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Q12144 (PER33_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pore and endoplasmic reticulum protein of 33 kDa
Gene names
Name:PER33
Ordered Locus Names:YLR064W
ORF Names:L2177
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus › nuclear pore complex Ref.4 Ref.7.

Miscellaneous

Present with 2240 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the PER33/POM33 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273Pore and endoplasmic reticulum protein of 33 kDa
PRO_0000247231

Regions

Topological domain1 – 2424Cytoplasmic Potential
Transmembrane25 – 4521Helical; Potential
Topological domain46 – 5611Lumenal Potential
Transmembrane57 – 7418Helical; Potential
Topological domain75 – 9824Cytoplasmic Potential
Transmembrane99 – 11921Helical; Potential
Topological domain120 – 1267Lumenal Potential
Transmembrane127 – 14721Helical; Potential
Topological domain148 – 17629Cytoplasmic Potential
Transmembrane177 – 19721Helical; Potential
Topological domain198 – 1992Lumenal Potential
Transmembrane200 – 22021Helical; Potential
Topological domain221 – 27353Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q12144 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F6B7E3A3D1D74F38

FASTA27332,637
        10         20         30         40         50         60 
MTVPRNRPMA PFGTIIKSRI KQPQFYWFIG HFLTIFNFIQ FHLSITSKQN QLSCYRRSLF 

        70         80         90        100        110        120 
YISVTYAIVL YQFFKSDQLK FNFTLLRQEM KKLDNLQYFA MLFILFLLSQ FNIIISGSLY 

       130        140        150        160        170        180 
SPVIFSIFHF LNYFKENLLP FLPLIPLNLK NLLNSKITVF IQNYNGFFLQ MAQVFEIICG 

       190        200        210        220        230        240 
LRVGLFLVPF NFFLLLVRRA NVSFEVVGTM LAGLTYVWFF KLRYLQSESM RQIFKQYVLR 

       250        260        270 
LDAYVSRTLP PYCSRLWNGY KNFVMTVFWK IPV

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[7]"Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution."
Chadrin A., Hess B., San Roman M., Gatti X., Lombard B., Loew D., Barral Y., Palancade B., Doye V.
J. Cell Biol. 189:795-811(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X94607 Genomic DNA. Translation: CAA64310.1.
Z73236 Genomic DNA. Translation: CAA97620.1.
AY692677 Genomic DNA. Translation: AAT92696.1.
BK006945 Genomic DNA. Translation: DAA09381.1.
PIRS61637.
RefSeqNP_013165.1. NM_001181951.1.

3D structure databases

ProteinModelPortalQ12144.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4778N.
IntActQ12144. 3 interactions.
MINTMINT-516871.
STRING4932.YLR064W.

Proteomic databases

PaxDbQ12144.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR064W; YLR064W; YLR064W.
GeneID850753.
KEGGsce:YLR064W.

Organism-specific databases

CYGDYLR064w.
SGDS000004054. PER33.

Phylogenomic databases

eggNOGNOG264936.
GeneTreeENSGT00530000068013.
OMAAIFAVFH.
OrthoDBEOG40GH1D.

Gene expression databases

GenevestigatorQ12144.
GermOnlineYLR064W. Saccharomyces cerevisiae.

Family and domain databases

ProtoNetSearch...

Other

NextBio966888.

Entry information

Entry namePER33_YEAST
AccessionPrimary (citable) accession number: Q12144
Secondary accession number(s): D6VY65
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents