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Q12118

- SGT2_YEAST

UniProt

Q12118 - SGT2_YEAST

Protein

Small glutamine-rich tetratricopeptide repeat-containing protein 2

Gene

SGT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity By similarity. Required for recovery from heat shock.By similarity1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein complex scaffold Source: SGD

    GO - Biological processi

    1. posttranslational protein targeting to membrane Source: SGD
    2. response to heat Source: SGD

    Keywords - Molecular functioni

    Chaperone

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33557-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small glutamine-rich tetratricopeptide repeat-containing protein 2
    Alternative name(s):
    SGT/UBP
    Viral protein U-binding protein
    Gene namesi
    Name:SGT2
    Ordered Locus Names:YOR007C
    ORF Names:UNF346
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOR007c.
    SGDiS000005533. SGT2.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. TRC complex Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Small glutamine-rich tetratricopeptide repeat-containing protein 2PRO_0000106370Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei308 – 3081Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ12118.
    PaxDbiQ12118.
    PeptideAtlasiQ12118.

    Expressioni

    Gene expression databases

    GenevestigatoriQ12118.

    Interactioni

    Subunit structurei

    Interacts with HSC82, HSP104, MDY2, SSA1 AND SSA2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MDY2Q122859EBI-31784,EBI-34904
    YDJ1P254912EBI-31784,EBI-10420

    Protein-protein interaction databases

    BioGridi34410. 99 interactions.
    DIPiDIP-1983N.
    IntActiQ12118. 11 interactions.
    MINTiMINT-411674.
    STRINGi4932.YOR007C.

    Structurei

    Secondary structure

    1
    346
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 2117
    Helixi27 – 4418
    Helixi48 – 503
    Helixi51 – 566
    Helixi58 – 6811
    Helixi69 – 713

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LXBNMR-A/B2-72[»]
    2LXCNMR-B/C2-72[»]
    3ZDMX-ray1.80A/B/D/E1-72[»]
    4ASVNMR-A/B1-78[»]
    4ASWNMR-A/B1-78[»]
    ProteinModelPortaliQ12118.
    SMRiQ12118. Positions 1-240.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati102 – 13534TPR 1Add
    BLAST
    Repeati136 – 16934TPR 2Add
    BLAST
    Repeati170 – 20334TPR 3Add
    BLAST
    Repeati205 – 22925TPR 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the SGT family.Curated
    Contains 4 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0457.
    GeneTreeiENSGT00730000110724.
    HOGENOMiHOG000208193.
    KOiK16365.
    OMAiDMMNNPQ.
    OrthoDBiEOG77T1FP.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF00515. TPR_1. 2 hits.
    PF07719. TPR_2. 1 hit.
    [Graphical view]
    SMARTiSM00028. TPR. 3 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12118-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSASKEEIAA LIVNYFSSIV EKKEISEDGA DSLNVAMDCI SEAFGFEREA    50
    VSGILGKSEF KGQHLADILN SASRVPESNK KDDAENVEIN IPEDDAETKA 100
    KAEDLKMQGN KAMANKDYEL AINKYTEAIK VLPTNAIYYA NRAAAHSSLK 150
    EYDQAVKDAE SAISIDPSYF RGYSRLGFAK YAQGKPEEAL EAYKKVLDIE 200
    GDNATEAMKR DYESAKKKVE QSLNLEKTVP EQSRDADVDA SQGASAGGLP 250
    DLGSLLGGGL GGLMNNPQLM QAAQKMMSNP GAMQNIQKMM QDPSIRQMAE 300
    GFASGGGTPN LSDLMNNPAL RNMAGNLFGG AGAQSTDETP DNENKQ 346
    Length:346
    Mass (Da):37,218
    Last modified:November 1, 1996 - v1
    Checksum:i33539B74F742BD3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43491 Genomic DNA. Translation: AAC49487.1.
    Z74915 Genomic DNA. Translation: CAA99195.1.
    BK006948 Genomic DNA. Translation: DAA10789.1.
    PIRiS61991.
    RefSeqiNP_014649.1. NM_001183426.1.

    Genome annotation databases

    EnsemblFungiiYOR007C; YOR007C; YOR007C.
    GeneIDi854168.
    KEGGisce:YOR007C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43491 Genomic DNA. Translation: AAC49487.1 .
    Z74915 Genomic DNA. Translation: CAA99195.1 .
    BK006948 Genomic DNA. Translation: DAA10789.1 .
    PIRi S61991.
    RefSeqi NP_014649.1. NM_001183426.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LXB NMR - A/B 2-72 [» ]
    2LXC NMR - B/C 2-72 [» ]
    3ZDM X-ray 1.80 A/B/D/E 1-72 [» ]
    4ASV NMR - A/B 1-78 [» ]
    4ASW NMR - A/B 1-78 [» ]
    ProteinModelPortali Q12118.
    SMRi Q12118. Positions 1-240.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34410. 99 interactions.
    DIPi DIP-1983N.
    IntActi Q12118. 11 interactions.
    MINTi MINT-411674.
    STRINGi 4932.YOR007C.

    Proteomic databases

    MaxQBi Q12118.
    PaxDbi Q12118.
    PeptideAtlasi Q12118.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOR007C ; YOR007C ; YOR007C .
    GeneIDi 854168.
    KEGGi sce:YOR007C.

    Organism-specific databases

    CYGDi YOR007c.
    SGDi S000005533. SGT2.

    Phylogenomic databases

    eggNOGi COG0457.
    GeneTreei ENSGT00730000110724.
    HOGENOMi HOG000208193.
    KOi K16365.
    OMAi DMMNNPQ.
    OrthoDBi EOG77T1FP.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33557-MONOMER.

    Miscellaneous databases

    NextBioi 975956.

    Gene expression databases

    Genevestigatori Q12118.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF00515. TPR_1. 2 hits.
    PF07719. TPR_2. 1 hit.
    [Graphical view ]
    SMARTi SM00028. TPR. 3 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of a 30 kb fragment on the left arm of chromosome XV from Saccharomyces cerevisiae reveals 15 open reading frames, five of which correspond to previously identified genes."
      Sterky F., Holmberg A., Pettersson B., Uhlen M.
      Yeast 12:1091-1095(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Bienvenut W.V., Peters C.
      Submitted (JUN-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 131-142 AND 158-171, IDENTIFICATION BY MASS SPECTROMETRY.
    5. "Small glutamine-rich protein/viral protein U-binding protein is a novel cochaperone that affects heat shock protein 70 activity."
      Angeletti P.C., Walker D., Panganiban A.T.
      Cell Stress Chaperones 7:258-268(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "SGT2 and MDY2 interact with molecular chaperone YDJ1 in Saccharomyces cerevisiae."
      Liou S.-T., Cheng M.-Y., Wang C.
      Cell Stress Chaperones 12:59-70(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HSC82; HSP104; MDY2; SSA1 AND SSA2.
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-308, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSGT2_YEAST
    AccessioniPrimary (citable) accession number: Q12118
    Secondary accession number(s): D6W273
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 9424 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3