ID   YD020_YEAST             Reviewed;         232 AA.
AC   Q12084;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 74.
DE   RecName: Full=Putative uridine kinase YDR020C;
DE            EC=2.7.1.48;
GN   OrderedLocusNames=YDR020C; ORFNames=PZE232;
OS   Saccharomyces cerevisiae (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=97051598; PubMed=8896275;
RX   DOI=10.1002/(SICI)1097-0061(199609)12:10B<1085::AID-YEA9>3.3.CO;2-S;
RA   Eide L.G., Sander C., Prydz H.;
RT   "Sequencing and analysis of a 35.4 kb region on the right arm of
RT   chromosome IV from Saccharomyces cerevisiae reveal 23 open reading
RT   frames.";
RL   Yeast 12:1085-1090(1996).
RN   [2]
RP   ERRATUM.
RA   Eide L.G., Sander C., Prydz H.;
RL   Yeast 13:189-189(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   MEDLINE=97313263; PubMed=9169867;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N.,
RA   Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M.,
RA   Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L.,
RA   Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M.,
RA   Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S.,
RA   Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M.,
RA   Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S.,
RA   Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K.,
RA   Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D.,
RA   Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C.,
RA   Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T.,
RA   Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W.,
RA   Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K.,
RA   Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S.,
RA   Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A.,
RA   Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S.,
RA   Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M.,
RA   Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y.,
RA   Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M.,
RA   Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E.,
RA   Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R.,
RA   Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A.,
RA   Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F.,
RA   Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G.,
RA   Kolodner R.D., LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-
RT   encoding clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   MEDLINE=22923954; PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [6]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   MEDLINE=22923965; PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
RA   Dephoure N., O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- CATALYTIC ACTIVITY: ATP + uridine = ADP + UMP.
CC   -!- CATALYTIC ACTIVITY: ATP + cytidine = ADP + CMP.
CC   -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage
CC       pathway; CTP from cytidine: step 1/3.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage
CC       pathway; UMP from uridine: step 1/1.
CC   -!- INTERACTION:
CC       Self; NbExp=1; IntAct=EBI-35824, EBI-35824;
CC       P27515:URK1; NbExp=1; IntAct=EBI-35824, EBI-20151;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC   -!- MISCELLANEOUS: Present with 4280 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the uridine kinase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; X95966; CAA65212.1; -; Genomic_DNA.
DR   EMBL; Z49770; CAA89845.1; -; Genomic_DNA.
DR   EMBL; Z74316; CAA98841.1; -; Genomic_DNA.
DR   EMBL; AY558571; AAS56897.1; -; Genomic_DNA.
DR   PIR; S54643; S54643.
DR   RefSeq; NP_010303.1; -.
DR   DIP; DIP:1721N; -.
DR   IntAct; Q12084; 2.
DR   Ensembl; YDR020C; Saccharomyces cerevisiae.
DR   GeneID; 851583; -.
DR   GenomeReviews; Z71256_GR; YDR020C.
DR   KEGG; sce:YDR020C; -.
DR   NMPDR; fig|4932.3.peg.1046; -.
DR   CYGD; YDR020c; -.
DR   SGD; S000002427; YDR020C.
DR   HOGENOM; Q12084; -.
DR   OMA; Q12084; CGCYALY.
DR   BRENDA; 2.7.1.48; 250.
DR   NextBio; 969052; -.
DR   ArrayExpress; Q12084; -.
DR   GermOnline; YDR020C; Saccharomyces cerevisiae.
DR   GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group ...; IEA:InterPro.
DR   GO; GO:0004849; F:uridine kinase activity; IEA:EC.
DR   InterPro; IPR000764; Uridine_kinase.
DR   PANTHER; PTHR10285:SF6; Uridine_kin; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding;
KW   Nucleus; Transferase.
FT   CHAIN         1    232       Putative uridine kinase YDR020C.
FT                                /FTId=PRO_0000242489.
FT   NP_BIND      17     24       ATP (Potential).
SQ   SEQUENCE   232 AA;  26595 MW;  4171B063EE750613 CRC64;
     MDRKAVEEKR IVISIGGGHA TGVGAIALDL QNTFKSLYNS INIRVINLDN MIEGNIKSYN
     NNDYDFDNIL NLVYEKHAVT SQNDMIQHDY EDPIDLIIVC GCYALYDKRI NEISQLKVFL
     DSDADKRLIS LIKKKNVGSN EQLAQLITEY MDHLRPEMQQ YIEPTRTFAD LIIPSTNENL
     GRAVLVDGIV KAIEDTKSQI EGNNTNNKIR PRLWDFEAET MDLEKDRYYD LS
//