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Q12144

- PER33_YEAST

UniProt

Q12144 - PER33_YEAST

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Protein
Pore and endoplasmic reticulum protein of 33 kDa
Gene
PER33, YLR064W, L2177
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. mRNA transport Source: UniProtKB-KW
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32217-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pore and endoplasmic reticulum protein of 33 kDa
Gene namesi
Name:PER33
Ordered Locus Names:YLR064W
ORF Names:L2177
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLR064w.
SGDiS000004054. PER33.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleusnuclear pore complex 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei25 – 4521Helical; Reviewed prediction
Add
BLAST
Topological domaini46 – 5611Lumenal Reviewed prediction
Add
BLAST
Transmembranei57 – 7418Helical; Reviewed prediction
Add
BLAST
Topological domaini75 – 9824Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei99 – 11921Helical; Reviewed prediction
Add
BLAST
Topological domaini120 – 1267Lumenal Reviewed prediction
Transmembranei127 – 14721Helical; Reviewed prediction
Add
BLAST
Topological domaini148 – 17629Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei177 – 19721Helical; Reviewed prediction
Add
BLAST
Topological domaini198 – 1992Lumenal Reviewed prediction
Transmembranei200 – 22021Helical; Reviewed prediction
Add
BLAST
Topological domaini221 – 27353Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. nuclear pore Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Pore and endoplasmic reticulum protein of 33 kDa
PRO_0000247231Add
BLAST

Proteomic databases

MaxQBiQ12144.
PaxDbiQ12144.

Expressioni

Gene expression databases

GenevestigatoriQ12144.

Interactioni

Protein-protein interaction databases

BioGridi31338. 37 interactions.
DIPiDIP-4778N.
IntActiQ12144. 3 interactions.
MINTiMINT-516871.
STRINGi4932.YLR064W.

Structurei

3D structure databases

ProteinModelPortaliQ12144.

Family & Domainsi

Sequence similaritiesi

Belongs to the PER33/POM33 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG264936.
OMAiIVHIAWI.
OrthoDBiEOG7WX0N1.

Sequencei

Sequence statusi: Complete.

Q12144-1 [UniParc]FASTAAdd to Basket

« Hide

MTVPRNRPMA PFGTIIKSRI KQPQFYWFIG HFLTIFNFIQ FHLSITSKQN    50
QLSCYRRSLF YISVTYAIVL YQFFKSDQLK FNFTLLRQEM KKLDNLQYFA 100
MLFILFLLSQ FNIIISGSLY SPVIFSIFHF LNYFKENLLP FLPLIPLNLK 150
NLLNSKITVF IQNYNGFFLQ MAQVFEIICG LRVGLFLVPF NFFLLLVRRA 200
NVSFEVVGTM LAGLTYVWFF KLRYLQSESM RQIFKQYVLR LDAYVSRTLP 250
PYCSRLWNGY KNFVMTVFWK IPV 273
Length:273
Mass (Da):32,637
Last modified:November 1, 1996 - v1
Checksum:iF6B7E3A3D1D74F38
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94607 Genomic DNA. Translation: CAA64310.1.
Z73236 Genomic DNA. Translation: CAA97620.1.
AY692677 Genomic DNA. Translation: AAT92696.1.
BK006945 Genomic DNA. Translation: DAA09381.1.
PIRiS61637.
RefSeqiNP_013165.1. NM_001181951.1.

Genome annotation databases

EnsemblFungiiYLR064W; YLR064W; YLR064W.
GeneIDi850753.
KEGGisce:YLR064W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94607 Genomic DNA. Translation: CAA64310.1 .
Z73236 Genomic DNA. Translation: CAA97620.1 .
AY692677 Genomic DNA. Translation: AAT92696.1 .
BK006945 Genomic DNA. Translation: DAA09381.1 .
PIRi S61637.
RefSeqi NP_013165.1. NM_001181951.1.

3D structure databases

ProteinModelPortali Q12144.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31338. 37 interactions.
DIPi DIP-4778N.
IntActi Q12144. 3 interactions.
MINTi MINT-516871.
STRINGi 4932.YLR064W.

Proteomic databases

MaxQBi Q12144.
PaxDbi Q12144.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR064W ; YLR064W ; YLR064W .
GeneIDi 850753.
KEGGi sce:YLR064W.

Organism-specific databases

CYGDi YLR064w.
SGDi S000004054. PER33.

Phylogenomic databases

eggNOGi NOG264936.
OMAi IVHIAWI.
OrthoDBi EOG7WX0N1.

Enzyme and pathway databases

BioCyci YEAST:G3O-32217-MONOMER.

Miscellaneous databases

NextBioi 966888.

Gene expression databases

Genevestigatori Q12144.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  7. "Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution."
    Chadrin A., Hess B., San Roman M., Gatti X., Lombard B., Loew D., Barral Y., Palancade B., Doye V.
    J. Cell Biol. 189:795-811(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPER33_YEAST
AccessioniPrimary (citable) accession number: Q12144
Secondary accession number(s): D6VY65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2240 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3

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