Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative serine/threonine-protein kinase YPL150W

Gene

YPL150W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative serine/threonine-protein kinase.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei70 – 701ATPPROSITE-ProRule annotation
Active sitei157 – 1571Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi47 – 559ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: SGD
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34047-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine/threonine-protein kinase YPL150W (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:YPL150W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL150W.
SGDiS000006071. YPL150W.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 901901Putative serine/threonine-protein kinase YPL150WPRO_0000234368Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei456 – 4561PhosphoserineCombined sources
Modified residuei533 – 5331PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12152.

PTM databases

iPTMnetiQ12152.

Expressioni

Inductioni

By methyl methanesulfonate (MMS).1 Publication

Interactioni

Protein-protein interaction databases

BioGridi36033. 127 interactions.
DIPiDIP-3996N.
IntActiQ12152. 3 interactions.
MINTiMINT-531665.

Structurei

3D structure databases

ProteinModelPortaliQ12152.
SMRiQ12152. Positions 11-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 287247Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi398 – 517120Ser-richAdd
BLAST
Compositional biasi588 – 712125Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00770000120521.
HOGENOMiHOG000141766.
InParanoidiQ12152.
OMAiFYDITTA.
OrthoDBiEOG092C28UW.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNPVGSSKL EQNNIKSIIG SSYNRLYSQF TSDELTEVGN YKILKQIGEG
60 70 80 90 100
SFGKVYLALH RPTHRKVCLK TSDKNDPNIV REVFYHRQFD FPYITKLYEV
110 120 130 140 150
IVTESKVWMA LEYCPGKELY DHLLSLRRIS LLECGELFAQ ISGAVYYAHS
160 170 180 190 200
MHCVHRDLKL ENILLDKNGN AKLTDFGFTR ECMTKTTLET VCGTTVYMAP
210 220 230 240 250
ELIERRTYDG FKIDIWSLGV ILYTLITGYL PFDDDDEAKT KWKIVNEEPK
260 270 280 290 300
YDAKVIPDDA RDLISRLLAK NPGERPSLSQ VLRHPFLQPY GSVVLDQTQK
310 320 330 340 350
ILCRQRSGGT QFKSKLERRL LKRLKQSGVD TQAIKQSILK KKCDSLSGLW
360 370 380 390 400
LLLLAQGKKQ ENCKYPKRSR SVLSVKKVIE SATHNDTNGI SEDVLKPSLE
410 420 430 440 450
LSRAASLSKM LNKGSDFVTS MTPVSRKKSK DSAKVLNPTL SKISSQRAYS
460 470 480 490 500
HSIAGSPRKS NNFLQKVSSF FKSKKSSNSN SNNSIHTNVS ESLIASNRGA
510 520 530 540 550
PSSGSFLKKN SGSIQKSRTD TVANPSRTES IGSLNENVAG AIVPRSANNT
560 570 580 590 600
TLENKKTSGN EIGLKVAPEL LLNEHIRIEE PRLKRFKSSI SSEISQTSTG
610 620 630 640 650
NYDSESAENS RSISFDGKVS PPPIRNRPLS EISQISNDTY ISEYSTDGNN
660 670 680 690 700
SSFKISDTIK PSYIRKGSET TSQYSASSEK MTNGYGRKFV RRDLSIVSTA
710 720 730 740 750
SSTSERSSRT DSFYDITTAT PVVTTDNRRN KNNNLKESVL PRFGTQRPWT
760 770 780 790 800
GKRTYTTSRH GKNARRSSKR GLFKITSSNT DSIIQEVSSS EEEDHNVIYS
810 820 830 840 850
KGKGLPTPVL QTKGLIENGL NERDEEGDDE YAIHTDGEFS IKPQFSDDVI
860 870 880 890 900
DKQNHLPSVK AVATKRSLSE GSNWSSSYLD SDNNRRRVSS LLVEDGGNPT

A
Length:901
Mass (Da):100,646
Last modified:November 1, 1996 - v1
Checksum:i7E32C5ECB353A06C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96770 Genomic DNA. Translation: CAA65571.1.
Z73506 Genomic DNA. Translation: CAA97855.1.
BK006949 Genomic DNA. Translation: DAA11285.1.
PIRiS65161.
RefSeqiNP_015175.1. NM_001183964.1.

Genome annotation databases

EnsemblFungiiYPL150W; YPL150W; YPL150W.
GeneIDi855953.
KEGGisce:YPL150W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96770 Genomic DNA. Translation: CAA65571.1.
Z73506 Genomic DNA. Translation: CAA97855.1.
BK006949 Genomic DNA. Translation: DAA11285.1.
PIRiS65161.
RefSeqiNP_015175.1. NM_001183964.1.

3D structure databases

ProteinModelPortaliQ12152.
SMRiQ12152. Positions 11-353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36033. 127 interactions.
DIPiDIP-3996N.
IntActiQ12152. 3 interactions.
MINTiMINT-531665.

PTM databases

iPTMnetiQ12152.

Proteomic databases

MaxQBiQ12152.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL150W; YPL150W; YPL150W.
GeneIDi855953.
KEGGisce:YPL150W.

Organism-specific databases

EuPathDBiFungiDB:YPL150W.
SGDiS000006071. YPL150W.

Phylogenomic databases

GeneTreeiENSGT00770000120521.
HOGENOMiHOG000141766.
InParanoidiQ12152.
OMAiFYDITTA.
OrthoDBiEOG092C28UW.

Enzyme and pathway databases

BioCyciYEAST:G3O-34047-MONOMER.

Miscellaneous databases

PROiQ12152.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYP150_YEAST
AccessioniPrimary (citable) accession number: Q12152
Secondary accession number(s): D6W3L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.