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Protein

Purine-cytosine permease FCY22

Gene

FCY22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable purine-cytosine permease.By similarity

GO - Molecular functioni

  1. nucleobase transmembrane transporter activity Source: SGD

GO - Biological processi

  1. cytosine transport Source: SGD
  2. purine-containing compound transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30354-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine-cytosine permease FCY22
Short name:
PCP FCY22
Alternative name(s):
Cytosine/purine transport protein FCY22
Fluorocytosine resistance protein 22
Gene namesi
Name:FCY22
Synonyms:FCYX
Ordered Locus Names:YER060W-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome V

Organism-specific databases

CYGDiYER060w-a.
EuPathDBiFungiDB:YER060W-A.
SGDiS000002958. FCY22.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei96 – 11621HelicalSequence AnalysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence AnalysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence AnalysisAdd
BLAST
Transmembranei298 – 31821HelicalSequence AnalysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence AnalysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence AnalysisAdd
BLAST
Transmembranei396 – 41621HelicalSequence AnalysisAdd
BLAST
Transmembranei418 – 43821HelicalSequence AnalysisAdd
BLAST
Transmembranei463 – 48321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Purine-cytosine permease FCY22PRO_0000197922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

GenevestigatoriQ12119.

Interactioni

Protein-protein interaction databases

BioGridi36802. 14 interactions.
DIPiDIP-8900N.
STRINGi4932.YER060W-A.

Structurei

3D structure databases

ProteinModelPortaliQ12119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine-cytosine permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1457.
GeneTreeiENSGT00390000004423.
HOGENOMiHOG000162981.
InParanoidiQ12119.
OMAiMNVIGYW.
OrthoDBiEOG75QRD0.

Family and domain databases

InterProiIPR001248. Cyt_pur_permease.
IPR012681. NCS1.
IPR026030. Pur-cyt_permease.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
PIRSFiPIRSF002744. Pur-cyt_permease. 1 hit.
TIGRFAMsiTIGR00800. ncs1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12119-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEKLAMSMV DIKDAGSELR DLESGALDTK SSAADVYYEG VELHRTNEFI
60 70 80 90 100
DNKPSFFNRI AAALNAETKG IEPVTEDEKN DDSILNAATI WFSANMVIVA
110 120 130 140 150
YSVGALGPLV FGLNFGQSVL VIIFFNILGL IPVALFSLFG VELGLRQMIL
160 170 180 190 200
SRYLAGNITA RFFSLVNVIA CVGWCVLNIS VSAQLLNMVN EGSGHNCPIW
210 220 230 240 250
AGCLIIAGGT VLVTFFGYSV VHAYEKWSWV PNFAAFLVII AQLSRSGKFK
260 270 280 290 300
GGEWVGGATT AGGVLSFGSS VFGSAAGWAT YAADYTVYMP KTTSKYKIFF
310 320 330 340 350
SVVAGLAFPL FFTMILGAAC GMAALNDPTW KSYYDKNAMG GVIYAILVPN
360 370 380 390 400
SLNGFGQFCC VLLALSTVAN NVPGMYTVAL SAQALWAPLA KIPRVVWTMA
410 420 430 440 450
GNAATLGISI PATYYFDGFM ENFMDSIGYY LAIYIAIACS EHFIYRRSFS
460 470 480 490 500
AYNIDDWDNW EHLPIGIAGT AALIAGAFGV ALGMCQTYWV GEISRLIGEY
510 520 530
GGDIGFELGG SWAFIIYNIV RPLELKYFGR
Length:530
Mass (Da):57,327
Last modified:November 1, 1996 - v1
Checksum:i620FF2F2F3A2702D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97346 Genomic DNA. Translation: CAA66033.1.
U18813 Genomic DNA. Translation: AAB64610.1.
BK006939 Genomic DNA. Translation: DAA07719.1.
RefSeqiNP_010982.1. NM_001180858.1.

Genome annotation databases

EnsemblFungiiYER060W-A; YER060W-A; YER060W-A.
GeneIDi856789.
KEGGisce:YER060W-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97346 Genomic DNA. Translation: CAA66033.1.
U18813 Genomic DNA. Translation: AAB64610.1.
BK006939 Genomic DNA. Translation: DAA07719.1.
RefSeqiNP_010982.1. NM_001180858.1.

3D structure databases

ProteinModelPortaliQ12119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36802. 14 interactions.
DIPiDIP-8900N.
STRINGi4932.YER060W-A.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER060W-A; YER060W-A; YER060W-A.
GeneIDi856789.
KEGGisce:YER060W-A.

Organism-specific databases

CYGDiYER060w-a.
EuPathDBiFungiDB:YER060W-A.
SGDiS000002958. FCY22.

Phylogenomic databases

eggNOGiCOG1457.
GeneTreeiENSGT00390000004423.
HOGENOMiHOG000162981.
InParanoidiQ12119.
OMAiMNVIGYW.
OrthoDBiEOG75QRD0.

Enzyme and pathway databases

BioCyciYEAST:G3O-30354-MONOMER.

Miscellaneous databases

NextBioi983015.
PROiQ12119.

Gene expression databases

GenevestigatoriQ12119.

Family and domain databases

InterProiIPR001248. Cyt_pur_permease.
IPR012681. NCS1.
IPR026030. Pur-cyt_permease.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
PIRSFiPIRSF002744. Pur-cyt_permease. 1 hit.
TIGRFAMsiTIGR00800. ncs1. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Straub M.-L., Souciet J.-L., Potier S., de Montigny J.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 28383 / FL100 / VTT C-80102.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiFCY22_YEAST
AccessioniPrimary (citable) accession number: Q12119
Secondary accession number(s): D3DLW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: April 29, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.