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Protein

Small glutamine-rich tetratricopeptide repeat-containing protein 2

Gene

SGT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.By similarity1 Publication

Miscellaneous

Present with 9424 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein-containing complex scaffold activity Source: SGD

GO - Biological processi

  • posttranslational protein targeting to endoplasmic reticulum membrane Source: SGD
  • response to heat Source: SGD

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-33557-MONOMER

Protein family/group databases

TCDBi3.A.21.1.1 the c-terminal tail-anchored membrane protein biogenesis/ insertion complex (tamp-b) family

Names & Taxonomyi

Protein namesi
Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein 2
Alternative name(s):
SGT/UBP
Viral protein U-binding protein
Gene namesi
Name:SGT2
Ordered Locus Names:YOR007C
ORF Names:UNF346
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR007C
SGDiS000005533 SGT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063701 – 346Small glutamine-rich tetratricopeptide repeat-containing protein 2Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei308PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12118
PaxDbiQ12118
PRIDEiQ12118

PTM databases

iPTMnetiQ12118

Interactioni

Subunit structurei

Interacts with HSC82, HSP104, MDY2, SSA1 AND SSA2.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein-containing complex scaffold activity Source: SGD

Protein-protein interaction databases

BioGridi34410, 242 interactors
DIPiDIP-1983N
IntActiQ12118, 19 interactors
MINTiQ12118
STRINGi4932.YOR007C

Structurei

Secondary structure

1346
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 21Combined sources17
Helixi27 – 44Combined sources18
Helixi48 – 50Combined sources3
Helixi51 – 56Combined sources6
Helixi58 – 68Combined sources11
Helixi69 – 71Combined sources3
Helixi96 – 114Combined sources19
Helixi118 – 131Combined sources14
Helixi136 – 148Combined sources13
Helixi152 – 165Combined sources14
Helixi170 – 182Combined sources13
Helixi186 – 200Combined sources15
Helixi201 – 203Combined sources3
Helixi206 – 224Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LXBNMR-A/B2-72[»]
2LXCNMR-B/C2-72[»]
3ZDMX-ray1.80A/B/D/E1-72[»]
4ASVNMR-A/B1-78[»]
4ASWNMR-A/B1-78[»]
5LYNX-ray2.00A/B96-225[»]
5LYPX-ray1.55A93-229[»]
ProteinModelPortaliQ12118
SMRiQ12118
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati102 – 135TPR 1Add BLAST34
Repeati136 – 169TPR 2Add BLAST34
Repeati170 – 203TPR 3Add BLAST34
Repeati205 – 229TPR 4Add BLAST25

Sequence similaritiesi

Belongs to the SGT family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

GeneTreeiENSGT00730000110724
HOGENOMiHOG000208193
InParanoidiQ12118
KOiK16365
OMAiPAMMNMA
OrthoDBiEOG092C1UGR

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR032374 SGTA_dimer
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF16546 SGTA_dimer, 1 hit
PF00515 TPR_1, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q12118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASKEEIAA LIVNYFSSIV EKKEISEDGA DSLNVAMDCI SEAFGFEREA
60 70 80 90 100
VSGILGKSEF KGQHLADILN SASRVPESNK KDDAENVEIN IPEDDAETKA
110 120 130 140 150
KAEDLKMQGN KAMANKDYEL AINKYTEAIK VLPTNAIYYA NRAAAHSSLK
160 170 180 190 200
EYDQAVKDAE SAISIDPSYF RGYSRLGFAK YAQGKPEEAL EAYKKVLDIE
210 220 230 240 250
GDNATEAMKR DYESAKKKVE QSLNLEKTVP EQSRDADVDA SQGASAGGLP
260 270 280 290 300
DLGSLLGGGL GGLMNNPQLM QAAQKMMSNP GAMQNIQKMM QDPSIRQMAE
310 320 330 340
GFASGGGTPN LSDLMNNPAL RNMAGNLFGG AGAQSTDETP DNENKQ
Length:346
Mass (Da):37,218
Last modified:November 1, 1996 - v1
Checksum:i33539B74F742BD3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43491 Genomic DNA Translation: AAC49487.1
Z74915 Genomic DNA Translation: CAA99195.1
BK006948 Genomic DNA Translation: DAA10789.1
PIRiS61991
RefSeqiNP_014649.1, NM_001183426.1

Genome annotation databases

EnsemblFungiiYOR007C; YOR007C; YOR007C
GeneIDi854168
KEGGisce:YOR007C

Similar proteinsi

Entry informationi

Entry nameiSGT2_YEAST
AccessioniPrimary (citable) accession number: Q12118
Secondary accession number(s): D6W273
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health