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Protein

Ribosome biogenesis protein SSF2

Gene

SSF2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for biogenesis of the 60S ribosomal subunit.1 Publication

GO - Molecular functioni

  • rRNA binding Source: SGD

GO - Biological processi

  • conjugation with cellular fusion Source: SGD
  • ribosomal large subunit assembly Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-29871-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein SSF2
Gene namesi
Name:SSF2
Ordered Locus Names:YDR312W
ORF Names:D9740.2
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR312W.
SGDiS000002720. SSF2.

Subcellular locationi

  • Nucleusnucleolus 1 Publication

GO - Cellular componenti

  • nucleolus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Ribosome biogenesis protein SSF2PRO_0000120260Add
BLAST

Proteomic databases

MaxQBiQ12153.

PTM databases

iPTMnetiQ12153.

Interactioni

Subunit structurei

Part of a complex that includes BRX1, RPF1, RPF2 and SSF1 or SSF2.

Binary interactionsi

WithEntry#Exp.IntActNotes
RRP15Q065115EBI-18168,EBI-34602

Protein-protein interaction databases

BioGridi32365. 54 interactions.
DIPiDIP-6502N.
IntActiQ12153. 14 interactions.
MINTiMINT-702724.

Structurei

3D structure databases

ProteinModelPortaliQ12153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 348323BrixPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Brix domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000064158.
HOGENOMiHOG000210038.
InParanoidiQ12153.
KOiK14859.
OMAiKQEQNIA.
OrthoDBiEOG7HHX3R.

Family and domain databases

InterProiIPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRRQKKRT HAQITPEQER DIPKSMVIRV GQTSLANHSL NQLVKDFRQI
60 70 80 90 100
MQPHTAVKLK ERKSNKLKDF VVMCGPLGVT HLFMFTQSEK TGNVSLKIAR
110 120 130 140 150
TPQGPTVTFQ VLDYSLGRDI KKFLKRPKSL NNDDVLNPPL LVLNGFSTSK
160 170 180 190 200
RSDEDDQDVN VEKVIVSMFQ NIFPPLNPAR TSLNSIKRIF MINKDRETGE
210 220 230 240 250
ISMRHYFIDI REVEISRNLK RLYKAKNNLS KTVPNLHRKE DISSLILDHD
260 270 280 290 300
LGAYTSESEI EDDAIVRVVD NQDVKAKHSQ TSLSQKTPVK MTDNEEREKG
310 320 330 340 350
IEEEDVEMEE PKPSENSQPT PRKKAIKLTE LGPRLTLKLV KIEDGICSGK
360 370 380 390 400
VLHHEFVQKS SEEIKALEKR HAAKMRLKEQ RRKEQEENIA KKKAVKDAKK
410 420 430 440 450
QRKLERRKAR AEEQGEGQGK DGAMSDDGSS SSEDEHYSDV PEDLDSDLFS

EVE
Length:453
Mass (Da):51,856
Last modified:November 1, 1996 - v1
Checksum:i83306767C4F58816
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18114 Genomic DNA. Translation: AAA79981.1.
U28374 Genomic DNA. Translation: AAB64748.1.
BK006938 Genomic DNA. Translation: DAA12151.1.
PIRiS50248.
RefSeqiNP_010598.3. NM_001180620.3.

Genome annotation databases

EnsemblFungiiYDR312W; YDR312W; YDR312W.
GeneIDi851907.
KEGGisce:YDR312W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18114 Genomic DNA. Translation: AAA79981.1.
U28374 Genomic DNA. Translation: AAB64748.1.
BK006938 Genomic DNA. Translation: DAA12151.1.
PIRiS50248.
RefSeqiNP_010598.3. NM_001180620.3.

3D structure databases

ProteinModelPortaliQ12153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32365. 54 interactions.
DIPiDIP-6502N.
IntActiQ12153. 14 interactions.
MINTiMINT-702724.

PTM databases

iPTMnetiQ12153.

Proteomic databases

MaxQBiQ12153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR312W; YDR312W; YDR312W.
GeneIDi851907.
KEGGisce:YDR312W.

Organism-specific databases

EuPathDBiFungiDB:YDR312W.
SGDiS000002720. SSF2.

Phylogenomic databases

GeneTreeiENSGT00530000064158.
HOGENOMiHOG000210038.
InParanoidiQ12153.
KOiK14859.
OMAiKQEQNIA.
OrthoDBiEOG7HHX3R.

Enzyme and pathway databases

BioCyciYEAST:G3O-29871-MONOMER.

Miscellaneous databases

NextBioi969924.
PROiQ12153.

Family and domain databases

InterProiIPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An essential gene pair in Saccharomyces cerevisiae with a potential role in mating."
    Yu Y., Hirsch J.P.
    DNA Cell Biol. 14:411-418(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "A nucleolar protein that affects mating efficiency in Saccharomyces cerevisiae by altering the morphological response to pheromone."
    Kim J., Hirsch J.P.
    Genetics 149:795-805(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. "Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes."
    Bogengruber E., Briza P., Doppler E., Wimmer H., Koller L., Fasiolo F., Senger B., Hegemann J.H., Breitenbach M.
    FEMS Yeast Res. 3:35-43(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSSF2_YEAST
AccessioniPrimary (citable) accession number: Q12153
Secondary accession number(s): D6VSU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1350 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.