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Q12100

- RTK1_YEAST

UniProt

Q12100 - RTK1_YEAST

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Protein

Probable serine/threonine-protein kinase RTK1

Gene
RTK1, YDL025C, D2810
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Probable serine/threonine-protein kinase that may be involved in ribosome biogenesis.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei330 – 3301ATP By similarity
Active sitei430 – 4301Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi308 – 3169ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein kinase activity Source: SGD
  3. protein serine/threonine kinase activity Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29452-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase RTK1 (EC:2.7.11.1)
Alternative name(s):
Ribosome biogenesis and tRNA synthetase-associated kinase 1
Gene namesi
Name:RTK1
Ordered Locus Names:YDL025C
ORF Names:D2810
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDL025c.
SGDiS000002183. RTK1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 620620Probable serine/threonine-protein kinase RTK1PRO_0000248408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581Phosphothreonine1 Publication
Modified residuei60 – 601Phosphoserine1 Publication
Modified residuei216 – 2161Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12100.
PaxDbiQ12100.

Expressioni

Inductioni

By the alkylating agent methyl methanesulfonate (MMS).1 Publication

Gene expression databases

GenevestigatoriQ12100.

Interactioni

Subunit structurei

Interacts with ribosome biogenesis factors ARC1, CKA2 and GUS1.

Protein-protein interaction databases

BioGridi32030. 76 interactions.
DIPiDIP-6483N.
IntActiQ12100. 19 interactions.
MINTiMINT-8285168.
STRINGi4932.YDL025C.

Structurei

3D structure databases

ProteinModelPortaliQ12100.
SMRiQ12100. Positions 259-613.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini302 – 575274Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00550000075309.
OMAiVARTHLP.
OrthoDBiEOG7008J9.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12100-1 [UniParc]FASTAAdd to Basket

« Hide

MVKETPLHSS SSTSLSSLFR PTKLKNLSAK IFNGGGNQSY SKTDDVSRSS    50
SRSSKKNTDS DQEDQIKYNK PNDRRSTIGK SPQGNGALSK ESHVVASSTL 100
TGISPTSAKK APIDYSPSRP LPNNHNPVRT GHTVPHLPHS IHNPINYIHQ 150
GSKDAFHHPH PVRSTAHSNI STVSSAKSDT PSSNLSYQAH MHPVEILQKQ 200
IEDKHFMDSQ ASTPGSVELQ HNSSSGSDDT SSRKKKSLRL TRFFKKIHND 250
YHDNHHHHHH HNRGSTPTKP KLNLNTNENI VESNGKALYE TDNPVELLEK 300
YGIPGRKLGE GASGSVSVVE RTDGKLFACK MFRKPHLNNE GTNQSQLANY 350
SKKVTTEFCI GSTLHHENIV ETLDMLTEGD TYLLVMEYAP YDFFNLVMSN 400
LMTQDEVNCY FKQLCHGVNY LHSMGLAHRD LKLDNCVVTK DGILKLIDFG 450
SAVVFQYPYE DTIVKSHGIV GSDPYLAPEL LKQTSYDPRV ADVWSIAIIF 500
YCMVLKRFPW KAPKKSFNSF RLFTEEPEDE DDIVRGPNKI LRLLPRHSRT 550
IIGRMLALEP KQRVLMNDVV KDDWLVSVPS CEVDPTSGDL VEKPKNHKHH 600
LVTEEELNEL TKQHGNKDSN 620
Length:620
Mass (Da):69,615
Last modified:November 1, 1996 - v1
Checksum:iAD6160F19F3B75CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z74073 Genomic DNA. Translation: CAA98584.1.
Z48432 Genomic DNA. Translation: CAA88334.1.
AY692716 Genomic DNA. Translation: AAT92735.1.
BK006938 Genomic DNA. Translation: DAA11826.1.
PIRiS52494.
RefSeqiNP_010259.1. NM_001180084.1.

Genome annotation databases

EnsemblFungiiYDL025C; YDL025C; YDL025C.
GeneIDi851536.
KEGGisce:YDL025C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z74073 Genomic DNA. Translation: CAA98584.1 .
Z48432 Genomic DNA. Translation: CAA88334.1 .
AY692716 Genomic DNA. Translation: AAT92735.1 .
BK006938 Genomic DNA. Translation: DAA11826.1 .
PIRi S52494.
RefSeqi NP_010259.1. NM_001180084.1.

3D structure databases

ProteinModelPortali Q12100.
SMRi Q12100. Positions 259-613.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32030. 76 interactions.
DIPi DIP-6483N.
IntActi Q12100. 19 interactions.
MINTi MINT-8285168.
STRINGi 4932.YDL025C.

Proteomic databases

MaxQBi Q12100.
PaxDbi Q12100.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDL025C ; YDL025C ; YDL025C .
GeneIDi 851536.
KEGGi sce:YDL025C.

Organism-specific databases

CYGDi YDL025c.
SGDi S000002183. RTK1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00550000075309.
OMAi VARTHLP.
OrthoDBi EOG7008J9.

Enzyme and pathway databases

BioCyci YEAST:G3O-29452-MONOMER.

Miscellaneous databases

NextBioi 968935.

Gene expression databases

Genevestigatori Q12100.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "The protein kinases of budding yeast: six score and more."
    Hunter T., Plowman G.D.
    Trends Biochem. Sci. 22:18-22(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PREDICTION OF FUNCTION.
  5. "Global response of Saccharomyces cerevisiae to an alkylating agent."
    Jelinsky S.A., Samson L.D.
    Proc. Natl. Acad. Sci. U.S.A. 96:1486-1491(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-58; SER-60 AND SER-216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: INTERACTION [LARGE SCALE ANALYSIS] WITH ARC1; CKA2 AND GUS1.
  10. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRTK1_YEAST
AccessioniPrimary (citable) accession number: Q12100
Secondary accession number(s): D6VRW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 861 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

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