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Protein

Something about silencing protein 10

Gene

SAS10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Primarily required at the G2/M phase. Essential for viability: involved in nucleolar processing of pre-18S ribosomal RNA as part of the ribosomal small subunit (SSU) processome.1 Publication

Miscellaneous

When overexpressed, has a role in the structure of silenced chromatin. Overproduction causes derepression of gene expression at both HML and HMR, as well as at the rDNA locus and at telomeres.

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein
Biological processCell cycle, Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-29548-MONOMER
ReactomeiR-SCE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Something about silencing protein 10
Alternative name(s):
U three protein 3
U3 small nucleolar RNA-associated protein 3
U3 snoRNA-associated protein 11
Gene namesi
Name:SAS10
Synonyms:UTP3
Ordered Locus Names:YDL153C
ORF Names:D1545
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL153C
SGDiS000002312 SAS10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001143301 – 610Something about silencing protein 10Add BLAST610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12136
PaxDbiQ12136
PRIDEiQ12136

PTM databases

iPTMnetiQ12136

Interactioni

Subunit structurei

Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi31910, 132 interactors
DIPiDIP-5047N
IntActiQ12136, 67 interactors
MINTiQ12136
STRINGi4932.YDL153C

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WLCelectron microscopy3.80NB1-610[»]
ProteinModelPortaliQ12136
SMRiQ12136
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 86Poly-GluAdd BLAST12
Compositional biasi167 – 172Poly-Glu6
Compositional biasi360 – 365Poly-Glu6

Sequence similaritiesi

Belongs to the SAS10 family.Curated

Phylogenomic databases

GeneTreeiENSGT00500000044947
HOGENOMiHOG000207285
InParanoidiQ12136
KOiK14767
OMAiDEYYDMV
OrthoDBiEOG092C4F9B

Family and domain databases

InterProiView protein in InterPro
IPR018972 Sas10_C_dom
PfamiView protein in Pfam
PF09368 Sas10, 1 hit

Sequencei

Sequence statusi: Complete.

Q12136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRKGSNRTK TSEVGDEINP YGLNEVDDFA SKREKVLLGQ STFGDSNKDD
60 70 80 90 100
DHSLLEDEDE EEVLAMDEDD ESIDEREDEE EEEEEELDGA AAYKKIFGRN
110 120 130 140 150
LETDQLPEED EENGMLDNEN AWGSTKGEYY GADDLDDDEA AKEIEKEALR
160 170 180 190 200
QQKKHLEELN MNDYLDEEEE EEWVKSAKEF DMGEFKNSTK QADTKTSITD
210 220 230 240 250
ILNMDDEARD NYLRTMFPEF APLSKEFTEL APKFDELKKS EENEFNKLKL
260 270 280 290 300
IALGSYLGTI SCYYSILLHE LHNNEDFTSM KGHPVMEKIL TTKEIWRQAS
310 320 330 340 350
ELPSSFDVNE GDGSESEETA NIEAFNEKKL NELQNSEDSD AEDGGKQKQE
360 370 380 390 400
IDEEERESDE EEEEEDVDID DFEEYVAQSR LHSKPKTSSM PEADDFIESE
410 420 430 440 450
IADVDAQDKK ARRRTLRFYT SKIDQQENKK TDRFKGDDDI PYKERLFERQ
460 470 480 490 500
QRLLDEARKR GMHDNNGADL DDKDYGSEDE AVSRSINTQG ENDYYQQVQR
510 520 530 540 550
GKQDKKISRK EAHKNAVIAA REGKLAELAE NVSGDGKRAI NYQILKNKGL
560 570 580 590 600
TPKRNKDNRN SRVKKRKKYQ KAQKKLKSVR AVYSGGQSGV YEGEKTGIKK
610
GLTRSVKFKN
Length:610
Mass (Da):70,259
Last modified:November 1, 1996 - v1
Checksum:i9278BF873834FC7E
GO

Sequence cautioni

The sequence CAA66339 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63063 mRNA Translation: AAB05801.1
X97751 Genomic DNA Translation: CAA66339.1 Different initiation.
Z74201 Genomic DNA Translation: CAA98726.1
AY692844 Genomic DNA Translation: AAT92863.1
BK006938 Genomic DNA Translation: DAA11707.1
PIRiS67701
RefSeqiNP_010128.1, NM_001180213.1

Genome annotation databases

EnsemblFungiiYDL153C; YDL153C; YDL153C
GeneIDi851403
KEGGisce:YDL153C

Similar proteinsi

Entry informationi

Entry nameiSAS10_YEAST
AccessioniPrimary (citable) accession number: Q12136
Secondary accession number(s): D6VRJ7, Q05842
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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