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Protein

Probable serine/threonine-protein kinase RTK1

Gene

RTK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable serine/threonine-protein kinase that may be involved in ribosome biogenesis.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei330ATPPROSITE-ProRule annotation1
Active sitei430Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi308 – 316ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: SGD
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29452-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase RTK1 (EC:2.7.11.1)
Alternative name(s):
Ribosome biogenesis and tRNA synthetase-associated kinase 1
Gene namesi
Name:RTK1
Ordered Locus Names:YDL025C
ORF Names:D2810
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL025C.
SGDiS000002183. RTK1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002484081 – 620Probable serine/threonine-protein kinase RTK1Add BLAST620

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphothreonineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Cross-linki334Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ12100.
PRIDEiQ12100.

PTM databases

iPTMnetiQ12100.

Expressioni

Inductioni

By the alkylating agent methyl methanesulfonate (MMS).1 Publication

Interactioni

Subunit structurei

Interacts with ribosome biogenesis factors ARC1, CKA2 and GUS1.1 Publication

Protein-protein interaction databases

BioGridi32030. 78 interactors.
DIPiDIP-6483N.
IntActiQ12100. 20 interactors.
MINTiMINT-8285168.

Structurei

3D structure databases

ProteinModelPortaliQ12100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini302 – 575Protein kinasePROSITE-ProRule annotationAdd BLAST274

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000075309.
InParanoidiQ12100.
OMAiHMHPVEI.
OrthoDBiEOG092C0ZCR.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKETPLHSS SSTSLSSLFR PTKLKNLSAK IFNGGGNQSY SKTDDVSRSS
60 70 80 90 100
SRSSKKNTDS DQEDQIKYNK PNDRRSTIGK SPQGNGALSK ESHVVASSTL
110 120 130 140 150
TGISPTSAKK APIDYSPSRP LPNNHNPVRT GHTVPHLPHS IHNPINYIHQ
160 170 180 190 200
GSKDAFHHPH PVRSTAHSNI STVSSAKSDT PSSNLSYQAH MHPVEILQKQ
210 220 230 240 250
IEDKHFMDSQ ASTPGSVELQ HNSSSGSDDT SSRKKKSLRL TRFFKKIHND
260 270 280 290 300
YHDNHHHHHH HNRGSTPTKP KLNLNTNENI VESNGKALYE TDNPVELLEK
310 320 330 340 350
YGIPGRKLGE GASGSVSVVE RTDGKLFACK MFRKPHLNNE GTNQSQLANY
360 370 380 390 400
SKKVTTEFCI GSTLHHENIV ETLDMLTEGD TYLLVMEYAP YDFFNLVMSN
410 420 430 440 450
LMTQDEVNCY FKQLCHGVNY LHSMGLAHRD LKLDNCVVTK DGILKLIDFG
460 470 480 490 500
SAVVFQYPYE DTIVKSHGIV GSDPYLAPEL LKQTSYDPRV ADVWSIAIIF
510 520 530 540 550
YCMVLKRFPW KAPKKSFNSF RLFTEEPEDE DDIVRGPNKI LRLLPRHSRT
560 570 580 590 600
IIGRMLALEP KQRVLMNDVV KDDWLVSVPS CEVDPTSGDL VEKPKNHKHH
610 620
LVTEEELNEL TKQHGNKDSN
Length:620
Mass (Da):69,615
Last modified:November 1, 1996 - v1
Checksum:iAD6160F19F3B75CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74073 Genomic DNA. Translation: CAA98584.1.
Z48432 Genomic DNA. Translation: CAA88334.1.
AY692716 Genomic DNA. Translation: AAT92735.1.
BK006938 Genomic DNA. Translation: DAA11826.1.
PIRiS52494.
RefSeqiNP_010259.1. NM_001180084.1.

Genome annotation databases

EnsemblFungiiYDL025C; YDL025C; YDL025C.
GeneIDi851536.
KEGGisce:YDL025C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74073 Genomic DNA. Translation: CAA98584.1.
Z48432 Genomic DNA. Translation: CAA88334.1.
AY692716 Genomic DNA. Translation: AAT92735.1.
BK006938 Genomic DNA. Translation: DAA11826.1.
PIRiS52494.
RefSeqiNP_010259.1. NM_001180084.1.

3D structure databases

ProteinModelPortaliQ12100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32030. 78 interactors.
DIPiDIP-6483N.
IntActiQ12100. 20 interactors.
MINTiMINT-8285168.

PTM databases

iPTMnetiQ12100.

Proteomic databases

MaxQBiQ12100.
PRIDEiQ12100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL025C; YDL025C; YDL025C.
GeneIDi851536.
KEGGisce:YDL025C.

Organism-specific databases

EuPathDBiFungiDB:YDL025C.
SGDiS000002183. RTK1.

Phylogenomic databases

GeneTreeiENSGT00550000075309.
InParanoidiQ12100.
OMAiHMHPVEI.
OrthoDBiEOG092C0ZCR.

Enzyme and pathway databases

BioCyciYEAST:G3O-29452-MONOMER.

Miscellaneous databases

PROiQ12100.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRTK1_YEAST
AccessioniPrimary (citable) accession number: Q12100
Secondary accession number(s): D6VRW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 861 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.