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Protein

Purine-cytosine permease FCY22

Gene

FCY22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable purine-cytosine permease.By similarity

GO - Molecular functioni

  • nucleobase transmembrane transporter activity Source: SGD

GO - Biological processi

  • cytosine transport Source: SGD
  • purine-containing compound transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30354-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine-cytosine permease FCY22
Short name:
PCP FCY22
Alternative name(s):
Cytosine/purine transport protein FCY22
Fluorocytosine resistance protein 22
Gene namesi
Name:FCY22
Synonyms:FCYX
Ordered Locus Names:YER060W-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER060W-A.
SGDiS000002958. FCY22.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Transmembranei463 – 483HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001979221 – 530Purine-cytosine permease FCY22Add BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

BioGridi36802. 14 interactors.
DIPiDIP-8900N.

Structurei

3D structure databases

ProteinModelPortaliQ12119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000004423.
HOGENOMiHOG000162981.
InParanoidiQ12119.
OMAiYIFISEA.
OrthoDBiEOG092C1MEG.

Family and domain databases

InterProiIPR012681. NCS1.
IPR001248. Pur-cyt_permease.
IPR026030. Pur-cyt_permease_Fcy2/21/22.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
PIRSFiPIRSF002744. Pur-cyt_permease. 1 hit.
TIGRFAMsiTIGR00800. ncs1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12119-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEKLAMSMV DIKDAGSELR DLESGALDTK SSAADVYYEG VELHRTNEFI
60 70 80 90 100
DNKPSFFNRI AAALNAETKG IEPVTEDEKN DDSILNAATI WFSANMVIVA
110 120 130 140 150
YSVGALGPLV FGLNFGQSVL VIIFFNILGL IPVALFSLFG VELGLRQMIL
160 170 180 190 200
SRYLAGNITA RFFSLVNVIA CVGWCVLNIS VSAQLLNMVN EGSGHNCPIW
210 220 230 240 250
AGCLIIAGGT VLVTFFGYSV VHAYEKWSWV PNFAAFLVII AQLSRSGKFK
260 270 280 290 300
GGEWVGGATT AGGVLSFGSS VFGSAAGWAT YAADYTVYMP KTTSKYKIFF
310 320 330 340 350
SVVAGLAFPL FFTMILGAAC GMAALNDPTW KSYYDKNAMG GVIYAILVPN
360 370 380 390 400
SLNGFGQFCC VLLALSTVAN NVPGMYTVAL SAQALWAPLA KIPRVVWTMA
410 420 430 440 450
GNAATLGISI PATYYFDGFM ENFMDSIGYY LAIYIAIACS EHFIYRRSFS
460 470 480 490 500
AYNIDDWDNW EHLPIGIAGT AALIAGAFGV ALGMCQTYWV GEISRLIGEY
510 520 530
GGDIGFELGG SWAFIIYNIV RPLELKYFGR
Length:530
Mass (Da):57,327
Last modified:November 1, 1996 - v1
Checksum:i620FF2F2F3A2702D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97346 Genomic DNA. Translation: CAA66033.1.
U18813 Genomic DNA. Translation: AAB64610.1.
BK006939 Genomic DNA. Translation: DAA07719.1.
RefSeqiNP_010982.1. NM_001180858.1.

Genome annotation databases

EnsemblFungiiYER060W-A; YER060W-A; YER060W-A.
GeneIDi856789.
KEGGisce:YER060W-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97346 Genomic DNA. Translation: CAA66033.1.
U18813 Genomic DNA. Translation: AAB64610.1.
BK006939 Genomic DNA. Translation: DAA07719.1.
RefSeqiNP_010982.1. NM_001180858.1.

3D structure databases

ProteinModelPortaliQ12119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36802. 14 interactors.
DIPiDIP-8900N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER060W-A; YER060W-A; YER060W-A.
GeneIDi856789.
KEGGisce:YER060W-A.

Organism-specific databases

EuPathDBiFungiDB:YER060W-A.
SGDiS000002958. FCY22.

Phylogenomic databases

GeneTreeiENSGT00390000004423.
HOGENOMiHOG000162981.
InParanoidiQ12119.
OMAiYIFISEA.
OrthoDBiEOG092C1MEG.

Enzyme and pathway databases

BioCyciYEAST:G3O-30354-MONOMER.

Miscellaneous databases

PROiQ12119.

Family and domain databases

InterProiIPR012681. NCS1.
IPR001248. Pur-cyt_permease.
IPR026030. Pur-cyt_permease_Fcy2/21/22.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
PIRSFiPIRSF002744. Pur-cyt_permease. 1 hit.
TIGRFAMsiTIGR00800. ncs1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFCY22_YEAST
AccessioniPrimary (citable) accession number: Q12119
Secondary accession number(s): D3DLW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.