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Protein

Metal homeostasis factor ATX2

Gene

ATX2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions in the homeostasis of manganese ions.

GO - Molecular functioni

  • manganese ion transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular manganese ion homeostasis Source: SGD
  • manganese ion transmembrane transport Source: GOC
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33616-MONOMER.

Protein family/group databases

TCDBi2.A.5.2.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Metal homeostasis factor ATX2
Gene namesi
Name:ATX2
Ordered Locus Names:YOR079C
ORF Names:YOR29-30
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR079C.
SGDiS000005605. ATX2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22LumenalSequence analysis
Transmembranei3 – 2321HelicalSequence analysisAdd
BLAST
Topological domaini24 – 6744CytoplasmicSequence analysisAdd
BLAST
Transmembranei68 – 8821HelicalSequence analysisAdd
BLAST
Topological domaini89 – 10315LumenalSequence analysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence analysisAdd
BLAST
Topological domaini125 – 15430CytoplasmicSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST
Topological domaini176 – 1838LumenalSequence analysis
Transmembranei184 – 20421HelicalSequence analysisAdd
BLAST
Topological domaini205 – 21713CytoplasmicSequence analysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence analysisAdd
BLAST
Topological domaini239 – 25113LumenalSequence analysisAdd
BLAST
Transmembranei252 – 27221HelicalSequence analysisAdd
BLAST
Topological domaini273 – 28513CytoplasmicSequence analysisAdd
BLAST
Transmembranei286 – 30621HelicalSequence analysisAdd
BLAST
Topological domaini307 – 3137LumenalSequence analysis

GO - Cellular componenti

  • Golgi membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: SGD
  • trans-Golgi network Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Metal homeostasis factor ATX2PRO_0000064758Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi34478. 16 interactions.
DIPiDIP-3832N.
IntActiQ12067. 1 interaction.
MINTiMINT-552711.

Structurei

3D structure databases

ProteinModelPortaliQ12067.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000000784.
InParanoidiQ12067.
KOiK14715.
OMAiIHKIPAV.
OrthoDBiEOG7RBZKM.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLGVILLA SFLLIATFLI GLIPLYYIDK QKSSIVTNQE GADSISDFTT
60 70 80 90 100
NADTQTINDD VSSYRVKIAV LSQFGIGMLL GTSFMLVIPE GIKACVEHDG
110 120 130 140 150
NVGVNLLIGF LGVYVLDRLV TLWVSRKQTV YTHDAVKFQS WKDIINHPRQ
160 170 180 190 200
IWMNLIQNNV VFALFIHGLS DGIALGTTTN NDSLLIVVLI AIVIHKIPAV
210 220 230 240 250
LSLTSLMVSR QNLMKWEVIC NVFLFASSTP IGYIVLSLLN LSHSPTMDWI
260 270 280 290 300
SGNLLLMSGG SLLYASFTAF VGGDSHDHDL SVEQEVVLPH DESVYVLIGV
310
CIPLVISYCI SEE
Length:313
Mass (Da):34,408
Last modified:November 1, 1997 - v1
Checksum:i81DAEFB0E4692268
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46033 Genomic DNA. Translation: AAB37236.1.
Z74987 Genomic DNA. Translation: CAA99272.1.
Z70678 Genomic DNA. Translation: CAA94564.1.
AY558037 Genomic DNA. Translation: AAS56363.1.
BK006948 Genomic DNA. Translation: DAA10858.1.
PIRiS66962.
RefSeqiNP_014722.1. NM_001183498.1.

Genome annotation databases

EnsemblFungiiYOR079C; YOR079C; YOR079C.
GeneIDi854246.
KEGGisce:YOR079C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46033 Genomic DNA. Translation: AAB37236.1.
Z74987 Genomic DNA. Translation: CAA99272.1.
Z70678 Genomic DNA. Translation: CAA94564.1.
AY558037 Genomic DNA. Translation: AAS56363.1.
BK006948 Genomic DNA. Translation: DAA10858.1.
PIRiS66962.
RefSeqiNP_014722.1. NM_001183498.1.

3D structure databases

ProteinModelPortaliQ12067.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34478. 16 interactions.
DIPiDIP-3832N.
IntActiQ12067. 1 interaction.
MINTiMINT-552711.

Protein family/group databases

TCDBi2.A.5.2.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR079C; YOR079C; YOR079C.
GeneIDi854246.
KEGGisce:YOR079C.

Organism-specific databases

EuPathDBiFungiDB:YOR079C.
SGDiS000005605. ATX2.

Phylogenomic databases

HOGENOMiHOG000000784.
InParanoidiQ12067.
KOiK14715.
OMAiIHKIPAV.
OrthoDBiEOG7RBZKM.

Enzyme and pathway databases

BioCyciYEAST:G3O-33616-MONOMER.

Miscellaneous databases

NextBioi976156.
PROiQ12067.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Suppression of oxidative damage by Saccharomyces cerevisiae ATX2, which encodes a manganese-trafficking protein that localizes to Golgi-like vesicles."
    Lin S.-J., Culotta V.C.
    Mol. Cell. Biol. 16:6303-6312(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The sequence of a 54.7 kb fragment of yeast chromosome XV reveals the presence of two tRNAs and 24 new open reading frames."
    Valens M., Bohn C., Daignan-Fornier B., Dang V.-D., Bolotin-Fukuhara M.
    Yeast 13:379-390(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiATX2_YEAST
AccessioniPrimary (citable) accession number: Q12067
Secondary accession number(s): D6W2E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.