Q12134 (HUA2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein HUA2

Gene names

Name:	HUA2
Ordered Locus Names:	YOR284W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have a role in actin patch assembly. Ref.6
Subcellular location	Cytoplasm Ref.4.
Miscellaneous	Present with 1360 molecules/cell in log phase SD medium.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay Ref.4. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABP1	P15891	3	EBI-37262,EBI-2036

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 243	243	Protein HUA2		PRO_0000270558

Sequences

	Sequence		Length	Mass (Da)
	Q12134 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: B1F3A81B7C0F65AC	FASTA	243	28,414
	10 20 30 40 50 60 MQQTKFGKMY LDHDSVVEYS EDEIVEADRI TLGYKKRLSM IENQMRHLLE DFSLDVQQIE 70 80 90 100 110 120 PILADLQKYY DAFLQLLQKR NKSLQCKRST HQPVPSPMNS QTSTNAKVNL SGKLMKFQLN 130 140 150 160 170 180 SVQKFDEENI LRILQNKIEF EHYFQIDKGK KQKVLLLAVY QCLNGPTRLH KVLNIEGIIH 190 200 210 220 230 240 NNSIRTILGK QVSSSKWTVF LYDVKLVLLA HRQDVPNLET SKMIVRYGDL FPCALYFKDH TAY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of Saccharomyces cerevisiae." Cheret G., Bernardi A., Sor F.J. Yeast 12:1059-1064(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Predicting protein functions from redundancies in large-scale protein interaction networks." Samanta M.P., Liang S. Proc. Natl. Acad. Sci. U.S.A. 100:12579-12583(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X89633 Genomic DNA. Translation: CAA61788.1. Z75192 Genomic DNA. Translation: CAA99511.1. BK006948 Genomic DNA. Translation: DAA11048.1.
PIR	S67186.
RefSeq	NP_014927.3. NM_001183703.3.
3D structure databases
ProteinModelPortal	Q12134.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1472N.
IntAct	Q12134. 23 interactions.
MINT	MINT-388764.
STRING	4932.YOR284W.
Proteomic databases
PaxDb	Q12134.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YOR284W; YOR284W; YOR284W.
GeneID	854458.
KEGG	sce:YOR284W. sce:YOR286W.
Organism-specific databases
CYGD	YOR284w.
SGD	S000005810. HUA2.
Gene expression databases
Genevestigator	Q12134.
Family and domain databases
ProtoNet	Search...
Other
NextBio	976730.

Entry information

Entry name

HUA2_YEAST

Accession

Primary (citable) accession number: Q12134
Secondary accession number(s): D6W2Y2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program