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Protein

Metal homeostasis factor ATX2

Gene

ATX2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in the homeostasis of manganese ions.

GO - Molecular functioni

  • manganese ion transmembrane transporter activity Source: SGD
  • zinc ion transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • cellular manganese ion homeostasis Source: SGD
  • zinc II ion transmembrane transport Source: GO_Central

Enzyme and pathway databases

BioCyciYEAST:G3O-33616-MONOMER

Protein family/group databases

TCDBi2.A.5.2.1 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Metal homeostasis factor ATX2
Gene namesi
Name:ATX2
Ordered Locus Names:YOR079C
ORF Names:YOR29-30
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR079C
SGDiS000005605 ATX2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2LumenalSequence analysis2
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Topological domaini24 – 67CytoplasmicSequence analysisAdd BLAST44
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 103LumenalSequence analysisAdd BLAST15
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 154CytoplasmicSequence analysisAdd BLAST30
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 183LumenalSequence analysis8
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 217CytoplasmicSequence analysisAdd BLAST13
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 251LumenalSequence analysisAdd BLAST13
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 285CytoplasmicSequence analysisAdd BLAST13
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Topological domaini307 – 313LumenalSequence analysis7

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000647581 – 313Metal homeostasis factor ATX2Add BLAST313

Proteomic databases

PaxDbiQ12067

Interactioni

Protein-protein interaction databases

BioGridi34478, 67 interactors
DIPiDIP-3832N
IntActiQ12067, 1 interactor
MINTiQ12067
STRINGi4932.YOR079C

Structurei

3D structure databases

ProteinModelPortaliQ12067
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000000784
InParanoidiQ12067
KOiK14715
OMAiVGGMGHS
OrthoDBiEOG092C3O8G

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit

Sequencei

Sequence statusi: Complete.

Q12067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLGVILLA SFLLIATFLI GLIPLYYIDK QKSSIVTNQE GADSISDFTT
60 70 80 90 100
NADTQTINDD VSSYRVKIAV LSQFGIGMLL GTSFMLVIPE GIKACVEHDG
110 120 130 140 150
NVGVNLLIGF LGVYVLDRLV TLWVSRKQTV YTHDAVKFQS WKDIINHPRQ
160 170 180 190 200
IWMNLIQNNV VFALFIHGLS DGIALGTTTN NDSLLIVVLI AIVIHKIPAV
210 220 230 240 250
LSLTSLMVSR QNLMKWEVIC NVFLFASSTP IGYIVLSLLN LSHSPTMDWI
260 270 280 290 300
SGNLLLMSGG SLLYASFTAF VGGDSHDHDL SVEQEVVLPH DESVYVLIGV
310
CIPLVISYCI SEE
Length:313
Mass (Da):34,408
Last modified:November 1, 1997 - v1
Checksum:i81DAEFB0E4692268
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46033 Genomic DNA Translation: AAB37236.1
Z74987 Genomic DNA Translation: CAA99272.1
Z70678 Genomic DNA Translation: CAA94564.1
AY558037 Genomic DNA Translation: AAS56363.1
BK006948 Genomic DNA Translation: DAA10858.1
PIRiS66962
RefSeqiNP_014722.1, NM_001183498.1

Genome annotation databases

EnsemblFungiiYOR079C; YOR079C; YOR079C
GeneIDi854246
KEGGisce:YOR079C

Similar proteinsi

Entry informationi

Entry nameiATX2_YEAST
AccessioniPrimary (citable) accession number: Q12067
Secondary accession number(s): D6W2E2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health