Reviewed, UniProtKB/Swiss-Prot Q12110 (YL049_YEAST)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein YLR049C

Gene names

Ordered Locus Names:	YLR049C
ORF Names:	L2121

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Miscellaneous

Present with 339 molecules/cell in log phase SD medium. Ref.2

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ACS1	Q01574	1	EBI-33635,EBI-2128

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	Uncharacterized protein YLR049C		PRO_0000247204
Regions
	Compositional bias	89 – 97	9	Poly-Ser
Amino acid modifications
	Modified residue	127	1	Phosphoserine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q12110-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 9414BB6CF379E682	FASTA	428	49,493
	10 20 30 40 50 60 MVNNIMHEYV PPSQRLFHSR HRITRNDLKE EALHSGTTDW TTILDTTIDK DTNLISYAVP 70 80 90 100 110 120 IIDNFAIPRA NSQGSPVAPS PNHRSTMYSS SSSSASSVFS DGLFTPNNNR NSSGSSSLVI 130 140 150 160 170 180 RPQKNLSVDS LIQENKRKIN SEKESLSLIA NNNDETLCTH TDPSIQNLIK SETKRNILNL 190 200 210 220 230 240 KFQNRNLFRR ELKLEKFWSN LRSCHTSGDE TDLLLVISKH NLYWFGIPND FRLPIYKRCL 250 260 270 280 290 300 YHYSELDEAG FFSQYANNSL YLAIRKCCNN EEQETLSRSI FINLTKNVTW LNSRFDDNKD 310 320 330 340 350 360 NKNSYTVTEG KFYQDFPNLY YHLKDKLKLN VIMDFIKPVI RNFMTNALNK HKLDGIGLEL 370 380 390 400 410 420 LDILIVTTYY GPNKINAFLM DTFILNLLKQ CHYKFFVSNI SELVIQISKI DCDLVILLED LRSRIDLD

References

[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D. Nature 387:87-90(1997) [PubMed: 9169871] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[3]	"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway." Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N. Mol. Cell. Proteomics 4:310-327(2005) [PubMed: 15665377] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z73221 Genomic DNA. Translation: CAA97579.1. X94607 Genomic DNA. Translation: CAA64296.1.
PIR	S61623.
RefSeq	NP_013150.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:1211N.
IntAct	Q12110. 3 interactions.
STRING	Q12110.
Proteomic databases
PRIDE	Q12110.
Genome annotation databases
Ensembl	YLR049C; YLR049C; YLR049C; Saccharomyces cerevisiae. [Genome view]
GeneID	850738.
KEGG	sce:YLR049C.
NMPDR	fig|4932.3.peg.4141.
Organism-specific databases
CYGD	YLR049c.
SGD	S000004039. YLR049C.
Phylogenomic databases
HOGENOM	Q12110.
OMA	YAVPIID
OrthoDB	EOG9HTB9C
Gene expression databases
ArrayExpress	Q12110.
Genevestigator	Q12110.
GermOnline	YLR049C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	966846.

Entry information

Entry name

YL049_YEAST

Accession

Primary (citable) accession number: Q12110

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	November 1, 1996
Last modified:	November 24, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)