Reviewed, UniProtKB/Swiss-Prot Q12134 (HUA2_YEAST)

Names and origin

Protein names

Recommended name:
    Protein HUA2

Gene names

Name:	HUA2
Ordered Locus Names:	YOR284W

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May have a role in actin patch assembly. Ref.5
Subcellular location	Cytoplasm Ref.3.
Miscellaneous	Present with 1360 molecules/cell in log phase SD medium. Ref.4

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Ref.3 Inferred from direct assay. Source: SGD
Molecular function	identical protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		1	EBI-37262,EBI-37262
ABP1	P15891	2	EBI-37262,EBI-2036
GCD7	P32502	1	EBI-37262,EBI-6260
SRP1	Q02821	1	EBI-37262,EBI-1797
TEM1	P38987	1	EBI-37262,EBI-19113

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 243	243	Protein HUA2		PRO_0000270558

Sequences

	Sequence		Length	Mass (Da)
	Q12134-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: B1F3A81B7C0F65AC	FASTA	243	28,414
	10 20 30 40 50 60 MQQTKFGKMY LDHDSVVEYS EDEIVEADRI TLGYKKRLSM IENQMRHLLE DFSLDVQQIE 70 80 90 100 110 120 PILADLQKYY DAFLQLLQKR NKSLQCKRST HQPVPSPMNS QTSTNAKVNL SGKLMKFQLN 130 140 150 160 170 180 SVQKFDEENI LRILQNKIEF EHYFQIDKGK KQKVLLLAVY QCLNGPTRLH KVLNIEGIIH 190 200 210 220 230 240 NNSIRTILGK QVSSSKWTVF LYDVKLVLLA HRQDVPNLET SKMIVRYGDL FPCALYFKDH TAY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of Saccharomyces cerevisiae." Cheret G., Bernardi A., Sor F.J. Yeast 12:1059-1064(1996) [PubMed: 8896271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed: 9169874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Predicting protein functions from redundancies in large-scale protein interaction networks." Samanta M.P., Liang S. Proc. Natl. Acad. Sci. U.S.A. 100:12579-12583(2003) [PubMed: 14566057] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X89633 Genomic DNA. Translation: CAA61788.1. Z75192 Genomic DNA. Translation: CAA99511.1.
PIR	S67186.
RefSeq	NP_014927.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1472N.
IntAct	Q12134. 29 interactions.
STRING	Q12134.
Genome annotation databases
Ensembl	YOR284W; YOR284W; YOR284W; Saccharomyces cerevisiae. [Genome view]
GeneID	854458.
KEGG	sce:YOR284W.
NMPDR	fig|4932.3.peg.6039.
Organism-specific databases
CYGD	YOR284w.
SGD	S000005810. HUA2.
Phylogenomic databases
OrthoDB	EOG969SC0.
PhylomeDB	Q12134.
Gene expression databases
ArrayExpress	Q12134.
Genevestigator	Q12134.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	976730.

Entry information

Entry name

HUA2_YEAST

Accession

Primary (citable) accession number: Q12134

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	November 1, 1996
Last modified:	January 19, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)