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Q12165

- ATPD_YEAST

UniProt

Q12165 - ATPD_YEAST

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Protein

ATP synthase subunit delta, mitochondrial

Gene

ATP16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

GO - Molecular functioni

  1. proton-transporting ATPase activity, rotational mechanism Source: InterPro
  2. proton-transporting ATP synthase activity, rotational mechanism Source: InterPro

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. ATP synthesis coupled proton transport Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29435-MONOMER.

Protein family/group databases

TCDBi3.A.2.1.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit delta, mitochondrial
Alternative name(s):
F-ATPase delta subunit
Gene namesi
Name:ATP16
Ordered Locus Names:YDL004W
ORF Names:D2935, YD8119.03
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDL004w.
SGDiS000002162. ATP16.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial proton-transporting ATP synthase, central stalk Source: SGD
  2. proton-transporting ATP synthase complex, catalytic core F(1) Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222Mitochondrion1 PublicationAdd
BLAST
Chaini23 – 160138ATP synthase subunit delta, mitochondrialPRO_0000002671Add
BLAST

Proteomic databases

MaxQBiQ12165.
PaxDbiQ12165.
PeptideAtlasiQ12165.

Expressioni

Gene expression databases

GenevestigatoriQ12165.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Protein-protein interaction databases

BioGridi32050. 11 interactions.
DIPiDIP-3032N.
IntActiQ12165. 3 interactions.
MINTiMINT-2781010.

Structurei

Secondary structure

1
160
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 374
Beta strandi44 – 463
Beta strandi51 – 544
Beta strandi56 – 594
Beta strandi61 – 633
Beta strandi70 – 745
Beta strandi78 – 836
Beta strandi86 – 927
Beta strandi95 – 1006
Turni101 – 1033
Beta strandi104 – 1107
Beta strandi112 – 1143
Helixi115 – 1173
Helixi120 – 13314
Beta strandi136 – 1394
Helixi140 – 15617

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HLDX-ray2.80H/Q/Z23-160[»]
2WPDX-ray3.43H23-160[»]
2XOKX-ray3.01H1-160[»]
3FKSX-ray3.59H/Q/Z23-160[»]
3OE7X-ray3.19H/Q/Z24-160[»]
3OEEX-ray2.74H/Q/Z23-160[»]
3OEHX-ray3.00H/Q/Z23-160[»]
3OFNX-ray3.20H/Q23-160[»]
3ZIAX-ray2.50H/R23-160[»]
3ZRYX-ray6.50H23-160[»]
4B2Qelectron microscopy37.00H/h29-160[»]
ProteinModelPortaliQ12165.
SMRiQ12165. Positions 29-160.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12165.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase epsilon chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0355.
GeneTreeiENSGT00390000017576.
HOGENOMiHOG000216023.
InParanoidiQ12165.
KOiK02134.
OMAiLPHQAIF.
OrthoDBiEOG7S7SSS.

Family and domain databases

Gene3Di2.60.15.10. 1 hit.
HAMAPiMF_00530. ATP_synth_epsil_bac.
InterProiIPR001469. ATPase_F1-cplx_dsu/esu.
IPR020546. ATPase_F1-cplx_dsu/esu_N.
[Graphical view]
PANTHERiPTHR13822. PTHR13822. 1 hit.
PfamiPF02823. ATP-synt_DE_N. 1 hit.
[Graphical view]
ProDomiPD000944. ATPase_F1-cplx_dsu/esu. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF51344. SSF51344. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12165 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRSIIGKSA SRSLNFVAKR SYAEAAAASS GLKLQFALPH ETLYSGSEVT
60 70 80 90 100
QVNLPAKSGR IGVLANHVPT VEQLLPGVVE VMEGSNSKKF FISGGFATVQ
110 120 130 140 150
PDSQLCVTAI EAFPLESFSQ ENIKNLLAEA KKNVSSSDAR EAAEAAIQVE
160
VLENLQSVLK
Length:160
Mass (Da):17,020
Last modified:November 1, 1996 - v1
Checksum:iAE8D0BA364107977
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z21857 Genomic DNA. Translation: CAA79912.1.
Z48008 Genomic DNA. Translation: CAA88057.1.
Z48432 Genomic DNA. Translation: CAA88355.1.
Z74052 Genomic DNA. Translation: CAA98560.1.
AY558155 Genomic DNA. Translation: AAS56481.1.
BK006938 Genomic DNA. Translation: DAA11844.1.
PIRiS45632.
RefSeqiNP_010280.1. NM_001180063.1.

