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Protein

Golgi to ER traffic protein 4

Gene

GET4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in insertion of tail-anchored proteins into the endoplasmic reticulum membrane.1 Publication

Miscellaneous

Present with 5350 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • posttranslational protein targeting to endoplasmic reticulum membrane Source: SGD
  • protein insertion into ER membrane Source: SGD
  • vesicle-mediated transport Source: UniProtKB-KW

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33680-MONOMER

Protein family/group databases

TCDBi3.A.21.1.1 the c-terminal tail-anchored membrane protein biogenesis/ insertion complex (tamp-b) family

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi to ER traffic protein 4
Alternative name(s):
Guided entry of tail-anchored proteins 4
Gene namesi
Name:GET4
Ordered Locus Names:YOR164C
ORF Names:O3580
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR164C
SGDiS000005690 GET4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002281071 – 312Golgi to ER traffic protein 4Add BLAST312

Proteomic databases

MaxQBiQ12125
PaxDbiQ12125
PRIDEiQ12125

Interactioni

Subunit structurei

Interacts with MDY2/GET5.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34560, 176 interactors
DIPiDIP-2005N
IntActiQ12125, 16 interactors
MINTiQ12125
STRINGi4932.YOR164C

Structurei

Secondary structure

1312
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 26Combined sources14
Helixi29 – 45Combined sources17
Helixi49 – 65Combined sources17
Helixi69 – 85Combined sources17
Helixi92 – 102Combined sources11
Helixi112 – 125Combined sources14
Helixi134 – 146Combined sources13
Helixi150 – 158Combined sources9
Helixi162 – 178Combined sources17
Helixi184 – 200Combined sources17
Helixi204 – 222Combined sources19
Beta strandi226 – 231Combined sources6
Beta strandi234 – 241Combined sources8
Helixi243 – 257Combined sources15
Helixi260 – 269Combined sources10
Helixi271 – 276Combined sources6
Helixi278 – 289Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WPVX-ray1.99A/C/E/G1-312[»]
3LKUX-ray2.80A/C/E11-300[»]
4PWXX-ray5.40C/E11-290[»]
5BW8X-ray2.80C1-290[»]
5BWKX-ray6.00E/G/I/K/Q/S/U/W11-311[»]
ProteinModelPortaliQ12125
SMRiQ12125
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12125

Family & Domainsi

Sequence similaritiesi

Belongs to the GET4 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000015750
InParanoidiQ12125
OMAiQMYRTLF
OrthoDBiEOG092C4XI0

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011990 TPR-like_helical_dom_sf
IPR007317 UPF0363
PANTHERiPTHR12875 PTHR12875, 1 hit
PfamiView protein in Pfam
PF04190 DUF410, 1 hit

Sequencei

Sequence statusi: Complete.

Q12125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPAESNAVQ AKLAKTLQRF ENKIKAGDYY EAHQTLRTIA NRYVRSKSYE
60 70 80 90 100
HAIELISQGA LSFLKAKQGG SGTDLIFYLL EVYDLAEVKV DDISVARLVR
110 120 130 140 150
LIAELDPSEP NLKDVITGMN NWSIKFSEYK FGDPYLHNTI GSKLLEGDFV
160 170 180 190 200
YEAERYFMLG THDSMIKYVD LLWDWLCQVD DIEDSTVAEF FSRLVFNYLF
210 220 230 240 250
ISNISFAHES KDIFLERFIE KFHPKYEKID KNGYEIVFFE DYSDLNFLQL
260 270 280 290 300
LLITCQTKDK SYFLNLKNHY LDFSQAYKSE LEFLGQEYFN IVAPKQTNFL
310
QDMMSGFLGG SK
Length:312
Mass (Da):36,280
Last modified:November 1, 1996 - v1
Checksum:i98AFFDB4EA51B40F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55021 Genomic DNA Translation: AAB47411.1
Z75072 Genomic DNA Translation: CAA99370.1
AY558036 Genomic DNA Translation: AAS56362.1
BK006948 Genomic DNA Translation: DAA10938.1
PIRiS67052
RefSeqiNP_014807.3, NM_001183583.3

Genome annotation databases

EnsemblFungiiYOR164C; YOR164C; YOR164C
GeneIDi854335
KEGGisce:YOR164C

Similar proteinsi

Entry informationi

Entry nameiGET4_YEAST
AccessioniPrimary (citable) accession number: Q12125
Secondary accession number(s): D6W2M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health