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Protein

Damage response protein 1

Gene

DAP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • heme binding Source: SGD

GO - Biological processi

  • regulation of ergosterol biosynthetic process Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-34066-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Damage response protein 1
Gene namesi
Name:DAP1
Ordered Locus Names:YPL170W
ORF Names:P2515
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL170W.
SGDiS000006091. DAP1.

Subcellular locationi

GO - Cellular componenti

  • endosome Source: SGD
  • membrane Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 152152Damage response protein 1PRO_0000121747Add
BLAST

Proteomic databases

MaxQBiQ12091.
PeptideAtlasiQ12091.
TopDownProteomicsiQ12091.

Interactioni

Protein-protein interaction databases

BioGridi36013. 42 interactions.
DIPiDIP-5226N.
IntActiQ12091. 1 interaction.
MINTiMINT-512159.

Structurei

3D structure databases

ProteinModelPortaliQ12091.
SMRiQ12091. Positions 44-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 145100Cytochrome b5 heme-bindingAdd
BLAST

Domaini

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 81 and 105.By similarity

Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00730000110959.
HOGENOMiHOG000187840.
InParanoidiQ12091.
KOiK17278.
OMAiDEKIFIA.
OrthoDBiEOG73JM6Z.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFIKNLLFG GVKTSEDPTG LTGNGASNTN DSNKGSEPVV AGNFFPRTLS
60 70 80 90 100
KFNGHDDEKI FIAIRGKVYD CTRGRQFYGP SGPYTNFAGH DASRGLALNS
110 120 130 140 150
FDLDVIKDWD QPIDPLDDLT KEQIDALDEW QEHFENKYPC IGTLIPEPGV

NV
Length:152
Mass (Da):16,758
Last modified:November 1, 1996 - v1
Checksum:i3E3CAC2403C3246F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96770 Genomic DNA. Translation: CAA65551.1.
Z73526 Genomic DNA. Translation: CAA97876.1.
AY558521 Genomic DNA. Translation: AAS56847.1.
BK006949 Genomic DNA. Translation: DAA11264.1.
PIRiS65181.
RefSeqiNP_015155.1. NM_001183984.1.

Genome annotation databases

EnsemblFungiiYPL170W; YPL170W; YPL170W.
GeneIDi855933.
KEGGisce:YPL170W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96770 Genomic DNA. Translation: CAA65551.1.
Z73526 Genomic DNA. Translation: CAA97876.1.
AY558521 Genomic DNA. Translation: AAS56847.1.
BK006949 Genomic DNA. Translation: DAA11264.1.
PIRiS65181.
RefSeqiNP_015155.1. NM_001183984.1.

3D structure databases

ProteinModelPortaliQ12091.
SMRiQ12091. Positions 44-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36013. 42 interactions.
DIPiDIP-5226N.
IntActiQ12091. 1 interaction.
MINTiMINT-512159.

Proteomic databases

MaxQBiQ12091.
PeptideAtlasiQ12091.
TopDownProteomicsiQ12091.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL170W; YPL170W; YPL170W.
GeneIDi855933.
KEGGisce:YPL170W.

Organism-specific databases

EuPathDBiFungiDB:YPL170W.
SGDiS000006091. DAP1.

Phylogenomic databases

GeneTreeiENSGT00730000110959.
HOGENOMiHOG000187840.
InParanoidiQ12091.
KOiK17278.
OMAiDEKIFIA.
OrthoDBiEOG73JM6Z.

Enzyme and pathway databases

BioCyciYEAST:G3O-34066-MONOMER.

Miscellaneous databases

NextBioi980678.
PROiQ12091.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of 55 kb on the left arm of yeast chromosome XVI identifies a small nuclear RNA, a new putative protein kinase and two new putative regulators."
    Purnelle B., Coster F., Goffeau A.
    Yeast 12:1483-1492(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor."
    Hand R.A., Jia N., Bard M., Craven R.J.
    Eukaryot. Cell 2:306-317(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDAP1_YEAST
AccessioniPrimary (citable) accession number: Q12091
Secondary accession number(s): D6W3J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.