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Q12119

- FCY22_YEAST

UniProt

Q12119 - FCY22_YEAST

Protein

Purine-cytosine permease FCY22

Gene

FCY22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Probable purine-cytosine permease.By similarity

    GO - Molecular functioni

    1. nucleobase transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. cytosine transport Source: SGD
    2. purine-containing compound transmembrane transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30354-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Purine-cytosine permease FCY22
    Short name:
    PCP FCY22
    Alternative name(s):
    Cytosine/purine transport protein FCY22
    Fluorocytosine resistance protein 22
    Gene namesi
    Name:FCY22
    Synonyms:FCYX
    Ordered Locus Names:YER060W-A
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER060w-a.
    SGDiS000002958. FCY22.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Purine-cytosine permease FCY22PRO_0000197922Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ12119.

    Interactioni

    Protein-protein interaction databases

    BioGridi36802. 14 interactions.
    DIPiDIP-8900N.
    STRINGi4932.YER060W-A.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12119.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei96 – 11621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei119 – 13921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei220 – 24021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei345 – 36521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei396 – 41621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei418 – 43821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei463 – 48321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the purine-cytosine permease family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1457.
    GeneTreeiENSGT00390000004423.
    HOGENOMiHOG000162981.
    OrthoDBiEOG75QRD0.

    Family and domain databases

    InterProiIPR001248. Cyt_pur_permease.
    IPR012681. NCS1.
    IPR026030. Pur-cyt_permease.
    [Graphical view]
    PfamiPF02133. Transp_cyt_pur. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002744. Pur-cyt_permease. 1 hit.
    TIGRFAMsiTIGR00800. ncs1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q12119-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPEKLAMSMV DIKDAGSELR DLESGALDTK SSAADVYYEG VELHRTNEFI    50
    DNKPSFFNRI AAALNAETKG IEPVTEDEKN DDSILNAATI WFSANMVIVA 100
    YSVGALGPLV FGLNFGQSVL VIIFFNILGL IPVALFSLFG VELGLRQMIL 150
    SRYLAGNITA RFFSLVNVIA CVGWCVLNIS VSAQLLNMVN EGSGHNCPIW 200
    AGCLIIAGGT VLVTFFGYSV VHAYEKWSWV PNFAAFLVII AQLSRSGKFK 250
    GGEWVGGATT AGGVLSFGSS VFGSAAGWAT YAADYTVYMP KTTSKYKIFF 300
    SVVAGLAFPL FFTMILGAAC GMAALNDPTW KSYYDKNAMG GVIYAILVPN 350
    SLNGFGQFCC VLLALSTVAN NVPGMYTVAL SAQALWAPLA KIPRVVWTMA 400
    GNAATLGISI PATYYFDGFM ENFMDSIGYY LAIYIAIACS EHFIYRRSFS 450
    AYNIDDWDNW EHLPIGIAGT AALIAGAFGV ALGMCQTYWV GEISRLIGEY 500
    GGDIGFELGG SWAFIIYNIV RPLELKYFGR 530
    Length:530
    Mass (Da):57,327
    Last modified:November 1, 1996 - v1
    Checksum:i620FF2F2F3A2702D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97346 Genomic DNA. Translation: CAA66033.1.
    U18813 Genomic DNA. Translation: AAB64610.1.
    BK006939 Genomic DNA. Translation: DAA07719.1.
    RefSeqiNP_010982.1. NM_001180858.1.

    Genome annotation databases

    EnsemblFungiiYER060W-A; YER060W-A; YER060W-A.
    GeneIDi856789.
    KEGGisce:YER060W-A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97346 Genomic DNA. Translation: CAA66033.1 .
    U18813 Genomic DNA. Translation: AAB64610.1 .
    BK006939 Genomic DNA. Translation: DAA07719.1 .
    RefSeqi NP_010982.1. NM_001180858.1.

    3D structure databases

    ProteinModelPortali Q12119.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36802. 14 interactions.
    DIPi DIP-8900N.
    STRINGi 4932.YER060W-A.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER060W-A ; YER060W-A ; YER060W-A .
    GeneIDi 856789.
    KEGGi sce:YER060W-A.

    Organism-specific databases

    CYGDi YER060w-a.
    SGDi S000002958. FCY22.

    Phylogenomic databases

    eggNOGi COG1457.
    GeneTreei ENSGT00390000004423.
    HOGENOMi HOG000162981.
    OrthoDBi EOG75QRD0.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30354-MONOMER.

    Miscellaneous databases

    NextBioi 983015.

    Gene expression databases

    Genevestigatori Q12119.

    Family and domain databases

    InterProi IPR001248. Cyt_pur_permease.
    IPR012681. NCS1.
    IPR026030. Pur-cyt_permease.
    [Graphical view ]
    Pfami PF02133. Transp_cyt_pur. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002744. Pur-cyt_permease. 1 hit.
    TIGRFAMsi TIGR00800. ncs1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Straub M.-L., Souciet J.-L., Potier S., de Montigny J.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 28383 / FL100 / VTT C-80102.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiFCY22_YEAST
    AccessioniPrimary (citable) accession number: Q12119
    Secondary accession number(s): D3DLW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3