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Protein

Probable serine/threonine-protein kinase RTK1

Gene

RTK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable serine/threonine-protein kinase that may be involved in ribosome biogenesis.

Miscellaneous

Present with 861 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei330ATPPROSITE-ProRule annotation1
Active sitei430Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi308 – 316ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: SGD
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29452-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase RTK1 (EC:2.7.11.1)
Alternative name(s):
Ribosome biogenesis and tRNA synthetase-associated kinase 1
Gene namesi
Name:RTK1
Ordered Locus Names:YDL025C
ORF Names:D2810
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL025C
SGDiS000002183 RTK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002484081 – 620Probable serine/threonine-protein kinase RTK1Add BLAST620

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphothreonineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Cross-linki334Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ12100
PaxDbiQ12100
PRIDEiQ12100

PTM databases

iPTMnetiQ12100

Expressioni

Inductioni

By the alkylating agent methyl methanesulfonate (MMS).1 Publication

Interactioni

Subunit structurei

Interacts with ribosome biogenesis factors ARC1, CKA2 and GUS1.1 Publication

Protein-protein interaction databases

BioGridi32030, 128 interactors
DIPiDIP-6483N
IntActiQ12100, 27 interactors
MINTiQ12100
STRINGi4932.YDL025C

Structurei

3D structure databases

ProteinModelPortaliQ12100
SMRiQ12100
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini302 – 575Protein kinasePROSITE-ProRule annotationAdd BLAST274

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000075309
InParanoidiQ12100
OMAiHMHPVEI
OrthoDBiEOG092C0ZCR

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q12100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKETPLHSS SSTSLSSLFR PTKLKNLSAK IFNGGGNQSY SKTDDVSRSS
60 70 80 90 100
SRSSKKNTDS DQEDQIKYNK PNDRRSTIGK SPQGNGALSK ESHVVASSTL
110 120 130 140 150
TGISPTSAKK APIDYSPSRP LPNNHNPVRT GHTVPHLPHS IHNPINYIHQ
160 170 180 190 200
GSKDAFHHPH PVRSTAHSNI STVSSAKSDT PSSNLSYQAH MHPVEILQKQ
210 220 230 240 250
IEDKHFMDSQ ASTPGSVELQ HNSSSGSDDT SSRKKKSLRL TRFFKKIHND
260 270 280 290 300
YHDNHHHHHH HNRGSTPTKP KLNLNTNENI VESNGKALYE TDNPVELLEK
310 320 330 340 350
YGIPGRKLGE GASGSVSVVE RTDGKLFACK MFRKPHLNNE GTNQSQLANY
360 370 380 390 400
SKKVTTEFCI GSTLHHENIV ETLDMLTEGD TYLLVMEYAP YDFFNLVMSN
410 420 430 440 450
LMTQDEVNCY FKQLCHGVNY LHSMGLAHRD LKLDNCVVTK DGILKLIDFG
460 470 480 490 500
SAVVFQYPYE DTIVKSHGIV GSDPYLAPEL LKQTSYDPRV ADVWSIAIIF
510 520 530 540 550
YCMVLKRFPW KAPKKSFNSF RLFTEEPEDE DDIVRGPNKI LRLLPRHSRT
560 570 580 590 600
IIGRMLALEP KQRVLMNDVV KDDWLVSVPS CEVDPTSGDL VEKPKNHKHH
610 620
LVTEEELNEL TKQHGNKDSN
Length:620
Mass (Da):69,615
Last modified:November 1, 1996 - v1
Checksum:iAD6160F19F3B75CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74073 Genomic DNA Translation: CAA98584.1
Z48432 Genomic DNA Translation: CAA88334.1
AY692716 Genomic DNA Translation: AAT92735.1
BK006938 Genomic DNA Translation: DAA11826.1
PIRiS52494
RefSeqiNP_010259.1, NM_001180084.1

Genome annotation databases

EnsemblFungiiYDL025C; YDL025C; YDL025C
GeneIDi851536
KEGGisce:YDL025C

Similar proteinsi

Entry informationi

Entry nameiRTK1_YEAST
AccessioniPrimary (citable) accession number: Q12100
Secondary accession number(s): D6VRW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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