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Q12118 (SGT2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein 2
Alternative name(s):
SGT/UBP
Viral protein U-binding protein
Gene names
Name:SGT2
Ordered Locus Names:YOR007C
ORF Names:UNF346
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity By similarity. Required for recovery from heat shock. Ref.5

Subunit structure

Interacts with HSC82, HSP104, MDY2, SSA1 AND SSA2. Ref.8

Subcellular location

Cytoplasm Ref.6.

Miscellaneous

Present with 9424 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the SGT family.

Contains 4 TPR repeats.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MDY2Q122859EBI-31784,EBI-34904
YDJ1P254912EBI-31784,EBI-10420

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Small glutamine-rich tetratricopeptide repeat-containing protein 2
PRO_0000106370

Regions

Repeat102 – 13534TPR 1
Repeat136 – 16934TPR 2
Repeat170 – 20334TPR 3
Repeat205 – 22925TPR 4

Amino acid modifications

Modified residue3081Phosphothreonine Ref.9

Secondary structure

........... 346
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q12118 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 33539B74F742BD3C

FASTA34637,218
        10         20         30         40         50         60 
MSASKEEIAA LIVNYFSSIV EKKEISEDGA DSLNVAMDCI SEAFGFEREA VSGILGKSEF 

        70         80         90        100        110        120 
KGQHLADILN SASRVPESNK KDDAENVEIN IPEDDAETKA KAEDLKMQGN KAMANKDYEL 

       130        140        150        160        170        180 
AINKYTEAIK VLPTNAIYYA NRAAAHSSLK EYDQAVKDAE SAISIDPSYF RGYSRLGFAK 

       190        200        210        220        230        240 
YAQGKPEEAL EAYKKVLDIE GDNATEAMKR DYESAKKKVE QSLNLEKTVP EQSRDADVDA 

       250        260        270        280        290        300 
SQGASAGGLP DLGSLLGGGL GGLMNNPQLM QAAQKMMSNP GAMQNIQKMM QDPSIRQMAE 

       310        320        330        340 
GFASGGGTPN LSDLMNNPAL RNMAGNLFGG AGAQSTDETP DNENKQ 

« Hide

References

« Hide 'large scale' references
[1]"The sequence of a 30 kb fragment on the left arm of chromosome XV from Saccharomyces cerevisiae reveals 15 open reading frames, five of which correspond to previously identified genes."
Sterky F., Holmberg A., Pettersson B., Uhlen M.
Yeast 12:1091-1095(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. expand/collapse author list , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Bienvenut W.V., Peters C.
Submitted (JUN-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 131-142 AND 158-171, IDENTIFICATION BY MASS SPECTROMETRY.
[5]"Small glutamine-rich protein/viral protein U-binding protein is a novel cochaperone that affects heat shock protein 70 activity."
Angeletti P.C., Walker D., Panganiban A.T.
Cell Stress Chaperones 7:258-268(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"SGT2 and MDY2 interact with molecular chaperone YDJ1 in Saccharomyces cerevisiae."
Liou S.-T., Cheng M.-Y., Wang C.
Cell Stress Chaperones 12:59-70(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HSC82; HSP104; MDY2; SSA1 AND SSA2.
[9]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-308, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U43491 Genomic DNA. Translation: AAC49487.1.
Z74915 Genomic DNA. Translation: CAA99195.1.
BK006948 Genomic DNA. Translation: DAA10789.1.
PIRS61991.
RefSeqNP_014649.1. NM_001183426.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2LXBNMR-A/B2-72[»]
2LXCNMR-B/C2-72[»]
3ZDMX-ray1.80A/B/D/E1-72[»]
4ASVNMR-A/B1-78[»]
4ASWNMR-A/B1-78[»]
ProteinModelPortalQ12118.
SMRQ12118. Positions 1-240.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34410. 99 interactions.
DIPDIP-1983N.
IntActQ12118. 11 interactions.
MINTMINT-411674.
STRING4932.YOR007C.

Proteomic databases

PaxDbQ12118.
PeptideAtlasQ12118.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYOR007C; YOR007C; YOR007C.
GeneID854168.
KEGGsce:YOR007C.

Organism-specific databases

CYGDYOR007c.
SGDS000005533. SGT2.

Phylogenomic databases

eggNOGCOG0457.
GeneTreeENSGT00730000110724.
HOGENOMHOG000208193.
KOK16365.
OMARLGFAKY.
OrthoDBEOG77T1FP.

Enzyme and pathway databases

BioCycYEAST:G3O-33557-MONOMER.

Gene expression databases

GenevestigatorQ12118.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamPF00515. TPR_1. 2 hits.
PF07719. TPR_2. 1 hit.
[Graphical view]
SMARTSM00028. TPR. 3 hits.
[Graphical view]
PROSITEPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio975956.

Entry information

Entry nameSGT2_YEAST
AccessionPrimary (citable) accession number: Q12118
Secondary accession number(s): D6W273
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XV

Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references