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Q120P0

- ACDH_POLSJ

UniProt

Q120P0 - ACDH_POLSJ

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Protein

Acetaldehyde dehydrogenase

Gene
Bpro_5135
Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei132 – 1321Acyl-thioester intermediate By similarity
Binding sitei291 – 2911NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 174NAD By similarity
Nucleotide bindingi163 – 1719NAD By similarity

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciPSP296591:GHI4-550-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene namesi
Ordered Locus Names:Bpro_5135
Encoded oniPlasmid pPOLSJ10 Publication
OrganismiPolaromonas sp. (strain JS666 / ATCC BAA-500)
Taxonomic identifieri296591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
ProteomesiUP000001983: Plasmid pPOLSJ1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Acetaldehyde dehydrogenaseUniRule annotationPRO_0000387704Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi296591.Bpro_5135.

Structurei

3D structure databases

ProteinModelPortaliQ120P0.
SMRiQ120P0. Positions 4-313.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiHARHEQL.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q120P0-1 [UniParc]FASTAAdd to Basket

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MTKSQRLQVA IIGSGNIGTD LMIKVMRNSK HLSMGAMVGI DAASDGLARA    50
GRLGVPVTHE GITGLVGLPN FGDIRIAFDA TSAGAHAGHN EVLQRHGVKV 100
IDLTPAAIGP YVIPVVNLEE QLSSPNINMV TCGGQATIPI VRAVSQIARV 150
RYAEIVASIA SKSAGPGTRA NIDEFTETTS AAIVSVGRAE HGKAIIVLNP 200
AEPSLMMRDT VFCLVDADAD QEAIRLSVRD MVRSVAAYVP GYRLKQDVQF 250
DVIPDKAPVN VPGIGRVSGL KVSVFLEVEG AAHYLPAYAG NLDIMTSAAL 300
AAADKIAASL ITAR 314
Length:314
Mass (Da):32,808
Last modified:August 22, 2006 - v1
Checksum:i7394F6A96D63FA43
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000317 Genomic DNA. Translation: ABE47002.1.
RefSeqiWP_011485985.1. NC_007949.1.
YP_551900.1. NC_007949.1.

Genome annotation databases

EnsemblBacteriaiABE47002; ABE47002; Bpro_5135.
GeneIDi4016057.
KEGGipol:Bpro_5135.
PATRICi22963511. VBIPolSp102244_5200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000317 Genomic DNA. Translation: ABE47002.1 .
RefSeqi WP_011485985.1. NC_007949.1.
YP_551900.1. NC_007949.1.

3D structure databases

ProteinModelPortali Q120P0.
SMRi Q120P0. Positions 4-313.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 296591.Bpro_5135.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE47002 ; ABE47002 ; Bpro_5135 .
GeneIDi 4016057.
KEGGi pol:Bpro_5135.
PATRICi 22963511. VBIPolSp102244_5200.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi HARHEQL.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci PSP296591:GHI4-550-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JS666 / ATCC BAA-500.

Entry informationi

Entry nameiACDH_POLSJ
AccessioniPrimary (citable) accession number: Q120P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: August 22, 2006
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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