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Protein

ATP synthase subunit delta, mitochondrial

Gene

ATP16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

GO - Molecular functioni

GO - Biological processi

  • ATP synthesis coupled proton transport Source: SGD

Keywordsi

Molecular functionHydrolase
Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29435-MONOMER.

Protein family/group databases

TCDBi3.A.2.1.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit delta, mitochondrial
Alternative name(s):
F-ATPase delta subunit
Gene namesi
Name:ATP16
Ordered Locus Names:YDL004W
ORF Names:D2935, YD8119.03
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL004W.
SGDiS000002162. ATP16.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 22Mitochondrion1 PublicationAdd BLAST22
ChainiPRO_000000267123 – 160ATP synthase subunit delta, mitochondrialAdd BLAST138

Proteomic databases

MaxQBiQ12165.
PRIDEiQ12165.

PTM databases

iPTMnetiQ12165.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Binary interactionsi

WithEntry#Exp.IntActNotes
DDR48P188992EBI-7926894,EBI-6165

Protein-protein interaction databases

BioGridi32050. 15 interactors.
DIPiDIP-3032N.
IntActiQ12165. 6 interactors.
MINTiMINT-2781010.
STRINGi4932.YDL004W.

Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 37Combined sources4
Beta strandi44 – 46Combined sources3
Beta strandi51 – 54Combined sources4
Beta strandi56 – 59Combined sources4
Beta strandi61 – 63Combined sources3
Beta strandi70 – 74Combined sources5
Beta strandi78 – 83Combined sources6
Beta strandi86 – 92Combined sources7
Beta strandi95 – 100Combined sources6
Turni101 – 103Combined sources3
Beta strandi104 – 110Combined sources7
Beta strandi112 – 114Combined sources3
Helixi115 – 117Combined sources3
Helixi120 – 133Combined sources14
Beta strandi136 – 139Combined sources4
Helixi140 – 156Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HLDX-ray2.80H/Q/Z23-160[»]
2WPDX-ray3.43H23-160[»]
2XOKX-ray3.01H1-160[»]
3FKSX-ray3.59H/Q/Z23-160[»]
3OE7X-ray3.19H/Q/Z24-160[»]
3OEEX-ray2.74H/Q/Z23-160[»]
3OEHX-ray3.00H/Q/Z23-160[»]
3OFNX-ray3.20H/Q23-160[»]
3ZIAX-ray2.50H/R23-160[»]
3ZRYX-ray6.50H23-160[»]
4B2Qelectron microscopy37.00H/h29-160[»]
ProteinModelPortaliQ12165.
SMRiQ12165.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12165.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase epsilon chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000017576.
HOGENOMiHOG000216023.
InParanoidiQ12165.
KOiK02134.
OMAiAANKTFY.
OrthoDBiEOG092C5CQA.

Family and domain databases

CDDicd12152. F1-ATPase_delta. 1 hit.
Gene3Di2.60.15.10. 1 hit.
HAMAPiMF_00530. ATP_synth_epsil_bac. 1 hit.
InterProiView protein in InterPro
IPR001469. ATP_synth_F1_dsu/esu.
IPR020546. ATP_synth_F1_dsu/esu_N.
PANTHERiPTHR13822. PTHR13822. 1 hit.
PfamiView protein in Pfam
PF02823. ATP-synt_DE_N. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000944. ATPase_F1-cplx_dsu/esu. 1 hit.
SUPFAMiSSF51344. SSF51344. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSIIGKSA SRSLNFVAKR SYAEAAAASS GLKLQFALPH ETLYSGSEVT
60 70 80 90 100
QVNLPAKSGR IGVLANHVPT VEQLLPGVVE VMEGSNSKKF FISGGFATVQ
110 120 130 140 150
PDSQLCVTAI EAFPLESFSQ ENIKNLLAEA KKNVSSSDAR EAAEAAIQVE
160
VLENLQSVLK
Length:160
Mass (Da):17,020
Last modified:November 1, 1996 - v1
Checksum:iAE8D0BA364107977
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21857 Genomic DNA. Translation: CAA79912.1.
Z48008 Genomic DNA. Translation: CAA88057.1.
Z48432 Genomic DNA. Translation: CAA88355.1.
Z74052 Genomic DNA. Translation: CAA98560.1.
AY558155 Genomic DNA. Translation: AAS56481.1.
BK006938 Genomic DNA. Translation: DAA11844.1.
PIRiS45632.
RefSeqiNP_010280.1. NM_001180063.1.

Genome annotation databases

EnsemblFungiiYDL004W; YDL004W; YDL004W.
GeneIDi851560.
KEGGisce:YDL004W.

Similar proteinsi

Entry informationi

Entry nameiATPD_YEAST
AccessioniPrimary (citable) accession number: Q12165
Secondary accession number(s): D6VRY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names