Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Small glutamine-rich tetratricopeptide repeat-containing protein 2

Gene

SGT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.By similarity1 Publication

GO - Molecular functioni

  • protein complex scaffold Source: SGD

GO - Biological processi

  • posttranslational protein targeting to membrane Source: SGD
  • response to heat Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-33557-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein 2
Alternative name(s):
SGT/UBP
Viral protein U-binding protein
Gene namesi
Name:SGT2
Ordered Locus Names:YOR007C
ORF Names:UNF346
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR007C.
SGDiS000005533. SGT2.

Subcellular locationi

GO - Cellular componenti

  • TRC complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063701 – 346Small glutamine-rich tetratricopeptide repeat-containing protein 2Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei308PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12118.
PRIDEiQ12118.

PTM databases

iPTMnetiQ12118.

Interactioni

Subunit structurei

Interacts with HSC82, HSP104, MDY2, SSA1 AND SSA2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MDY2Q122859EBI-31784,EBI-34904
YDJ1P254912EBI-31784,EBI-10420

GO - Molecular functioni

  • protein complex scaffold Source: SGD

Protein-protein interaction databases

BioGridi34410. 105 interactors.
DIPiDIP-1983N.
IntActiQ12118. 11 interactors.
MINTiMINT-411674.

Structurei

Secondary structure

1346
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 21Combined sources17
Helixi27 – 44Combined sources18
Helixi48 – 50Combined sources3
Helixi51 – 56Combined sources6
Helixi58 – 68Combined sources11
Helixi69 – 71Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LXBNMR-A/B2-72[»]
2LXCNMR-B/C2-72[»]
3ZDMX-ray1.80A/B/D/E1-72[»]
4ASVNMR-A/B1-78[»]
4ASWNMR-A/B1-78[»]
ProteinModelPortaliQ12118.
SMRiQ12118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati102 – 135TPR 1Add BLAST34
Repeati136 – 169TPR 2Add BLAST34
Repeati170 – 203TPR 3Add BLAST34
Repeati205 – 229TPR 4Add BLAST25

Sequence similaritiesi

Belongs to the SGT family.Curated
Contains 4 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

GeneTreeiENSGT00730000110724.
HOGENOMiHOG000208193.
InParanoidiQ12118.
KOiK16365.
OMAiNCIGEAF.
OrthoDBiEOG092C1UGR.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR032374. SGTA_dimer.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF16546. SGTA_dimer. 1 hit.
PF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASKEEIAA LIVNYFSSIV EKKEISEDGA DSLNVAMDCI SEAFGFEREA
60 70 80 90 100
VSGILGKSEF KGQHLADILN SASRVPESNK KDDAENVEIN IPEDDAETKA
110 120 130 140 150
KAEDLKMQGN KAMANKDYEL AINKYTEAIK VLPTNAIYYA NRAAAHSSLK
160 170 180 190 200
EYDQAVKDAE SAISIDPSYF RGYSRLGFAK YAQGKPEEAL EAYKKVLDIE
210 220 230 240 250
GDNATEAMKR DYESAKKKVE QSLNLEKTVP EQSRDADVDA SQGASAGGLP
260 270 280 290 300
DLGSLLGGGL GGLMNNPQLM QAAQKMMSNP GAMQNIQKMM QDPSIRQMAE
310 320 330 340
GFASGGGTPN LSDLMNNPAL RNMAGNLFGG AGAQSTDETP DNENKQ
Length:346
Mass (Da):37,218
Last modified:November 1, 1996 - v1
Checksum:i33539B74F742BD3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43491 Genomic DNA. Translation: AAC49487.1.
Z74915 Genomic DNA. Translation: CAA99195.1.
BK006948 Genomic DNA. Translation: DAA10789.1.
PIRiS61991.
RefSeqiNP_014649.1. NM_001183426.1.

Genome annotation databases

EnsemblFungiiYOR007C; YOR007C; YOR007C.
GeneIDi854168.
KEGGisce:YOR007C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43491 Genomic DNA. Translation: AAC49487.1.
Z74915 Genomic DNA. Translation: CAA99195.1.
BK006948 Genomic DNA. Translation: DAA10789.1.
PIRiS61991.
RefSeqiNP_014649.1. NM_001183426.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LXBNMR-A/B2-72[»]
2LXCNMR-B/C2-72[»]
3ZDMX-ray1.80A/B/D/E1-72[»]
4ASVNMR-A/B1-78[»]
4ASWNMR-A/B1-78[»]
ProteinModelPortaliQ12118.
SMRiQ12118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34410. 105 interactors.
DIPiDIP-1983N.
IntActiQ12118. 11 interactors.
MINTiMINT-411674.

PTM databases

iPTMnetiQ12118.

Proteomic databases

MaxQBiQ12118.
PRIDEiQ12118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR007C; YOR007C; YOR007C.
GeneIDi854168.
KEGGisce:YOR007C.

Organism-specific databases

EuPathDBiFungiDB:YOR007C.
SGDiS000005533. SGT2.

Phylogenomic databases

GeneTreeiENSGT00730000110724.
HOGENOMiHOG000208193.
InParanoidiQ12118.
KOiK16365.
OMAiNCIGEAF.
OrthoDBiEOG092C1UGR.

Enzyme and pathway databases

BioCyciYEAST:G3O-33557-MONOMER.

Miscellaneous databases

PROiQ12118.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR032374. SGTA_dimer.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF16546. SGTA_dimer. 1 hit.
PF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSGT2_YEAST
AccessioniPrimary (citable) accession number: Q12118
Secondary accession number(s): D6W273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 9424 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.