Q12119 (FCY22_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Purine-cytosine permease FCY22
Short name=PCP FCY22

Alternative name(s):
Cytosine/purine transport protein FCY22
Fluorocytosine resistance protein 22

Gene names

Name:	FCY22
Synonyms:	FCYX
Ordered Locus Names:	YER060W-A

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable purine-cytosine permease By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the purine-cytosine permease family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from sequence model PubMed 12192589. Source: SGD
Molecular_function	nucleobase transmembrane transporter activity Inferred from sequence or structural similarity PubMed 11418581. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ECM4	P36156	1	EBI-2059805,EBI-2042717
YHR080C	P38800	1	EBI-2059805,EBI-24597

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 530	530	Purine-cytosine permease FCY22		PRO_0000197922
Regions
	Transmembrane	96 – 116	21	Helical; Potential
	Transmembrane	119 – 139	21	Helical; Potential
	Transmembrane	162 – 182	21	Helical; Potential
	Transmembrane	197 – 217	21	Helical; Potential
	Transmembrane	220 – 240	21	Helical; Potential
	Transmembrane	263 – 283	21	Helical; Potential
	Transmembrane	298 – 318	21	Helical; Potential
	Transmembrane	345 – 365	21	Helical; Potential
	Transmembrane	372 – 392	21	Helical; Potential
	Transmembrane	396 – 416	21	Helical; Potential
	Transmembrane	418 – 438	21	Helical; Potential
	Transmembrane	463 – 483	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q12119 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 620FF2F2F3A2702D	FASTA	530	57,327
	10 20 30 40 50 60 MPEKLAMSMV DIKDAGSELR DLESGALDTK SSAADVYYEG VELHRTNEFI DNKPSFFNRI 70 80 90 100 110 120 AAALNAETKG IEPVTEDEKN DDSILNAATI WFSANMVIVA YSVGALGPLV FGLNFGQSVL 130 140 150 160 170 180 VIIFFNILGL IPVALFSLFG VELGLRQMIL SRYLAGNITA RFFSLVNVIA CVGWCVLNIS 190 200 210 220 230 240 VSAQLLNMVN EGSGHNCPIW AGCLIIAGGT VLVTFFGYSV VHAYEKWSWV PNFAAFLVII 250 260 270 280 290 300 AQLSRSGKFK GGEWVGGATT AGGVLSFGSS VFGSAAGWAT YAADYTVYMP KTTSKYKIFF 310 320 330 340 350 360 SVVAGLAFPL FFTMILGAAC GMAALNDPTW KSYYDKNAMG GVIYAILVPN SLNGFGQFCC 370 380 390 400 410 420 VLLALSTVAN NVPGMYTVAL SAQALWAPLA KIPRVVWTMA GNAATLGISI PATYYFDGFM 430 440 450 460 470 480 ENFMDSIGYY LAIYIAIACS EHFIYRRSFS AYNIDDWDNW EHLPIGIAGT AALIAGAFGV 490 500 510 520 530 ALGMCQTYWV GEISRLIGEY GGDIGFELGG SWAFIIYNIV RPLELKYFGR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Straub M.-L., Souciet J.-L., Potier S., de Montigny J. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 28383 / FL100 / VTT C-80102.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X97346 Genomic DNA. Translation: CAA66033.1. U18813 Genomic DNA. Translation: AAB64610.1. BK006939 Genomic DNA. Translation: DAA07719.1.
RefSeq	NP_010982.1. NM_001180858.1.
3D structure databases
ProteinModelPortal	Q12119.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-8900N.
STRING	4932.YER060W-A.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YER060W-A; YER060W-A; YER060W-A.
GeneID	856789.
KEGG	sce:YER060W-A.
Organism-specific databases
CYGD	YER060w-a.
SGD	S000002958. FCY22.
Phylogenomic databases
eggNOG	COG1457.
GeneTree	ENSGT00390000004423.
HOGENOM	HOG000162981.
OMA	TASATNI.
OrthoDB	EOG4Z0FF0.
Gene expression databases
Genevestigator	Q12119.
GermOnline	YER060W-A. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001248. Cyt_pur_permease. IPR012681. NCS1. IPR026030. Pur-cyt_permease. [Graphical view]
Pfam	PF02133. Transp_cyt_pur. 1 hit. [Graphical view]
PIRSF	PIRSF002744. Pur-cyt_permease. 1 hit.
TIGRFAMs	TIGR00800. ncs1. 1 hit.
ProtoNet	Search...
Other
NextBio	983015.

Entry information

Entry name

FCY22_YEAST

Accession

Primary (citable) accession number: Q12119
Secondary accession number(s): D3DLW5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program