Genome annotation databases

EnsemblFungiiYDL004W; YDL004W; YDL004W.
GeneIDi851560.
KEGGisce:YDL004W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z21857 Genomic DNA. Translation: CAA79912.1 .
Z48008 Genomic DNA. Translation: CAA88057.1 .
Z48432 Genomic DNA. Translation: CAA88355.1 .
Z74052 Genomic DNA. Translation: CAA98560.1 .
AY558155 Genomic DNA. Translation: AAS56481.1 .
BK006938 Genomic DNA. Translation: DAA11844.1 .
PIRi S45632.
RefSeqi NP_010280.1. NM_001180063.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HLD X-ray 2.80 H/Q/Z 23-160 [» ]
2WPD X-ray 3.43 H 23-160 [» ]
2XOK X-ray 3.01 H 1-160 [» ]
3FKS X-ray 3.59 H/Q/Z 23-160 [» ]
3OE7 X-ray 3.19 H/Q/Z 24-160 [» ]
3OEE X-ray 2.74 H/Q/Z 23-160 [» ]
3OEH X-ray 3.00 H/Q/Z 23-160 [» ]
3OFN X-ray 3.20 H/Q 23-160 [» ]
3ZIA X-ray 2.50 H/R 23-160 [» ]
3ZRY X-ray 6.50 H 23-160 [» ]
4B2Q electron microscopy 37.00 H/h 29-160 [» ]
ProteinModelPortali Q12165.
SMRi Q12165. Positions 29-160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32050. 11 interactions.
DIPi DIP-3032N.
IntActi Q12165. 3 interactions.
MINTi MINT-2781010.

Protein family/group databases

TCDBi 3.A.2.1.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Proteomic databases

MaxQBi Q12165.
PaxDbi Q12165.
PeptideAtlasi Q12165.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDL004W ; YDL004W ; YDL004W .
GeneIDi 851560.
KEGGi sce:YDL004W.

Organism-specific databases

CYGDi YDL004w.
SGDi S000002162. ATP16.

Phylogenomic databases

eggNOGi COG0355.
GeneTreei ENSGT00390000017576.
HOGENOMi HOG000216023.
InParanoidi Q12165.
KOi K02134.
OMAi LPHQAIF.
OrthoDBi EOG7S7SSS.

Enzyme and pathway databases

BioCyci YEAST:G3O-29435-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q12165.
NextBioi 968992.
PROi Q12165.

Gene expression databases

Genevestigatori Q12165.

Family and domain databases

Gene3Di 2.60.15.10. 1 hit.
HAMAPi MF_00530. ATP_synth_epsil_bac.
InterProi IPR001469. ATPase_F1-cplx_dsu/esu.
IPR020546. ATPase_F1-cplx_dsu/esu_N.
[Graphical view ]
PANTHERi PTHR13822. PTHR13822. 1 hit.
Pfami PF02823. ATP-synt_DE_N. 1 hit.
[Graphical view ]
ProDomi PD000944. ATPase_F1-cplx_dsu/esu. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF51344. SSF51344. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ATP synthase of yeast mitochondria. Isolation of the F1 delta subunit, sequence and disruption of the structural gene."
    Giraud M.-F., Velours J.
    Eur. J. Biochem. 222:851-859(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 23-72; 112-121 AND 141-160.
    Strain: D273-10B/A.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase."
    Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.
    Mol. Cell. Proteomics 6:1896-1906(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  6. "Molecular architecture of the rotary motor in ATP synthase."
    Stock D., Leslie A.G., Walker J.E.
    Science 286:1700-1705(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiATPD_YEAST
AccessioniPrimary (citable) accession number: Q12165
Secondary accession number(s): D6VRY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3