., Miyakawa T.
    Mol. Microbiol. 29:1307-1315(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Functional analysis of the promoter of the yeast SNQ2 gene encoding a multidrug resistance transporter that confers the resistance to 4-nitroquinoline N-oxide."
    Cui Z., Hirata D., Miyakawa T.
    Biosci. Biotechnol. Biochem. 63:162-167(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system."
    Le Crom S., Devaux F., Marc P., Zhang X., Moye-Rowley W.S., Jacq C.
    Mol. Cell. Biol. 22:2642-2649(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon."
    Lucau-Danila A., Delaveau T., Lelandais G., Devaux F., Jacq C.
    J. Biol. Chem. 278:52641-52650(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  10. "Analysis of gene network regulating yeast multidrug resistance by artificial activation of transcription factors: involvement of Pdr3 in salt tolerance."
    Onda M., Ota K., Chiba T., Sakaki Y., Ito T.
    Gene 332:51-59(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYRR1_YEAST
AccessioniPrimary (citable) accession number: Q12172
Secondary accession number(s): D6W2M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.